scholarly journals The investigation of acute toxicity of water-soluble polysaccharides extracted from calamus root (Acorus calamus L.)

2010 ◽  
Vol 9 (1) ◽  
pp. 36-39
Author(s):  
A. M. Guriyev ◽  
M. V. Belousov ◽  
M. S. Yusubov ◽  
R. R. Akhmedzhanov ◽  
Ye. P. Zuyeva ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Toxic Effect ◽  
State Standard Gost ◽  
Maximum Dose ◽  
Water Soluble ◽  
Acorus Calamus ◽  
Hazard Class ◽  
Experimental Animals ◽  
Intravenous Introduction ◽  
Class Iv

An investigation for a possible acute toxicity of the complex of water-soluble polysaccharides (WSPS) extracted from calamus root (Acorus calamus L.) has been performed. No toxic effect has been observed on the organisms of experimental animals after a twofold intragastric, subcutaneous, and intravenous introduction of the highest maximum dose of the WSPS being investigated. The results of the experiments did not allow detecting the average fatal dose (LD50) of the WSPS being investigated as no deaths among the experimental animals had been observed. The obtained data lead to the conclusion that the WSPS of calamus root are to be added to Substance Hazard Class IV (low hazard substances) in compliance with State Standard GOST 12.1.007-76.

scholarly journals An investigation of the introduction of water-soluble polysaccharides calamus root (Acorus calamus L.) effect on the experimental animals functions

2010 ◽  
Vol 9 (6) ◽  
pp. 18-23
Author(s):  
A. M. Gurieyv ◽  
M. V. Belousov ◽  
R. R. Akhmedzhanov ◽  
M. S. Yusubov ◽  
A. A. Churin ◽  
...  
Keyword(s):  
General Condition ◽  
Functional Activity ◽  
Water Soluble ◽  
Acorus Calamus ◽  
Pathological Changes ◽  
Internal Organs ◽  
Experimental Animals ◽  
General Weight ◽  
Intravenous Introduction

An investigation has been performed as to the effect of a long-term parenteral introduction of the sum of water-soluble polysaccharides (WSPS) calamus root (Acorus calamus L.) extracted by means of the in-house technology on the functions of experimental animals. As it follows from the results of the experiments, the intragastric introduction of the WSPS to rats in the doses of 20, 100, and 200 mg/kg during a three-month term and the intravenous introduction to rabbits in the doses of 25 and 50 mg/kg during a one-month term do not lead to the death of the animals or to any pathological changes in their general condition, the dynamics of the general weight, or the functional activity of the investigated internal organs and systems.

ACUTE TOXICITY OF A NEW BENZIMIDAZOLE DERIVATIVE WITH ANTITHROMBOGENIC PROPERTIES

2021 ◽  
Vol 1 (1) ◽  
pp. 52-57
Author(s):  
A. A. Spasov ◽  
A. F. Kucheryavenko ◽  
D. V. Maltsev ◽  
М. V. Miroshnikov ◽  
V. S. Sirotenko ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Toxic Effect ◽  
Benzimidazole Derivative ◽  
Test Sample ◽  
The Body ◽  
Peroral Administration ◽  
Toxic Dose ◽  
Pharmaceutical Substance ◽  
Experimental Animals ◽  
Toxicological Profile

The paper presents the results of studying the toxicological profile of a new pharmaceutical substance RU891 with antithrombogenic properties. The minimum toxic dose (TDmin) for RU-891 by peroral administration is 230 mg/kg < TDmin ≤ 460 mg/kg. In experiments on the acute toxicity of the compound RU-891, the nature and severity of its damaging effect on the body of experimental animals were established and the safety of its action was evaluated. When studying the toxic effect of the test sample, the tolerated and toxic doses of RU-891 were determined, and the most sensitive organs and systems of the body were identified.

scholarly journals A investigation of the influence of water-soluble polysaccharides of calamus root (Acorus calamus L.) introduction on the functions of experimental animals (pathomorphological aspects)

