Clinicopathological characteristics and prognostic factors of primary pulmonary lymphoma

Primary pulmonary lymphoma is a relatively rare extranodal lymphoma, and the incidence rate has increased in recent years. In the past, the disease mainly relied on surgery to obtain the pathological basis, so the clinical misdiagnosis rate was high. How to improve its early diagnosis and treatment has attracted much attention. By exploring the imaging manifestations of primary pulmonary lymphoma, we can further understand and improve the imaging diagnosis level of primary pulmonary lymphoma. This paper discusses the classification, imaging manifestations, diagnosis and identification of pulmonary lymphoma. The clinical data and imaging findings of primary pulmonary lymphoma diagnosed in a hospital were retrospectively summarized, and their imaging features were analyzed. We observe the clinicopathological characteristics and immunohistochemical phenotypes of multiple masses with cavitation type primary lung lymphoma, and analyze the virus and imaging characteristics of hybridization. The results of the study show that the CT (Computed Tomography) manifestations of primary lung lymphoma are diverse. The characteristics of cross-leaf distribution are more characteristic, and enhanced scanning lesions are usually mild to moderate. In the case of simultaneous masses and pneumonialike consolidation in the lungs, this disease needs to be considered.

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Prognostic factors and nomogram for survival prediction in patients with primary pulmonary lymphoma: a SEER population-based study

Leukemia & Lymphoma ◽

10.1080/10428194.2019.1633636 ◽

2019 ◽

Vol 60 (14) ◽

pp. 3406-3416 ◽

Cited By ~ 1

Author(s):

Soon Khai Low ◽

Ahmad Helmy Zayan ◽

Obaida Istanbuly ◽

Minh Duc Nguyen Tran ◽

Amr Ebied ◽

...

Keyword(s):

Prognostic Factors ◽

Population Based ◽

Survival Prediction ◽

Population Based Study ◽

Primary Pulmonary Lymphoma ◽

Pulmonary Lymphoma

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Primary Pulmonary Lymphoma: A Report of 2 Cases

Journal of the Korean Radiological Society ◽

10.3348/jkrs.1995.32.5.725 ◽

1995 ◽

Vol 32 (5) ◽

pp. 725

Author(s):

Soo Jeon Choi ◽

Yong Hoon Kim ◽

Gham Hur ◽

Jeong Sook Kim ◽

Seung Eun Chung ◽

...

Keyword(s):

Primary Pulmonary Lymphoma ◽

Pulmonary Lymphoma

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Clinical Characteristics and Prognostic Factors of Early-Onset Pancreatic Neuroendocrine Tumors

Cancer Control ◽

10.1177/1073274820986827 ◽

2021 ◽

Vol 28 ◽

pp. 107327482098682

Author(s):

Min Shi ◽

Biao Zhou

Keyword(s):

Prognostic Factors ◽

Neuroendocrine Tumors ◽

Early Onset ◽

Older Patients ◽

Clinical Characteristics ◽

Clinicopathological Characteristics ◽

Pancreatic Neuroendocrine Tumors ◽

Chi Square ◽

Younger Patients ◽

Significant Difference

Background: The incidence of pancreatic neuroendocrine tumors (PNETs) has increased significantly. The purpose of this study was to analyze the clinical characteristics and prognosis of patients under 50 years old. Methods: Patients with PNETs recorded in the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2015 were analyzed. The clinical characteristics were analyzed by Chi-square test. The Kaplan-Meier method was used to estimate overall survival (OS). Multivariate Cox proportional risk regression analysis was used to determine independent prognostic factors. Results: 2,303 patients included, of which 547 (23.8%) patients were younger than 50 years old. The number of younger patients has increased steadily, while the proportion in total PNETs decreased recently. Compared with older group, the proportion of the Black, grade I/II, and surgery were higher in early-onset PNETs. Liver was the most frequent metastatic site. There was no significant difference in the incidence of different metastatic sites between younger and older PNETs patients, while younger patients had better OS (P < 0.05). Grade, N stage, M stage, and surgery were independent prognostic factors for OS in early-onset PNETs. Conclusions: Younger patients have unique clinicopathological characteristics compared with older patients in PNETs. Better OS was observed in younger patients which might due to the higher proportion of well-differentiated tumor and surgery than older patients.

