scholarly journals Changes in Body Weight and Blood Pressure among Women Using Depo-Provera injection in Northwest Ethiopia

2019 ◽  
Author(s):  
Muluken Fekadie Zerihun ◽  
Tabarak Malik ◽  
Yohannes Mulu Ferede ◽  
Tesfahun Bekele ◽  
Yigizie Yeshaw
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Weight ◽  
Weight Gain ◽  
Body Mass ◽  
T Test ◽  
P Value ◽  
Arterial Blood ◽  
Significant Difference ◽  
Depo Provera

Abstract Objectives: Depo-Provera is an injectable contraceptive method containing medroxyprogesterone acetate. It has some adverse effects like changes in menstrual pattern, loss in bone mineral density and risk of weight gain. Therefore, this study is aimed at to investigate the effects of Depo-Provera on body weight and blood pressure among Ethiopian women. Institution based cross-sectional study design was conducted from January 2017 to April 2017. Data were analyzed using SPSS version 21 software. Paired t-test, independent t-test and ANOVA were used to evaluate the presence of mean difference and relationship between changes in variables and duration of use of Depo-Provera. P-value ≤ 0.05 were considered as statistically significant. Results: The mean weight and body mass index (BMI) of Depo-Provera users were increased significantly (p=0.02 for mean body weight and p=0.019, for body mass index). There was no significant difference in mean arterial blood pressure (MAP) of Depo-Provera users compared to controls or their respective pretreatment value (p-value=0.85 for Depo-Provera users and 0.67 for non-users). The finding of this study revealed that there is an increased weight gain and BMI among Depo-Provera users compared to non-users, which really requires attention of health professionals and other stake holders.

scholarly journals Changes in Body Weight and Blood Pressure among Women Using Depo-Provera injection in Northwest Ethiopia

2019 ◽  
Author(s):  
Muluken Fekadie Zerihun ◽  
Tabarak Malik ◽  
Yohannes Mulu Ferede ◽  
Tesfahun Bekele ◽  
Yigizie Yeshaw
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Weight ◽  
Weight Gain ◽  
Body Mass ◽  
T Test ◽  
P Value ◽  
Arterial Blood ◽  
Significant Difference ◽  
Depo Provera

Abstract Objectives: Depo-Provera is an injectable contraceptive method containing medroxyprogesterone acetate. It has some adverse effects like changes in menstrual pattern, loss in bone mineral density and risk of weight gain. Therefore, this study is aimed at to investigate the effects of Depo-Provera on body weight and blood pressure among Ethiopian women. Institution based cross-sectional study design was conducted from January 2017 to April 2017. Data were analyzed using SPSS version 21 software. Paired t-test, independent t-test and ANOVA were used to evaluate the presence of mean difference and relationship between changes in variables and duration of use of Depo-Provera. P-value ≤ 0.05 were considered as statistically significant. Results: The mean weight and body mass index (BMI) of Depo-Provera users were increased significantly (p=0.02 for mean body weight and p=0.019, for body mass index). There was no significant difference in mean arterial blood pressure (MAP) of Depo-Provera users compared to controls or their respective pretreatment value (p-value=0.85 for Depo-Provera users and 0.67 for non-users). The finding of this study revealed that there is an increased weight gain and BMI among Depo-Provera users compared to non-users, which really requires attention of health professionals and other stake holders.

scholarly journals Changes in Body Weight and Blood Pressure among Women Using Depo-Provera injection in Northwest Ethiopia

2019 ◽  
Author(s):  
Muluken Fekadie Zerihun ◽  
Tabarak Malik ◽  
Yohannes Mulu Ferede ◽  
Tesfahun Bekele ◽  
Yigizie Yeshaw
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Weight ◽  
Weight Gain ◽  
Body Mass ◽  
T Test ◽  
P Value ◽  
Arterial Blood ◽  
Significant Difference ◽  
Depo Provera

