scholarly journals Anti-toxicity test of Peperomia pellucida steeping on liver function in diabetic-induced rat

Molekul ◽  
2020 ◽  
Vol 15 (2) ◽  
pp. 97
Author(s):  
Saryono Saryono ◽  
Hernayanti Hernayanti ◽  
Atikah Proverawati
Keyword(s):  
Liver Function ◽  
Defense Mechanism ◽  
Cell Damage ◽  
Negative Control ◽  
Effective Dosage ◽  
Control Group ◽  
Control Group Design ◽  
Significance Level ◽  
Before And After ◽  
Post Test

Liver is important for both defense mechanism and protein synthesis in the human body. This study examined the anti-toxicity of Peperomia pellucida on liver function of diabetic-induced rats. It was an experimental study using pre- and post-test control group design. Rats were categorized into five groups, i.e., groups of healthy control (A), negative control (B), and treatment (C-E) with dosages of 150, 300, and 600 mg/kg of P. pellucida, respectively. Each group comprises of 5 rats. The TNF-a, IL-12, and GSH were measured before and after a 14 days administration of P. pellucida. The data were analyzed by using one-way ANOVA test followed by Duncan's post hoc test with a significance level of 5%. The result showed that P. pellucida steeping can improve liver cell damage, which was shown from the parameters of liver function, inflammation, and antioxidants. The mean of TNF-a and IL-12 levels decreased while the total protein, albumin, and GSH levels increased significantly after administration of P. pellucida steeping. Our study concluded that P. pellucida steeping might reduce TNF-a and IL-12 levels, and increased GSH level in diabetic-induced rat. A 300 mg/kg was the most effective dosage to reduce IL-12 and increase GSH.

scholarly journals Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium

Molekul ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. 202
Author(s):  
Hernayanti Hernayanti ◽  
Sri Lestari ◽  
Saryono Saryono ◽  
Puji Lestari
Keyword(s):  
Centella Asiatica ◽  
Negative Control ◽  
Effective Dosage ◽  
Control Group ◽  
Control Group Design ◽  
Toxic Heavy Metal ◽  
Significance Level ◽  
Tnf Α ◽  
Post Test ◽  
Anti Inflammatory

Cadmium is  a toxic heavy metal. The present of cadmium caused inflammation in liver. This study aims to know the anti inflammatory of Centella asiatica extract on rat induced by cadmium. This research was an experimental study using post test only control group design. Twenty four rats divided into six groups  with four replications, i.e group of healthy control (C1), negative control induced by CdSO4 with dosage 56 mg/kg for 14 days and treatment (C3-C6) with dosage of 100, 200 ,300 and 400 mg/kg of C. asiatica. The blood Cd, GST, GSH, TNF- α and COx2 were measured after a 21 days administration of C. asiatica. The data were analyzed by ANOVA test followed by Duncan test with a significance level of 5%. The result showed that administrating C.asiatica can neutralized cadmium, improve inflammation in liver.The conclusion of our research that C.asiatica extract can decrease Cd level, TNF-α and COx2 levels and increase GST and GSH level in rat induced by cadmium. A 200 mg/kg was the effective dosage to reduce Cd, TNF-α and COx2 levels and increase GST and GSH levels. Key words : anti inflammatory, Cd, Centella asiatica, GST, COX2

scholarly journals Improvement of Anxiety, Coughing, Breathlessness and Pain Control in The Management of Bronchoscopy by Adding Alprazolam

2019 ◽  
Vol 39 (4) ◽  
pp. 245-255
Author(s):  
Yanny Octavia Sally Ride ◽  
Yusup Subagio Sutanto ◽  
Debree Septiawan
Keyword(s):  
Lung Tumor ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Control Group ◽  
Control Group Design ◽  
Before And After ◽  
Post Test ◽  
Vas Scores ◽  
And Control ◽  
Test Control

