Changes in body weight and blood pressure in women using Depo-Provera in Northwest Ethiopia

Abstract Objectives: Depo-Provera is an injectable contraceptive method containing medroxyprogesterone acetate. It has some adverse effects like changes in menstrual pattern, loss in bone mineral density and risk of weight gain. Therefore, this study is aimed at to investigate the effects of Depo-Provera on body weight and blood pressure among Ethiopian women. Institution based cross-sectional study design was conducted from January 2017 to April 2017. Data were analyzed using SPSS version 21 software. Paired t-test, independent t-test and ANOVA were used to evaluate the presence of mean difference and relationship between changes in variables and duration of use of Depo-Provera. P-value ≤ 0.05 were considered as statistically significant. Results: The mean weight and body mass index (BMI) of Depo-Provera users were increased significantly (p=0.02 for mean body weight and p=0.019, for body mass index). There was no significant difference in mean arterial blood pressure (MAP) of Depo-Provera users compared to controls or their respective pretreatment value (p-value=0.85 for Depo-Provera users and 0.67 for non-users). The finding of this study revealed that there is an increased weight gain and BMI among Depo-Provera users compared to non-users, which really requires attention of health professionals and other stake holders.

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Changes in Body Weight and Blood Pressure among Women Using Depo-Provera injection in Northwest Ethiopia

10.21203/rs.2.10852/v3 ◽

2019 ◽

Author(s):

Muluken Fekadie Zerihun ◽

Tabarak Malik ◽

Yohannes Mulu Ferede ◽

Tesfahun Bekele ◽

Yigizie Yeshaw

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Body Weight ◽

Weight Gain ◽

Body Mass ◽

T Test ◽

P Value ◽

Arterial Blood ◽

Significant Difference ◽

Depo Provera

Abstract Objectives: Depo-Provera is an injectable contraceptive method containing medroxyprogesterone acetate. It has some adverse effects like changes in menstrual pattern, loss in bone mineral density and risk of weight gain. Therefore, this study is aimed at to investigate the effects of Depo-Provera on body weight and blood pressure among Ethiopian women. Institution based cross-sectional study design was conducted from January 2017 to April 2017. Data were analyzed using SPSS version 21 software. Paired t-test, independent t-test and ANOVA were used to evaluate the presence of mean difference and relationship between changes in variables and duration of use of Depo-Provera. P-value ≤ 0.05 were considered as statistically significant. Results: The mean weight and body mass index (BMI) of Depo-Provera users were increased significantly (p=0.02 for mean body weight and p=0.019, for body mass index). There was no significant difference in mean arterial blood pressure (MAP) of Depo-Provera users compared to controls or their respective pretreatment value (p-value=0.85 for Depo-Provera users and 0.67 for non-users). The finding of this study revealed that there is an increased weight gain and BMI among Depo-Provera users compared to non-users, which really requires attention of health professionals and other stake holders.

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Changes in Body Weight and Blood Pressure among Women Using Depo-Provera injection in Northwest Ethiopia

10.21203/rs.2.10852/v4 ◽

2019 ◽

Author(s):

