scholarly journals ANTIFUNGAL ACTIVITY OF DMSO EXTRACTS OF TEN SELECTED HERBS USED FOR THE TREATMENT OF ORAL CAVITY INFECTIONS WITH REFERENCE TO ORAL CARCINOMA

2016 ◽  
Vol 9 ◽  
pp. 24-30
Author(s):  
Shaista Suhail ◽  
Neeta Sharma ◽  
Ritu Srivastava ◽  
Madhu Srivastava ◽  
Shalini Gupta
Keyword(s):  
Antifungal Activity ◽  
Oral Cavity ◽  
Oral Carcinoma

scholarly journals Distribution of oral carcinoma case requiring radiotherapy in the Oral and Maxillofacial Surgery Clinics

2015 ◽  
Vol 27 (2) ◽  
Author(s):  
Dinda Tegar Jelita ◽  
Lucky Riawan ◽  
Herman Hambali
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adjuvant Radiotherapy ◽  
Maxillofacial Surgery ◽  
Oral Carcinoma ◽  
Oral And Maxillofacial Surgery ◽  
Age Group ◽  
Common Area

Introduction: Carcinoma is a highly malignant tumour of epithelium that occurred in the oral cavity. One of the most common therapies given is radiotherapy, with healing, adjuvant, and palliative intentions. This research was aimed to discover the distribution of oral carcinoma requiring radiotherapy. Methods: This study was a retrospective, descriptive method. Samples were taken from the medical record of patients with oral cavity carcinoma requiring radiotherapy at the Oral and Maxillofacial Surgery Clinics of Hasan Sadikin Hospital, Bandung, of January 2006–December 2010. Results: This study indicated that as many as 23 (20.9%) cases of oral carcinoma requiring radiotherapy from a total of 110 oral carcinoma cases in that period. Type of radiotherapy most frequently found was adjuvant radiotherapy, by 14 (60.8%) cases. The most frequent type of oral carcinoma case requiring radiotherapy was squamous cell carcinoma, by 12 (52.1%) cases. Tongue become the most common area of oral carcinoma requiring radiotherapy, by 7 (30.4%) cases. Oral carcinoma case requiring radiotherapy was most frequently found in men by 14 (60.8%) cases. The age group of 41-50 was become the majority by 7 (30.4%) cases from all of the oral carcinoma case requiring radiotherapy. Conclusion: Distribution of oral carcinoma case requiring radiotherapy in the Oral and Maxillofacial Surgery Clinics of Hasan Sadikin Hospital is found in as many as 23 (20.9%) cases. Most frequent radiotherapy given is adjuvant radiotherapy (14 (60.8%) cases). The most frequent type of oral carcinoma case requiring radiotherapy is squamous cell carcinoma (12 (52.1%) cases). The most common area of oral carcinoma requiring radiotherapy is tongue (7 (30.4%) cases). Oral carcinoma case requiring radiotherapy was most frequently found in men (14 (60.8%) cases). The age group of 41-50 is the majority age suffered from disease (7 (30.4%) cases).

scholarly journals Level I Nodal Positivity as a Factor for Involvement of the Submandibular Gland in Oral Cavity Carcinoma: A Case Series Report

2020 ◽  
Author(s):  
Hamdan Ahmed Pasha ◽  
Rahim Dhanani ◽  
Shayan Khalid Ghaloo ◽  
Kulsoom Ghias ◽  
Mumtaz Jamshed Khan
Keyword(s):  
Oral Cavity ◽  
Lymph Nodes ◽  
Neck Dissection ◽  
Submandibular Gland ◽  
Primary Tumor ◽  
Oral Carcinoma ◽  
Care Hospital ◽  
Direct Extension ◽  
Oral Cavity Carcinoma ◽  
Level I

Abstract Introduction The routine practice of neck dissection in the surgical management of oral carcinoma has evolved into a more functionally conservative approach. Over time, the rationale for removal of the submandibular gland has been questioned. Routine extirpation of the submandibular gland can aggravate the xerostomia experienced by many patients, significantly affecting their quality of life. Objective The objective of the present study was to determine the incidence of submandibular gland metastases in oral cavity carcinoma and to identify possible factors that may affect their involvement. Methods A total of 149 cases of oral carcinoma presenting at a private tertiary care hospital in Karachi, Pakistan, over the course of 1 year were reviewed retrospectively. Results Histopathological data showed that the submandibular gland was involved in 7 (4.7%) cases. Involvement of level I lymph nodes was found in all of the cases. Direct extension of primary tumor was noted in two cases when the primary tumor was in the floor of the mouth. Conclusion The results suggest that preservation of the submandibular gland during neck dissection for oral carcinoma can be practiced safely when there is no evidence of direct extension of the primary tumor toward the submandibular gland or when there is no clinical or radiological evidence of neck disease in level I. Presence of pathological lymph nodes in level I requires caution when contemplating preservation of the submandibular gland.