Abstract Objectives: Depo-Provera is an injectable contraceptive method containing medroxyprogesterone acetate. It has some adverse effects like changes in menstrual pattern, loss in bone mineral density and risk of weight gain. Therefore, this study is aimed at to investigate the effects of Depo-Provera on body weight and blood pressure among Ethiopian women. Institution based cross-sectional study design was conducted from January 2017 to April 2017. Data were analyzed using SPSS version 21 software. Paired t-test, independent t-test and ANOVA were used to evaluate the presence of mean difference and relationship between changes in variables and duration of use of Depo-Provera. P-value ≤ 0.05 were considered as statistically significant. Results: The mean weight and body mass index (BMI) of Depo-Provera users were increased significantly (p=0.02 for mean body weight and p=0.019, for body mass index). There was no significant difference in mean arterial blood pressure (MAP) of Depo-Provera users compared to controls or their respective pretreatment value (p-value=0.85 for Depo-Provera users and 0.67 for non-users). The finding of this study revealed that there is an increased weight gain and BMI among Depo-Provera users compared to non-users, which really requires attention of health professionals and other stake holders.

scholarly journals Changes in body weight and blood pressure in women using Depo-Provera in Northwest Ethiopia

2019 ◽  
Author(s):  
Muluken Fekadie Zerihun ◽  
Tabarak Malik Malik ◽  
Yohannes Mulu Ferede ◽  
Tesfahun Bekele ◽  
Yigizie Yeshaw
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Weight Gain ◽  
T Test ◽  
P Value ◽  
Mineral Density ◽  
Bone Mineral Density Loss ◽  
Arterial Blood ◽  
Significant Difference ◽  
Depo Provera

Abstract Objectives: Depo-Provera is a widely known brand name for medroxyprogesterone acetate. It has some adverse effects which is reversible after discontinuation include changes in bleeding patterns and bone mineral density loss risk of weight gain in obese adolescents. The study aims to investigate the effects of Depo-Provera on body weight and blood pressure of Ethiopian women. Institutional based cross-sectional study design was conducted. The data was analyzed using SPSS version 21 software packages. Paired t-test, independent t-test and ANOVA were used to evaluate the presence of mean difference and relationship between changes in variables and duration of use of Depo-Provera. The p-values less than 0.05 were considered as statistically significant. Results The mean weight and body mass index (BMI) of Depo-Provera users were increased significantly (p-value-0.02 and p-value-0.019 respectively). There was no significant difference in mean arterial blood pressure (MAP) of Depo-Provera users compared to controls or their respective pretreatment value (p-value-0.85, p-value-0.67, respectively). Depo-Provera users showed weight gain and an increased BMI, which requires attention of stake holders.

scholarly journals Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index

2021 ◽  
Author(s):  
Allan Gurtan ◽  
John Dominy ◽  
Shareef Khalid ◽  
Linh Vong ◽  
Shari Caplan ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Drug Targets ◽  
P Value ◽  
Loss Of Function ◽  
Sustained Reduction ◽  
Significant Difference ◽  
Normal Chow

Novel drug targets for sustained reduction in body mass index (BMI) are needed to curb the epidemic of obesity, which affects 650 million individuals worldwide and is a causal driver of cardiovascular and metabolic disease and mortality. Previous studies reported that the Arg95Ter nonsense variant of GPR151, an orphan G protein-coupled receptor, is associated with reduced BMI and reduced risk of Type 2 Diabetes (T2D). Here, we follow up on GPR151 with the Pakistan Genome Resource (PGR), which is one of the largest exome biobanks of human homozygous loss-of-function carriers (knockouts) in the world. Among PGR participants, we identify 3 GPR151 putative loss-of-function (plof) variants (Arg95Ter, Tyr99Ter, and Phe175LeufsTer7) with a cumulative allele frequency of 2.2% and present at homozygosity. We confirm these alleles in vitro as loss-of-function. We test if GPR151 plof is associated with BMI, T2D, or other metabolic traits. GPR151 deficiency is not associated with a significant difference in BMI. Moreover, loss of GPR151 confers a nominally significant increase in risk of T2D (odds ratio = 1.2, p value = 0.03). Relative to wild-type mice, Gpr151-/- animals exhibit no difference in body weight on normal chow, and higher body weight on a high-fat diet, consistent with the findings in humans. Together, our findings indicate that GPR151 antagonism is not a compelling therapeutic approach for obesity.

scholarly journals Vitamin D status, hypertension and body mass index in an urban black community in Mangaung, South Africa

