scholarly journals MATRIX METALLOPROTEINASES AND ACUTE PHASE PROTEINS IN INFLAMMATORY PROCESSES OF THE LUNGS IN CHILDREN

2016 ◽  
Vol 0 (2) ◽  
pp. 10
Author(s):  
Nikolay Alekseevich Dorokhov ◽  
Evgeny Vasilevich Skudarnov ◽  
Denis Aleksandrovich Antropov ◽  
Olga Vyacheslavovna Nevskaya
Keyword(s):  
Matrix Metalloproteinases ◽  
Acute Phase ◽  
Acute Phase Proteins ◽  
Inflammatory Processes

scholarly journals Inhibition of the activity of pro-inflammatory secretory phospholipase A2by acute phase proteins

1996 ◽  
Vol 5 (3) ◽  
pp. 196-201 ◽  
Author(s):  
W. Pruzanski ◽  
E. Stefanski ◽  
P. Vadas
Keyword(s):  
Acute Phase ◽  
Inhibitory Activity ◽  
Acute Phase Proteins ◽  
Acute Phase Reaction ◽  
Phase Reaction ◽  
Protective Mechanisms ◽  
Spla2 Activity ◽  
Pancreatic Phospholipase ◽  
Inflammatory Processes ◽  
Bacteriostatic Property

Pro-Inflammatory non-pancreatic phospholipase A2(sPLA2) is markedly over-expressed in acute systemic and chronic local inflammatory processes. Since in acute phase reaction sPLA2is often over-expressed simultaneously with acute phase proteins (APP), it is important to determine whether APP interacts with sPLA2. We tested ten APPs for interaction with sPLA2using as a substrate multilamellar Hposomes composed either of PC:Lyso PC or PE:Lyso PE. Using PC:Lyso PC substrate, CRP, lactoferrin and SAP were found to inhibit sPLA2activity with an IC50of 25 μg/ml, 7.5 μg/ml and 50 μg/ml, respectively, corresponding to 0.21 μM, 0.1 μM and 0.21 μM respectively. Using PE:Lyso PE substrate only SAP was inhibitory, with an IC50of 10 μg/ml (0.04 μM). Phosphorylcholine abolished the inhibitory activity of CRP but not of SAP or lactoferrin. Addition of phosphorylethanolamine or of excess calcium had no effect on the inhibitory activity of APP. Limulin, lysozyme, transferrin, β2-microglobulin, α2-macroglobulin, human and bovine albumins had no effect on sPLA2 activity. Therefore neither the structure of pentraxins, or ironbinding, bacteriostatic property or amyloidogenic property preclude whether APP modulates sPLA2activity. Inhibition of pro-inflammatory sPLA2by APP may be one of the protective mechanisms of the acute phase reaction.

scholarly journals Glycosylation Changes on Serum Glycoproteins in Ovarian Cancer May Contribute to Disease Pathogenesis

2008 ◽  
Vol 25 (4-5) ◽  
pp. 219-232 ◽  
Author(s):  
Radka Saldova ◽  
Mark R. Wormald ◽  
Raymond A. Dwek ◽  
Pauline M. Rudd
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Acute Phase ◽  
Iron Homeostasis ◽  
Acute Phase Proteins ◽  
Sialyl Lewis X ◽  
Altered Glycosylation ◽  
Serum Ca125 ◽  
Inflammatory Processes ◽  
Parenchymal Cells

Ovarian cancer is the most lethal of all gynaecological cancers among women. Serum CA125 is the only biomarker that is used routinely and there is a need for further complementary biomarkers both in terms of sensitivity and specificity.N-glycosylation changes in ovarian cancer serum glycoproteins include a decrease in galactosylation of IgG and an increase in sialyl Lewis X (SLex) on haptoglobinβ-chain,α1-acid glycoprotein andα1-antichymotrypsin. These changes are also present in chronic inflammation but not in malignant melanoma, where there are low levels of inflammatory processes. Acute phase proteins carrying increased amounts of SLexhave an increased half-life. Sialylation of acute phase proteins also decreases apoptosis favouring survival of cancer cells. Cancer cells produce inflammatory cytokines which influence glycosylation processing in liver parenchymal cells. Altered glycosylation of the acute phase protein transferrin plays an important role in iron homeostasis. Glycosylated transferrin and its glycans have anti-apoptotic properties and many transferrin receptors in carcinoma could play a role in development of anaemia. Decreased galactosylation and sialylation of IgG increases the cytotoxicity of natural killer cells and complement activation via mannose-binding lectin (MBL). Altered glycosylation of acute phase proteins and IgG suggests that cancer regulates certain pathways favouring cancer cells survival.

