The lung-gut axis and COVID-19

2021 ◽  
Vol 19 (1) ◽  
pp. 91-96
Author(s):  
V.P. Novikova ◽  
◽  
A.I. Khavkin ◽  
A.V. Polunina ◽  
A.V. Gorelov ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Gastrointestinal Tract ◽  
Scientific Literature ◽  
Intestinal Microbiome ◽  
Disease Course ◽  
Qualitative And Quantitative ◽  
Commensal Flora ◽  
Gastrointestinal Lesions ◽  
Coronavirus Infection ◽  
Quantitative Changes

This review summarizes relevant scientific literature analyzing the lung-gut axis and its association with coronavirus infection (COVID-19), lesions to the gastrointestinal tract caused by this infection, and state of the microbiome. Approximately 20%–50% of COVID-19 patients have such symptoms as nausea, vomiting, and diarrhea, as well as SARS-CoV-2 RNA detected in their feces. Therefore, investigation of the virus effect on the gastrointestinal tract and its commensal flora is important not only for research purposes, but for clinical practice, since patients with COVID-19 demonstrate both qualitative and quantitative changes in their microbiome. The latter may serve as a basis for the development of additional probiotic therapy for gastrointestinal lesions in COVID-19 patients. Despite the existing evidence, it is still necessary to clarify the effect of the intestinal microbiome on the pathogenesis of coronavirus infection and the disease course. Key words: COVID-19, coronavirus infection, microbiome, intestinal microbiota, SARS-CoV-2, probiotics, probiotic therapy

STRUCTURE AND DYNAMICS OF ENVIRONMENTAL PARAMETERS OF HUMAN INTESTINAL MICROBIOME IN DIFFERENT CLIMATIC AND ECOLOGICAL ZONES OF ST. PETERSBURG

2020 ◽  
pp. 31-36
Author(s):  
Bugero N.V. ◽  
Ilyina N.A. ◽  
Aleksandrova S.M.
Keyword(s):  
Environmental Parameters ◽  
Intestinal Microbiome ◽  
Ecological Niches ◽  
Horizontal Structure ◽  
Ecological Zones ◽  
Qualitative And Quantitative ◽  
Symbiotic Relationships ◽  
Structure And Dynamics ◽  
Quantitative Changes ◽  
Micro Organisms

In order to understand the structure and dynamics of symbiotic relationships of human intestinal biotope micro-organisms, taxonomic constancy indices, the degree of contagion of the biocenosis under study and floristic significance were investigated, which made it possible to detect qualitative and quantitative changes in the microecology of the biotope being studied in persons living in different ecologically heterogeneous territories of Saint Petersburg. The contagiosity index estimated the distribution of species in space. Persons living in the ecologically disadvantaged Kirov district of the city have been found to show a reliable increase in this indicator for the obligate microflora: bifido and lacto bacteria, intestinal columns and bacteroids, compared to the resort district, which is considered a relatively favourable area for residence. On the contrary, there has been a reliable decrease in this indicator in the group of opportunistic micro-organisms (fungi of the genus Candida, staphylococcus, clostridium, etc.), resulting in the liberation of ecological niches successfully occupied by transient flora. This ratio reveals an imbalance of participation in the horizontal structure of the intestine ecosystem of the main symbiotes and representatives of the transient flora. To analyse the structure of symbiotic relationships, the constancy indices that form the microflora of the individuals of the groups studied were investigated. The analysis of the data obtained suggested that the dominant species in both groups were optional-anaerobic bifido and lactobacteria and oblique-anaerobic bacteroids. It should be noted, however, that in the residents of the dysfunctional Kirovsky district, against the background of the reduced constancy of the normal flora, opportunistic micro-organisms have entered. The floral significance index was also declining in the obligate flora of this group and increased for opportunistic species. Thus, the study of the environmental characteristics of the intestinal biotope using different ecological parameters for persons living in different technogenic load regions of St. Petersburg has shown that in the Kirov district with an unfavourable environmental situation there are compensated qualitative and quantitative changes in the intestinal microbiocenosis, resulting in a change in the hierarchy in the overall structure of micro-organisms.

