scholarly journals A investigation of the influence of water-soluble polysaccharides of calamus root (Acorus calamus L.) introduction on the functions of experimental animals (pathomorphological aspects)

2010 ◽  
Vol 9 (3) ◽  
pp. 57-64
Author(s):  
A. M. Guriyev ◽  
M. V. Belousov ◽  
R. R. Akhmedzhanov ◽  
M. S. Yusubov ◽  
A. A. Churin ◽  
...  
Keyword(s):  
Body Mass ◽  
The State ◽  
Water Soluble ◽  
Parenteral Administration ◽  
Acorus Calamus ◽  
Pathological Changes ◽  
Internal Organs ◽  
Experimental Animals ◽  
Influence Of Water

The influence of the sum of water-soluble polysaccharides (WSPSs) extracted from sedge (Acorus calamus L.) rhizomes on the state of internal organs of rats and rabbits at a long parenteral administration has been studied. The intraperitoneal WSPS introduction to rats in doses of 20, 100, and 200 mg/kg of body mass for 3 months and the intravenous WSPS introduction to rabbits in doses of 25 and 50 mg/kg of body mass for 1 months caused no pathological changes in the morphology of internal organs and systems.

scholarly journals An investigation of the introduction of water-soluble polysaccharides calamus root (Acorus calamus L.) effect on the experimental animals functions

2010 ◽  
Vol 9 (6) ◽  
pp. 18-23
Author(s):  
A. M. Gurieyv ◽  
M. V. Belousov ◽  
R. R. Akhmedzhanov ◽  
M. S. Yusubov ◽  
A. A. Churin ◽  
...  
Keyword(s):  
General Condition ◽  
Functional Activity ◽  
Water Soluble ◽  
Acorus Calamus ◽  
Pathological Changes ◽  
Internal Organs ◽  
Experimental Animals ◽  
General Weight ◽  
Intravenous Introduction

An investigation has been performed as to the effect of a long-term parenteral introduction of the sum of water-soluble polysaccharides (WSPS) calamus root (Acorus calamus L.) extracted by means of the in-house technology on the functions of experimental animals. As it follows from the results of the experiments, the intragastric introduction of the WSPS to rats in the doses of 20, 100, and 200 mg/kg during a three-month term and the intravenous introduction to rabbits in the doses of 25 and 50 mg/kg during a one-month term do not lead to the death of the animals or to any pathological changes in their general condition, the dynamics of the general weight, or the functional activity of the investigated internal organs and systems.

scholarly journals Pathological Changes in Internal Organs after Blocking Low Hydraulic Resistance Channels along the Stomach Meridian in Pigs

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Wen-Ting Zhou ◽  
Shu-Yong Jia ◽  
Yu-Qing Zhang ◽  
Yu-Ying Tian ◽  
Guang-Jun Wang ◽  
...  
Keyword(s):  
Hydraulic Resistance ◽  
The State ◽  
Pathological Changes ◽  
Internal Organs ◽  
Stomach Meridian ◽  
Normal States ◽  
Low Hydraulic Resistance ◽  
Insight Into ◽  
Experimental Pigs

Objective.The correlation between meridians and organs (Zang-fu) is an important aspect of meridian theory. The objective of this paper is to investigate the pathological changes in the organs resulting from blocking low hydraulic resistance channel (LHRC) along the stomach meridian by injecting gel in pigs so as to offer some insight into the correlation between meridians and internal organs.Methods.Four white piglets and twelve black minipigs were divided into four batches and were observed in different periods. Each batch included two pairs of pigs and each pair matched two pigs with similar conditions among which gel was injected into 6~8 low hydraulic resistance points along the the stomach meridian in the experimental pig and the same amount of saline was injected into the same points in the control pig. The state of stomach and intestine was observed 6~10 weeks after the blocking model was developed.Results.The results showed that there were bloated stomach or/and intestine in all the experimental pigs while there were normal states in seven control pigs except one dead during the experiment.Conclusion.The findings confirmed that the blockage of LHRC along the stomach meridian can influence the state of stomach and intestine, leading to a distension on stomach or/and intestine.

scholarly journals Toxicopathological study of aqueous extract of beetle cocoon Larinus maculatus F. on some internal organs in male albino mice

2012 ◽  
Vol 36 (0E) ◽  
pp. 315-321
Author(s):  
Iqbal Naji Tawfiq
Keyword(s):  
Oral Administration ◽  
Aqueous Extract ◽  
Mus Musculus ◽  
Folk Medicine ◽  
Low Doses ◽  
Undesirable Effect ◽  
Male Mice ◽  
Pathological Changes ◽  
Internal Organs ◽  
Experimental Animals

The present study was carried out to investigate the effect of oral administration of hot aqueous extract of beetle cocoon Larinus maculatus Faldermann, in a two doses 50and100mg/Kg/Bw for 25 and 45days respect- tively on some organs such as liver, lung, kidney, intestine, heart, spleen, and brain in male mice Mus musculus. The results indicated that there were toxicopathological changes in many tissues of experimental animals. Histo -pathological changes was dose and period dependent . It was found that the aqueous extract of beetle cocoon has undesirable effect at the administered doses, since the raw extract of this cocoon is currently being used in Folk medicine as treatment for cough, bronchitis in Iraq. This study revealed that the low doses of this extract have some deleterious effects on certain organs, so it should not be used for long durations in control of respiratory disease.

scholarly journals The investigation of acute toxicity of water-soluble polysaccharides extracted from calamus root (Acorus calamus L.)