Muluken Fekadie Zerihun ◽

Tabarak Malik ◽

Yohannes Mulu Ferede ◽

Tesfahun Bekele ◽

Yigizie Yeshaw

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Body Weight ◽

Weight Gain ◽

Body Mass ◽

T Test ◽

P Value ◽

Arterial Blood ◽

Significant Difference ◽

Depo Provera

Abstract Objectives: Depo-Provera is an injectable contraceptive method containing medroxyprogesterone acetate. It has some adverse effects like changes in menstrual pattern, loss in bone mineral density and risk of weight gain. Therefore, this study is aimed at to investigate the effects of Depo-Provera on body weight and blood pressure among Ethiopian women. Institution based cross-sectional study design was conducted from January 2017 to April 2017. Data were analyzed using SPSS version 21 software. Paired t-test, independent t-test and ANOVA were used to evaluate the presence of mean difference and relationship between changes in variables and duration of use of Depo-Provera. P-value ≤ 0.05 were considered as statistically significant. Results: The mean weight and body mass index (BMI) of Depo-Provera users were increased significantly (p=0.02 for mean body weight and p=0.019, for body mass index). There was no significant difference in mean arterial blood pressure (MAP) of Depo-Provera users compared to controls or their respective pretreatment value (p-value=0.85 for Depo-Provera users and 0.67 for non-users). The finding of this study revealed that there is an increased weight gain and BMI among Depo-Provera users compared to non-users, which really requires attention of health professionals and other stake holders.

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PENGARUH STIMULASI PIJAT BAYI TERHADAP KENAIKAN BERAT BADAN PADA BAYI BERAT LAHIR RENDAH DI KOTA YOGYAKARTA

10.31227/osf.io/ehfcr ◽

2018 ◽

Author(s):

Dwi Nur Octaviani Katili

Keyword(s):

Body Weight ◽

Weight Gain ◽

Birth Weight ◽

Low Birth Weight ◽

Group Treatment ◽

T Test ◽

Bivariate Analysis ◽

Control Group ◽

P Value ◽

Infant Massage

THE EFFECT OF INFANT MASSAGE STIMULATION TOWARDS THE WEIGHT GAIN ON INFANTS WITH LOW BIRTH WEIGHT IN YOGYAKARTADwi Nur Octaviani Katili1, Djaswadi Dasuki2, Retno Mawarti3Universitas Muhammadiyah GorontaloEmail: [email protected]: Infants with low birth weight (LBW) require more nutrients inputs in order to optimize their growth and development. The increase of infants weight is used as the best indicator to determine the growth of infants with LBW. The massage on infant with LBW is a form of stimulus/kinesthetic tactile stimulation as a verbal communication to the infants. It can increase endurance, the activity of the digestive function, and the activity of the vagus nerve.Objective: To determine the benefits of infant massage stimulation as an effective non-medical way in gaining body weight on infants with low birth weight (LBW).Methods: The design of the study is Randomized Controlled Trial. The sampling technique is concecutive sample with the total samples are 15 respondents for each group (treatment and control). The data were analyzed with bivariate analysis stage by using independent t-test with a significance level of p value <0.05 as well as multivariate analysisby using linear regression.Results: The t-test results showed that there is average difference in the gaining of body weight on infants with the low birth weight in the treatment and the control group as big as 53.67 grams with a p value <0.001, 95% CI = -79.02 - (- 28.38).Conclusions: The weight gain on infants with low birth weight who do massage stimulation for 14 days is greater than infants who are not massaged.

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His-Leu, an angiotensin I-derived peptide, does not affect haemodynamics in rats

Journal of the Renin-Angiotensin-Aldosterone System ◽

10.1177/1470320318808879 ◽

2018 ◽

Vol 19 (4) ◽

pp. 147032031880887 ◽

Cited By ~ 1

Author(s):

Adrian Drapała ◽

Klaudia Bielińska ◽

Piotr Konopelski ◽

Leszek Pączek ◽

Marcin Ufnal

Keyword(s):

