Asymmetric one-pot synthesis of cyclopropanes
2016 ◽
Vol 35
(1)
◽
pp. 45
Keyword(s):
One Pot
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Cycloaddition of the diazoalkanes to electron-deficient olefins (in situ) affords polysubstituted cyclopropanes in high yields (up to 85%). Deprotection of the ketal protecting group provided water-soluble cyclopropane-bearing carbohydrate in good yields. Antimicrobial activity screening of the synthesized compounds 8 and 9, utilizing a variety of Gram-positive (Staphylococcus aureus and Enterococcus fecalis), Gram-negative bacteria (Escherichia coli and Klebsiella pneumoniae) and yeast (Candida albicans), exhibited that all the prepared analogues acquire promising activities against both Gram-positive and Gram-negative bacteria especially compounds 9b and 9c (antimicrobial active agents against Gram-negative bacteria).
2019 ◽
Vol 18
(5)
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pp. 1147-1155
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1988 ◽
Vol 55
(4)
◽
pp. 597-602
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2006 ◽
Vol 50
(1)
◽
pp. 385-387
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2012 ◽
Vol 3
◽
pp. 684-691
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2015 ◽
Vol 14
(10)
◽
pp. 1872-1879
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Keyword(s):
1988 ◽
Vol 34
(4)
◽
pp. 526-535
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Keyword(s):