scholarly journals Optimasi Asam Glikolat dan Asam Sitrat dalam Krim Tabir Surya Kombinasi Titanium Dioksida, Avobenzone dan Octyl Methoxycinnamate

2020 ◽  
Vol 8 (3) ◽  
pp. 139
Author(s):  
Desy Diana Sari ◽  
Lidya Ameliana ◽  
Dwi Nurahmanto
Keyword(s):  
Titanium Dioxide ◽  
Citric Acid ◽  
Adverse Effects ◽  
Uv Radiation ◽  
Glycolic Acid ◽  
Design Method ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
Optimum Formula

Ultraviolet (UV) radiation is the main cause of sunburn and skin cancer. The adverse effects of UV radiation are solved by sunscreen as protection for longer outdoors. In this study, optimization of glycolic acid and citric acid in sunscreen cream combination of titanium dioxide, avobenzone, and octyl methoxycinnamate were investigated using simplex lattice design method. The sunscreen cream evaluation includes physicochemical testing (organoleptic, homogeneity, emulsion type, spreadability, viscosity, and pH) and sunscreen effectiveness (SPF, % erythema transmission, and % pigmentation transmission). The value of physicochemical testing are 5,96 cm - 6,3 cm of  spreadability testing; 83,33 dPa.s – 108,33 dPa.s of viscosity testing; 4,06 – 4,67 of pH testing. The value of sunscreen effectiveness are 9,79 – 13,35 of SPF testing; 4,55x10-06 - 0,15x10-06% of % erythema transmission; 5,77 – 7,16 % of % pigmentation transmission. The optimum formula was obtained by combining glycolic acid 2% and citric acid 0% with a desirability value of 0,649.

scholarly journals Optimasi Formula Tablet Piroksikam Menggunakan Eksipien Laktosa, Avicel pH-101, dan Amprotab dengan Metode Simplex Lattice Design

2020 ◽  
Vol 17 (1) ◽  
pp. 31-44
Author(s):  
Ikhwan Yuda Kusuma ◽  
Rani Prabandari
Keyword(s):  
Physical Properties ◽  
Design Method ◽  
Dominant Factor ◽  
Content Uniformity ◽  
Compression Tests ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Contour Plots ◽  
Simplex Lattice ◽  
Optimum Formula

Piroxicam solubility in water is very small this cause problem in the process of absorption so that it’s required an optimal formula to establish the physical properties of tablet quality for piroxicam tablets. The purpose of this research was creating formulas with the optimal combination of excipients lactose, Avicel pH 101, and piroxicam amprotab to obtain tablets with good physical properties and disolution. Seven piroxicam tablet formulas were made with a combination of lactose, avicel PH-101, and Amprotab on 2 batches. Method for making tablets piroxicam was established by direct compression. Tests included were the physical properties of piroxicam tablets tablets weight uniformity, uniformity of size, hardness, brittleness, disintegration test, as well as dissolution test, and content uniformity. Based on the simplex lattice design method, lactose is a dominant factor to improved the uniformity of tablet’s concentartions. Interaction of two components avicel PH-101 and amprotab is a dominant factor to reduced vulnerability. Interaction of three components lactose, avicel PH-101 and amprotab is a dominant factor to lowered the value coefisien variation of weight uniformity, increased hardness, decreased the disintegration, and improved dissolution of tablets. Selection of the optimum formula was determined by the method of simplex lattice design through diagrams superimposed contour plots and contour plots for obtaining the optimal proportions of each ingredient as follows: lactose (85,154–100%), avicel PH-101 (0–12,437%), and amprotab (0–5,425%).

scholarly journals OPTIMASI ASAM STEARAT DAN TEA PADA FORMULA SEDIAAN KRIM EKSTRAK KULIT PISANG KEPOK (Musa paradisiaca L.)