2010 ◽  
Vol 9 (3) ◽  
pp. 57-64
Author(s):  
A. M. Guriyev ◽  
M. V. Belousov ◽  
R. R. Akhmedzhanov ◽  
M. S. Yusubov ◽  
A. A. Churin ◽  
...  
Keyword(s):  
Body Mass ◽  
The State ◽  
Water Soluble ◽  
Parenteral Administration ◽  
Acorus Calamus ◽  
Pathological Changes ◽  
Internal Organs ◽  
Experimental Animals ◽  
Influence Of Water

The influence of the sum of water-soluble polysaccharides (WSPSs) extracted from sedge (Acorus calamus L.) rhizomes on the state of internal organs of rats and rabbits at a long parenteral administration has been studied. The intraperitoneal WSPS introduction to rats in doses of 20, 100, and 200 mg/kg of body mass for 3 months and the intravenous WSPS introduction to rabbits in doses of 25 and 50 mg/kg of body mass for 1 months caused no pathological changes in the morphology of internal organs and systems.

scholarly journals Acute and subchronic oral toxicities of “Da day An Chau” tablets in experimental animals

2021 ◽  
Vol 141 (5) ◽  
pp. 1-9
Author(s):  
Tran Thanh Tung ◽  
Dao Viet Hoang ◽  
Pham Thi Van Anh ◽  
Dang Thi Thu Hien
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
World Health Organization ◽  
Biochemical Parameters ◽  
Maximum Dose ◽  
Toxicity Study ◽  
World Health ◽  
Subchronic Toxicity ◽  
Experimental Animals ◽  
Health Organization

In this study, the toxicities of “Da day An Chau” tablets (DDAC) were assessed on experimental animals. To evaluate the acute toxicity on Swiss mice according to World Health Organization Guidance and to determine LD50 refer to the method of Litchfield – Wilcoxon. The subchronic toxicity study of DDAC at two doses (0.58 g/kg/day and 1.74 g/kg/day) was conducted in rats for four consecutive weeks. Evaluation of general conditions and weight of rats during the study period. Rat’s blood was taken for hematological and biochemical evaluations. The livers and kidneys microscopes were evaluated at the end of the experiment. The result revealed that mice were taken up to a maximum dose of 25.71 g/kg with no symptoms of acute toxicity; LD50 of DDAC has not been determined. At two doses, the subchronic toxicity study did not change rats’ body weight, hematological, biochemical parameters, and microscopic of the livers and kidneys during the study period.

scholarly journals Acute and sub-acute toxicity assessment of ‘Rybozuril’ on common carp

2019 ◽  
Vol 5 (1) ◽  
pp. 27-33
Author(s):  
A. V. Yevtushenko ◽  
V. S. Boyko ◽  
M. Ye. Romanko
Keyword(s):  
Acute Toxicity ◽  
Toxic Effect ◽  
Live Weight ◽  
Toxicity Assessment ◽  
Activity Level ◽  
Control Fish ◽  
Control Group ◽  
Hazard Class ◽  
Physiological Level ◽  
Daily Dose