scholarly journals Diagnosis value of some acute-phase proteins in purulent-inflammatory diseases of uterine appendages

2006 ◽  
Vol 5 (3) ◽  
pp. 112-116
Author(s):  
S. V. Shramko ◽  
S. V. Arkhipova ◽  
L. G. Bazhenova ◽  
R. M. Zorina
Keyword(s):  
Acute Phase ◽  
Acute Phase Proteins ◽  
Inflammatory Diseases ◽  
Treatment Options ◽  
Organic Destruction ◽  
Monospecific Antiserum ◽  
Inflammatory Processes ◽  
Diagnostic Criterion ◽  
The Given ◽  
Selection Of

We investigated concentrations of acute-phase proteins a-2-macroglobulin (MG) and lactoferrin (LF) in blood serum of 78 women with various types of uterine appendages inflammatory processes. Coefficient MG/LF was used as an additional diagnostic criterum of purulent-necrotic destruction of organs and tissues and allowed us to choose proper treatment options. MG values were assessed by method of rocket immune electroforesis using monospecific antiserum to the given protein, LF level was assessed by enzyme linked immunoassay based method (ELISA). Standard was performed when coefficient MG/LF was greater than 1, and if value of coefficient MG/LF was less than 1, we performed surgical treatment. Using coefficient MG/LF as a diagnostic criterion of existence of organic destruction in uterine appendages allowed us to optimize the selection of treatment program.

scholarly journals THE EFFECTS OF STRESS ON ACUTE PHASE PROTEINS OF CATTLE

2016 ◽  
Vol 18 (4(72)) ◽  
pp. 107-113
Author(s):  
S.M. Sevgisunar ◽  
S. Şahinduran
Keyword(s):  
Acute Phase ◽  
Serum Amyloid A ◽  
Acute Phase Proteins ◽  
Clinical Signs ◽  
Stress Factors ◽  
Stress Effect ◽  
Hormonal Changes ◽  
Acid Glycoprotein ◽  
Amyloid A ◽  
Inflammatory Processes

Stress occurs with the pressure of external and internal (infectious or non–infectious) causes which forces change in animals. This stress not only emerge with behavioral or clinical signs, but also will result with immune response formed by body. Understanding and evaluating this subclinic response is also possible with the help of Acute Phase Proteins (APP–AFP) which are released by tissues and organs when exposed to external and internal changes as well as known hormonal changes. Cattle are fed because of their economical importance and the inflammatory processes have influence on their yield levels. Because the stress is laying under all these health problems, also it is getting attention how stress effect the animals. Stress can be divided into main four groups: physical (mechanical), inflammatory (infectious), behavioral and other stress factors. The main APPs which all groups mostly using in their studies are serum amyloid A (SAA) haptoglobin (Hp), ceruloplasmin (Cp), fibrinogen (Fb), lipopolisakkarit binding protein (LBP) ve α1–Acid Glycoprotein (AGP).

scholarly journals Acute phase proteins in diagnostics: more than expected

2017 ◽  
Vol 65 (3) ◽  
pp. 197 ◽  
Author(s):  
J. J. CERON ◽  
S. MARTINEZ-SUBIELA ◽  
F. TECLES ◽  
M. CALDIN
Keyword(s):  
Veterinary Medicine ◽  
Inflammatory Response ◽  
Clinical Application ◽  
Acute Phase ◽  
Acute Phase Proteins ◽  
Basic Principles ◽  
Inflammatory Processes ◽  
Detection And Quantification

The objective of this review is to provide updated information about how acute phase proteins (APPs) can be used in the process of diagnosis in veterinary medicine. For this purpose, recommendations about assay methodologies and basic principles regarding clinical application of APPs will be provided. In addition, the use of APPs for (1) the detection and quantification of inflammatory response, (2) the diagnosis of the underlying etiology and (3) the detection of selected non-inflammatory processes will be reviewed with practical examples.