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Lobar Primary Pulmonary Lymphoma

Journal of Computer Assisted Tomography ◽

10.1097/00004728-199107000-00028 ◽

1991 ◽

Vol 15 (4) ◽

pp. 679-682 ◽

Cited By ~ 9

Author(s):

Carol Mae M. Bosanko ◽

Melvyn Korobkin ◽

Joseph C. Fantone ◽

Steven B. Rubin ◽

Joseph P. Lynch

Keyword(s):

Primary Pulmonary Lymphoma ◽

Pulmonary Lymphoma

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Prognostic Factors for Wilms Tumor Recurrence: A Review of the Literature

Cancers ◽

10.3390/cancers13133142 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3142

Author(s):

Alissa Groenendijk ◽

Filippo Spreafico ◽

Ronald R. de Krijger ◽

Jarno Drost ◽

Jesper Brok ◽

...

Keyword(s):

Prognostic Factors ◽

Tumor Recurrence ◽

Wilms Tumor ◽

Clinicopathological Characteristics ◽

Copy Number Variations ◽

First Line ◽

Prognostic Variables ◽

Treatment Regimens ◽

International Collaborations ◽

Patients Experience

In high-income countries, the overall survival of children with Wilms tumors (WT) is ~90%. However, overall, 15% of patients experience tumor recurrence. The adverse prognostic factors currently used for risk stratification (advanced stage, high risk histology, and combined loss of heterozygosity at 1p and 16q in chemotherapy-naïve WTs) are present in only one third of these cases, and the significance of these factors is prone to change with advancing knowledge and improved treatment regimens. Therefore, we present a comprehensive, updated overview of the published prognostic variables for WT recurrence, ranging from patient-, tumor- and treatment-related characteristics to geographic and socioeconomic factors. Improved first-line treatment regimens based on clinicopathological characteristics and advancing knowledge on copy number variations unveil the importance of further investigating the significance of biological markers for WT recurrence in international collaborations.

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Clinicopathological Characteristics and Prognostic Factors in Axial Chondroblastomas: A Retrospective Analysis of 61 Cases and Comparison with Extra-Axial Chondroblastomas

10.21203/rs.3.rs-1242480/v1 ◽

2022 ◽

Author(s):

Bo-Wen Zheng ◽

Bo-Yv Zheng ◽

Hua-Qing Niu ◽

Xiao-Bin Wang ◽

Guo-Hua Lv ◽

...

Keyword(s):

Overall Survival ◽

Multivariate Analysis ◽

Prognostic Factors ◽

Univariate Analysis ◽

Prognostic Significance ◽

Clinicopathological Characteristics ◽

Motor Dysfunction ◽

Surrounding Tissue ◽

Wide Resection ◽

Tissue Specimens

Abstract Background The clinical characteristics and prognostic factors of axial chondroblastoma (ACB) are still poorly understood. Purpose To characterize clinicopathological characteristics in a large ACB cohort and investigate their correlation with survival. We also sought to compare these results with extra-axial CB (EACB). Methods Our institution's local database was retrospectively reviewed and included a total of 132 CB patients, including 61 ACB patients and 71 EACB patients. Immunohistochemistry was used to assess the expression levels of Vimentin (Vim), S100, and cytokeratin (CK) on tumor cells in 132 tissue specimens. Results Overall, ACB and EACB had similar characteristics, except for older age and tumor size, as well as higher Vim expression, incidence of surrounding tissue invasion and postoperative sensory or motor dysfunction. Whereas wide resection and absence of invasion of surrounding tissues were consistently associated with favorable survival in the ACB and EACB cohorts in univariate analysis, most parameters showed differential prognostic significance between the 2 groups. Significant prognostic factors for local recurrence-free survival in multivariate analysis included the type of resection and chicken-wire calcification in the ACB cohort. Multivariate analysis of overall survival demonstrated that the type of resection was a significant predictor in the ACB cohort, whereas the type of resection and postoperative sensory or motor dysfunction were predictive of overall survival in the EACB group. Conclusion These data suggest that there may be distinct biological behaviors between ACB and EACB and may provide useful information to better understand the prognostic characteristics of patients with ACB and to improve outcome prediction in patients with ACB.

