scholarly journals AMBN gene polymorphism Alters the Caries Susceptibility of Adolescents in South China

2019 ◽  
Author(s):  
Ketian Wang ◽  
Liangyue Pang ◽  
Luoping Yin ◽  
Xia Li ◽  
Jianming Zhang ◽  
...  
Keyword(s):  
South China ◽  
Protective Factor ◽  
Additive Model ◽  
Assessment System ◽  
Caries Detection ◽  
Protective Effects ◽  
Nucleotide Polymorphisms ◽  
Dominance Model ◽  
Reference Allele ◽  
Cross Sectional

Abstract The aim of this study was to identify genetic factors under additive and dominance models that contribute to caries susceptibility, and to investigate into the interactions between these genes. A cross-sectional study was conducted among 1055 adolescents in Foshan, South China. The International Caries Detection and Assessment System (ICDAS) was used to identify caries. Demographic and environmental variables were analyzed. Twenty-three single nucleotide polymorphisms (SNPs) in 14 genes were identified from saliva samples. Regression analysis was used for the evaluation of direct and epistasis of genes under the hypothesis of an additive model and using the minor allele as the reference allele. After the adjustment by environmental factors, the G allele in AMBN (rs13115627) was a protective factor for caries under both additive model (P=0.007; OR=0.728; 95% CI, 0.579-0.916) and dominance model (P=0.021; OR=0.728; 95% CI, 0.556-0.953). No interactions between selected genes met the Bonferroni correction significance cutoff for multiple testing. Our results suggests that gender, one-child family, Cariostat score and Plaque Index have independent protective effects on dental caries. The polymorphisms in AMBN (rs13115627), under both additive and dominance models alters caries susceptibility of Adolescents in South China. No epistatic effect has been found between selected genes.

Body Mass Index and Association With Caries in School-Aged Children With Orofacial Cleft: A Case-Control Study

2019 ◽  
Vol 57 (2) ◽  
pp. 169-176
Author(s):  
Anna Lena Sundell ◽  
Anna-Karin Nilsson ◽  
Agneta Marcusson ◽  
Carl-Johan Törnhage
Keyword(s):  
Body Mass Index ◽  
Dental Caries ◽  
Body Mass ◽  
Cleft Lip ◽  
Case Control ◽  
Assessment System ◽  
Caries Detection ◽  
Adopted Children ◽  
Cross Sectional ◽  
The Impact

Objective: Data on the association between body mass index (BMI) and dental caries in children with orofacial clefts are sparse. Therefore, studies on the impact of BMI on caries frequency in children with cleft lip and/or palate (CL/P) are of importance. The aim of the current study was to investigate the association between BMI and frequency of dental caries in children with and without CL/P. Height, weight, and BMI in children with CL/P were also compared to controls. Design: This study used a cross-sectional case-control design. Participants: One hundred and thirty-nine 5- and 10-year-old children with CL/P and 299 age-matched controls. Main Outcome Measures: Caries was recorded according to the International Caries Detection and Assessment System. Height and weight were recorded, and BMI was calculated as weight/height2. Results: There was no correlation between BMI and caries frequency. Weight, height, and BMI were significantly lower in all children with CL/P compared to controls. After adjustment for international adoption, only BMI was significantly lower in CL/P children compared to controls. Non-adopted children with CL/P were significantly heavier and longer than adopted children with CL/P. Conclusions: Five- and 10-year-old children with corrected CL/P seemed to have a lower BMI than controls, but there was no association between BMI and caries frequency. Internationally adopted children with CL/P were lighter and shorter than non-adopted CL/P children and controls.

scholarly journals Caries Prevalence Evolution and Risk Factors among Schoolchildren and Adolescents from Valencia (Spain): Trends 1998–2018

2020 ◽  
Vol 17 (18) ◽  
pp. 6561
Author(s):  
Teresa Almerich-Torres ◽  
José María Montiel-Company ◽  
Carlos Bellot-Arcís ◽  
José Enrique Iranzo-Cortés ◽  
José Carmelo Ortolá-Siscar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Permanent Dentition ◽  
Assessment System ◽  
Caries Detection ◽  
Cluster Sampling ◽  
Caries Prevalence ◽  
Deciduous Dentition ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Icdas Ii

