scholarly journals Epidemiology and comorbidities of patients with rheumatoid arthritis in Spain during the period 2002-2017

2019 ◽  
Author(s):  
Juan Antonio Del-Moral-Luque ◽  
Mario Gil-Conesa ◽  
Ruth Gil-Prieto ◽  
Ángel Gil-de-Miguel ◽  
Ramón Mazzuccheli-Esteban ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Circulatory System ◽  
Length Of Hospital Stay ◽  
Hospitalization Rate ◽  
Main Diagnosis ◽  
Autoimmune Rheumatic Disease ◽  
Hospitalization Rates ◽  
Spanish Health ◽  
Observational Descriptive Study ◽  
Continental Climate

Abstract Background: Rheumatoid arthritis (RA) is a chronic autoimmune rheumatic disease that is associated with multiple comorbidities and has a significant economic impact on the Spanish health system. The objective of this study was to estimate the hospital burden of rheumatoid arthritis, its variants and their associated comorbidities. Methods: Observational descriptive study that reviewed hospital records from the CMBD. We included all hospitalizations of patients in Spain whose main diagnosis or comorbidity in the ICD-9-CM was rheumatoid arthritis during the period of 2002-2017. Results: A total of 315,190 hospitalizations with the RA code were recorded; 67.3% were in women. The mean age of the patients was 68.5 ± 13.9 years. The median length of hospital stay was 7 days (IQR 3-11 days). In 29,809 of the admissions, RA was coded as the main diagnosis (9.4%). When RA was not coded as the main diagnosis, the most frequent main diagnoses were diseases of the circulatory system (18.9%) and diseases of the respiratory system (17.4%). The hospitalization rate during the period of 2002-2017 was 43.8 (95% CI: 43.7-44.0) per 100,000 inhabitants. The total cost for the healthcare system was 1.476 million euros, with a median of 3,542 euros per hospitalization (IQR 2,646-5,222 euros). Conclusions: In Spain, the highest hospitalization rates for RA were registered within the continental climate region. The hospitalization rate of patients with RA increased during the study period, despite the decrease in the hospitalization rate when RA was the main diagnosis.

scholarly journals Hospitalization burden and comorbidities of patients with rheumatoid arthritis in Spain during the period 2002-2017

2020 ◽  
Author(s):  
Mario Gil-Conesa ◽  
Juan Antonio Del-Moral-Luque ◽  
Ruth Gil-Prieto ◽  
Ángel Gil-de-Miguel ◽  
Ramón Mazzuccheli-Esteban ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Circulatory System ◽  
Length Of Hospital Stay ◽  
Hospitalization Rate ◽  
Main Diagnosis ◽  
Autoimmune Rheumatic Disease ◽  
Hospitalization Rates ◽  
The Mean ◽  
Spanish Health ◽  
Observational Descriptive Study

Abstract Background: Rheumatoid arthritis (RA) is a chronic autoimmune rheumatic disease that is associated with multiple comorbidities and has a significant economic impact on the Spanish health system. The objective of this study was to estimate the rates of hospitalization of rheumatoid arthritis in Spain, and describing hospitalization rates and it's changing by age, region, RA variant, and when RA as a main cause of hospitalization or a comorbidity. Methods: Observational descriptive study that reviewed hospital records from the CMBD. We included all hospitalizations of patients in Spain whose main diagnosis or comorbidity in the ICD-9-CM was rheumatoid arthritis during the period of 2002-2017. Results: A total of 315,190 hospitalizations with the RA code were recorded; 67.3% were in women. The mean age of the patients was 68.5 ± 13.9 years. The median length of hospital stay was 7 days (IQR 3-11 days). In 29,809 of the admissions, RA was coded as the main diagnosis (9.4%). When RA was not coded as the main diagnosis, the most frequent main diagnoses were diseases of the circulatory system (18.9%) and diseases of the respiratory system (17.4%). The hospitalization rate during the period of 2002-2017 was 43.8 (95% CI: 43.7-44.0) per 100,000 inhabitants. The total cost for the healthcare system was 1.476 million euros, with a median of 3,542 euros per hospitalization (IQR 2,646-5,222 euros). Conclusions: In Spain, the hospitalization rate of patients with RA increased during the study period, despite the decrease in the hospitalization rate when RA was the main diagnosis.

