Evaluation of anti-obesity activity of Thespesia populnea (L.) and flavonoid isolated quercetin on high fat diet –induced obese rats

2016 ◽  
Vol 2 (1) ◽  
pp. 46 ◽  
Author(s):  
Gandhimathi Retnasamy ◽  
Sreedevi Adikay
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Tween 80 ◽  
Coronary Risk ◽  
High Fat ◽  
Thespesia Populnea ◽  
Risk Indices ◽  
Obese Rats

The anti-obesity activity of ethanol extract of the stem bark of Thespesia populnea L., (EETP) was evaluated in High Fat Diet (HFD) induced obese rats and flavonoid isolated of Quercetin was characterized. Acute oral toxicity studies revealed that EETP is safe up to 2000mg/kg and doses were selected. Six groups of rats were used and administered orally with vehicle 0.2ml of 1% tween 80 (normal control), fed on HFD+0.2ml of 1% tween 80 (negative control), fed on HFD+EETP (100, 200 & 400 mg/kg) and fed on HFD+ Orlistat 50 mg/kg (positive control), for 40 days respectively. The body rectal temperature, food intake, Lee index and body weight of the animals were recorded and the whole brain was dissected out for estimation of serotonin on day 41. The blood samples were collected by cardiac puncture and used for the estimation of lipid profile. The atherogenic and coronary risk indices were calculated from lipid profile. Obese rats pretreated with EETP or Orlistat exhibited significant increase in body rectal temperature and decrease in food intake, Lee index and body weight of the animals. Moreover, the tested extracts showed beneficial effects on brain serotonin, lipid profile, atherogenic and coronary risk indices in rats. In conclusion, EETP exerts potential anti-obesity activity that could be partly attributed to its flavonoid Quercetin and other bioactive phytoconstituents.

High fat diet-induced estrus cycle disruption: effects of Ficus asperifolia

2015 ◽  
Vol 12 (3) ◽  
Author(s):  
Esther Ngadjui ◽  
Pepin Alango Nkeng-Efouet ◽  
Telesphore Benoit Nguelefack ◽  
Albert Kamanyi ◽  
Pierre Watcho
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
Tween 80 ◽  
The Body ◽  
Female Rats ◽  
Vaginal Smear ◽  
High Fat ◽  
Methanolic Extracts ◽  
Obese Rats

Abstract:: Obesity was reached by feeding female rats with a HFD for 10 weeks. Vaginal smear was observed daily for 3 weeks after animals were obese. Then, 70 animals with abnormal estrus cyclicity were selected and partitioned into two sets of 35 animals. Each set was further divided into seven groups of five rats. These obese rats with disrupted estrus cyclicity were orally administered the aqueous and methanolic extracts (100 and 500 mg/kg), distilled water (10 mL/kg), 5% Tween 80 (10 mL/kg) or lutenyl (0.8 µg/kg) once a day for 1 week (set I) or 4 weeks (set II). Estrus cyclicity, body weight gain, hematocrit, lipid profile, ovarian, uterine and hepatic growth indices were determined at the end of each treatment.: HFD increased the body weight of the animals by 27% and disrupted the estrus cyclicity by 98.44%. Aqueous extract (100 mg/kg) of: Our data support the anecdotal claims of

scholarly journals POTENTIAL OF DUNALIELLA SALINA MICROALGAE TO AMELIORATE HIGH-FAT DIET‑INDUCED OBESITY IN ANIMALS’ RODENT

2018 ◽  
Vol 11 (3) ◽  
pp. 312 ◽  
Author(s):  
Farouk K El-baz ◽  
Hanan F Aly
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Dunaliella Salina ◽  
Body Weight Gain ◽  
Ethanolic Extract ◽  
High Fat ◽  
Related Complication ◽  
Standard Drug ◽  
Reduced Body ◽  
Obese Rats

 Objective: This study was carried out to investigate the potential of Dunaliella salina microalgae to ameliorate obesity induced by high-fat diet (HFD) in male Wistar rats.Methods: Fifty rats weighing 150–160 g were fed HFD for 12 weeks. The rats were randomly divided into five groups of ten rats each. Obese rats were orally administered D. salina ethanolic extract (150 mg/Kg body weight), and orlistat as standard drug (12 mg/Kg body weight), for 6 weeks.Results: Treatment of obese rats with both D. salina and orlistat had a significant effect in reducing body and liver weights as well as visceral fat, inhibiting pancreatic lipase activity, decreased lipid profile, and increased fecal fat and ameliorating liver function enzymes activity, insulin, blood glucose, and leptin levels. Besides, food intake was insignificantly increased as a result of D. salina and orlistat treatments compared with normal control rats.Conclusion: It could be concluded that D. salina rich in β-carotene significantly reduced body weight gain and ameliorated several metabolic pathways implicated in obesity and its related complication. Hence, further intensive study must be carried out to formulate D. Salina extracts to apply as a promising natural anti-obesity nutraceutical drug.