2016 ◽  
Vol 8 (1) ◽  
Author(s):  
Ronette Lategan ◽  
Violet L. Van den Berg ◽  
Jasminka Z. Ilich ◽  
Corinna M. Walsh
Keyword(s):  
South Africa ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Vitamin D ◽  
Body Weight ◽  
Body Mass ◽  
Black Community ◽  
Low Income ◽  
Vitamin D Status ◽  
Arterial Blood

Background: A strong relationship exists between hypertension and body weight. Research has linked both higher blood pressure and body weight with lower vitamin D status.Objective: This study assessed the vitamin D status of a low-income, urban, black community in South Africa, to examine whether serum levels of 25-hydroxy vitamin D [25(OH)D] are associated with hypertension and body mass index (BMI).Methods: Data collected from 339 adults (25–64 years) from the Assuring Health for All in the Free State (AHA-FS) study were analysed. Variables measured include serum 25(OH)D, blood pressure, weight and height to determine BMI, and HIV status.Results: Mean 25(OH)D level was 38.4 ± 11.2 ng/mL for the group; 43.5 ± 11.8 ng/mL and 37.0 ± 10.6 ng/mL for males and females, respectively. Approximately 40% of the participants were HIV-positive and 63.4% hypertensive. Based on BMI, 11.8% were underweight, 33.0% normal weight, 23.0% overweight and 32.1% obese. HIV status showed no correlation with 25(OH)D levels when controlling for BMI. Poor inverse relationships were found between BMI and 25(OH)D (p = 0.01), and between mean arterial blood pressure and 25(OH)D (p = 0.05). When controlling for BMI, no correlation was found between 25(OH)D and the prevalence of hypertension or mean arterial blood pressure.Conclusion: Approximately 96% of participants had an adequate vitamin D status, which could be attributed to latitude, sunny conditions and expected high levels of sun exposure because of living conditions. Results confirmed a poor inverse relationship between vitamin D status and hypertension, which seems to be dependent on BMI.

scholarly journals Association of pre-pregnancy body mass index and rate of weight gain during pregnancy with maternal indicators of cardiometabolic risk

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Luz Isabel Omaña-Guzmán ◽  
Luis Ortiz-Hernández ◽  
Mónica Ancira-Moreno ◽  
Vanesa Morales-Hernández ◽  
Marie S. O’Neill ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Weight Gain ◽  
Body Mass ◽  
Cardiometabolic Risk ◽  
Maternal Obesity ◽  
Risk Indicators ◽  
Mixed Effect ◽  
Arterial Blood ◽  
Increased Risk

Abstract Background/objective Changes in metabolism and extensive hemodynamic adjustments occur during normal pregnancy. The presence of maternal obesity imposes an overload to these physiological adaptations that may result in increased risk for the development of cardiometabolic complications during and after pregnancy. The aim of this study is to describe total cholesterol (TC), triglycerides (TG), glucose, and arterial blood pressure (BP) trajectories and to analyze the association of these cardiometabolic risk indicators during pregnancy with pre-pregnancy body mass index (pBMI) and monthly gestational weight gain (MGWG). Subjects/methods A prospective cohort study of pregnant women was conducted in Mexico City. Monthly samples of blood were taken during clinical follow-up and biochemical and blood pressure were measured during each visit. Adjusted linear mixed-effect regression models were fit to describe the trajectories of these biomarkers during pregnancy and to analyze the association with pBMI and MGWG. Results Seven hundred and twenty women were included of which 16.6% had pre-gestational obesity, 33.2% had pre-gestational overweight, 45.8% had normal pBMI and 4.4% had pre-gestational underweight. Women with pre-gestational obesity had higher lipids concentrations in the beginning of pregnancy (TC: $$\hat \beta$$ β ̂ = 33.08, p = 0.010; TG: $$\hat \beta$$ β ̂ = 31.29, p = <0.001) but the concentrations increased less than in women with normal pBMI (TC: $$\hat \beta$$ β ̂ = −14.18, p = 0.001; TG: $$\hat \beta$$ β ̂ = −5.42, p < 0.001). By the end of pregnancy, women with pre-gestational obesity had lower concentrations of lipids than women with normal pBMI. By contrast, women with pre-gestational obesity had higher glucose concentrations and higher BP levels than women with normal pBMI over pregnancy. Conclusions pBMI is differentially associated with longitudinal trajectories of maternal biochemical markers of cardiometabolic risk. MGWG did not significantly affect the biochemical indicators or BP trajectories. Our results suggest that pBMI is more relevant to predicting adverse cardiometabolic markers trajectories during pregnancy than MGWG.