Background: Anxiolytic premedication can reduce anxiety, improving procedural tolerance, and reduce postbronchoscopic complications. There was ongoing debate about the safety of bronchoscopist-administered sedation. Alprazolam as a surgical premedication can reduce anxiety. Alprazolam can be used as an adjuvant analgesic, to reduce anxiety-related breathlessness, and to reduce coughing as adjuvant antitussive. The study aimed to evaluate the effectiveness of alprazolam in patients undergoing bronchoscopy. Methods: A clinical study with experimental quasi pre-post test control group design, using consecutive sampling was performed in patients with lung tumor undergoing bronchoscopy in dr.Moewardi Hospital from February to March 2019. The study subjects were divided in experimental (alprazolam) and control groups (without alprazolam). The Hospital Anxiety and Depression Scale (HADS), VAS for pain score, modified Borg score, and VAS for cough were measured in baseline, before, and after bronchoscopy. Results: Thirty two lung subjects were included in this study. The intervention groups showed decreased HADS score pre and post bronchoscopy (6.56±2.83 and 6.88±2.63), pain VAS scores (15.00±10.95 and 9.69±11.61), cough VAS score (11.56±8.89 and 27.19±17.89), and these were different significantly compared to control group. We found decreased mean of modified Borg in the study group though they were not significant compared to the control group. Conclusion: Alprazolam controlled anxiety, coughing, and pain in patients undergoing bronchoscopy. Alprazolam minimized breathlessness after bronchoscopy. (J Respir Indo. 2019; 39(4): 245-55)

scholarly journals Potensi Ekstrak Daun Kelor (Moringa Oleifera) sebagai Hepatoprotektor pada Tikus Putih (Rattus novergicus) yang Diinduksi Parasetamol Dosis toksik

2018 ◽  
Vol 5 (1) ◽  
pp. 58
Author(s):  
Noer Kumala Indahsari ◽  
Masfufatun Masfufatun ◽  
Emilia Devi D.R
Keyword(s):  
Treatment Group ◽  
Moringa Oleifera ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Flavonoid Compound ◽  
Control Group ◽  
High Dose ◽  
Control Group Design ◽  
Post Test

Moringa Oleifera is a plant that contains chemical compounds that are useful, such as flavonoids. The ability of this flavonoid compound that can capture free radicals cause damage and hepatoprotektan hepar. Purpose of study was to determined levels of Moringa leaf extract which can overcome the effects of liver damage caused by toxic doses of paracetamol through MDA, SGOT and SGPT Method used in this laboratory experimental study is a Randomized Post Test Only Control Group Design with the following stages: 1. Moringa Leaf Extraction with Ethanol 96%; Try 2.Preparasi animals, 3. Treatment of Animals Try the extract of leaves of Moringa 3 dose is: 250mg / 200BB rat (dose of A), 500mg / 200BB mice (dose B), 1000mg / 200BB mice (dose C) for 14 days in combination with paracetamol 2 g / 200BB mice, compared to the negative control group (group given just paracetamol 2 g / 200BB rat) and the positive control group (the group who were given regular feed) for 14 days.Results : turned out to be no difference in the reduction in SGOT levels are statistically significant between the negative control group with high-dose treatment group ie the dose C with =0,016 smaller than 0.05, whereas a decrease in ALT levels were significantly decreased in the treatment group high dose is the dose C with =0,009 smaller than 0.05. While MDA group treated with the negative control group experienced an overall decline for the dose A with =0,05, dose B with =0,0011 and dose C with =0,001. Conclusion of this study showed that the extract of Moringa leaves can be potentially as an antioxidant in all doses at once can be as hepatoprotektor at high doses is 1000mg / 200BB Rattus Novergicus.

scholarly journals PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE JIGSAW TERHADAP HASIL BELAJAR SISWA PADA MATA PELAJARAN DASAR KELISTRIKAN DAN ELEKTRONIKA KELAS X TAV DI SMKN 1 PADANG

2018 ◽  
Vol 2 (2) ◽  
Author(s):  
Nora Mawinda ◽  
Zulkifli Naansah ◽  
Hanesman Hanesman
Keyword(s):  
Cooperative Learning ◽  
Learning Outcomes ◽  
Learning Model ◽  
Control Group ◽  
Control Group Design ◽  
Significance Level ◽  
Group Design ◽  
Design Learning ◽  
Post Test ◽  
And Control

The problem in this study is the low learning outcomes achieved by students on the subjects of Basic Electrical and Electronics which is below the minimum completeness criteria (KKM) set a school that is 75 This is presumably because they are learning is often used during the learning model is applied directly proven yet effective. The purpose of this research is to reveal how much influence the Jigsaw cooperative learning model to study the results of class X students on subjects TAV Basic Electricity and Electronics. This research is an experimental study with a draft Post-test only control group design. The sample were students of class X TAV at SMK 1 Padang Academic Year 2014 / 2015. Class experiment is treated using Jigsaw Cooperative Learning Model and the control group is a class that uses the direct teaching model. The data is taken from the test results in the form of learning about the objective as many as 31 items. Data were analyzed manually to test for normality, homogeneity testing, and hypothesis testing. The result of the calculation hypothesis at significance level α = 0.05 was found that t count> t table is 3.35> 1.670. The results of these tests give an interpretation that H0 is rejected and H1 is accepted, this means that on average significantly experimental class learning outcomes greater than the average control class learning outcomes.  Key words :   Models of Learning, Jigsaw, Learning Direct, Post-test only control group design, Learning outcomes, Experimental, and Control.