scholarly journals Role of Bacterial Flora in Oral Cancer- An Insight

2021 ◽  
Author(s):  
R Ananthalakshmi ◽  
M Priya ◽  
Nadeem Jeddy ◽  
LJ Sailakshmi
Keyword(s):  
Oral Cavity ◽  
Human Body ◽  
Bacterial Species ◽  
Bacterial Flora ◽  
Fungal Species ◽  
The Body ◽  
Oral Carcinoma ◽  
Oral Diseases ◽  
Organ Systems

The human body contains about 1014 bacteria which usually colonise different parts of the body. The bacterial flora is important for a person’s health as well as normal functioning of tissue and organ systems. Bacteria are single celled organisms and are found on almost all surfaces of human body. They act in synergy with host immune mechanism and provide protection against various undesirable foreign invasions, especially in the oral cavity, where they exist in a diversified form which survive in a symbiotic relationship with the host. When there is a disturbance in this equilibrium due to various factors like trauma or tobacco smoking, betel nut chewing and alcohol intake, which makes the mucous membrane more permeable to invading microorganisms, these commensal bacterial species can become virulent and give rise to oral diseases ranging from dental caries to oral carcinoma. The effects of these bacteria can be either direct or indirect initiation of chronic inflammation, formation of procarcinogens that contribute to the development of oral carcinoma. This article focuses on the role of oral bacterial flora in initiation and progression of oral carcinogenesis. Various bacterial and fungal species associated with oral carcinoma and predominant bacterial species in oral cavity and oropharyngeal region along with measures to prevent their adverse effects are described.

scholarly journals Sensitivity of antifungal preparations of Сandida isolates from sub-biotopes of the human oral cavity

2020 ◽  
Vol 11 (1) ◽  
pp. 82-87
Author(s):  
N. О. Osypchuk ◽  
V. B. Nastenko ◽  
V. P. Shirobokov ◽  
Y. V. Korotkyi
Keyword(s):  
Immune Deficiency ◽  
Antifungal Activity ◽  
Oral Cavity ◽  
Mucous Membrane ◽  
Analytical Methods ◽  
Clinical Signs ◽  
Amino Alcohols ◽  
Clinical Isolates ◽  
And Control ◽  
Derivatives Of

Candidiasis is the commonest opportunistic infection of the oral cavity. As a result of immune-deficiency of the organism, yeasts of Candida genus by acting as commensal organisms transmute into pathogenic organisms. The article presents frequency of isolation, topographic peculiarities, species range, sensitivity of the Candida yeasts to antimycotics and newly-synthesized derivatives of amino alcohols isolated from the sub-biotopes of the oral cavity of patients with oncopathologies. The survey of the material included microscopic, mycologic, statistical-analytical methods. For all the clinical isolates the sensitivity to antifungal preparations was determined. Over the study 492 sub-biotopes of the oral cavity were examined. The extraction of the material was made from the mucous membrane of the cheek, angle of the mouth, mucous membrane of the surface of the tongue and the palate. According to the results of the conducted studies, the level of candidal carriage on the mucous membrane of the oral cavity in the patients with oncopathologies without clinical signs of candidiasis equaled 25.0%, active candidiasis infection was found in 47.0% of cases. Among the clinical strains, we isolated: C. albicans, C. glabrata, C. tropicalis and C. krusei. Among all the isolated strains, in all 4 sub-biotopes C. albicans dominated accounting for 73.1%. In 4 sub-biotopes we detected the association of two species of Candida. Analysis of the obtained results of the susceptibility of strains to modern antymicotics and newly-synthesized substances revealed that the representatives of non-albicans are more resistant to the antifungal preparations. Among the commercial preparations, amphotericin B exerted the highest activity against the clinical isolates of yeast-like fungi. The concentration of 0.97 µg/mL inhibited 50.0% of representatives of non-albicans, and also 75.0% of isolates of C. albicans. Fluconazole exhibited activity in the concentration of 1 µg/mL towards 17.0% of non-albicans and 25.0% of С. albicans. Itraconazole was observed to have no significant antifungal activity. Among the newly-synthesized aryl acyclic amino alcohols, compound Kc22 displayed high activity against both groups of Candida (experimental and control) making it promising for creating new therapeutic preparations. The parameters of resistance of clinical isolates to modern antimycotics indicate the necessity of constant monitoring of the sensitivity of the pathogens of candidiasis and precise species identification for rational use of antifungal preparations and prevention of the development of antimycotic resistance.