scholarly journals Correlation of Body Mass Index with Oncologic Outcomes in Colorectal Cancer Patients: A Large Population-Based Study

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3592
Author(s):  
Chong-Chi Chiu ◽  
Chung-Han Ho ◽  
Chao-Ming Hung ◽  
Chien-Ming Chao ◽  
Chih-Cheng Lai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Survival Rates ◽  
Normal Weight ◽  
P Value ◽  
Administrative Claims ◽  
The Impact

It has been acknowledged that excess body weight increases the risk of colorectal cancer (CRC); however, there is little evidence on the impact of body mass index (BMI) on CRC patients’ long-term oncologic results in Asian populations. We studied the influence of BMI on overall survival (OS), disease-free survival (DFS), and CRC-specific survival rates in CRC patients from the administrative claims datasets of Taiwan using the Kaplan–Meier survival curves and the log-rank test to estimate the statistical differences among BMI groups. Underweight patients (<18.50 kg/m2) presented higher mortality (56.40%) and recurrence (5.34%) rates. Besides this, they had worse OS (aHR:1.61; 95% CI: 1.53–1.70; p-value: < 0.0001) and CRC-specific survival (aHR:1.52; 95% CI: 1.43–1.62; p-value: < 0.0001) rates compared with those of normal weight patients (18.50–24.99 kg/m2). On the contrary, CRC patients belonging to the overweight (25.00–29.99 kg/m2), class I obesity (30.00–34.99 kg/m2), and class II obesity (≥35.00 kg/m2) categories had better OS, DFS, and CRC-specific survival rates in the analysis than the patients in the normal weight category. Overweight patients consistently had the lowest mortality rate after a CRC diagnosis. The associations with being underweight may reflect a reverse causation. CRC patients should maintain a long-term healthy body weight.

scholarly journals Relationship between Body Mass Index, Blood Pressure, and Visual Acuity in Residents of Esan West Local Government Area of Edo State, Nigeria

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
I. O. Ernest-Nwoke ◽  
M. O. Ozor ◽  
U. Akpamu ◽  
M. O. Oyakhire
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Visual Acuity ◽  
Body Weight ◽  
Local Government ◽  
Body Mass ◽  
Local Government Area ◽  
Cross Sectional ◽  
Snellen Chart ◽  
Edo State

Aim. To study the relationship between body mass index (BMI) and blood pressure (BP) on visual acuity among apparently healthy residents of Ekpoma, Esan West Local Government Area of Edo State, Nigeria. Methodology. This is a cross-sectional descriptive study among 225 subjects (ages of 18–35 years) from whom BP, body weight, and height were collected. Visual acuity was measured using the Snellen chart following standard procedures of number of letters seen at 6-metre distance. The data were then analyzed using SPSS version 17. Results. The sampled population consists of 112 male and 113 female (mean age 31.72±14.2 years). Majority (180) of the respondents had normal visual acuity. However, compared with the respondents with normal BMI (R19.61±1.5; L19.67±1.70), visual acuity of underweight (R18.53±2.30; L18.53±2.70) and obese (R15.68±4.79; L17.73±1.70) were more deviated. Similarly, compared with respondent with normal BP (120–125/80–85 mmHg; R18.00±2.53; L18.07±3.11), hypotensive (R15.5±7.35; L15.00±10.20), and hypertensive (R15.01±21.25; L15.00±11.91) respondents had deviated visual acuity. Conclusion. Abnormal body weight (underweight and obese) and BP (hypotension and hypertension) have potential negative impacts on visual acuity. Based on the observed relationship between weights, BP, and visual acuity, eye examinations can be included as regular screening exercise for abnormal BMI and BP conditions.

scholarly journals Pattern of Fasting Blood Sugar, Blood Pressure and Body Mass Index among Combined Oral Contraceptive (COC) Pills Users in Chencha, Southern Ethiopia: a cross-sectional study