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Primary cutaneous diffuse large B cell lymphoma relapsed solely as a huge lung tumor mimicking a primary pulmonary lymphoma

International Journal of Hematology ◽

10.1007/s12185-009-0455-6 ◽

2009 ◽

Vol 91 (1) ◽

pp. 112-116 ◽

Cited By ~ 2

Author(s):

Yu-Feng Chen ◽

Yu-Ching Li ◽

Li-Mien Chen ◽

Chane-Chou Tu ◽

Chen-Chu Chang ◽

...

Keyword(s):

B Cell ◽

Cell Lymphoma ◽

Lung Tumor ◽

B Cell Lymphoma ◽

Large B Cell Lymphoma ◽

Primary Pulmonary Lymphoma ◽

Pulmonary Lymphoma ◽

Large B Cell

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Clinicopathological characteristics and prognostic factors of malignant melanoma: A retrospective analysis of a 12-year study

Annals of Oncology ◽

10.1093/annonc/mdx667.009 ◽

2017 ◽

Vol 28 ◽

pp. x115

Author(s):

C. Chayangsu

Keyword(s):

Prognostic Factors ◽

Malignant Melanoma ◽

Retrospective Analysis ◽

Clinicopathological Characteristics

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Clinicopathological Characteristics and Prognosis of Proximal and Distal Gastric Cancer during 1997–2017 in China National Cancer Center

Journal of Oncology ◽

10.1155/2019/9784039 ◽

2019 ◽

Vol 2019 ◽

pp. 1-13 ◽

Cited By ~ 5

Author(s):

Lulu Zhao ◽

Huang Huang ◽

Dongbin Zhao ◽

Chengfeng Wang ◽

Yantao Tian ◽

...

Keyword(s):

Gastric Cancer ◽

Multivariate Analysis ◽

Prognostic Factors ◽

Tumor Location ◽

Clinicopathological Characteristics ◽

Survival Outcome ◽

Cancer Center ◽

Poor Survival ◽

Node Metastasis ◽

Distal Gastric Cancer

Background. The prognostic relevance of gastric tumor location has been reported and debated. Our study was conducted to examine the differences in clinicopathological features, prognostic factors, and overall survival (OS) between patients with proximal gastric cancer (PGC) and distal gastric cancer (DGC). Patients and Methods. Patients with PGC or DGC were identified from the China National Cancer Center Gastric Cancer Database (NCCGCDB) during 1997–2017. Survival analysis was performed via Kaplan-Meier estimates and Cox proportional hazards models. Results. We reviewed 16,119 cases of gastric cancer patients, including 6,479 of PGC and 9,640 of DGC. PGC patients presented as older patients (61.5 versus 56.4 years, P<0.001) and more males (82.9% versus 68.2%, P<0.001). Compared with DGC, PGC was more likely to be in later pT stage (pT3 and pT4, 65.0% versus 52.8%, P<0.001) and lymph node metastasis (54.8% versus 50.9%, P<0.001). In univariate analysis, PGC patients had a worse survival outcome in stage I (Hazard ratio [HR] = 2.04, 95% CI: 1.42-2.94) but a better prognosis in stage IV (HR = 0.85, 95% CI: 0.73-0.98) when compared to DGC patients. However, multivariate analysis demonstrated that PGC was not an independent predictor for poor survival (HR = 1.07, 95% CI: 1.00-1.14). Results from multivariate analysis also revealed that pT4, lymph node metastasis, distant metastasis, no gastrectomy, and Borrmann IV were independent predictors associated with poor survival for both PGC and DGC patients. Additional prognostic factors for PGC patients included underweight (BMI < 18.5) (HR = 1.29, 95% CI: 1.06-1.58), linitis plastica (HR = 2.13, 95% CI: 1.25-3.65), and overweight (23 ≤ BMI <27.5) (HR = 0.80, 95% CI: 0.71-0.90). During the 20-year study period, the 5-year OS increased significantly for both PGC and DGC, with the increase rate of 91.7% and 67.7%, respectively. Conclusion. In China, PGC significantly differed from DGC in clinicopathological characteristics and prognostic factors. However, there was no significant relationship between survival outcome and gastric tumor location.

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