Positive Effect of Single-Dose Measles Vaccination in Reducing the Incidence of Pneumonia in Children with Measles

2020 ◽  
Author(s):  
Zafer Bağcı ◽  
Yunis Yusuf Daki
Keyword(s):  
Single Dose ◽  
Length Of Hospital Stay ◽  
Vaccination Rate ◽  
Hospitalization Rate ◽  
High Morbidity ◽  
Measles Vaccine ◽  
Hospitalization Rates ◽  
Training And Research ◽  
Measles Vaccination ◽  
Positive Effect

Abstract Aim Measles is a worldwide common, highly infectious and vaccine-preventable contagious disease with high morbidity and mortality rates. We investigated the effects of administering single-dose measles vaccination in children with measles on the incidence of pneumonia and hospitalization. Materials and methods We retrospectively analysed the hospital records of children aged 0–18 years who were diagnosed with measles within a year before the study in a training and research hospital in Mogadishu, Somalia. We compared the measles vaccine ratios, hospitalization rates, hospitalization duration and pneumonia development rates. Results We found that 34 (15.6%) patients had received measles vaccination, while 184 (84.4%) did not receive the vaccination. All the vaccinated patients received only a single dose of the vaccine. The proportion of those who had received pneumonia vaccine (14/34, 41.2%) was significantly lower than that of those who had never received a dose of measles containing vaccine (179/184, 97.3%) (p = 0.001). Moreover, patients who were immunized [n = 3 (3.1%)] had a significantly lower hospitalization rate than those who were not immunized [n = 94 (96.9%)] (p = 0.001). Conclusion The risk of pneumonia in children with measles vaccination, rate of hospitalization and length of hospital stay was significantly lower in children who had received even a single dose of the vaccine when compared with that in those who had not vaccinated. The results of this study reiterate the need for more effective global measles vaccination.

scholarly journals Effects of Hurricane Katrina on Nursing Facility Resident Mortality, Hospitalization, and Functional Decline

2010 ◽  
Vol 4 (S1) ◽  
pp. S28-S32 ◽  
Author(s):  
David Dosa ◽  
Zhanlian Feng ◽  
Kathy Hyer ◽  
Lisa M. Brown ◽  
Kali Thomas ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Hurricane Katrina ◽  
Functional Decline ◽  
Secondary Data ◽  
Hospitalization Rate ◽  
Minimum Data Set ◽  
Nursing Facility ◽  
Data Set ◽  
Hospitalization Rates ◽  
Minimum Data

ABSTRACTBackground: The study was designed to examine the 30- and 90-day mortality and hospitalization rates among nursing facility (NF) residents in the affected areas of Louisiana and Mississippi following Hurricane Katrina and to assess the rate of significant posthurricane functional decline.Methods: A secondary data analysis was conducted using Medicare claims merged with NF resident data from the Minimum Data Set. Thirty- and 90-day mortality and hospitalization rates for long-stay (>90 days) residents residing in 141 at-risk NFs during Hurricane Katrina were compared to rates for residents residing at the same facilities during the same time period in prior nonhurricane years (2003 and 2004). Functional decline was assessed as a 4+ drop in function using a 28-point Minimum Data Set Activities of Daily Living Scale.Results: There were statistically significant differences (all P < .0001) in mortality, hospitalization, and functional decline among residents exposed to Hurricane Katrina. At 30 days, the mortality rate was 3.88% among the exposed cohort compared with 2.10% and 2.28% for residents in 2003 and 2004, respectively. The 90-day mortality rate was 9.27% compared with 6.71% and 6.31%, respectively. These mortality differences translated into an additional 148 deaths at 30 days and 230 deaths at 90 days. The 30-day hospitalization rate was 9.87% compared with 7.21% and 7.53%, respectively. The 90-day hospitalization rate was 20.39% compared with 18.61% and 17.82%, respectively. Finally, the rate of significant functional decline among survivors was 6.77% compared with 5.81% in 2003 and 5.10% in 2004.Conclusions: NF residents experienced a significant increase in mortality, hospitalization, and functional decline during Hurricane Katrina.(Disaster Med Public Health Preparedness. 2010;4:S28-S32)

scholarly journals Platelets Disseminate Extracellular Vesicles in Lymph in Rheumatoid Arthritis