The role of oncogenic viruses in the etiopathogenesis of oral squamous cell carcinoma – literature review

2018 ◽  
Vol 68 (3) ◽  
pp. 327-338
Author(s):  
Magdalena Sawczuk ◽  
Beata Sawczuk ◽  
Agnieszka Miąsko ◽  
Izabela Szarmach
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oral Carcinoma ◽  
Common Denominator ◽  
Oncogenic Viruses ◽  
Oncogenic Virus

The most common kind of oral cancer is known to be the epithelial cells cancer. The disease develops under the influence of many factors. Extensive studies confirms relationship of the occurrence of cancer in the mouth area and infection with oncogenic virus. Papilloma virus (HPV) and Ebstein-Barr (EBV) are considerate to be the most potent oncogenic viruses. Aim. The aim of the studies was to present the role of the oncogenic virus in the development of squamous cell of oral cancer. Materials and methods. Literature was carried out from November 2014 to January 2018 period using „Pub-Med”, MEDLINE, SCOPUS with keywords: squamous cell carcinoma of the Oral Cavity, oncogenic factors in squamous cell in oral carcinoma, oncogenic virus, role of Ebstein-Barr virus in the development of squamous cell of oral carcinoma, role of human papillomavirus in the development of squamous cell carcinoma. Results. To the review 16 publications were qualified that meet certain criteria for good literature. Identification of comparative characteristics was aimed at finding a common denominator of research results. Discussion. In the review the focus point was on the role of factors which is oncogenic virus. Analysis of the available data has confirmed that more and more frequent cause of commonly known factors such as tobacco smoke, alcohol, neglect hygiene, and genetic factor became undoubtedly the role of virus factor. Summary. High incidence of cancers has led to the search for relevant etiological factors in the development carcinoma process, especially in and around oral cavity. Knowledge of the most cancerogenic factors is important in order to prevent, and the search of effective treatments. In addition, the cited publications, draws attention to the fact the use of saliva as research material. This throws a new light on the work of dentists and the possibility of their involvement in the process of tumor detection and the initiating factor of oncogenesis.

Repair Of The Oral Cavity After Irradiation And Resection For Oral Carcinoma

1973 ◽  
Vol 75 (2-6) ◽  
pp. 304-307 ◽  
Author(s):  
P. Å. Jakobsson ◽  
B. Körlof ◽  
B. Nylén ◽  
B. Meder ◽  
J. Wersäll
Keyword(s):  
Oral Cavity ◽  
Oral Carcinoma

scholarly journals Comparison of Aesthetic and Functional Outcomes of Microvascular Reconstruction with Other Forms of Reconstruction in Oral Cavity Malignancies

2020 ◽  
Vol 7 (48) ◽  
pp. 2867-2871
Author(s):  
Tarun Chowdary Gogineni ◽  
Sriphani Puvvala ◽  
Ajay Chanakya Vallabhaneni ◽  
Sreekanth Kotagiri ◽  
Jaya Chandra
Keyword(s):  
Oral Cavity ◽  
Randomized Study ◽  
Oral Carcinoma ◽  
Research Centre ◽  
Large Sample Size ◽  
Microvascular Reconstruction ◽  
Female Ratio ◽  
Reconstruction Methods ◽  
Oral Cavity Reconstruction ◽  
Significant Difference

BACKGROUND Surgical resection is the main stay treatment in oral cancer. Different techniques were used by the surgeons for reconstruction of the normal anatomy. With these, a study was conducted to evaluate the outcome and quality of life in terms of conventional forms of reconstruction and functional outcome in both genders for oral cavity reconstruction. METHODS It was a hospital based non randomized study, conducted in the department of surgical oncology, Vydehi Institute of Medical Sciences and research centre, Bangalore from January 2017 to June 2018. Individuals aged 20 – 70 years with confirmed oral carcinoma were included; poor vascular supply of donor area, distant metastasis proved by chest X ray or abdominal ultrasound were excluded. Pre-structured proforma was used to collect the baseline data. ANOVA tests were used. P <0.05 was considered statistically significant. RESULTS Majority (27.7 %) were in the age group 51 to 60 years and the male to female ratio was 0.56. Statistically, there was no significant association between gender and type of flaps. 60 % had carcinoma of left buccal mucosa and 40 % had right side carcinoma, statistically there was no significant difference. The mean number of nodes was 20.85 ± 9.52. Statistically, there was no significant association between type of flaps and number of lymph nodes. CONCLUSIONS PMMC flap reconstruction is reliable and an affordable procedure with high success rate in achieving treatment goals. However, studies on large sample size for long term is required. KEYWORDS Oral Carcinoma, Microvascular Techniques, Local Flaps, Regional Flaps