2019 ◽  
Author(s):  
Zelalem Kofole ◽  
Diresbachew Haile ◽  
Yerukneh Solomon ◽  
Eyayu Girma
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Oral Contraceptive ◽  
Blood Sugar ◽  
Arterial Blood Pressure ◽  
Body Mass ◽  
Mean Arterial Blood Pressure ◽  
Fasting Blood Sugar ◽  
Cross Sectional ◽  
Arterial Blood

Abstract Background: The use of contraceptives has become prevalent among women in Ethiopia. Oral contraceptive use has been suggested to trigger changes in glucose metabolism, energy expenditure, blood pressure, and body weight, among the various populations and ethnic groups. Objective: To elucidate the pattern of fasting blood sugar (FBS), blood pressure and body mass index (BMI) among combined oral contraceptive (COC) pills users, taking into account other confounding factors including socioeconomic conditions and physical activity status. Methods: An institution based cross-sectional study design was employed. A total of 110 healthy women using pills were recruited as cases. Another 110 healthy women not using any hormonal contraceptives were recruited as matched controls. A study was conducted between October 2018 and January 2019. Fasting Capillary blood sample was collected from the study participants for the estimation of the FBS level. Systolic and diastolic blood pressures were measured and means arterial blood pressure was calculated for each participant. Body weight and height were measured to compute body mass index. Data obtained was entered and analyzed using IBM SPSS version 23 software packages. Results: FBS level in users was significantly increased compared to controls (88.55 ± 7.89 vs. 86.00 ± 9.85 in users and controls respectively, P = 0.025). There was a significant difference in mean arterial blood pressure of users compared to controls (88.2 ± 8.48 vs. 86.0 ± 6.74 respectively, P=0.04). The mean weight and body mass index of users were significantly increased (P = 0.03 and P = 0.003, respectively). Changes in mean fasting blood sugar level and mean weight of users were independent (P = 0.27 and P = 0.46) to the duration of use (3-12, 13-24 and ≥ 25 months). On the other hand, changes in mean body mass index and mean arterial blood pressure of users were dependent of the duration of use (P = 0.03 and P = 0.000 respectively). Conclusions: Overall, oral contraceptive pills use appears to cause a 2.9% increase in fasting blood glucose level, a 2.5% increase in mean arterial blood pressure and a 3.9% increase in body mass index among the users.

scholarly journals The Relationship of Perceived Body Image, Body Mass Index and Physical Activity with Weight Status among Students at King Abdulaziz University Hospital

2021 ◽  
pp. 218-227
Author(s):  
Futoon S. Alobiri ◽  
Roaa A. Alharbi ◽  
Mohammed R. Algethami ◽  
Raghdah H. Ateeq ◽  
Aseel M. Badurayq ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Body Image ◽  
Body Weight ◽  
Body Mass ◽  
Body Satisfaction ◽  
Weight Status ◽  
Rating Scale ◽  
Significant Difference ◽  
King Abdulaziz University

Aim: Identify the relation between poor esteem for body image and weight-related behaviors. The results will help increase awareness and improve students’ lifestyles to have a better body image and achieve ideal body weight. Methods: A cross-sectional study was conducted among King Abdulaziz University medical students (n= 460) between July to the end of August 2019. Data was collected using the International physical activity questionnaire (IPAQ), figure rating scale (FRS) and analyzed using SPSS software. Result: The results showed that the average Body Mass Index (BMI) was 24.80 ± 11.89. Participant sex was an important factor influencing the prevalence of obesity; male students were more obese than female students with a significant difference (p<0.001). The level of body satisfaction was also affected by gender. Students in preclinical years were more likely to gain weight more than clinical years students. Conclusion: The results show a significant relationship between body satisfaction and gender (P<0.0001) despite having diverse BMIs. Overweight and obese males and females' participants had the lowest body satisfaction. Females who were too thin and had low BMIs described themselves as normal, while males describe themselves as too thin. Conversely, females with high BMIs described themselves as too fat, while males described themselves as normal. This could be due to different factors. Also, underweight females and males have high body satisfaction, which can lead to dangerous behaviors to maintain low body weight which cause negative health consequences.

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