scholarly journals Effect of Moringa oleifera Leaf Extract on Histopathology of Heart Tissues on Silk Dye Waste Effluent Induced Swiss Albino Male Mice Mus musculus

2018 ◽  
Vol 7 (2) ◽  
pp. 2094-2100
Author(s):  
Serina Khatun
Keyword(s):  
Mus Musculus ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
Male Mice

scholarly journals EFFECTIVENESS ANTIPYRETIK RANDU SYRUP LEAF EXTRACT ETHANOL (Ceiba pentandra L) ONWHITE MALE Mice (Mus musculus)

2019 ◽  
Vol 6 (2) ◽  
Author(s):  
Setya Enti Rikomah
Keyword(s):  
Mus Musculus ◽  
Leaf Extract ◽  
Male Mice ◽  
Ceiba Pentandra ◽  
One Way Anova

Tumbuhan sebagai obat tradisional masih sangat di butuhkan di masyarakat Indonesia terutama di daerah pedesaan yang masih kaya dengan keanekaragaman tumbuhannya. Tanaman randu ( Ceiba pentandra L ) telah banyak digunakan di dunia kefarmasian dalam berbagai bentuk sediaan salah satunya sirup. Penelitian ini bertujuan untuk mengetahui efektifitas antipyretik sirup ekstrak etanol daun randu.    Penelitian ini menggunakan metode induksi vaksin DPT-Hb 0,022/20gr BB mencit sebagai induksi demam, menggunakan 5 kelompok perlakuan yaitu Kontrol Positif (Parasetamol), Kontrol Negatif (F0), Formula I (5%), Formula II (10%), Formula III (15%). Pengamatan dilakukan setiap 30 menit selama 180 menit. Data di analisa menggunakan One Way Anova dengan taraf kepercayaan 95%.    Hasil penelitian di dapatkan semua perlakuan Signifikan dengan nilai P 0.000 <0,05. Hasil Duncan menunjukkan Formula III memiliki efek Antipyretik lebih baik dibandingkan kontrol positif, formula II, kontrol negatif, formula I.

scholarly journals MUNTINGIA CALABURA’S LEAVES EXTRACT OINTMENT INCREASED COLLAGEN DENSITY AND ENHANCED HEALING OF SKIN INCISION WOUND IN HYPERGLYCEMIC MICE

2021 ◽  
Vol 10 (2) ◽  
pp. 189-199
Author(s):  
Irene Cristina Br Sembiring ◽  
Anak Agung Gede Wardhita ◽  
Anak Agung Ayu Mirah Adi
Keyword(s):  
Wound Healing ◽  
Body Weight ◽  
Mus Musculus ◽  
Leaf Extract ◽  
Skin Incision ◽  
Male Mice ◽  
Experimental Animals ◽  
The Mean ◽  
Collagen Density ◽  
Incision Wound

This study aims to determine the effect of Muntingia calabura‘s leaves extract ointment on the healing of cuts in the skin of hyperglycemic mice in terms of collagen density. This study used 24 male mice (Mus musculus) with alloxan induced hyperglycemia (150 mg/kg body weight) intraperitoneal. Skin incisions are made on the back using a scalpel with a length of ± 15 mm and a depth reaching the subcutaneous. The experimental animals were randomly divided into four treatments and each treatment consisted of six replications, namely the control was given a placebo, and the treatment of cherry leaf extract ointment with a concentration of 30%, 40%, and 50%. The process of wound healing was observed histopathological with collagen density parameters. Based on the results, there was an increase in collagen density in each treatment. The mean collagen density in treatment (T) 0% (T0) 0.60; at treatment 30% (T1) 0.73; at treatment 40% (T3) 1,46; at 50% treatment (T3) was 2.20. The results of the study through the Kruskal Wallis test stated that the cherry leaf extract ointment had a very significant effect on the healing of the incision wound of hyperglycemic mice as seen from the density of collagen. We conclude that the administration of 50% cherry leaf extract ointment is the most effective in accelerating the healing of the hyperlycemic mice incision wounds in terms of collagen density.