Blood Pressure ◽

Body Weight ◽

Arterial Blood Pressure ◽

Haemodynamic Effects ◽

Hypertensive Rats ◽

Angiotensin I ◽

Arterial Blood ◽

Freely Moving Rats ◽

Significant Difference ◽

Freely Moving

Introduction: The dipeptide histidine-leucine (His-Leu) is formed in the process of converting angiotensin I into angiotensin II. Several studies show that short peptides containing His-Leu may produce significant haemodynamic effects; however, to the best of our knowledge, data on haemodynamic effects of His-Leu are not available in medical databases. Materials and methods: We evaluated acute haemodynamic effects of intravenous administration of either 0.9% NaCl (vehicle) or His-Leu at a dose of 3–15 mg/kg body weight in anaesthetized 15–16-week-old, male, normotensive Wistar Kyoto and spontaneously hypertensive rats. Chronic effects of treatment with either the vehicle or His-Leu at a dose of 15 mg/kg body weight given subcutaneously daily were determined during continuous telemetry recordings in freely moving rats. Results: In anaesthetized rats both the vehicle and His-Leu produced a mild and transient increase in blood pressure and no change in plasma renin activity. There was no significant difference in haemodynamics between the rats infused with the vehicle and the rats infused with His-Leu. In chronic studies, seven-day treatment with vehicle and with His-Leu did not affect arterial blood pressure in freely moving rats. Conclusion: His-Leu does not produce either acute or chronic changes in arterial blood pressure in normotensive and hypertensive rats.

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Efficacy and tolerability of vitamin C as an add on therapy to standard antihypertensive regimen

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20205545 ◽

2020 ◽

Vol 10 (1) ◽

pp. 90

Author(s):

Vivek Singh ◽

Ujjwal Sourav

Keyword(s):

Blood Pressure ◽

Vitamin C ◽

Developed Countries ◽

Public Health Issue ◽

P Value ◽

Protein Levels ◽

Arterial Blood ◽

Antihypertensive Regimen ◽

Significant Difference ◽

Significant Public Health

Background: In both developing and developed countries, elevated arterial blood pressure is perhaps the most significant public health issue. It is widespread, often asymptomatic, readily observable, typically easily treatable and, if left untreated, frequently leads to lethal complications. According to the Framingham report, the prevalence of hypertension in the white suburban population is almost one-fifth of those with blood pressure >160/95 mm Hg, while almost half of those with blood pressure >140/90 mm Hg. Aim and objectives were to estimate the efficacy of vitamin C as an add-on therapy to the antihypertensive regimen.Methods: The prospective comparative study was undertaken in mild to moderate hypertensive patients to find out the efficacy and tolerability of vitamin C as an add-on therapy to the standard anti-hypertensive regimen in the reduction of blood pressure and C-reactive protein levels. This study was done at the Saraswathi institute of medical sciences, Hapur, UP.Results: For Systolic BP as well as DBP, at baseline there was non-significant difference among all the four group with p value 0.28, whereas at all the visit at 1, 3 and 6 month there was significant difference among the four group with p value<0.01, <0.001 and<0.001.Conclusions: There was significant addon benefit of vit C when added with standard antihypertensive regimen.

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Pattern of symptom improvement following endoscopic sinus surgery for chronic rhinosinusitis

BMC Surgery ◽

10.1186/s12893-021-01269-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Salma S. Al Sharhan ◽

Mohammed H. Al Bar ◽

Shahad Y. Assiri ◽

Assayl R. AlOtiabi ◽

Deemah M. Bin-Nooh ◽

...

Keyword(s):