The aim of this study was to determine the caries status and risk factors in the schoolchildren of Spain’s Valencia region in 2018 and to compare them to the 20-year evolution of caries indicators in the region. A cross-sectional survey was conducted with 1722 children and adolescents aged between 6 and 15 using cluster sampling. Caries status, using International Caries Detection and Assessment System II (ICDAS II) criteria, and sociodemographic variables were recorded. To ensure the comparison with previous studies using WHO caries criteria, the cut-off point was established at ICDAS II code 4. Caries prevalence was found to be 37.4% and the decayed and filled teeth index (dft) was 1.23 at 6 years for deciduous dentition (DD). In permanent dentition (PD) at 12 years, caries prevalence was 30.1% with a 0.66 decayed, missing and filled teeth index (DMFT), and at 15 years, prevalence was 44.6% and DMFT was 1.21. Socioeconomic status poses a major risk factor for caries prevalence in deciduous dentition; it is 1.8 times higher in the lowest socioeconomic group. Deciduous dentition status has worsened in the most recent eight-year period, whereas in permanent dentition the 12- and 15-year values are similar to those of the 2010 survey. Evolution analysis suggests that community dental care programs be enhanced, involving preventive activities staring at the first year and targeting disadvantaged groups.

scholarly journals Association Analysis between SNPs in LATS1 and LATS2 and Non-Cardia Gastric Cancer

2020 ◽  
Author(s):  
Licong Ma ◽  
Xuyang Tian ◽  
Fang Gao ◽  
Wenjie Dong ◽  
Tong Dang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protective Factor ◽  
Serological Test ◽  
Additive Model ◽  
Nucleotide Polymorphisms ◽  
Large Tumor ◽  
Additive Inheritance ◽  
And Gender ◽  
H Pylori ◽  
Control Association

Abstract Background: Many studies have found that large tumor suppressor kinase 1 (LATS1) and LATS2 play important roles in many diseases, but studies have been rare on the relationship between these genes and non-cardia gastric cancer (GC). We performed a case-control association study to investigate the associations between single nucleotide polymorphisms (SNPs) in LATS1 and LATS2 genes and Helicobacter pylori (H. pylori) infection as well as the risk of non-cardia GC. Methods: First, H. pylori infection was determined by the serological test using enzyme-linked immunoassay. Then genotyping of SNPs was performed for 808 samples by the Taqman method. Finally, unconditional logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for age and gender, for the association of each SNP with the infection of H. pylori, the risk of non-cardia gastric cancer, as well as the expression of LATS1 and LATS2 proteins in non-cardia GC tissues, using the codominant, dominant, recessive, overdominant, and additive inheritance models, respectively. Results: The statistical results showed that LATS2 rs9552315 was associated with H. pylori infection, and the CC+CT genotype could reduce the risk of H. pylori infection (odds ratio [OR]: 0.549, 95% confidence interval [CI]: 0.339–0.881, P<0.05) compared with the TT genotype in a dominant model. LATS1 rs9393175 was associated with the risk of non-cardia GC, and the AG genotype reduced the risk of non-cardia GC (OR: 0.702, 95% CI: 0.516–0.952, P<0.05) compared with the GG+AA genotype in an overdominant model. LATS2 rs9509492 was associated with the risk of GC in an additive model. No associations were found between five SNPs and expression of LATS1 and LATS2 proteins in non-cardia GC tissue. Conclusions: LATS2 rs9552315 CT genotype may be a protective factor against infection of H. pylori. LATS1 rs9393175 AG genotype and LATS2 rs9509492 GG genotype may be protective factors for non-cardia GC.