2020 ◽  
Vol 40 (4) ◽  
pp. 929-942 ◽  
Author(s):  
Nicolas Tessandier ◽  
Imene Melki ◽  
Nathalie Cloutier ◽  
Isabelle Allaeys ◽  
Adam Miszta ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Extracellular Vesicles ◽  
Lymphatic System ◽  
Circulatory System ◽  
Donor Cell ◽  
Vascular Leakage ◽  
In Vivo Model ◽  
Interstitial Tissue ◽  
Tissue Fluid

Objective: The lymphatic system is a circulatory system that unidirectionally drains the interstitial tissue fluid back to blood circulation. Although lymph is utilized by leukocytes for immune surveillance, it remains inaccessible to platelets and erythrocytes. Activated cells release submicron extracellular vesicles (EV) that transport molecules from the donor cell. In rheumatoid arthritis, EV accumulate in the joint where they can interact with numerous cellular lineages. However, whether EV can exit the inflamed tissue to recirculate is unknown. Here, we investigated whether vascular leakage that occurs during inflammation could favor EV access to the lymphatic system. Approach and Results: Using an in vivo model of autoimmune inflammatory arthritis, we show that there is an influx of platelet EV, but not EV from erythrocytes or leukocytes, in joint-draining lymph. In contrast to blood platelet EV, lymph platelet EV lacked mitochondrial organelles and failed to promote coagulation. Platelet EV influx in lymph was consistent with joint vascular leakage and implicated the fibrinogen receptor α2bβ 3 and platelet-derived serotonin. Conclusions: These findings show that platelets can disseminate their EV in fluid that is inaccessible to platelets and beyond the joint in this disease.

scholarly journals Adverse Drug Reaction (ADR) as a Cause of Hospitalization at a Government Hospital in Saudi Arabia: A Prospective Observational Study

2019 ◽  
Vol 14 (3) ◽  
pp. 192-198 ◽  
Author(s):  
Nouf Alayed ◽  
Bushra Alkhalifah ◽  
Munirah Alharbi ◽  
Naief Alwohaibi ◽  
Maryam Farooqui
Keyword(s):  
Saudi Arabia ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Hospital Admissions ◽  
Financial Burden ◽  
Length Of Hospital Stay ◽  
Morbidity And Mortality ◽  
Severity Assessment ◽  
Hospitalization Rates ◽  
Naranjo Algorithm

Background: ADRs represent a substantial burden on health care resources worldwide and are considered as one of the leading causes of morbidity and mortality which significantly affects hospitalization rates. However, ADR related hospital admissions are not well explored in Saudi Arabia. Objectives: The current study aims to evaluate ADR-related admissions at King Saud Hospital, Unaizah, Qassim, Saudi Arabia. Method: A prospective, observational study was conducted at King Saud Hospital Unaizah. Over a period of 6 months, patients above 12 years of age who visited the Emergency Department (ED) with an ADR were included in this study. The investigators collected patient data by reviewing the patient's medical records and the ED records for admission. The Naranjo algorithm was used to assess the causality of the suspected ADR, and Hartwig’s Severity Assessment Scale was used to assess the severity of the ADR. Results: Out of 4739 admissions to the wards, 38 (0.801%) were related to an ADR. The majority of patients were male (52.6%), with a mean age of ± 49.08 years. The total length of hospital stay was 565 days with a mean of ± 14.87 days. The causality assessment shows that 35 (92.1%) cases were probable ADRs, whereas 3 (7.9%) cases were possible ADRs. Moreover, the severity assessment showed that 6 (15.1%) cases were mild, and 27 (71.1%) and 5 (13.2%) cases were moderate and severe, respectively. In regard to the outcome of patients, most patients recovered after the ADR, and 2 ADRs resulted in the death of the patient. Conclusion: Our study shows that ADRs as a cause of hospitalization in Qassim population is considerably low. However, ADRs may contribute to morbidity and mortality and result in a considerable financial burden.