Features of the Development and Application of Diagnostic ELISA Systems for the Detection of Antibodies to the SARS-CoV-2 Coronavirus in Clinical Practice

2021 ◽  
Vol 21 (1) ◽  
pp. 19-30
Author(s):  
Elena I. Zagoruyko ◽  
Dmitriy A. Kudlay ◽  
Maryana A. Lysenko ◽  
Darya S. Fomina ◽  
Ilya V. Vinogradov ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Scientific Literature ◽  
Disease Onset ◽  
Test System ◽  
Test Systems ◽  
Healthy Donors ◽  
National Production ◽  
Coronavirus Infection ◽  
Kinetics Of ◽  
Real Clinical Practice

Introduction. The new coronavirus infection, COVID-19, caused by SARS-CoV-2 has reached the scale of a pandemic. Detection of antibodies to SARS-CoV-2 is an aid in the diagnosis of COVID-19, and is also used to assess the immune response to the infection. Since COVID-19 is a new disease, seroconversions and kinetics of antibody to SARS-CoV-2 are not well understood. The aim of the study is to evaluate seroconversions and kinetics of antibodies to SARS-CoV-2 (IgA, IgM, IgG and total) in real clinical practice using test systems of national production. Materials and methods. 327 blood samples obtained from patients with a confirmed diagnosis of COVID-19 with active infection, convalescents and healthy donors were analyzed. Detection of antibodies to SARS-CoV-2 was carried out by enzyme immunoassay method using registered test systems Antigma-A, Antigma-G, Antigma-Screen and an unregistered test system for the detection of class M immunoglobulins. Results. When testing for total antibodies, 50.0% of samples were positive on days 1-7; 89.4% on days 8-14; 96.2% on days 15-45; and 93.3% after the 46th day after disease onset. The earliest seroconversions occurred on the 3rd day; antibodies were detected up to 81 days after the disease onset. Conclusions. The frequency of detecting seroconversions when using test systems of the Antigma series in real clinical practice is comparable to the data published in the world scientific literature and is high enough to use these test systems in the COVID-19 diagnostics.

scholarly journals Comparative analysis of the concepts of "dysontogenesis, developmental disorder, developmental disorder"

2021 ◽  
pp. 19-24
Author(s):  
Наталья Николаевна Шельшакова
Keyword(s):  
Comparative Analysis ◽  
Child Development ◽  
Developmental Disorder ◽  
Scientific Literature ◽  
Interdisciplinary Work ◽  
Qualitative And Quantitative ◽  
Number Of Children ◽  
Quantitative Changes ◽  
Definition Of ◽  
The Individual

В статье проводится анализ понятий «дизонтогенез», «нарушение развития», «расстройство развития», описываются факторы нарушений. Проведен анализ научных источников, описывающих данные виды отклонений в развитии. Сделан акцент на необходимости понимания индивидуальных норм развития ребенка. Описываются результаты деятельности междисциплинарной работы специалистов. В научной литературе нет четкого разграничения в определении понятий дигонтогенез, расстройство развития, нарушение развития, эти понятия дополняют друг друга и тесным образом переплетаются при описании различных нарушений, однако эти термины имеют существенные отличия и не являются синонимами. Часто среди ученых мы слышим расхожую фразу «в настоящее время растет число детей с различными отклонениями в развитии». Однако, при этом сложно дать определение понятию «отклонение развития», так как термин «развитие предполагает установление качественных и количественных изменений психики в необозначенный промежуток времени». The article analyzes the concepts of "dysontogenesis", "developmental disorder", "developmental disorder", describes the factors of disorders. The analysis of scientific sources describing these types of deviations in development is carried out. The emphasis is placed on the need to understand the individual norms of child development. The results of the interdisciplinary work of specialists are described. In the scientific literature, there is no clear distinction in the definition of the concepts of digontogenesis, developmental disorder, developmental disorder, these concepts complement each other and are closely intertwined when describing various disorders, but these terms have significant differences and are not synonyms. We often hear the popular phrase among scientists: "currently, the number of children with various developmental disabilities is growing." However, it is difficult to define the concept of "developmental deviation", since the term "development implies the establishment of qualitative and quantitative changes in the psyche in an unspecified period of time".