scholarly journals Uji Efektivitas Sediaan Hand Sanitizer Kombinasi Ekstrak Daun Kemangi (Ocimum Sanctum L) Dan Ekstrak Kulit Jeruk Purut (Citrus Hystrix)

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Indri Kusuma Dewi ◽  
Bambang Yunianto
Keyword(s):  
Confidence Level ◽  
Negative Control ◽  
Ocimum Sanctum ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Hand Sanitizer ◽  
Post Test ◽  
Test Control ◽  
Optimal Formula

Absctract : Antiseptic Activity, Kemangi Leaf- Cytrus Hystrix Leather, Gel Antiseptic (Hand Sanitizer). It is known kemangi leaf had contained saponins, flavonoids and tannins that benefit as antibacterial, while in research by Susanti, 2010 had proven that leather of Citrus hystrix contained essential oil as antibacterial and used as antiseptic in pharmaceutical case. So, to get the optimal formula as hand sanitizer or antiseptic gels used combination two extracts kemangi leaf and Citrus hystrix leather. This research is an experimental research with Post Test Control Group Design to analyze antiseptic activity using the Replica methods with to account the number of colonies of microorganism. Statistic test to the number of colonies of microorganism with Anova Test one way that confidence level 95% and obtained significance 0,000 the result P < 0,05 and continued to Tukey HSD test that confidence level 95%. The result statistic tes showed that have significan differences between negative control with the formula of gel antiseptic combination extract of kemangi leaf and extract Cytrus hystrix leather, so this formula have activity as antiseptic. The most effective variation concentration is concentration extract of kemangi leaf 75% and extract Cytrus hystrix leather 25%.

scholarly journals Promoting the Increase of Mathematical Representative Skill in Vocational Students through Blended Problem-Based Learning

2019 ◽  
Vol 2 (2) ◽  
pp. 65
Author(s):  
Sri Rahayu Setiyorini ◽  
Azalina Nurul Fajariah
Keyword(s):  
High School ◽  
Problem Based Learning ◽  
Mathematical Representation ◽  
Control Group ◽  
Vocational Students ◽  
Vocational High School ◽  
Control Group Design ◽  
Significance Level ◽  
Lecture Method ◽  
Post Test

Low mathematical representation skill causes the inability of vocational students solving problems creatively as demanded by industries. Researches showed that blended problem-based learning (BL-PBL) combining online and offline learning to train students to independently solve problems was proven to increase mathematical skills in education levels other than vocational school. Therefore, this research aimed to evaluate BL-PBL effect to mathematical representation skill escalation in vocational high school. Quantitative study with pre-test and post-test control group design was performed to two randomly-chosen classes over vocational schools in Kabupaten Bandung Barat, West Java, Indonesia. Samples were divided into two groups: experimental (BL-PBL method) and control (lecture method). Initial skill was determined by pre-test while learning outcome was determined using post-test. Data was analysed by t-test and two-way ANOVA with 0.05 significance level using IBM SPSS. Result showed the initial skill of two groups was similar. After treatment, N-gain data uncovered a significant increase of representative skill in experimental group. While, two-way ANOVA test showed no interaction between learning model used and student grouping based on initial skill to representation skill. Finally, BL-PBL was proven to increase mathematical representation skill in vocational students and, hence, is suggested to be implemented in vocational high school

scholarly journals PENGARUH BRISK WALKING (JALAN CEPAT) TERHADAP FUNGSI HATI PADA OBESITAS SENTRAL

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Heri Nuryanto ◽  
Frans E. N. Wantania ◽  
B. J. Waleleng
Keyword(s):  
Waist Circumference ◽  
Liver Function ◽  
Central Obesity ◽  
Control Group ◽  
P Value ◽  
Brisk Walking ◽  
Group Data ◽  
Significant Difference ◽  
Before And After ◽  
Post Test