scholarly journals IMMUNOMODULATORY EFFECT TEST FROM MORINGA LEAF EXTRACT (MORINGA OLEIFERA L.) WITH CARBON CLEARANCE METHOD IN MALE WHITE MICE

2018 ◽  
Vol 11 (9) ◽  
pp. 241
Author(s):  
Dwisari Dillasamola ◽  
Yufri Aldi ◽  
Mutia Fakhri ◽  
Skunda Diliarosta ◽  
Biomechy Oktomalio P ◽  
...  
Keyword(s):  
Analysis Of Variance ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
White Male ◽  
Immunomodulatory Effect ◽  
Male Mice ◽  
Carbon Clearance ◽  
Phagocytosis Index ◽  
Effect Test ◽  
Moringa Leaf Extract

Objective: Moringa oleifera leaf has chemical compounds that have been utilized by the community to cure health problems. One of its activities is an immunomodulator. The aim of this study is to determine the immunomodulatory effect from M. oleifera leaf using a carbon clearance method to measure the activity of phagocytic cells in exterminating pathogens that enter the body then followed by calculating the total leukocyte cells. The parameters of this test are phagocytosis index and total leukocyte cells.Methods: Twenty white male mice were divided into four groups. Group I (vehicle control) was treated with sodium-carboxymethyl cellulose (NaCMC) 0.5%, Group II-IV were treated by M. oleifera leaf extract given to the mice for six consecutive days orally in doses of 10, 30, 100 mg/kg. On the seventh day, white male mice were given with intravenous carbon suspension through their tails. The value of phagocytosis index (PI > 1) indicated immunostimulant activity. The data were analyzed by using one-way analysis of variance and Duncan test.Results: The analysis of variance results showed that the groups treated with Moringa leaf extract are significantly different with the vehicle groups (NaCMC 0.5%) (p<0.05). Increased doses of Moringa leaf extract are effective to improve the immunomodulator effect. It was included that Moringa leaf extract had the immunomodulatory capabilities as an immunostimulant.Conclusion: Immunomodulatory effect test of M. oleifera Lam. Based on the result of the research about immunomodulatory effect test from Moringa leaf extract (Moringa Oleifera L.) with carbon clearance method in male white mice, it can be concluded that Moringa leaf extract (Moringa Oleifera L.) has effect as an Immunomodulator.

PENGARUH EKSTRAK DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav.) TERHADAP GLUKOSA DARAH MENCIT (Mus musculus L.) JANTAN YANG DIINDUKSI SUKROSA

BioScience ◽  
2018 ◽  
Vol 2 (1) ◽  
pp. 61
Author(s):  
Elsa Yuniarti
Keyword(s):  
Blood Glucose ◽  
Mus Musculus ◽  
Leaf Extract ◽  
Negative Control ◽  
State University ◽  
Betel Leaf ◽  
Randomized Design ◽  
The Subject ◽  
Effective Drugs ◽  
Zoology Department

Patients withdiabetes mellitus (DM) continues to grow because prosperity and people's lifestyles.Treatment of diabetes often usei njections of insulin and oral antidiabetic drugs. Thetreatment has no side effects. Therefore, it is necessary to find effective drugs using plants thatred betel leaf (Piper crocatum Ruiz & Pav.). Red betel leaf contains flavonoids which are antioxidants. This study aims to determine the effect and dose of extract of red betel leaf (Piper crocatum Ruiz & Pav.) The most effective agains blood glucose in mice(Mus musculusL.) male induced sucrose.This study was an experimental study. The research was conducted in October 2015 in the Division of Laboratory Animal and Zoology Department of Biology, State University of Padang. The subject of research in the form of mice (Mus musculus L.) males totaled 24 tails. The design used was completely randomized design (CRD) with 6 treatments and 4 repetitions. The treatment is given as follows: treatment I: the diabetes control without any treatment given, treatment II: as a negative control (sucrose 3 g/kg bw), treatment III: sucrose+suspension of red betel leaf extract (dosage 0,7 g/kg bw), treatment IV: sucrose+suspension of red betel leaf extract (dosage 1,4 g/kg bw), treatment V: sucrose+suspension of red betel leaf extract (dosage of 2,1 g/kg bw) and treatment VI: sucrose+suspension extracts red betel leaf (dosage 2,8 g/kg bw).The results showed that the extract of red betel leaf (Piper crocatum Ruiz & Pav.) at a dose of 0,8 g/kg bw 1,4 g/kg bw 2,1 g/kg bw and 2,8 g/kg bw can lowers blood glucose in mice. However, the most appropriate dose in lowering blood glucose in mice (Mus musculus L.) at 2,8 g/kg bw in mice.