2019 ◽  
Vol 1 (3) ◽  
pp. 225-237
Author(s):  
Dwi Saryanti ◽  
Iwan Setiawan ◽  
Romadona Ayu Safitri
Keyword(s):  
Stearic Acid ◽  
Maximum Concentration ◽  
Design Method ◽  
Minimum Concentration ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Significant Difference ◽  
Simplex Lattice ◽  
Optimum Formula ◽  
Optimal Formula

Banana kepok peel has flavonoid compounds used as antioxidants. The aim of this research is to get optimum formula of cream by combination of stearic acid and trietanolamin on good physical propertie of cream. Cream was made with stearic acid 15% minimum concentration and maximum concentration 17%, triethanolamine with minimum concentration 2% and maximum concentration 4%. The optimization of the formula was using the simplex lattice design method with parameters are pH, viscosity, spreadability, adhesion and protection. The optimum cream formula on the combination of stearic acid 16.7 grams and triethanolamine 2.3 grams. Verification results of optimal formula cream for pH got 6.1, viscosity 237.47, adhesion 12.32, power spread 18.11, protection 14.98 which showed no significant difference in the test, and has good stability.

scholarly journals Optimasi Propilen Glikol dan Etanol sebagai Peningkat Penetrasi Ibuprofen dalam Sediaan Gel dengan Metode Simplex Lattice Design (Propylene Glycol and Ethanol Optimization as Ibuprofen Penetration Enhancer in Gel Dosage using Simplex Lattice Design Metho

2018 ◽  
Vol 6 (1) ◽  
pp. 11
Author(s):  
Baiq Wahyudyati Karnia Qisti ◽  
Dwi Nurahmanto ◽  
Viddy Agustian Rosyidi
Keyword(s):  
Propylene Glycol ◽  
Penetration Rate ◽  
Design Method ◽  
Penetration Enhancers ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
Rate Optimization ◽  
Optimum Formula ◽  
Optimum Solution

Ibuprofen is a non-steroid anti inflammatory drug (NSAID) used for rheumatoid arthritis treatment. In this study, formulation, evaluation, and optimization of ibuprofen gel formula were conducted in order to determine the best ibuprofen penetration rate through the rats skin using propylene glycol and ethanol as penetration enhancers and to find out the optimum formula to get the best penetration rate with simplex lattice design method. Evaluations included organoleptic, pH, viscosity, gel dispersive, assay of gel formulations, and ibuprofen penetration rate assay. Penetration rate was determined by paddle type dissolution and the samples were analyzed by spectrophotometry UV-Vis. The results of ibuprofen penetration rate assay were analyzed and optimized using design expert trial version 10. The results of ibuprofen penetration rate were F1 1.524 ± 0.121 µg/cm2.minute; F2 1.945 ± 0.0104 µg/cm2.minute; and F3 1.173 ± 0.216 µg/cm2.minute. Penetration rate optimization resulted in one optimum solution formula which was 18.000% propylene glycol and 12.000% ethanol with a maximum flux of 1.957 ug/cm2.minute and desirability 1. It can be concluded that the best ibuprofen penetration rate was F2 with flux 1.945 ± 0.0104 µg/cm2.minute with 15% propylene glycol and 15% ethanol.   Keywords: gel, ibuprofen, propylene glycol, ethanol, simplex lattice design  

scholarly journals OPTIMASI GEL HAND SANITIZER OLEUM CITRI DENGAN KOMBINASI CARBOPOL, LIDAH BUAYA DAN TEA MENGGUNAKAN SIMPLEX LATTICE DESIGN

2021 ◽  
Vol 6 (1) ◽  
pp. 21-28
Author(s):  
Joko Santoso ◽  
◽  
Heru Nurcahyo
Keyword(s):  
Physical Properties ◽  
Design Method ◽  
Aloe Vera ◽  
Homogeneity Test ◽  
Stabilizing Agents ◽  
Hand Sanitizer ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
Optimum Formula

