scholarly journals Chitosan Based Self-assembled Nanoparticles in Drug Delivery

2018 ◽  
Author(s):  
Javier Perez Quinones ◽  
Hazel Peniche ◽  
Carlos Peniche
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Chitosan Nanoparticles ◽  
Biological Properties ◽  
Polyelectrolyte Complexes ◽  
Non Invasive ◽  
Hydrophobic Moiety ◽  
Specificity And Sensitivity ◽  
Self Assembled ◽  
Routes Of Drug Administration

Chitosan is a cationic polysaccharide usually obtained by alkaline deacetylation of chitin poly(N-acetylglucosamine). It is biocompatible, biodegradable, mucoadhesive and non-toxic. These excellent biological properties make chitosan a good candidate for a platform in developing drug delivery systems having improved biodistribution, increased specificity and sensitivity, and reduced pharmacological toxicity. In particular, chitosan nanoparticles are found to be appropriate for non-invasive routes of drug administration: oral, nasal, pulmonary and ocular routes. These applications are facilitated by the absorption-enhancing effect of chitosan. Many procedures for obtaining chitosan nanoparticles have been proposed. Particularly, the introduction of hydrophobic moieties into chitosan molecules by grafting to generate a hydrophobic-hydrophilic balance promoting self-assembly is a current and appealing approach. The grafting agent can be a hydrophobic moiety forming micelles that can entrap lipophilic drugs or it can be the drug itself. Another suitable way to generate self-assembled chitosan nanoparticles is through the formation of polyelectrolyte complexes with polyanions. This paper reviews the main approaches for preparing chitosan nanoparticles by self-assembly through both procedures and illustrates the state of the art of their application in drug delivery.

scholarly journals Chitosan Based Self-assembled Nanoparticles in Drug Delivery

2018 ◽  
Author(s):  
Carlos Peniche ◽  
Hazel Peniche ◽  
Javier Pérez
Keyword(s):  
Drug Delivery ◽  
Chitosan Nanoparticles ◽  
Biological Properties ◽  
Polyelectrolyte Complexes ◽  
Non Invasive ◽  
Self Assembling ◽  
Hydrophobic Moiety ◽  
Specificity And Sensitivity ◽  
Self Assembled ◽  
Routes Of Drug Administration

Chitosan is a cationic polysaccharide usually obtained by alkaline deacetylation of chitin poly(N-acetylglucosamine). It is biocompatible, biodegradable, mucoadhesive and non-toxic. These excellent biological properties make chitosan a good candidate as platform for developing drug delivery systems with improved biodistribution, increased specificity and sensitivity, and reduced pharmacological toxicity. In particular, chitosan nanoparticles have been found appropriate for non-invasive routes of drug administration: oral, nasal, pulmonary and ocular routes. These applications are facilitated by the absorption-enhancing effect of chitosan. Many different procedures have been proposed for obtaining chitosan nanoparticles. Particularly, the introduction of hydrophobic moieties into chitosan molecules by grafting to generate a hydrophobic-hydrophilic balance promoting self-assembling is a current and appealing approach. The grafting agent can be a hydrophobic moiety to form micelles that can entrap lipophilic drugs or it can be the drug itself. Another suitable way to generate self-assembled chitosan nanoparticles is through the formation of polyelectrolyte complexes with polyanions. This paper reviews the main approaches developed for preparing chitosan nanoparticles by self-assembling by both procedures and illustrates the state of the art of their application in drug delivery.

scholarly journals Chitosan Based Self-assembled Nanoparticles in Drug Delivery

2018 ◽  
Author(s):  
Javier Perez Quinones ◽  
Hazel Peniche ◽  
Carlos Peniche
Keyword(s):  
Drug Delivery ◽  
Chitosan Nanoparticles ◽  
Biological Properties ◽  
Polyelectrolyte Complexes ◽  
Non Invasive ◽  
Self Assembling ◽  
Hydrophobic Moiety ◽  
Specificity And Sensitivity ◽  
Self Assembled ◽  
Routes Of Drug Administration