scholarly journals Maintenance of Increased Mouth Opening in Oral Submucous Fibrosis Patient Treated with Nasolabial Flap Technique

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Milind Naphade ◽  
Bhushan Bhagat ◽  
Dwarkadas Adwani ◽  
Ranjit Mandwe
Keyword(s):  
Chronic Disease ◽  
Oral Cavity ◽  
Oral Mucosa ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Oral Carcinoma ◽  
Nasolabial Flap ◽  
Flap Technique ◽  
Submucous Fibrosis ◽  
Malignant Changes

Oral submucous fibrosis (OSMF) is an insidious chronic disease affecting any part of the oral cavity and sometimes the pharynx with epithelial atrophy leading to stiffness of the oral mucosa, causing trismus and inability to eat. However, a more serious complication of this disease is the risk of the development of oral carcinoma. A case of OSMF reported with initial interincisal mouth opening; 8 mm which was treated surgically with nasolabial flap technique followed by active mouth opening exercises for 6 months with Hister’s jaw exerciser. The patient could maintain mouth opening of 32 mm at the end of 18-months followup. The patient was observed closely for any malignant changes in the oral cavity.

scholarly journals Development of Probiotic Formulations for Oral Candidiasis Prevention: Gellan Gum as a Carrier To Deliver Lactobacillus paracasei 28.4

2020 ◽  
Vol 64 (6) ◽  
Author(s):  
Felipe de Camargo Ribeiro ◽  
Juliana Campos Junqueira ◽  
Jéssica Diane dos Santos ◽  
Patrícia Pimentel de Barros ◽  
Rodnei Dennis Rossoni ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Oral Cavity ◽  
Oral Candidiasis ◽  
Microscopic Analysis ◽  
Gellan Gum ◽  
Lactobacillus Paracasei ◽  
Control Group ◽  
Total Biomass ◽  
Content Type ◽  
Oral Colonization

ABSTRACT Probiotics might provide an alternative approach for the control of oral candidiasis. However, studies on the antifungal activity of probiotics in the oral cavity are based on the consumption of yogurt or other dietary products, and it is necessary to use appropriate biomaterials and specific strains to obtain probiotic formulations targeted for local oral administration. In this study, we impregnated gellan gum, a natural biopolymer used as a food additive, with a probiotic and investigated its antifungal activity against Candida albicans. Lactobacillus paracasei 28.4, a strain recently isolated from the oral cavity of a caries-free individual, was incorporated in several concentrations of gellan gum (0.6% to 1% [wt/vol]). All tested concentrations could incorporate L. paracasei cells while maintaining bacterial viability. Probiotic-gellan gum formulations were stable for 7 days when stored at room temperature or 4°C. Long-term storage of bacterium-impregnated gellan gum was achieved when L. paracasei 28.4 was lyophilized. The probiotic-gellan gum formulations provided a release of L. paracasei cells over 24 h that was sufficient to inhibit the growth of C. albicans, with effects dependent on the cell concentrations incorporated into gellan gum. The probiotic-gellan gum formulations also had inhibitory activity against Candida sp. biofilms by reducing the number of Candida sp. cells (P < 0.0001), decreasing the total biomass (P = 0.0003), and impairing hyphae formation (P = 0.0002), compared to the control group which received no treatment. Interestingly, a probiotic formulation of 1% (wt/vol) gellan gum provided an oral colonization of L. paracasei in mice with approximately 6 log CFU/ml after 10 days. This formulation inhibited C. albicans growth (P < 0.0001), prevented the development of candidiasis lesions (P = 0.0013), and suppressed inflammation (P = 0.0006) compared to the mice not treated in the microscopic analysis of the tongue dorsum. These results indicate that gellan gum is a promising biomaterial and can be used as a carrier system to promote oral colonization for probiotics that prevent oral candidiasis.

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