Abstract: Central obesity is considered as a risk factor that strongly associated with several chronic diseases. Men with waist circumference ≥ 90 cm and women with waist circumference ≥80 cm are stated as central obesity. This study aimed to determine the effect of brisk walking on liver function in central obesity. This was an experimental field study with a non-randomized pre-post one group test and control group. This study used consecutive sampling method. There were 30 samples divided into two groups; 15 samples were given intervention and 15 samples as the control group. Data were analyzed with Wilcoxon signed ranks test.   The results showed that brisk walking for 1 month decreased the SGPT and SGOT levels, however, statistically there was no significant difference before and after intervention with a p value >0.05. Conclusion: There was no significant influence of brisk walking on liver function in central obesity. Keywords: central obesity, liver function, brisk walking  Abstrak: Obesitas sentral dianggap sebagai faktor risiko yang berkaitan erat dengan beberapa penyakit kronis. Laki-laki dengan lingkar pinggang ≥90 cm atau perempuan dengan lingkar pinggang ≥80 cm dinyatakan sebagai obesitas sentral. Penelitian ini bertujuan untuk mengetahui pengaruh brisk walking (jalan cepat) terhadap fungsi hati pada obesitas sentral.  Metode penelitian ini yaitu eksperimental lapangan dengan rancangan non – randomized pre-post test with control. Sampel ditentukan dengan teknik pengambilan sampel konsekutif sampling. Terdapat 30 sampel yang dibagi menjadi 2 kelompok yakni 15 sampel yang diberi perlakuan dan 15 sampel sebagai kontrol. Data dianalisis dengan SPSS 20 dan uji Wilcoxon Signed Ranks Test. Hasil penelitian memperlihatkan terjadi penurunan kadar enzim hati SGPT dan SGOT pada sampel yang melakukan brisk walking selama 1 bulan tetapi secara statistik tidak ada perbedaan bermakna sebelum dan sesudah mendapatkan perlakuan dengan nilai p > 0,05.  Simpulan: Tidak terdapat pengaruh bermakna dari brisk walking (jalan cepat) terhadap fungsi hati pada obesitas sentral. Kata kunci: obesitas sentral,  fungsi hati,  brisk walking

scholarly journals Porositas Lempeng Resin Akrilik Pasca Perendaman Rebusan Daun Sirih dan Kayu Siwak

2018 ◽  
Vol 4 (1) ◽  
pp. 39
Author(s):  
Yustin Nur Khoiriyah
Keyword(s):  
Acrylic Resin ◽  
Negative Control ◽  
Control Group ◽  
Control Group Design ◽  
Betel Leaf ◽  
Significant Difference ◽  
Antimicrobial Function ◽  
Post Test ◽  
Boiled Water ◽  
One Way Anova

Abstract: Porosity Of Acrylic Resin After Immersion In The Boiled Water Of Betel Leaves And Siwak Wood. Denture acrylic resin can be a collection point for stain, tar, and plaque and this will adversely affect the oral health of the denture wearer. One way to clean the oral cavity of denture users is to use mouthwash and soak the teeth with a cleaning solution/denture cleanser. Mouthwash solutions and chemical-based cleaning solutions at relatively high prices, and affect the porosity of dentures. Therefore, the need for alternative materials that are safe, cheap, natural as well as having antimicrobial function without affecting the level of porosity of denture. This study was to determine the effect of the combination of boiled water of betel leaves and siwak wood to the porosity of the acrylic resin plate. This study was an experimental study, posttest only design with the control group has been done at the integrated laboratory of Poltekkes Tanjungkarang, July – December 2015. Data were analyzed by One Way ANOVA and continued with Least Significant Difference test. The results showed that the combination of betel leaves and siwak wood does not affect the porosity of the acrylic resin plate. The highest concentration of the combination of betel leaf water and siwak wood that did not differ significantly with negative control (aquades) was 75% with longest immersion period was 59 days. Abstrak: Porositas Lempeng Resin Akrilik Pasca Perendaman Rebusan Daun Sirih Dan Kayu Siwak. Gigi tiruan resin akrilik dapat menjadi tempat pengumpulan stain, tar, dan plak dan hal ini akan berpengaruh jelek terhadap kesehatan mulut pemakai gigi tiruan. Salah satu cara menjaga kebersihan rongga mulut pengguna gigi tiruan adalah dengan menggunakan obat kumur dan merendam gigi-tiruan tersebut dengan larutan pembersih/denture cleanser. Larutan obat kumur dan larutan pembersih berbahan dasar dari bahan kimia dengan harga yang relatif mahal, serta mempengaruhi porositas gigi tiruan. Oleh karena itu, perlu adanya bahan alternatif yang aman, murah, alami sekaligus memiliki fungsi antimikroba dengan tanpa mempengaruhi tingkat porositas gigi tiruan. Tujuan penelitian ini adalah untuk mengetahui pengaruh kombinasi air rebusan daun sirih dan kayu siwak terhadap porositas lempeng resin akrilik. Penelitian ini adalah penelitian eksperimental, rancangan post test only with control group design, dilaksanakan di Laboratorium Terpadu Poltekkes Tanjungkarang, Juli-Desember 2015. Analisis data dengan uji One Way ANOVA dan dilanjutkan uji Least Significant Difference. Hasil penelitian menunjukkan bahwa kombinasi air rebusan daun sirih dan kayu siwak tidak mempengaruhi porositas lempeng resin akrilik. Konsentrasi tertinggi dari kombinasi air rebusan daun sirih dan kayu siwak yang tidak berbeda signifikan dengan kontrol negatif (aquades) adalah 75% dengan lama perendaman terpanjang yaitu 59 hari.