The goal of the work was to study of acute and sub-acute toxicity parameters of ‘Rybozuril’ biological product (AI — diclazuril) on the model of carp. This drug is effective in the treatment of diseases caused by parasitic Eimeriidae. Carp scales of two years old were used in experiments. To determine acute toxicity, the fish were prescribed with diclazuril in doses of 1 g/kg, 5, 10, and 15 g/kg of live weight. Two experimental and control fish groups of 30 individuals each were formed to determine sub-acute toxicity of ‘Rybozuril’. Experimental groups of fish were prescribed with ‘Rybozuril’ in a dose (by AI) of 50 and 10 mg/kg for two consecutive days. Blood samples were collected from six fish from each group for clinical and biochemical indicators after 2, 7, 14, 21, and 28 days. The hemoglobin content, number of red blood cells and leukocytes blood was determined. The intensity of peroxide oxidation of lipids (PОL), catalase activity, level of total antioxidant capacity (TAC), total proteins, albumin, globulins and glucose, circulating immune complexes (CІC) and seromucoids concentration, level of enzymatic activity: aspartate transaminase (АSТ), alanine transaminase (АLТ), α-amylase blood plasma were determined. The acute toxicity of diclazuril for carp was estimated, LD50 is more than 15,000 mg/kg of live weight, the toxicity of diclazuril can be classified as undifferentiated and, in terms of toxicity, it can be classified as hazard class IV. Two administrations of the drug ‘Rybozuril’ in a daily dose of 50.0 mg/kg of live weight, the maximum expression of metabolic changes in fish was detected from the initial terms of the studies and up to day 21. According to the results the toxic effect of the drug in fish was estimated, which did not influence to a number of indicators. The drug in such dose was shown immunosuppression and membrane-toxic effects in fish. Two-time administration of the ‘Rybozuril’ drug in a daily dose of 10.0 mg/kg body weight leads to metabolic alterations in fish due to the activation of detoxification processes and lipoperoxidation maintenance in cell membranes at the physiological level. At the end of the experiment the toxic effect of ‘Rybozuril’ in fish characterized by stable parameters in comparing to the control group.

Initial Studies of a Potent Antiheparin Agent (Ubiquin®)

1968 ◽  
Vol 20 (03/04) ◽  
pp. 588-595 ◽  
Author(s):  
E. B Goodsell ◽  
R. A Krause ◽  
E. T Kimura
Keyword(s):  
Side Effects ◽  
Acute Toxicity ◽  
Propylene Oxide ◽  
Toluidine Blue ◽  
Water Soluble ◽  
Per Se

SummaryUbiquin (oligo-3-(N-methylmorpholinium)-l,2-propylene oxide chloride) is a stable, water soluble, active heparin antagonist producing prompt neutralization when administered in a 1:1 ratio to rats and dogs. Initial studies indicate that it is devoid of any effect on coagulation per se; nor are there any obvious side effects manifested during the process of neutralization. The acute toxicity is less than that of other compounds in use: toluidine blue, protamine and hexadimethrine.

EFFECT OF KAGOCEL PREPARATION ON THE GENERATIVE FUNCTION OF EXPERIMENTAL ANIMALS AT ITS ADMINISTRATION IN THE INFANTILE PERIOD OF THEIR DEVELOPMENT

2017 ◽  
pp. 42-49
Author(s):  
T. A. Borovskaya ◽  
M. E. Poluektova ◽  
A. V. Vychuzhanina ◽  
V. A. Mashanova ◽  
Yu. A. Shchemerova
Keyword(s):  
Toxic Effect ◽  
Reproductive System ◽  
Safety Profile ◽  
Therapeutic Dose ◽  
Antiviral Drug ◽  
Experimental Studies ◽  
Reproductive Age ◽  
Pathological Changes ◽  
Pediatric Practice ◽  
Experimental Animals

In experimental studies on rats (males, females) at their infantile stage starting from 10 days, a potential delayed toxic effect of the antiviral drug Kagocel on the reproductive system was studied. The drug was administered for 12 days in a therapeutic dose and at a dose 10-fold higher than the therapeutic one. Reproductive safety was estimated after animals reached the reproductive age (2.5 months). It was found out that the drug, when administered in both doses, does not decrease the fertility of animals, does not induce morphological and pathological changes in the sex glands, and does not have toxic effect on the offspring. Obtained data characterize Kagocel as a preparation with a wide reproductive safety profile and show that it can be used in pediatric practice for infants.

