Acute phase proteins in relation to various inflammatory diseases of calves

We investigated concentrations of acute-phase proteins a-2-macroglobulin (MG) and lactoferrin (LF) in blood serum of 78 women with various types of uterine appendages inflammatory processes. Coefficient MG/LF was used as an additional diagnostic criterum of purulent-necrotic destruction of organs and tissues and allowed us to choose proper treatment options. MG values were assessed by method of rocket immune electroforesis using monospecific antiserum to the given protein, LF level was assessed by enzyme linked immunoassay based method (ELISA). Standard was performed when coefficient MG/LF was greater than 1, and if value of coefficient MG/LF was less than 1, we performed surgical treatment. Using coefficient MG/LF as a diagnostic criterion of existence of organic destruction in uterine appendages allowed us to optimize the selection of treatment program.

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Blocking IL-1 in systemic inflammation

Journal of Experimental Medicine ◽

10.1084/jem.20050640 ◽

2005 ◽

Vol 201 (9) ◽

pp. 1355-1359 ◽

Cited By ~ 335

Author(s):

Charles A. Dinarello

Keyword(s):

Juvenile Idiopathic Arthritis ◽

Acute Phase ◽

Systemic Inflammation ◽

Acute Phase Proteins ◽

Inflammatory Diseases ◽

Common Mechanism ◽

Loss Of Control ◽

Local Inflammation ◽

Rapid Resolution ◽

Systemic Onset

A growing number of systemic inflammatory diseases characterized in part by recurrent fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-1 activity since rapid and sustained resolution is observed upon specific blockade of IL-1 receptors. Rapid resolution of systemic and local inflammation is now also reported in systemic onset juvenile idiopathic arthritis (SoJIA). Loss of control of the secretion of IL-1β might be a common mechanism explaining the aberrant activity of IL-1 in these diseases.

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Pathogenic Role of IL-6 Combined with TNF-α or IL-1 in the Induction of Acute Phase Proteins SAA and CRP in Chronic Inflammatory Diseases

Advances in Experimental Medicine and Biology - Advances in TNF Family Research ◽

10.1007/978-1-4419-6612-4_15 ◽

2010 ◽

pp. 141-150 ◽

Cited By ~ 13

Author(s):

Kazuyuki Yoshizaki

Keyword(s):

Acute Phase ◽

Acute Phase Proteins ◽

Inflammatory Diseases ◽

Pathogenic Role ◽

Chronic Inflammatory Diseases ◽

Tnf Α

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The Acute-Phase Protein Serum Amyloid A Induces G-CSF Expression.

Blood ◽

10.1182/blood.v108.11.3855.3855 ◽

2006 ◽

Vol 108 (11) ◽

pp. 3855-3855

Author(s):

Rong He ◽

Jian Zhou ◽

Richard D. Ye

Keyword(s):

Acute Phase ◽

Blood Circulation ◽

Serum Amyloid A ◽

Acute Phase Proteins ◽

Acute Phase Protein ◽

Inflammatory Diseases ◽

Serum Amyloid ◽

Amyloid A ◽

Phase Protein ◽

Blood Neutrophils

Abstract Host response to injury and infection is accompanied by a rapid rise of acute-phase proteins in the blood. Serum amyloid A (SAA) is a major acute-phase protein, and has been used as a marker for inflammatory diseases. However, its precise role in inflammation has not been defined. In our previous study, we found that SAA can induce IL-8 and TNF-alpha secretion from peripheral blood neutrophils, which indicates that SAA has cytokine-like functions. We have also identified SAA as an endogenous ligand that induces the expression of interleukin-23 (IL-23), a hetero-dimeric cytokine that promotes autoimmune inflammation. In this study, we reported that SAA stimulates monocytes to secret granulocyte colony-stimulated factor (G-CSF), a cytokine and a major hematopoietic growth factor. Injection of SAA into mouse peritoneum significantly increases the number of neutrophils in both peritoneal cavity and blood circulation. These results suggest that SAA can induce granulocytosis during infection and inflammation. We hypothesize that during the inflammation, locally or systematically produced SAA can increase the number of neutrophils in blood circulation and recruits them to injured or infected sites through induction of G-CSF.