Surgical Outcomes ◽

Endoscopic Sinus Surgery ◽

T Test ◽

Sinus Surgery ◽

Symptom Improvement ◽

P Value ◽

Psychological Dysfunction ◽

Significant Difference ◽

The Mean ◽

Snot 22

Abstract Background Chronic rhinosinusitis (CRS) is a common inflammation of the nose and the paranasal sinuses. Intractable CRS cases are generally treated with endoscopic sinus surgery (ESS). Although the effect of ESS on CRS symptoms has been studied, the pattern of symptom improvement after ESS for CRS is yet to be investigated. The aim of this study was to determine the magnitude and sequence of symptom improvement after ESS for CRS, and to assess the possible preoperative factors that predict surgical outcomes in CRS patients. Methods This was a longitudinal prospective study of 68 patients who had CRS (with or without nasal polyps). The patients underwent ESS at King Fahd Hospital of the University, Al Khobar, Saudi Arabia. The Sino-nasal Outcome Test-22 (SNOT-22) questionnaire was used for assessment at four time points during the study: pre-ESS, 1-week post-ESS, 4 weeks post-ESS, and 6 months post-ESS. Results The difference between the mean scores recorded for the five SNOT-22 domains pre-ESS and 6 months post-ESS were as follows: rhinologic symptoms (t-test = 7.22, p-value = < 0.001); extra-nasal rhinologic symptoms (t-test = 4.87, p-value = < 0.001); ear/facial symptoms (t-test = 6.34, p-value = < 0.001); psychological dysfunction (t-test = 1.99, p-value = 0.049); and sleep dysfunction (t-test = 5.58, p-value = < 0.001). There was a significant difference between the mean scores recorded for the five domains pre-ESS and 6 months post-ESS. Rhinologic symptoms had the largest effect size (d = 1.12), whereas psychological dysfunction had the least effect size (d = 0.24). The only statistically significant difference in the SNOT-22 mean scores recorded 4 weeks post-ESS was observed between allergic and non-allergic patients (t = − 2.16, df = 66, p = 0.035). Conclusion Understanding the pattern of symptom improvement following ESS for CRS will facilitate patient counselling and aid the optimization of the current treatment protocols to maximize surgical outcomes and quality of life. Level of evidence Prospective observational.

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Abstract P489: Effect of Continuous Intake of Hesperidin on Blood Pressure in 2-kidney, 1-clip Renovasucular Hypertensive Rats

Hypertension ◽

10.1161/hyp.70.suppl_1.p489 ◽

2017 ◽

Vol 70 (suppl_1) ◽

Author(s):

Ayuna Yamaoka ◽

Yukiko Segawa ◽

Saki Maruyama ◽

Natsumi Saito ◽

Hiroko Hashimoto ◽

...

Keyword(s):

Blood Pressure ◽

Mrna Expression ◽

Control Diet ◽

Left Renal Artery ◽

Sham Operation ◽

Hypertensive Rats ◽

Fruit Peel ◽

Arterial Blood ◽

Significant Difference ◽

Enos Mrna

Objective: Hesperidin (HES) is a flavonoid which is contained in citrus fruit peel. It has physiological effects on blood vessels such as strengthening capillary vessels. Thus, it is known to be one of the effective ingredients of herbal medicine. Some studies have shown that the intake of HES decreases blood pressure (BP) in spontaneously hypertensive rats. The antihypertensive effect of HES is suggested to be due to vasodilation by nitric oxide (NO). However, its mechanism has not been clarified in detail. In this study, we observed whether HES intake decreases BP in 2-kidney, 1-clip renovasucular hypertensive rats (2K1C) and evaluated endothelial NO synthase (eNOS) mRNA to investigate its role in the mechanism. Methods: Male Sprague-Dawley rats (6 weeks old) were treated with sham operation (SHAM) or clipping the left renal artery (2K1C). After surgery, the rats started receiving continuously a control diet (C) or a diet containing 0.1% (w/w) HES for 6 weeks. The systolic BP (SBP) was measured by a tail-cuff method every week. At the end of the protocol, mean arterial blood pressure (MAP) was measured in each rat under anesthesia. Then, the aortas were removed for extracting mRNA. eNOS mRNA expression was evaluated using real-time RT-PCR. Results: At the end of the protocol, SBP in 2K1C-C was significantly higher than in SHAM-C (170±6 vs 117±6 mmHg, p <0.001). On the other hand, 2K1C-HES was lower in SBP (141±4 mmHg) than 2K1C-C ( p <0.01). There were no significant differences between SHAM-HES (122±7 mmHg) and SHAM-C. MAP at the end of the protocol were similar to in SBP. ANOVA revealed mRNA expression of eNOS was significantly higher in 2K1C than in SHAM ( p <0.05), and showed no significant difference between C and HES, nor a significant interaction. Conclusion: Continuous intake of HES may suppress BP increase in 2K1C. The role of eNOS mRNA expression may not be involved in the mechanism.