DSRIP’s innovation and collaboration in population health management: A cross-sectional segmented time series model

2019 ◽  
Vol 33 (1) ◽  
pp. 2-12
Author(s):  
Amrita Gopinath Shenoy
Keyword(s):  
Time Series ◽  
Population Health ◽  
Development Program ◽  
Hospitalization Rate ◽  
Health Improvement ◽  
Infrastructure Development ◽  
Cross Sectional ◽  
Preventable Hospitalization ◽  
Hospitalization Rates ◽  
The Impact

Texas Medicaid Section 1115 waiver approved Delivery System Reform Incentive Payment (DSRIP) program has four categories, namely infrastructure development, program innovation and redesign, reporting of quality improvement outcomes, and population health improvement. A metric of the fourth category, preventable hospitalization rate, was analyzed for a set of eight diagnostic conditions to assess the impact of DSRIP on participating- and non-participating hospitals over two time periods, pre-DSRIP and post-DSRIP, with the help of a cross-sectional segmented time series regression model. Texas Healthcare Information Collection database was leveraged to obtain preventable hospitalization rate data. The dependent variables were preventable hospitalization rates of eight program-specified conditions and the independent variables were time, intervention, and post-implementation intervention. The overall combined preventable hospitalization rate for DSRIP hospitals was observed to decrease by 25.73%, whereas the overall combined preventable hospitalization rate for non-DSRIP hospitals was observed to increase by 37.57%. DSRIP hospitals had invested in coordinating healthcare projects and were subsequently reimbursed by the state for healthcare improvements. The implementation of DSRIP may have had the capacity to decrease preventable hospitalization rates in regions wherein its adoption may have improved the health of the population.

scholarly journals Increased hospitalization rates following heart failure diagnosis in rheumatoid arthritis as compared to the general population

2020 ◽  
Vol 50 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Elena Myasoedova ◽  
John M. Davis ◽  
Eric L. Matteson ◽  
Sara J. Achenbach ◽  
Soko Setoguchi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Heart Failure ◽  
General Population ◽  
Failure Diagnosis ◽  
Hospitalization Rates ◽  
Heart Failure Diagnosis

scholarly journals Analysis of measles-related hospitalizations in Tuscany from 2000 to 2014

2016 ◽  
Vol 144 (12) ◽  
pp. 2605-2612 ◽  
Author(s):  
E. BERTI ◽  
S. SOLLAI ◽  
E. ORLANDINI ◽  
L. GALLI ◽  
M. DE MARTINO ◽  
...  
Keyword(s):  
Young Adults ◽  
Age Groups ◽  
Public Health Problem ◽  
Hospitalization Rate ◽  
Measles Elimination ◽  
Hospitalization Rates ◽  
Significant Difference ◽  
Measles Outbreaks ◽  
Measles Incidence ◽  
Discharge Database

SUMMARYTo evaluate measles incidence and its relevant changes over a 14-year period (2000–2014), we analysed data from the regional hospital discharge database on children and adults hospitalized in Tuscany, Italy. A total of 181 paediatric and 413 adult cases were identified. Despite all the efforts towards regional measles elimination, we observed that the overall measles hospitalization rates for children and adults living in Tuscany globally increased from 0·45 to 0·85/100 000 during the study period (P = 0·001) showing fluctuations due to periodic measles outbreaks. Data stratified by age group showed that the hospitalization rate significantly increased in young adults over the study period, confirming an increase in susceptibility to measles in this subpopulation. Conversely, no statistically significant difference was observed in the hospitalization rate in the other age groups. However, children aged <1 year still exhibit the highest hospitalization rate. Pneumonia represented the most common complication in both the adult and children subsets. No death was reported. Measles still represents a public health problem, and national strategies should be implemented, focusing on emergent susceptible subsets, such as infants and young adults.