scholarly journals Association between Single Nucleotide Polymorphisms in Cardiovascular Developmental Critical Genes and Hypertension: A Propensity Score Matching Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Zhiqiang Zhao ◽  
Chunmei Gong ◽  
Yanfang Gao ◽  
Xiaoli Liu ◽  
Sai Wu ◽  
...  
Keyword(s):  
Propensity Score ◽  
Propensity Score Matching ◽  
Additive Model ◽  
Recessive Model ◽  
Cardiovascular Development ◽  
Dominant Model ◽  
Nucleotide Polymorphisms ◽  
Cross Sectional ◽  
Single Nucleotide ◽  
Propensity Score Matching Analysis

Cardiovascular development critical genes are key determinants in cardiovascular diseases. We hypothesize that SNPs in these genes may play critical roles in the development of hypertension. Therefore, we enrolled 516 paired hypertension patients and controls in a total of 2,742 subjects in a cross-sectional population study by the propensity score matching (PSM) method. Twenty-one SNPs from 5 cardiovascular developmental related genes were detected by the improved multiplex ligase detection reaction (iMLDR) method. Conditioned logistic regression under three different genetic models, namely, additive model, dominant model, and recessive model, was performed. The odds ratio (ORs) and 95% confidence intervals (95% CIs) were used to estimate the associations of SNPs with hypertension. We found that the distribution of genotypes at rs833061, rs3025010, and rs699947 within the VEGFA gene and the distribution of alleles at rs3025010 in hypertension subjects were different from those in controls. Both rs833061 and rs3025010 were associated with hypertension in crude models, but only rs3025010 remains associated with hypertension after adjusting with confounding factors in the additive model and the dominant model. We also found that hypertension subjects with C/T and C/C genotypes at rs3025010 had lower SBP and DBP levels. In addition, rs3025010 could interact with rs6784267 within the CCM3 gene in the association. In conclusion, our findings suggest that rs3025010 may play a role in the pathogenesis of hypertension, which may be a potential target for individualized prevention and treatment of hypertension.

scholarly journals Comparison of ICDAS, CAST, Nyvad’s Criteria, and WHO-DMFT for Caries Detection in a Sample of Italian Schoolchildren

2019 ◽  
Vol 16 (21) ◽  
pp. 4120 ◽  
Author(s):  
Campus ◽  
Cocco ◽  
Ottolenghi ◽  
Cagetti
Keyword(s):  
Cross Sectional Study ◽  
Measurement Methods ◽  
Assessment System ◽  
Caries Detection ◽  
Sectional Study ◽  
Cross Sectional ◽  
Significant Difference ◽  
Misclassification Errors ◽  
Examiner Agreement ◽  
Caries Assessment

Caries measurement methods vary considerably in terms of the stages of lesion considered making the comparison problematic among different surveys. In this cross-sectional study, four caries measurement methods, the WHO-DMFT, the International Caries Detection and Assessment System (ICDAS), the Caries Assessment Spectrum and Treatment (CAST), and the Nyvad Criteria were tested in a sample of children. Five-hundred 12-year old children (236 males and 264 females) were examined four times by four calibrated examiners. The calibration process showed that Cohen’s Kappa exceeded the criterion of K = 0.75 and K = 0.80 for inter/intra-examiner agreement, respectively. In the survey, the total number of misclassification errors for the four methods amounted to 312 observations (67.94% regarding enamel lesions). The greatest difference among methods was shown by number of sound teeth (p < 0.01): WHO-DMFT n = 9505, 74.14%; ICDAS n = 2628, 20.49%; CAST n = 5053, 39.41%; and Nyvad Criteria n = 4117, 32.11%. At the level of dentinal Distinct/Active Cavity lesions, no statistically significant difference was observed (p = 0.40) between ICDAS (n = 1373, 10.71%), CAST (n = 1371, 0.69%), and Nyvad Criteria (n = 1720, 13.41%). In the severe caries levels, all methods were partially in agreement, while no accordance was found for the initial (enamel) lesions. A common language in caries detection is critical when different studies are compared.

scholarly journals Association between root/coronal caries and individual factors in institutionalised elderly using ICDAS severity and activity