Keratins 8/18 represent type II acute-phase proteins which are differentially regulated in human liver disease

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
N Güldiken ◽  
V Usachov ◽  
K Levada ◽  
M Ziol ◽  
P Nahon ◽  
...  
Keyword(s):  
Liver Disease ◽  
Acute Phase ◽  
Human Liver ◽  
Acute Phase Proteins ◽  
Type Ii ◽  
Human Liver Disease

scholarly journals Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study

Critical Care ◽  
2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Pavan K. Bhatraju ◽  
Eric D. Morrell ◽  
Leila Zelnick ◽  
Neha A. Sathe ◽  
Xin-Ya Chai ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Epithelial Cell ◽  
Acute Phase ◽  
Cell Injury ◽  
Acute Phase Proteins ◽  
Invasive Mechanical Ventilation ◽  
Icu Patients ◽  
Icu Admission ◽  
Amyloid A ◽  
Epithelial Cell Injury

Abstract Background Analyses of blood biomarkers involved in the host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection can reveal distinct biological pathways and inform development and testing of therapeutics for COVID-19. Our objective was to evaluate host endothelial, epithelial and inflammatory biomarkers in COVID-19. Methods We prospectively enrolled 171 ICU patients, including 78 (46%) patients positive and 93 (54%) negative for SARS-CoV-2 infection from April to September, 2020. We compared 22 plasma biomarkers in blood collected within 24 h and 3 days after ICU admission. Results In critically ill COVID-19 and non-COVID-19 patients, the most common ICU admission diagnoses were respiratory failure or pneumonia, followed by sepsis and other diagnoses. Similar proportions of patients in both groups received invasive mechanical ventilation at the time of study enrollment. COVID-19 and non-COVID-19 patients had similar rates of acute respiratory distress syndrome, severe acute kidney injury, and in-hospital mortality. While concentrations of interleukin 6 and 8 were not different between groups, markers of epithelial cell injury (soluble receptor for advanced glycation end products, sRAGE) and acute phase proteins (serum amyloid A, SAA) were significantly higher in COVID-19 compared to non-COVID-19, adjusting for demographics and APACHE III scores. In contrast, angiopoietin 2:1 (Ang-2:1 ratio) and soluble tumor necrosis factor receptor 1 (sTNFR-1), markers of endothelial dysfunction and inflammation, were significantly lower in COVID-19 (p < 0.002). Ang-2:1 ratio and SAA were associated with mortality only in non-COVID-19 patients. Conclusions These studies demonstrate that, unlike other well-studied causes of critical illness, endothelial dysfunction may not be characteristic of severe COVID-19 early after ICU admission. Pathways resulting in elaboration of acute phase proteins and inducing epithelial cell injury may be promising targets for therapeutics in COVID-19.

scholarly journals Effects of Stocking and Transport Conditions on Physicochemical Properties of Meat and Acute-Phase Proteins in Cattle

Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 252
Author(s):  
Ahmed A. Abubakar ◽  
Idrus Zulkifli ◽  
Yong M. Goh ◽  
Ubedullah Kaka ◽  
Azad B. Sabow ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Acute Phase ◽  
Acute Phase Proteins ◽  
Stocking Density ◽  
Road Transport ◽  
Long Distance ◽  
Amyloid A ◽  
Tropical Conditions ◽  
Meat Samples ◽  
Water Holding

This study’s objective was to evaluate the effects of distance and stocking density on physicochemical properties and oxidative stability of meat and acute-phase proteins in Brahman crossbred cattle transported by road under hot and humid tropical conditions. Sixty Brahman crossbred heifers were subjected to road transport from a cattle feedlot farm located in Universiti Putra Malaysia (UPM), Serdang, to a commercial ruminant abattoir in Shah Alam, Selangor. Animals were assigned to long and short distances and high, medium, and low stocking densities. The results revealed that the intensity of response significantly increased in meat samples from animals subjected to long-distance transportation and higher stocking density. Alpha-1-acid glycoprotein and serum amyloid-A values increased considerably and were different from the baseline values recorded at preload. In conclusion, the current results revealed that the color, pH, shear force values, water holding capacity (WHC), glycogen level, and malondilaldehyde assay (MDA) concentrations in meat and acute-phase proteins (APP) were affected by both distances and stocking densities, as evidenced by the significant changes recorded from the parameters above.

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