Trend of hospital utilization for encephalitis

2011 ◽  
Vol 140 (4) ◽  
pp. 753-764 ◽  
Author(s):  
P. BARBADORO ◽  
A. MARIGLIANO ◽  
A. RICCIARDI ◽  
M. M. D'ERRICO ◽  
E. PROSPERO
Keyword(s):  
Potential Role ◽  
Viral Encephalitis ◽  
Seasonal Pattern ◽  
Hospitalization Rate ◽  
Preventive Interventions ◽  
Emerging Pathogens ◽  
Hospitalization Rates ◽  
Not Otherwise Specified ◽  
The Mean

SUMMARYEncephalitis generally results in a serious illness requiring hospitalization. The aim of this study was to describe the epidemiology of hospitalization for encephalitis in Italy, taking into account the geographical distribution, aetiology, seasonality and evolution of hospitalization rates over recent years. The mean hospitalization rate was 5·88/100 000. For most of these hospitalizations (n=13 119, 55·6%), no specific cause of encephalitis was reported. The most common aetiological category was ‘viral’, which accounted for 40·1% (n=4205) of such hospitalizations (rate 1·05/100 000). Within this category, herpes virus was the leading causative agent (n=1579, 0·39/100 000). This report highlights a significant increase of ‘viral encephalitis not otherwise specified’ (ICD-9 code 049·9) vs. a reduction of all other causes. A seasonal pattern was noted in people aged ⩾65 years in this group. Specific surveillance of encephalitis without known origin should be reinforced in order to identify the potential role of emerging pathogens and to design preventive interventions.

scholarly journals Hospitalization in Pediatric Diabetes: A Nationwide Analysis of all Admission Causes for Germany in 2015

2019 ◽  
Vol 128 (09) ◽  
pp. 615-623 ◽  
Author(s):  
Marie Auzanneau ◽  
Joachim Rosenbauer ◽  
Andrea Icks ◽  
Beate Karges ◽  
Andreas Neu ◽  
...  
Keyword(s):  
Diagnosis Related Groups ◽  
Hospitalization Rate ◽  
Median Length ◽  
Hospitalization Rates ◽  
Pediatric Diabetes ◽  
Acute Complications ◽  
Total Burden ◽  
East West

Abstract Introduction Regarding pediatric diabetes, hospital admission for acute complications of type 1 diabetes (T1D) has often been investigated, but little is known about other causes of hospitalization. This study aimed to explore the total burden of hospitalization in individuals with diabetes<20 years of age in Germany. Methods Using the German Diagnosis-Related Groups data for 2015, we examined the frequencies of hospitalization with diabetes (20 251 inpatient cases), stratified by diabetes type [T1D, type 2 diabetes (T2D), other specified diabetes types (T3D), and unclear diabetes], and without diabetes (1 269 631 inpatient cases). Using estimates of the population at risk with T1D, T2D, and without diabetes, we evaluated hospitalization rates (per patient-year) by Poisson regression. For T1D, T2D, and T3D, we investigated the most frequent diagnoses and the median length of stay. Most analyses were stratified by sex, age-group and east/west residence. Results Children and adolescents with diabetes had a 6 to 9 times higher hospitalization risk than peers without diabetes (hospitalization rate 0.09). The hospitalization rate was higher for T2D compared with T1D (0.84 vs. 0.53, P<0.001). In T2D, two-third of inpatient cases were not directly related to diabetes, and stay was shorter compared with T1D and T3D (3 vs. 4 and 5 days, respectively). In T1D, hospitalization was more frequent among girls than boys (0.58 vs. 0.49, P<0.001), and mostly due to “diabetes without complications” (65.7%). Hospitalization tended to be more frequent and longer in the youngest patients, and in those with east residence. Conclusion Hospitalization rate in pediatric diabetes in Germany remained high, especially for T2D patients, girls with T1D, and young children.

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