Anti-obesity action of gingerol: effect on lipid profile, insulin, leptin, amylase and lipase in male obese rats induced by a high-fat diet

2014 ◽  
Vol 94 (14) ◽  
pp. 2972-2977 ◽  
Author(s):  
Ganapathy Saravanan ◽  
Ponnusamy Ponmurugan ◽  
Machampalayam Arumugam Deepa ◽  
Balasubramanian Senthilkumar
Keyword(s):  
Lipid Profile ◽  
High Fat Diet ◽  
High Fat ◽  
Obese Rats

Lipid profile lowering effect of SoyproTMfermented with lactic acid bacteria isolated from Kimchi in high-fat diet-induced obese rats

BioFactors ◽  
2008 ◽  
Vol 33 (1) ◽  
pp. 49-60 ◽  
Author(s):  
Na-Hyung Kim ◽  
Hyung-Min Kim ◽  
Hyo-Jin An ◽  
Jae-Young Um ◽  
Phil-Dong Moon ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Lipid Profile ◽  
High Fat Diet ◽  
High Fat ◽  
Lowering Effect ◽  
Obese Rats

scholarly journals Modulation of Cognition: The Role of Gnidia glauca on Spatial Learning and Memory Retention in High-Fat Diet-Induced Obese Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-16
Author(s):  
Wycliffe Makori Arika ◽  
Cromwell Mwiti Kibiti ◽  
Joan Murugi Njagi ◽  
Mathew Piero Ngugi
Keyword(s):  
Body Weight ◽  
Learning And Memory ◽  
Spatial Learning ◽  
High Fat Diet ◽  
Spatial Learning And Memory ◽  
Therapeutic Effects ◽  
Memory Retention ◽  
High Fat ◽  
Obesity Index ◽  
Obese Rats

Chronic exposures to high-fat diets are linked to neuropathological changes that culminate in obesity-related cognitive dysfunction and brain alteration. Learning, memory performance, and executive function are the main domains affected by an obesogenic diet. There are limited effective therapies for addressing cognitive deficits. Thus, it is important to identify additional and alternative therapies. In African traditional medicine, Gnidia glauca has putative efficacy in the management of obesity and associated complications. The use of Gnidia glauca is largely based on its long-term traditional use. Its therapeutic application has not been accompanied by sufficient scientific evaluation to validate its use. Therefore, the current study sought to explore the modulatory effects of dichloromethane leaf extracts of Gnidia glauca on cognitive function in the high-fat diet- (HFD-) induced obese rats. Obesity was induced by feeding the rats with prepared HFD and water ad libitum for 6 weeks. The in vivo antiobesity effects were determined by oral administration of G. glauca at dosage levels of 200, 250, and 300 mg/kg body weight in HFD-induced obese rats from the 6th to the 12th weeks. The Lee obesity index was used as a diagnostic criterion of obesity. The Morris water maze was employed to test spatial learning and memory retention in rats. The results indicated that Gnidia glauca showed potent antiobesity effects as indicated in the reduction of body weight and obesity index in extract-treated rats. Moreover, Gnidia glauca exhibited cognitive-enhancing effects in obese rats. The positive influences on cognitive functions might be attributed to the extracts’ phytochemicals that have been suggested to confer protection against obesity-induced oxidative damage, reduction of central inflammation, and increased neurogenesis. The therapeutic effects observed suggest that Gnidia glauca might be an alternative to current medications for the symptomatic complications of obesity, such as learning and memory loss. Further studies are therefore needed to establish its toxicity profiles.

scholarly journals The Main and Interactive Effects of Fat and Sodium Contents of the Diet on Characteristics of Metabolic Syndrome in Male Wistar Rats (P08-038-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Alireza Jahan-Mihan ◽  
Kea Schwarz ◽  
Leila Nynia ◽  
Tatyana Kimble
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
High Fat Diet ◽  
Sodium Content ◽  
Fat Content ◽  
High Fat ◽  
High Sodium ◽  
Sodium Diet ◽  
Male Wistar Rats ◽  
High Sodium Diet