Chemosensitizing Activity of Histone Deacetylases Inhibitory Cyclic Hydroxamic Acids for Combination Chemotherapy of Lymphatic Leukemia

2018 ◽  
Vol 18 (4) ◽  
pp. 365-371 ◽  
Author(s):  
Denis V. Mishchenko ◽  
Margarita E. Neganova ◽  
Elena N. Klimanova ◽  
Tatyana E. Sashenkova ◽  
Sergey G. Klochkov ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Acute Toxicity ◽  
Histone Deacetylases ◽  
Hydroxamic Acids ◽  
Water Soluble ◽  
Male Rat ◽  
Hybrid Male ◽  
Cyclic Hydroxamic Acids

Background: Anti-tumor effect of hydroxamic acid derivatives is largely connected with its properties as efficient inhibitors of histone deacetylases, and other metalloenzymes involved in carcinogenesis. Objective: The work was aimed to (i) determine the anti-tumor and chemosensitizing activity of the novel racemic spirocyclic hydroxamic acids using experimental drug sensitive leukemia P388 of mice, and (ii) determine the structure-activity relationships as metal chelating and HDAC inhibitory agents. Method: Outbreed male rat of 200-220 g weights were used in biochemical experiments. In vivo experiments were performed using the BDF1 hybrid male mice of 22-24 g weight. Lipid peroxidation, Fe (II) -chelating activity, HDAC fluorescent activity, anti-tumor and anti-metastatic activity, acute toxicity techniques were used in this study. Results: Chemosensitizing properties of water soluble cyclic hydroxamic acids (CHA) are evaluated using in vitro activities and in vivo methods and found significant results. These compounds possess iron (II) chelating properties, and slightly inhibit lipid peroxidation. CHA prepared from triacetonamine (1a-e) are more effective Fe (II) ions cheaters, as compared to CHA prepared from 1- methylpiperidone (2a-e). The histone deacetylase (HDAC) inhibitory activity, lipophilicity and acute toxicity were influenced by the length amino acids (size) (Glycine < Alanine < Valine < Leucine < Phenylalanine). All compounds bearing spiro-N-methylpiperidine ring (2a-e) are non-toxic up to 1250 mg/kg dose, while compounds bearing spiro-tetramethylpiperidine ring (1a-e) exhibit moderate toxicity which increases with increasing lipophility, but not excite at 400 mg/kg. Conclusion: It was shown that the use of combination of non-toxic doses of cisplatin (cPt) or cyclophosphamide with CHA in most cases result in the appearance of a considerable anti-tumor effect of cytostatics. The highest chemosensitizing activity with respect to leukemia Р388 is demonstrated by the CHA derivatives of Valine 1c or 2c.

Potential anticonvulsants: Substituted N-benzylidene derivatives of 10-(4-aminopiperazino)-10,11-dihydrodibenzo[b,f]thiepins

1983 ◽  
Vol 48 (4) ◽  
pp. 1173-1186 ◽  
Author(s):  
Václav Bártl ◽  
Jiří Holubek ◽  
Emil Svátek ◽  
Marie Bartošová ◽  
Miroslav Protiva
Keyword(s):  
Acute Toxicity ◽  
Water Soluble ◽  
Hypotensive Activity ◽  
Anticonvulsant Effect ◽  
Maximal Electroshock ◽  
Soluble Salts ◽  
Sleeping Time ◽  
Central Depression ◽  
Derivatives Of ◽  
Electroshock Seizures

Reactions of 10-(4-aminopiperazino)-10,11-dihydrodibenzo[b,f]thiepins XIVa-XIVd with benzaldehyde, 3,4-dimethoxybenzaldehyde, 4-dimethylaminobenzaldehyde, salicylaldehyde, 3-ethoxy-4-hydroxybenzaldehyde, 2-(2-dimethylaminoethoxy)benzaldehyde, 3-(2-dimethylaminoethoxy)benzaldehyde and 3-ethoxy-4-(2-dimethylaminoethoxy)benzaldehyde afforded a series of 19 hydrazones IIIa-Xc. Some of them showed the expected anticonvulsant effect but only towards pentetrazole; antagonism of maximal electroshock seizures was not observed. In general, the products have a character of tranquillizers: in higher does they produce central depression, potentiate the thiopental sleeping time, have hypothermic action; in single cases antiamphetamine, antireserpine, antihistamine and cataleptic effects were observed. The water-soluble salts of the basic hydrazones VIIIa, VIIIc, IXc and Xc, administered parenterally, showed a rather high acute toxicity and revealed also adrenolytic and hypotensive activity.

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