Chitosan is a cationic polysaccharide usually obtained by alkaline deacetylation of chitin poly(N-acetylglucosamine). It is biocompatible, biodegradable, mucoadhesive and non-toxic. These excellent biological properties make chitosan a good candidate as platform for developing drug delivery systems with improved biodistribution, increased specificity and sensitivity, and reduced pharmacological toxicity. In particular, chitosan nanoparticles have been found appropriate for non-invasive routes of drug administration: oral, nasal, pulmonary and ocular routes. These applications are facilitated by the absorption-enhancing effect of chitosan. Many different procedures have been proposed for obtaining chitosan nanoparticles. Particularly, the introduction of hydrophobic moieties into chitosan molecules by grafting to generate a hydrophobic-hydrophilic balance promoting self-assembling is a current and appealing approach. The grafting agent can be a hydrophobic moiety to form micelles that can entrap lipophilic drugs or it can be the drug itself. Another suitable way to generate self-assembled chitosan nanoparticles is through the formation of polyelectrolyte complexes with polyanions. This paper reviews the main approaches developed for preparing chitosan nanoparticles by self-assembling by both procedures and illustrates the state of the art of their application in drug delivery.

scholarly journals Self-Assembled Nanogels Based on Ionic Gelation of Natural Polysaccharides for Drug Delivery

2021 ◽  
Vol 9 ◽  
Author(s):  
Huimin Wang ◽  
Hong Deng ◽  
Menghan Gao ◽  
Weiqi Zhang
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Biomedical Application ◽  
Biological Activities ◽  
Drug Loading ◽  
Biological Properties ◽  
The Self ◽  
Hydroxyl Groups ◽  
Self Assembled ◽  
Potent Drug

The polysaccharides (PS) have been widely used as biomaterials in drug delivery, due to their excellent biocompatibility, ease of functionalization, and intrinsic biological activities. Among the various PS-based biomaterials, the self-assembled PS nanogels (NG) featuring facile preparation are attracting evergrowing interests in various biomedical applications. Specifically, NG derived from the self-assembly of natural PS well maintain both the physicochemical and biological properties of PS while avoiding the chemical modification or alteration of PS structure, representing a potent drug delivery system for various therapeutic agents. In this review, the natural PS, such as chitosan, alginate, and hyaluronan, for self-assembled NG construction and their advantages in the applications of drug delivery have been summarized. The residues, such as amine, carboxyl, and hydroxyl groups, on these PS provide multiple sites for both ionic cross-linking and metal coordination, which greatly contribute to the formation of self-assembled NG as well as the drug loading, thus enabling a wide biomedical application of PS NG, especially for drug delivery. Future developments and considerations in the clinical translation of these self-assembled PS NG have also been discussed.

scholarly journals FOLDNA, a Web Server for Self-Assembled DNA Nanostructure Autoscaffolds and Autostaples

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Chensheng Zhou ◽  
Heng Luo ◽  
Xiaolu Feng ◽  
Xingwang Li ◽  
Jie Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dna Sequences ◽  
Self Assembly ◽  
Web Server ◽  
Automatic Design ◽  
Dna Nanostructures ◽  
Complementary Dna ◽  
Dna Nanostructure ◽  
Comprehensive Information ◽  
Self Assembled

DNA self-assembly is a nanotechnology that folds DNA into desired shapes. Self-assembled DNA nanostructures, also known as origami, are increasingly valuable in nanomaterial and biosensing applications. Two ways to use DNA nanostructures in medicine are to form nanoarrays, and to work as vehicles in drug delivery. The DNA nanostructures perform well as a biomaterial in these areas because they have spatially addressable and size controllable properties. However, manually designing complementary DNA sequences for self-assembly is a technically demanding and time consuming task, which makes it advantageous for computers to do this job instead. We have developed a web server, FOLDNA, which can automatically design 2D self-assembled DNA nanostructures according to custom pictures and scaffold sequences provided by the users. It is the first web server to provide an entirely automatic design of self-assembled DNA nanostructure, and it takes merely a second to generate comprehensive information for molecular experiments including: scaffold DNA pathways, staple DNA directions, and staple DNA sequences. This program could save as much as several hours in the designing step for each DNA nanostructure. We randomly selected some shapes and corresponding outputs from our server and validated its performance in molecular experiments.

Synthesis and Self-Assembly of a Peptide - Amphiphile as a Drug Delivery Vehicle

2013 ◽  
Vol 66 (1) ◽  
pp. 23 ◽  
Author(s):  
Soo Jung Son ◽  
Margaret A. Brimble ◽  
Sunghyun Yang ◽  
Paul W. R. Harris ◽  
Tom Reddingius ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glutamic Acid ◽  
Long Range ◽  
Self Assembly ◽  
The Self ◽  
Long Range Order ◽  
Delivery Vehicle ◽  
Peptide Amphiphile ◽  
Drug Delivery Vehicle ◽  
Hydrophobic Moiety

The formation of functional liposomes by the self assembly of a peptide–amphiphile that comprises the neuroprotective tripeptide motif glycyl-prolyl-glutamic acid linked to a hydrophobic moiety is reported. The self-assembled peptide–lipid conjugate displays long range order and can be dispersed as nanometre sized particles.