Abstract Objectives The objective of this study was to investigate the main and interactive effects of fat and sodium content of the diet on food intake, body weight and composition, glucose metabolism and blood pressure in male Wistar rats. Methods Male Wistar Rats (n = 48, initial body weight: 115.30 ± 1.73 g) were allocated into 4 groups (n = 12/group) and received one of the following diets: Normal sodium normal fat (NSNF), normal sodium high fat (NSHF), high sodium normal fat (HSNF), high sodium high fat (HSHF) diet for 12 weeks. Body weight (BW) and food intake (FI) were measured weekly. Short-term food intake (1, 2 and 12 hours food intake after 12 hours fasting) was measured at week 6. Body composition and organs’ weight were measured at week 12. Systolic (SBP) and diastolic (DBP) blood pressure, pulse and fasting blood glucose (FBG) were measured and oral glucose tolerance test (OGTT) was conducted at weeks 1, 4, 8 and 12. Results Regardless of sodium content, a greater FI (both gram and cal) was observed in rats fed normal fat diet compared with those fed high fat diet. Consistently, FI (g) at 1, 2 and 12 hours was higher in rats fed a normal fat diet. However, no difference in calorie intake was observed at any time point. Higher BW and fat (%) was observed in high fat diet groups. Moreover, greater kidneys’ weights was observed in high sodium diet groups. Fasting blood glucose was higher in rats fed a normal sodium diet compared with those fed a high sodium diet while the tAUC glucose response to glucose preload was higher in rats fed a high fat diet compared with those fed a normal fat diet which is consistent with higher body weight in high fat diet groups. Regardless of fat content of the diet, pulse was higher in rats fed a high sodium diet compared with those fed a normal sodium diet. No effect of either dietary sodium or fat content of the diet on SBP or DBP was observed. Conclusions Fat but not sodium content of the diet is a determining factor in regulation of FI and BW. Moreover, both fat and sodium content of the diet influence the glucose metabolism potentially through different mechanisms. While pulse is influenced by sodium content, the results of this study do not support the effect of sodium or fat content of the diet on either SBP or DBP. Funding Sources UNF, Brooks College of Health internal grant.

scholarly journals Cyanidin-3-O-Galactoside-Enriched Aronia melanocarpa Extract Attenuates Weight Gain and Adipogenic Pathways in High-Fat Diet-Induced Obese C57BL/6 Mice

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1190 ◽  
Author(s):  
Su-Min Lim ◽  
Hyun Sook Lee ◽  
Jae In Jung ◽  
So Mi Kim ◽  
Nam Young Kim ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
High Fat Diet ◽  
Fatty Acid Synthase ◽  
Binding Protein ◽  
Peroxisome Proliferator ◽  
High Fat ◽  
Peroxisome Proliferator Activated Receptor ◽  
Aronia Melanocarpa

Aronia melanocarpa are a rich source of anthocyanins that have received considerable interest for their relations to human health. In this study, the anti-adipogenic effect of cyanidin-3-O-galactoside-enriched Aronia melanocarpa extract (AM-Ex) and its underlying mechanisms were investigated in an in vivo system. Five-week-old male C57BL/6N mice were randomly divided into five groups for 8-week feeding with a control diet (CD), a high-fat diet (HFD), or a HFD with 50 (AM-Ex 50), 100 (AM-Ex 100), or 200 AM-Ex (AM-Ex 200) mg/kg body weight/day. HFD-fed mice showed a significant increase in body weight compared to the CD group, and AM-Ex dose-dependently inhibited this weight gain. AM-Ex significantly reduced the food intake and the weight of white fat tissue, including epididymal fat, retroperitoneal fat, mesenteric fat, and inguinal fat. Treatment with AM-Ex (50 to 200 mg/kg) reduced serum levels of leptin, insulin, triglyceride, total cholesterol, and low density lipoprotein (LDL)-cholesterol. Real-time reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed that AM-Ex suppressed adipogenesis by decreasing CCAAT/enhancer binding protein α, peroxisome proliferator-activated receptor γ, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma coactivator-1α, acetyl-CoA carboxylase 1, ATP-citrate lyase, fatty acid synthase, and adipocyte protein 2 messenger RNA (mRNA) expressions. These results suggest that AM-Ex is potentially beneficial for the suppression of HFD-induced obesity by modulating multiple pathways associated with adipogenesis and food intake.

scholarly journals Oat bran β-glucan improves glucose homeostasis in mice fed on a high-fat diet

RSC Advances ◽  
2017 ◽  
Vol 7 (86) ◽  
pp. 54717-54725 ◽  
Author(s):  
Yuliang Cheng ◽  
Jie Zhang ◽  
Kaiyun Luo ◽  
Genyi Zhang
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Glucose Homeostasis ◽  
High Fat Diet ◽  
High Fat ◽  
Low Fat ◽  
Oat Bran

The changes of body weight (A) and food intake (B) of mice fed on different diets of low-fat (LF), high-fat (HF), HF + grain form β-glucan (HFGF), and HF + extracted β-glucan (HFEX).

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