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Abstract P124: Repeat Manual Office Blood Pressure By A Physician Is Lower Than Automated Office Blood Pressure

Hypertension ◽

10.1161/hyp.78.suppl_1.p124 ◽

2021 ◽

Vol 78 (Suppl_1) ◽

Author(s):

Bryce Rhodehouse ◽

Courtney Shaver ◽

Jerry Fan ◽

Bright Izekor ◽

Clinton Jones ◽

...

Keyword(s):

Blood Pressure ◽

Vital Signs ◽

Outpatient Setting ◽

Office Blood Pressure ◽

P Value ◽

Signed Rank ◽

Significant Difference ◽

Minute Interval ◽

The Difference ◽

Automated Office Blood Pressure

Introduction: An accurate measurement of blood pressure (BP) is critical to diagnosing and treating hypertension (HTN). Manual office BP (MOBP) often results in higher readings than automated office BP (AOBP). In previous studies, a repeat MOBP by a physician resulted in a lower BP than the initial MOBP by nursing staff. We evaluated our hypothesis that a repeat MOBP by a physician is statistically equivalent to AOBP. Methods: In an ambulatory outpatient setting, patients were roomed and at least a 5-minute interval lapsed before an AOBP was performed using a Welch Allyn Connex Vital Signs Monitor. The physician was blinded to the AOBP. The physician then entered the room and obtained a MOBP with a manual aneroid sphygmomanometer. The difference between the AOBP and the MOBP was calculated. A Wilcoxon signed rank sum test was used to determine if a significant difference between AOBP and MOBP exists. Results: A total of 186 patients (112 females, 74 male) had BP measured with a mean age of 66 years. AOBP resulted in a median systolic BP (SBP) 136 mmHg (IQR 121-150 mmHg) and median diastolic BP (DBP) of 78 mmHg (IQR 72-85 mmHg). MOBP SBP had a median of 132 mmHg (IQR 120-142 mmHg) and DBP had a median of 76 mmHg (IQR 70-81 mmHg). SBP and DBP were significantly lower in the MOBP group with a mean difference between AOBP and MOBP of 4.0 and 2.7 mmHg respectively (p-value of <0.0001). Conclusions: Repeat MOBP performed by the physician resulted in a significantly lower BP compared to AOBP. The lower BP may be due to an overall longer interval between the AOBP measurement and MOBP measurement. MOBP may be a viable option for accurate diagnosis and treatment of HTN clinics without access to a AOBP machine.

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EFFECTIVENESS OF GLUTEAL MUSCLE STRENGTHENING ON FLAT FOOT

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i6.17719 ◽

2017 ◽

Vol 10 (6) ◽

pp. 219

Author(s):

Pooja A Mulchandani ◽

Trupti Warude ◽

Amrutkuvar Pawar

Keyword(s):

T Test ◽

P Value ◽

Random Allocation ◽

Gluteal Muscle ◽

Flat Foot ◽

Muscle Strengthening ◽

Intrinsic Muscle ◽

Navicular Drop ◽

Significant Difference ◽

Paired T Test

Objectives: To compare the effect of gluteal muscle strengthening along with conventional exercises versus conventional exercises alone on flat foot.Method: An experimental study conducted at Physiotherapy Department of Krishna Institute of Medical Sciences, Karad. A total of 52 subjects were equally divided into two groups using convenient sampling with random allocation (Groups A and B). Baseline treatment was given to both groups (intrinsic muscle strengthening). Group A was given intrinsic muscle strengthening alone while Group B was given gluteal muscle strengthening along with intrinsic muscle strengthening.Result: Statistical analysis was performed using paired t-test and unpaired t-test. In pre-intervention there was no statistically significant difference seen with p values for the navicular drop was 0.3563 and for Ink test was 0.7342. While on comparing the post-interventional values, the results between the two groups using paired t-test revealed that there was extremely significant difference seen with p-value for the navicular drop was <0.0001 and for Ink test was <0.0001.Conclusion: From the study, it can be concluded that there was a significant effect of gluteal muscle strengthening on the flat foot.

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