2010 ◽  
Vol 9 (1) ◽  
pp. 36-39
Author(s):  
A. M. Guriyev ◽  
M. V. Belousov ◽  
M. S. Yusubov ◽  
R. R. Akhmedzhanov ◽  
Ye. P. Zuyeva ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Toxic Effect ◽  
State Standard Gost ◽  
Maximum Dose ◽  
Water Soluble ◽  
Acorus Calamus ◽  
Hazard Class ◽  
Experimental Animals ◽  
Intravenous Introduction ◽  
Class Iv

An investigation for a possible acute toxicity of the complex of water-soluble polysaccharides (WSPS) extracted from calamus root (Acorus calamus L.) has been performed. No toxic effect has been observed on the organisms of experimental animals after a twofold intragastric, subcutaneous, and intravenous introduction of the highest maximum dose of the WSPS being investigated. The results of the experiments did not allow detecting the average fatal dose (LD50) of the WSPS being investigated as no deaths among the experimental animals had been observed. The obtained data lead to the conclusion that the WSPS of calamus root are to be added to Substance Hazard Class IV (low hazard substances) in compliance with State Standard GOST 12.1.007-76.

EFFECT OF KAGOCEL PREPARATION ON THE GENERATIVE FUNCTION OF EXPERIMENTAL ANIMALS AT ITS ADMINISTRATION IN THE INFANTILE PERIOD OF THEIR DEVELOPMENT

2017 ◽  
pp. 42-49
Author(s):  
T. A. Borovskaya ◽  
M. E. Poluektova ◽  
A. V. Vychuzhanina ◽  
V. A. Mashanova ◽  
Yu. A. Shchemerova
Keyword(s):  
Toxic Effect ◽  
Reproductive System ◽  
Safety Profile ◽  
Therapeutic Dose ◽  
Antiviral Drug ◽  
Experimental Studies ◽  
Reproductive Age ◽  
Pathological Changes ◽  
Pediatric Practice ◽  
Experimental Animals

In experimental studies on rats (males, females) at their infantile stage starting from 10 days, a potential delayed toxic effect of the antiviral drug Kagocel on the reproductive system was studied. The drug was administered for 12 days in a therapeutic dose and at a dose 10-fold higher than the therapeutic one. Reproductive safety was estimated after animals reached the reproductive age (2.5 months). It was found out that the drug, when administered in both doses, does not decrease the fertility of animals, does not induce morphological and pathological changes in the sex glands, and does not have toxic effect on the offspring. Obtained data characterize Kagocel as a preparation with a wide reproductive safety profile and show that it can be used in pediatric practice for infants.

Influence of water-soluble derivatives of [60]fullerene on therapeutically important targets related to neurodegenerative diseases

MedChemComm ◽  
2014 ◽  
Vol 5 (11) ◽  
pp. 1664-1668 ◽  
Author(s):  
R. A. Kotelnikova ◽  
A. V. Smolina ◽  
V. V. Grigoryev ◽  
I. I. Faingold ◽  
D. V. Mischenko ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Cognitive Functioning ◽  
Water Soluble ◽  
Neuroprotective Agents ◽  
Fullerene Derivatives ◽  
Influence Of Water ◽  
Derivatives Of

Water soluble fullerene derivatives I and II were shown to behave as promising neuroprotective agents that improve cognitive functioning in animals.

scholarly journals Distribution of Acid-fast Bacilli in the Skin, Extremities and Internal Organs of Various Experimental Animals

Repura ◽  
1966 ◽  
Vol 35 (1) ◽  
pp. 27-32
Author(s):  
TATSUO MORI ◽  
KENJI KOHSAKA ◽  
YOSHIHARU KISHI ◽  
MASAXO KAMEI ◽  
SHINJI NISHIMURA
Keyword(s):  
Internal Organs ◽  
Experimental Animals ◽  
Acid Fast Bacilli

scholarly journals THE EFFECTIVENES OF COMPLEX DRUG “BIFIDUM BAG” FOR STATUS CORRECTION OF LARGE INTESTINE MICROBOICENOSIS AND ANTIOXIDANT PROPERTIES OF COLONOCYTES IN EXPERIMENTAL DYSBIOSIS

2019 ◽  
Vol 23 (2) ◽  
pp. 203-210
Author(s):  
O. A. Medvedeva ◽  
V. A. Korolev ◽  
N. A. Verevkina ◽  
V. A. Riadnova
Keyword(s):  
Superoxide Dismutase ◽  
Large Intestine ◽  
Antioxidant Properties ◽  
Malonic Dialdehyde ◽  
The State ◽  
Control Group ◽  
Experimental Animals ◽  
Bacteriological Method ◽  
Complex Preparation ◽  
Complex Drug

The effectiveness of complex drug “Bifidum BAG” for status correction of large intestine microbiocenosis and antioxidant properties of colonocytes in experimental dysbiosis has been studied. Acomplex drug was administered to experimental animals, which includes Bifidobacterium and Dihydroquercetin. Quantitative and qualitative study of large intestine was done in mices by bacteriological method. The state of lipid peroxidation system was evaluatedaccoding to the content of acylhydroperoxide and malonic dialdehyde. The state of antioxidant protective system was reached by means of catalase and superoxide dismutase activity. Experimental dysbiosis was shown as significant changes in mucosal microflora, changes colonocytes antioxidant properties. The use of the complex preparation “Bifidum BAG”, led to the normalization of the colon microbiota (11 of 16 microorganisms were recovered). After correction gentamicin-associated dysbiosis with a complex probiotic, a positive effect of the drug on the colonocytes antioxidant defense was noted. So the activity of catalase increased 1.1 times, compared with the determined index in the group “dysbiosis”. The activity of superoxide dismutase increased 2 times in comparison with the group “dysbiosis”, exceeding the value of the control group. The concentration of LPO products in colonocytes of experimental animals decreased significantly. The content of malonicdialdehyde and acylhydroperoxide decreased 1.6 times and 5.6 times in comparison with the determined index of the group “dysbiosis”, respectively.

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