scholarly journals A bio-orthogonal functionalization strategy for site-specific coupling of antibodies on vesicle surfaces after self-assembly

2020 ◽  
Vol 11 (2) ◽  
pp. 527-540 ◽  
Author(s):  
Meiyu Gai ◽  
Johanna Simon ◽  
Ingo Lieberwirth ◽  
Volker Mailänder ◽  
Svenja Morsbach ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Site Specific ◽  
Self Assembled

Attaching targeting ligands on the surface of self-assembled drug delivery systems is one of the key requests for a controlled transport of the drug to a desired location.

scholarly journals Review of Contemporary Self-Assembled Systems for the Controlled Delivery of Therapeutics in Medicine

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 278
Author(s):  
Laura Osorno ◽  
Alyssa Brandley ◽  
Daniel Maldonado ◽  
Alex Yiantsos ◽  
Robert Mosley ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Deep Understanding ◽  
Drug Bioavailability ◽  
Medical Needs ◽  
Self Assembling ◽  
Amphiphilic Molecules ◽  
Self Assembled ◽  
Assembly Behavior ◽  
External Stimuli

The novel and unique design of self-assembled micro and nanostructures can be tailored and controlled through the deep understanding of the self-assembly behavior of amphiphilic molecules. The most commonly known amphiphilic molecules are surfactants, phospholipids, and block copolymers. These molecules present a dual attraction in aqueous solutions that lead to the formation of structures like micelles, hydrogels, and liposomes. These structures can respond to external stimuli and can be further modified making them ideal for specific, targeted medical needs and localized drug delivery treatments. Biodegradability, biocompatibility, drug protection, drug bioavailability, and improved patient compliance are among the most important benefits of these self-assembled structures for drug delivery purposes. Furthermore, there are numerous FDA-approved biomaterials with self-assembling properties that can help shorten the approval pathway of efficient platforms, allowing them to reach the therapeutic market faster. This review focuses on providing a thorough description of the current use of self-assembled micelles, hydrogels, and vesicles (polymersomes/liposomes) for the extended and controlled release of therapeutics, with relevant medical applications. FDA-approved polymers, as well as clinically and commercially available nanoplatforms, are described throughout the paper.

scholarly journals Peptide Nanomaterials for Drug Delivery Applications

2020 ◽  
Vol 21 (4) ◽  
pp. 401-412 ◽  
Author(s):  
Sreekanth Pentlavalli ◽  
Sophie Coulter ◽  
Garry Laverty
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Diverse Range ◽  
Drug Molecules ◽  
Sustained Drug Delivery ◽  
Self Assembling ◽  
Wide Range ◽  
Methods Of Synthesis ◽  
Self Assembled

Self-assembled peptides have been shown to form well-defined nanostructures which display outstanding characteristics for many biomedical applications and especially in controlled drug delivery. Such biomaterials are becoming increasingly popular due to routine, standardized methods of synthesis, high biocompatibility, biodegradability and ease of upscale. Moreover, one can modify the structure at the molecular level to form various nanostructures with a wide range of applications in the field of medicine. Through environmental modifications such as changes in pH and ionic strength and the introduction of enzymes or light, it is possible to trigger self-assembly and design a host of different self-assembled nanostructures. The resulting nanostructures include nanotubes, nanofibers, hydrogels and nanovesicles which all display a diverse range of physico-chemical and mechanical properties. Depending on their design, peptide self-assembling nanostructures can be manufactured with improved biocompatibility and in vivo stability and the ability to encapsulate drugs with the capacity for sustained drug delivery. These molecules can act as carriers for drug molecules to ferry cargo intracellularly and respond to stimuli changes for both hydrophilic and hydrophobic drugs. This review explores the types of self-assembling nanostructures, the effects of external stimuli on and the mechanisms behind the assembly process, and applications for such technology in drug delivery.

De novo design of Self-assembly Hydrogels based on Fmoc-diphenylalanine Providing with Drug Release

2021 ◽  
Author(s):  
Xiang Li ◽  
Huijun Zhang ◽  
Lingyan Liu ◽  
Chunyan Cao ◽  
Peng Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Self Assembly ◽  
De Novo ◽  
De Novo Design ◽  
Short Peptides ◽  
Self Assembled

The short peptides with self-assembled nanostructures are widely applied in the areas of drug delivery system and biomaterials. In this article, we create a new peptide-based hydrogelator (Fmoc-FFRRVR) based on...

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