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Margarita Usuga-Vacca ◽  
Dairo Javier Marin-Zuluaga ◽  
Jaime Eduardo Castellanos ◽  
Stefania Martignon
Keyword(s):  
Oral Health ◽  
Health Knowledge ◽  
Assessment System ◽  
Caries Detection ◽  
Caries Experience ◽  
Individual Factors ◽  
Root Caries ◽  
Cross Sectional ◽  
Root Surfaces ◽  
Exposed Root

Abstract Background Caries in the elderly has been associated with dependence, oral-health status and -care practices. This cross-sectional study aimed to investigate the association between root/coronal caries and individual factors among institutionalised elderly people in Bogotá, Colombia, using the International Caries Detection and Assessment System severity and activity criteria (ICDAS). Methods A total of 226 institutionalised elderly were clinically examined for root and coronal caries in 40 institutions. Caries risk was assessed with Cariogram, and demographics, oral health knowledge and practices, oral health-related quality of life and denture-use habits using a questionnaire. Results Participants (mean age: 80.1 ± 9.3 years; 63.7% female) presented a mean number of 10.8 ± 7.3 teeth and 19.4 ± 18.8 exposed root surfaces. Prevalence of Coronal-ICDAS caries experience (C-ICDAS DF) was of 100% and of 54.4% for C-ICDAS D; mean number of C-ICDAS DFS was 16.76 ± 27.36, with 50.9% of subjects having ≥ one active C-ICDAS DS. Prevalence of Root Caries Index was of 49.1% and of R-ICDAS DF of 46%; mean number of R-ICDAS DFS was 2.03 ± 2.78, with 40.3% of subjects having ≥ one active R-ICDAS DS. Most individuals had a systemic condition (94.2%) and required oral-hygiene assistance (58%). Logistic regression analyses showed significant associations (p < 0.05): for coronal active caries when having over six teeth (OR: 2.7), and for root caries, when having coronal caries (OR: 2.41), being a man (OR: 1.95), and having over 14 teeth (OR: 0.30). Those presenting with > eight exposed root surfaces were 4.04 more likely to have root caries and 2.4 times more likely to have active root caries. Conclusion In the institutionalised elderly population in Bogotá significant associations were found, both for the presence as for the activity status of root and coronal caries, with individual clinical factors including coronal caries, exposed root surfaces and number of teeth.

scholarly journals Effect of Primary Molar Caries on Caries Development in the Adjacent Permanent First Molars

2021 ◽  
Author(s):  
Ahmad Jafari ◽  
Saideh Aslani ◽  
Mahboobeh Zangooei ◽  
Hossein Hessari ◽  
Ahmad Reza Shamshiri ◽  
...  
Keyword(s):  
Dental Caries ◽  
Cross Sectional Study ◽  
Assessment System ◽  
Caries Detection ◽  
Caries Experience ◽  
Primary Molars ◽  
Primary Molar ◽  
Cross Sectional ◽  
Second Molar ◽  
Dental Instruments

Objectives: Dental caries is among the most common chronic diseases of the childhood. This study sought to assess the effect of caries experience in primary molars on caries development in the adjacent permanent first molars. Materials and Methods: This cross-sectional study evaluated 413 students aged 7 and 8 years. Clinical dental examination was performed by two independent examiners using disposable dental instruments and a head light. Dental caries was evaluated using the International Caries Detection and Assessment System (ICDAS) for all four permanent first molars and the decayed, missing, and filled teeth (dmft) index for the primary molars. Data were analyzed using the Pearson’s Chi-squared test and Fisher’s exact test. Results: When primary first molars were sound, 22.9% of the permanent first molars of the same quadrant were sound. When primary second molars were sound, 25.7% of the adjacent permanent first molars were sound. A carious primary second molar had a stronger correlation with development of dentin caries in the adjacent permanent first molar than a carious primary first molar (P<0.001). Conclusion: The current results confirmed that carious primary molars can significantly affect caries development in the adjacent permanent first molars, and a carious primary second molar has a significantly greater effect than a carious primary first molar in this respect. Thus, special attention should be paid to oral hygiene and proper tooth brushing of primary molars, particularly second molars.