scholarly journals UJI EFEKTIFITAS BIOLARVASIDA EKSTRAK ETANOL BUAH LAMPESU (Baccaurea lanceolata) TERHADAP LARVA INSTAR III Culex quinquefasciatus

2020 ◽  
Vol 3 (3) ◽  
pp. 7
Author(s):  
Dea Alfani Nandjan
Keyword(s):  
Culex Quinquefasciatus ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Chemical Insecticide ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
Infection Disease

Filariasis is chronic infection disease caused by worm and carried by Culex quinquefasciatus mosquito. One of theways to controlling mosquitoes vectors are use biolarvacide or chemical insecticide. Chemical insecticide causingresistance Culex quinquefasciatus larvae and toxic for human. This research aim to determine the biolarvacideeffectiviteness of ethanol extract lampesu fruit (Baccaurea lanceolata) to Culex quinquefasciatus larvae instars III.This study was true experimental with a Post test-only control group design. This study used 700 larvae instars III ofCulex quinquefasciatus divided into 7 groups consentration of 0,2%, 0,4%, 0,6%, 0,8% and 1%, the positive control(abate) and negative control (aquadest). The observation was did after treatment in 3 hours, 6 hours, 12  hours and 24hours. The experiment is replicated four times. At 24 hours exposure concentration of 0,6% the test larvae mortalityreached 38% and at concentration of 1% the test larvae mortality reached 30%. In this stuy the concentration of1,531 % was effective to kill larvae with of 50% mortality(LC50) and concentration of 10,729 % was effective to killlarvae with of 90% mortality(LC90). Ethanol Ekstract of Lampesu Fruit (Baccaurea lanceolata) not effective asbiolarvacide ofCulex quinquefasciatus larvae instars III.

scholarly journals PSYCHOEDUCATION INTERVENTION INCREASE ON THE ABILITY OF THE PRE-SENILE HYPERTENSION MANAGEMENT

Jurnal NERS ◽  
2017 ◽  
Vol 9 (1) ◽  
pp. 66
Author(s):  
Nyoman Sudja ◽  
Meirina Meirina
Keyword(s):  
Intervention Group ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Before And After ◽  
Post Test ◽  
Quasi Experimental ◽  
Physical Changes ◽  
And Behavior ◽  
The City

Introduction: Increasing age in pre-senile, causes a deterioration abilities and physical changes, including the cardiovascular system. Blood vessels lose their elasticity thus be increased peripheral vascular resistance that results in hypertension. This study aims to gain an idea of the effect on the ability of pre-senile people’s psychoeducation in the management of hypertension. Method: Quasi-experimental, the pre-post test with control group design, psychoeducation intervention with a sample size of 72 people . Result: The results showed signifi cant difference of pre-aged knowledge and behavior before and after getting psychoeducation intervention in the intervention group (p-value = 0.000 knowledge, and behaviors = 0.000) . Whereas in the control group there was no difference in knowledge (p-value = 0.896), but there are signifi cant differences in behavior of pre-senile people (p-value = 0.049). There are differences in knowledge and behavior after they were given psychoeducation intervention (post-test ) in the intervention group and the control group (p-value = 0.001 knowledge , behavior=0.018). Discussion: Psychoeducation had effect on the ability of pre-senile in the management of hypertension, so this program can be applied to groups of Posbindu for pre-senile people throughout the areas of the city of Bogor.Key words: psychoeducation, skills, pre-senile, hypertension

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