Handsanitizer gel is composed of various additives such as geling agents, humectants and neutralizing / stabilizing agents. This material is certainly a basic ingredient that will affect the shape and quality of the preparation. Carbopol is very good when used, so that low levels can provide a significant viscosity response. Eleven hand sanitizer gel formulas with variations of carbomer, aloe vera and TEA were tested for their physical properties including organoleptic, homogeneity test, pH test, spreadability and adhesion test . The optimum formula is obtained by using the Simplex Lattice Design method, then the results are analyzed using an expert design software. The optimum formula for oleum citri hand sanitizer gel contains 0.944 with carbomer 0 (0.5%), aloe vera 0.471 (5.239%) and TEA 0.529 (0.576%). The t test results obtained showed insignificant differences between the response of the physical properties of the experiment results and the prediction software.

scholarly journals Formula Optimization of Fast Disintegrating Tablet (FDT) of Centella asiatica (L.) Urb. Ethanolic Extract

2018 ◽  
Vol 16 (1) ◽  
pp. 94
Author(s):  
Agatha Budi Susiana Lestari ◽  
Achmad Fudholi ◽  
Akhmad Kharis Nugroho ◽  
Erna Prawita Setyowati
Keyword(s):  
Dosage Form ◽  
Design Method ◽  
Ethanolic Extract ◽  
Centella Asiatica ◽  
Disintegration Time ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Fast Disintegrating Tablet ◽  
Simplex Lattice ◽  
Optimum Formula

It has been proven that Centella asiatica (L.) Urb. herbs have an antioxidant activity that make it possible to used in preventing degenerative illness. Centella asiatica (L.) extract has been formulated to fast disintegrating tablet (FDT) dosage form. The aims of this study are to find the optimum formula of FDT of Centella asiatica (L.) Urb. The simplex lattice design method with 3 factors (which are mannitol as diluents, crospovidone as superdisintegrant and povidone as binder) and 2 levels of each was used. Centella asiatica (L.) Urb. extract was produce from maceration process using ethanol-water in ratio 75%:25% as a solvent. Direct compress method was used to produce the FDT. The results show that the optimum composition between excipients FDT formula could be reached, which fullfiled the physical properties parameter which are the hardness, friability and disintegration time of FDT.

scholarly journals Application of Simplex Lattice Design Method on The Optimisation of Deodorant Roll-on Formula of Ashitaba (Angelica keiskei)

2021 ◽  
Vol 21 (2) ◽  
pp. 501
Author(s):  
Wahida Hajrin ◽  
Windah Anugrah Subaidah ◽  
Yohanes Juliantoni ◽  
Dyke Gita Wirasisya
Keyword(s):  
Optimization Design ◽  
Design Method ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Optimization Parameters ◽  
Angelica Keiskei ◽  
Potential Activity ◽  
Simplex Lattice ◽  
Optimum Formula ◽  
The Right

Ashitaba is known to have antioxidant activity and gram-positive antibacterial activity that causes body odor. This is the potential activity for an active substance to be developed as deodorant. The appropriate formula is needed, so it is necessary to optimize the formula using the right method. This study aimed was to determine the application of the simplex lattice design method on the optimization of a deodorant roll-on formula of ashitaba extract. Ashitaba was extracted by the maceration method. The formula optimization design was determined using the simplex lattice design method by Design Expert®7.5.1. The components for optimization were the concentration of carbopol and concentration of TEA, and the optimization parameters were the spreadability test, sticky power, and pH test. The optimum formula of deodorant consists of 0.45% carbopol and 2.05% TEA. The responses of optimum formula obtained spreadability test 6.32 ± 0.33 cm, sticky power 44.67 ± 3.94 seconds, and pH 7.73 ± 0.17. These results meet the criteria for good preparation but need further testing related to the effectiveness of the preparation and the level of acceptance of the preparation by the user.

scholarly journals Optimization Formula Tablet Extract of Bengkuang (Pachyrrhizus erosus) Variation Avicel® Ph 101 and Crospovidone