Development of Ultrasensitive and Arsenic (III) Selective Upconverting (NaYF4: Yb3+, Er3+) Platform

2020 ◽  
Author(s):  
Suman Duhan ◽  
Kedar Sahoo ◽  
Sudhir Kumar Singh ◽  
Manoj Kumar
Keyword(s):  
Heavy Ions ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
Solid Phase ◽  
Selective Detection ◽  
Arsenic Pollution ◽  
Apparent Effect ◽  
Safe Limit ◽  
Interfering Ions ◽  
Resonance Transfer

The development of a sensitive alpha-NaYF4:Yb3+, Er3+ solid-phase upconverting platform (UCP) has been realized using Moringa oleifera leaf extract for selective detection of arsenic (As III) contamination in drinking water. The presence of polyphenols in the leaves extract is shown to induce luminescence resonance transfer (LRET), diminishing thereby the Er3+ upconverting red and green emissions activated by 980 nm excitation. However, addition of As3+ species interrupts the LRET process and restores emission proportionately. This feature allows platform to selectively detect arsenic pollution in water below the safe limit of 10 ppt. The uniqueness of UCP lies in monitoring the As3+ contamination in samples containing heavy ions (Cd2+, Hg2+) as well, without apparent effect on the signal reproducibility. UCP is also found to be insensitive to other interfering ions like Pb2+, H2PO4-, F-, Cl-, Ca2+, Mg2+, Sn2+, Cr6+, Fe2+ and Co2+, if present.<br><br>

Analgesic Effectivty Of Nanoparticles Chitosan-Ethanol Leaf Extract Papaya (Carica Papaya L.) In White Male Mice (Mus Mucculus)

2017 ◽  
Vol 15 (2) ◽  
pp. 228
Author(s):  
Juliferd Gredi ◽  
Wintari Taurina ◽  
Mohamad Andrie
Keyword(s):  
Leaf Extract ◽  
Carica Papaya ◽  
White Male ◽  
Ethanol Extract ◽  
Test Method ◽  
Ionic Gelation ◽  
Male Mice ◽  
Writhing Test ◽  
Effi Ciency ◽  
Optimal Formula

Papaya leaves has been shown to have efficacy as an analgesic. Analgesic effect caused by the flavonoids in leaves of papaya. To enhance the analgesic effi cacy papaya into dosage formulatio of nanoparticles. The purpose of this research was to create and characterized nanoparticles from ethanol extract of papaya leaves then tested for effectiveness as an analgesic. This study used polymer chitosan and NaTPP to created nanoparticles through ionic gelation method and analgesic activity tested using writhing test method and statistical tested. Optimal formula of nanoparticles were produced at concentration of 0.2% chitosan, Na-TPP extract 0.1% and 4% with a ratio of 6: 1: 1. The nanoparticles was formed a size of 255.4 nm with polidispers index of 0.7, the zeta potential of + 11,1mV, the adsorption effi ciency by 87% and rounded morphology (spherical). Analgesic effectiveness tested by comparison between the groups ethanol extract of papaya and the groups nanoparticles of chitosan-ethanol extract papaya statistically using the T-test Independent. The results of this research indicate that there are statistically signifi cant differences (p <0.05). This results shows that the preparation nanoparticles of chitosan-ethanol extract papaya is more effective as an analgesic than the ethanol extract of papaya leaves.

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