scholarly journals Dental Fear in Children: Association with Dental Caries and Molar Incisor Hypomineralization

2020 ◽  
Vol 31 (6) ◽  
pp. 673-679
Author(s):  
Isla Camilla Carvalho Laureano ◽  
Lunna Farias ◽  
Liege Helena Freitas Fernandes ◽  
Catarina Ribeiro Barros de Alencar ◽  
Franklin Delano Soares Forte ◽  
...  
Keyword(s):  
Public Schools ◽  
Dental Caries ◽  
Family Income ◽  
Dental Fear ◽  
Assessment System ◽  
Northeastern Brazil ◽  
Caries Detection ◽  
Cross Sectional ◽  
Icdas Ii ◽  
Molar Incisor Hypomineralization

Abstract The aim of this study was to investigate the prevalence of dental fear and to evaluate its association with dental caries and molar incisor hypomineralization (MIH) in schoolchildren aged 8-10 years from a municipality in Northeastern Brazil. Data from 466 students enrolled in urban public schools in a cross-sectional study were collected. Parents/guardians answered a questionnaire addressing sociodemographic characteristics, dental fear was measured by means of the Children’s Fear Survey Schedule-Dental Subscale (CFSS-DS) and clinical examinations were performed by three calibrated examiners for diagnosis of dental caries, using the International Caries Detection & Assessment System - ICDAS II and a previously validated index for MIH. Descriptive data analysis was performed, and associations between dental fear, dental caries and MIH were analyzed using robust Poisson regression for complex samples (p<0,05). The prevalence of dental fear was 21.6%, and the mean total CFSS-DS score was 29.97 (CI 95%=29.05-30.89). In the multivariate adjusted model, the prevalence of dental fear was associated to family income (PR=1.78; CI 95%=1.02-3.08; p= 0.041). Monthly family income was associated with dental fear in children, whereas dental caries and MIH were not associated with dental fear.

Sweet Taste Perception and Dental Caries in 13- to 15-Year-Olds: A Multicenter Cross-Sectional Study

2017 ◽  
Vol 51 (4) ◽  
pp. 443-450 ◽  
Author(s):  
H. Ashi ◽  
C. Lara-Capi ◽  
G. Campus ◽  
G. Klingberg ◽  
P. Lingström
Keyword(s):  
Dental Caries ◽  
Dietary Habits ◽  
Sweet Taste ◽  
Assessment System ◽  
Taste Perception ◽  
Caries Detection ◽  
Caries Experience ◽  
Cross Sectional ◽  
Initial Caries ◽  
Significant Difference

Dietary habits and, in particular, the intake frequency of sucrose are of major importance for the development of dental caries. The perception of sweet taste is believed to have an influence on sucrose intake and therefore affects the predisposition to dental caries. The aim was to study the caries experience and sweet taste perception and to further analyze the possible relationship between the 2 tested variables in 13- to 15-year-old children from 3 different geographical areas. A cross-sectional survey comprising 669 children (220 Italian, 224 Mexican, and 225 Saudi Arabian) was conducted. The children were examined in their school setting. A sweet taste perception level was determined by the sweet taste threshold (TT) and sweet taste preference (TP). The sweet test was performed with sucrose solutions varying in concentration from 1.63 to 821.52 g/L. The International Caries Detection and Assessment System (ICDAS) and DMFS indices were used to diagnose caries. The highest mean value for TT was found for Italian children followed by Saudi and Mexican. Saudi schoolchildren showed the highest mean values for TP and DMFS, followed by Italian and Mexican. A statistically significant difference for TP, TT, DMFS, and initial caries was found between the 3 countries. A weak yet positive correlation was found between taste perception (TT and TP) versus DMFS and manifest caries in all 3 countries (r = 0.137-0.313). The findings of the present study showed a variation in sweet taste perception between the 3 countries, which may influence the caries outcome of the children in the individual countries.

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