Expression of laminin and beta-1 integrin in embryonic, neonatal, and adult rat heart

1991 ◽  
Vol 49 ◽  
pp. 182-183
Author(s):  
R.L. Price ◽  
T.K. Borg ◽  
L. Terracio ◽  
M. Nakagawa
Keyword(s):  
Temporal Expression ◽  
Qualitative And Quantitative ◽  
Adult Rat ◽  
Cytoplasmic Face ◽  
Extracellular Matrix Components ◽  
Basement Membrane Component ◽  
Beta 1 Integrin ◽  
Quantitative Changes ◽  
Cytoskeletal Elements ◽  
External Face

Little is known about the temporal expression of extracellular matrix components (ECM) and its receptors during development of the heart. Recent reports have shown that ECM components undergo both qualitative and quantitative changes during development, and it is believed that ECM components are important in the regulation of cell migration and cell:cell and cell:ECM recognition and adhesion.Integrins are transmembrane glycoproteins which bind several ECM components on their external face and cytoskeletal elements on the cytoplasmic face. Laminin is a basement membrane component which has been recognized as an important site for cell adhesion. Both the integrins and laminin are expressed early in development and continue to be expressed in the adult heart. With their documented roles in cell recognition, and cell:cell and cell:ECM migration and adhesion these proteins appear to be important components in development of the heart, and their temporal expression may play a pivotal role in morphogenesis and myofibrillogenesis of the heart.

Functional MR Imaging of the Motor Cortex in Active and Passive Movement: Qualitative and Quantitative Changes

2002 ◽  
Vol 46 (5) ◽  
pp. 425
Author(s):  
Ki Bong Yu ◽  
Myung Kwan Lim ◽  
Hyung Jin Kim ◽  
Jun Soo Byun ◽  
Young Kook Cho ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Mr Imaging ◽  
Passive Movement ◽  
Qualitative And Quantitative ◽  
Functional Mr Imaging ◽  
Quantitative Changes

Changes in Seryl-tRNA Formative in Developing Chick Muscle

1974 ◽  
Vol 52 (10) ◽  
pp. 838-844 ◽  
Author(s):  
Mark Nwagwu ◽  
John Lianga
Keyword(s):  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Deae Cellulose ◽  
The Other ◽  
Embryonic Chick ◽  
Qualitative And Quantitative ◽  
Embryonic Muscle ◽  
Quantitative Changes ◽  
The One

As a prelude to an analysis of the dependence of muscle protein synthesis on aminoacyl tRNA's, we have investigated the rates of seryl-tRNA formation, in vitro, by aminoacylating systems isolated from 11-, 14-, and 17-day chick embryonic muscle. The results show that the combination of 14-day tRNA and 14-day aminoacyl synthetase is the most efficient in seryl-tRNA formation. We have also studied the qualitative and quantitative changes in seryl-tRNA prepared from 11-, 14-, and 17-day embryonic chick muscle by chromatography of seryl-tRNA on benzoylated DEAE-cellulose columns. The results show that, although there are no qualitative differences in the chromatographic patterns of seryl-tRNA from the different ages, there are significant quantitative differences between the patterns for 11-day and 17-day seryl-tRNA on the one hand, and the pattern for 14-day seryl-tRNA on the other.

‘Nucleated red blood cells’ as hypoxia marker in clinical analysis of blood in patients with coronavirus infection

2021 ◽  
pp. 23-24
Author(s):  
O. Yu. Dorn ◽  
F. M. Orifova ◽  
E. G. Stepanova
Keyword(s):  
Clinical Practice ◽  
Blood Cells ◽  
Blood Test ◽  
Clinical Analysis ◽  
Lung Damage ◽  
Hypoxic Stress ◽  
Urgent Problem ◽  
Nucleated Red Blood Cells ◽  
Hypoxia Marker ◽  
Coronavirus Infection

Assessment of the condition of a patient with coronavirus infection is an urgent problem in clinical practice. The parameter ’nucleated erythrocytes’ in a clinical blood test can be used in clinical practice as a marker of hypoxia in case of lung damage, since it objectively reflects the consequences of acute hypoxic stress in the patient’s body.

Sign in / Sign up

Export Citation Format

Share Document