2018 ◽  
Vol 23 (1) ◽  
pp. 9
Author(s):  
Rizki Kharisma ◽  
Ika Puspita Sari ◽  
Angi Nadya Bestari
Keyword(s):  
Design Method ◽  
Wet Granulation ◽  
Flow Properties ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Menopausal Women ◽  
Simplex Lattice ◽  
The Stability ◽  
Optimum Formula ◽  
Tuber Extract

Bengkuang (Pachyrrhizus erosus) contains daidzein which is pro-estrogenic compound, suppressing bone restoration by directing mechanism in bone estrogen receptor. Bengkuang can be developed into a useful source of phytoestrogens as a supplement in menopausal women. This study aims to determine the stability and influence of Avicel® PH 101 and crospovidone on granular flow properties and physical properties of Bengkuang tuber extract. Bengkuang tuber extracts were made into tablet preparations by wet granulation method. Variation of crospovidone composition was between 2-5%, while Avicel® PH 101 was between 38.86 to 41.86%. The tablet formulation is optimized using the Simplex Lattice Design method. The results show that the addition of Avicel® PH 101 can improve the index of determination, water absorption, moisture content, hardness, time of disintegration, and friability of the tablet, as well as crospovidone addition. Avicel® PH 101 and crospovidone interactions increase water content, decrease hardness, and tablet friability. The optimum tablet formula consists of composition of 293 mg of Avicel® PH 101 and 14 mg of crospovidone per tablet. Testing of optimum formula results with SLD method did not differ significantly to the response of the compression index, hardness and friability of the tablet. The tablet was stable at room temperature (30ºC ± 2 ºC) for four weeks.

scholarly journals Metoclopramide-OROS Dispersible Tablets Optimized Formula Bioavailability Study

2020 ◽  
Vol 8 (A) ◽  
pp. 338-341
Author(s):  
Samran Samran ◽  
Hari Ronaldo Tanjung
Keyword(s):  
High Performance ◽  
Corn Starch ◽  
Reference Product ◽  
Design Method ◽  
In Vivo Test ◽  
Lattice Design ◽  
Dispersible Tablet ◽  
Simplex Lattice ◽  
Optimum Formula

BACKGROUND: Bioavailability and bioequivalence studies required by regulations to ensure therapeutic equivalence between a pharmaceutically equivalent test product and a reference product. AIM: This study aimed to evaluate the bioavailability performance between the optimum formula of OROS dispersible tablet-metoclopramide dosage forms (FCL-6) and the Primperan® as the reference product. METHODS: The FCL-6 formula was design by simplex lattice design model with a three components mixture of excipients: Solid tapai extract, corn starch, and Avicel. The optimum formula of OROS dispersible tablet (ODT)-metoclopramide consists of solid tapai extract (27.038 mg), corn starch (27.407 mg), and Avicel (53.555 mg), metoclopramide hydrochloric acid (HCl) (10.00 mg), LH-11 (22.50 mg), aspartame (5.00 mg), talcum BP (3.00 mg), and Mg stearate (1.50 mg). The in vivo test was done by cross-over design method using six rabbits. The level of metoclopramide concentration from in vivo test was measured by high-performance liquid chromatography instrument. RESULTS: The study revealed that the tmax, Cmax, and area under curve (AUC) of ODT-metoclopramide FCL-6 were 60 min, 1.95 ± 0.13 μg/mL, and 1118.20 ± 150 μg/mL. min consecutively. The Cmax and the concentration of the drug absorbed in the blood (AUC) of ODT-metoclopramide were larger than Primperan® tablets. Statistical data of the optimized ODT-metoclopramide compared with Primperan® showed that the Cmax and AUC significance values were <0.05 (p < 0.05). CONCLUSION: The optimized formula of ODT-metoclopramide revealed a better characteristic of Cmax and AUC concentration compared with Primperan®. The optimized ODT-metoclopramide with tapai extract was found to be promising to improved bioavailability of metoclopramide.

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