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Keratins 8/18 represent type II acute-phase proteins which are differentially regulated in human liver disease

Zeitschrift für Gastroenterologie ◽

10.1055/s-0032-1331972 ◽

2013 ◽

Vol 51 (01) ◽

Author(s):

N Güldiken ◽

V Usachov ◽

K Levada ◽

M Ziol ◽

P Nahon ◽

...

Keyword(s):

Liver Disease ◽

Acute Phase ◽

Human Liver ◽

Acute Phase Proteins ◽

Type Ii ◽

Human Liver Disease

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Supplementation of postbiotic RI11 improves antioxidant enzymes activity, upregulated gut barrier genes and reduced cytokines, acute phase proteins and heat shock protein70 gene expression levels in heat-stressed broilers

Poultry Science ◽

10.1016/j.psj.2020.12.011 ◽

2020 ◽

Author(s):

Ali Merzza Humam ◽

Teck Chwen Loh ◽

Hooi Ling Foo ◽

Wan Ibrahim Izuddin ◽

Idrus Zulkifli ◽

...

Keyword(s):

Gene Expression ◽

Antioxidant Enzymes ◽

Heat Shock ◽

Acute Phase ◽

Acute Phase Proteins ◽

Gut Barrier ◽

Expression Levels ◽

Enzymes Activity ◽

Gene Expression Levels

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Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study

Critical Care ◽

10.1186/s13054-021-03547-z ◽

2021 ◽

Vol 25 (1) ◽

Author(s):

Pavan K. Bhatraju ◽

Eric D. Morrell ◽

Leila Zelnick ◽

Neha A. Sathe ◽

Xin-Ya Chai ◽

...

Keyword(s):

Endothelial Dysfunction ◽

Epithelial Cell ◽

Acute Phase ◽

Cell Injury ◽

Acute Phase Proteins ◽

Invasive Mechanical Ventilation ◽

Icu Patients ◽

Icu Admission ◽

Amyloid A ◽

Epithelial Cell Injury

Abstract Background Analyses of blood biomarkers involved in the host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection can reveal distinct biological pathways and inform development and testing of therapeutics for COVID-19. Our objective was to evaluate host endothelial, epithelial and inflammatory biomarkers in COVID-19. Methods We prospectively enrolled 171 ICU patients, including 78 (46%) patients positive and 93 (54%) negative for SARS-CoV-2 infection from April to September, 2020. We compared 22 plasma biomarkers in blood collected within 24 h and 3 days after ICU admission. Results In critically ill COVID-19 and non-COVID-19 patients, the most common ICU admission diagnoses were respiratory failure or pneumonia, followed by sepsis and other diagnoses. Similar proportions of patients in both groups received invasive mechanical ventilation at the time of study enrollment. COVID-19 and non-COVID-19 patients had similar rates of acute respiratory distress syndrome, severe acute kidney injury, and in-hospital mortality. While concentrations of interleukin 6 and 8 were not different between groups, markers of epithelial cell injury (soluble receptor for advanced glycation end products, sRAGE) and acute phase proteins (serum amyloid A, SAA) were significantly higher in COVID-19 compared to non-COVID-19, adjusting for demographics and APACHE III scores. In contrast, angiopoietin 2:1 (Ang-2:1 ratio) and soluble tumor necrosis factor receptor 1 (sTNFR-1), markers of endothelial dysfunction and inflammation, were significantly lower in COVID-19 (p < 0.002). Ang-2:1 ratio and SAA were associated with mortality only in non-COVID-19 patients. Conclusions These studies demonstrate that, unlike other well-studied causes of critical illness, endothelial dysfunction may not be characteristic of severe COVID-19 early after ICU admission. Pathways resulting in elaboration of acute phase proteins and inducing epithelial cell injury may be promising targets for therapeutics in COVID-19.

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