scholarly journals Lower levels of TSH in vitamin D sufficient Graves patients and higher rates of vitamin D deficiency in graves patients: a case-control study

2019 ◽  
Author(s):  
Salma Ahi ◽  
Mehrdad Kazemi ◽  
Naser Hatemi
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Control Group ◽  
P Value ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
The Difference ◽  
And Control ◽  
Hyperthyroid Patients ◽  
Tsh Levels

Abstract Vitamin D deficiency is associated with an increased incidence of autoimmune thyroid diseases. Its association with Hashimoto has previously been discussed in several studies, but its role in Graves' disease is yet to be elucidated; the aim of this study was to evaluate the effect of vitamin D on hyperthyroid patients regardless of the cause (autoimmune, non-autoimmune and control) ‏. A total of 187 patients were divided into three groups: 74 patients with autoimmune hyperthyroidism (Graves), 43 non-immune patients (Toxic thyroid adenoma and goiter multi-nodular) and 70 healthy patients as the control group. The primary outcome was the frequency of vitamin D deficient patients and the level of vitamin D in each group. The secondary outcomes were measured as the values ​​of anti-thyroid antibody and anti-thyroglobulin antibodies, TSH, T3, and T4. Based on the results, higher levels of TSH were observed in Graves patients who were vitamin D sufficient in comparison to Graves subjects with moderate vitamin D deficiency (P=0.022). Also, vitamin D sufficient control subjects had higher TSH levels than subjects with severe (p<0.0001) and moderate (P<0.0001) vitamin D deficiency. Vitamin D deficiency was more frequent in Graves patients, however the difference was not significant (P-value>0.05). Vitamin D deficiency as an effective factor in thyroid autoimmune diseases is more frequent in autoimmune hyperthyroid disease patients. Moreover, vitamin D sufficient Graves' participants had higher TSH levels compared with vitamin D deficient ones, probably protecting them from developing osteoporosis. Low TSH levels in hyperthyroid patients are one of the osteoporosis risk factors‏.

scholarly journals Correlation of psoriasis and serum vitamin D

2021 ◽  
Vol 7 (4) ◽  
pp. 320-323
Author(s):  
Ritika Gujrati ◽  
Krishnendra Varma ◽  
Ujjwal Kumar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Psoriasis Vulgaris ◽  
Systemic Disease ◽  
Serum Vitamin ◽  
Psoriatic Skin ◽  
Control Group ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Psoriasis is an immuno-mediated chronic systemic disease involving cytokines of helper Th1 pathway. Vitamin D has an effect on keratinocyte proliferation, differentiation and immune modulation of immune system especially Th1 pathway, which is altered in psoriatic skin suggesting that Vitamin D may have a role in pathogenesis of psoriasis. To study correlation between psoriasis vulgaris and serum vitamin D. To evaluate serum vitamin D level in psoriasis cases and in control group and correlating vitamin D level with severity and duration of the psoriasis. 57 cases (&#62;15years of age) with psoriasis and 57 healthy subjects were recruited. Psoriasis was clinically diagnosed and severity evaluated by PASI scale. Vitamin D was analysed by enhanced chemilumine scence on vitrus Eci autoanalyzer of Orth clinical diagnostic. Vitamin D deficiency defined as &#60;20ng/ml, insufficiency 20-30ng/ml and sufficient 30-100ng/ml. Vitamin D deficiency in the study was 22.8% in patients and 14% in control group. Vitamin D insufficiency was found in 42.1% of cases and 19.3% of control. According to chi-square the p-value is 0.003 showing significant association. There was a tendency towards decrease in vitamin D level with increase in disease duration. There was negative correlation between vitamin D and PASI score. The study found a significant relationship between vitamin D and psoriasis. Further metanalysis involving larger study population will be required to establish whether vitamin D levels benefits patient with psoriasis vulgaris.

scholarly journals Thoracic periaortic adipose tissue is increased in patients with subclinical hypothyroidism

2015 ◽  
Vol 172 (5) ◽  
pp. 553-559
Author(s):  
Ömer Akyürek ◽  
Duran Efe ◽  
Zeynettin Kaya
Keyword(s):  
Adipose Tissue ◽  
Subclinical Hypothyroidism ◽  
Smoking Status ◽  
Control Group ◽  
Laboratory Findings ◽  
Significant Difference ◽  
Sh Group ◽  
The Difference ◽  
And Control ◽  
Tsh Levels

ObjectiveTo evaluate thoracic periaortic adipose tissue (TAT) volume in patients with subclinical hypothyroidism (SH) in comparison with controls and in relation to cardiovascular risk factors.MethodsThe study population consisted of 28 newly diagnosed SH patients (mean (s.d.) age: 37.3 (±11.4) years, 85.7% were females) and 37 healthy volunteers (mean (s.d.) age: 35.3 (±10.7) years, 81.5% were females). Comparisons between patient and control groups used demographic characteristics, anthropometrics, and laboratory findings. All participants underwent thoracic radiographic assessment in the supine position, using an eight-slice multidetector computed tomography scanner and TAT volume was measured.ResultsThe TAT volume was determined to be 27.2 (±12.7) cm3 in the SH group and 16.3 (±8.1) cm3 in the control group, and the difference was statistically significant (P<0.001). In addition, TSH levels were significantly higher in the patient group compared with the control group (P<0.001). A significant correlation was also found between TSH levels and TAT volume (r=0.572; P<0.001). In SH patients, no significant difference was noted in TAT levels with respect to sex (P=0.383) or concomitant smoking status (P=0.426).ConclusionsOur findings indicate that SH patients have significantly higher TAT values than controls and that increased TAT levels correlate with increased TSH levels.

RELATIONSHIP OF VITAMIN D DEFICIENCY AND AUTOIMMUNE THYROID DISEASES

2011 ◽  
Vol 22 ◽  
pp. S87 ◽  
Author(s):  
Gulbuz Sezgin ◽  
M. Esref Ozer ◽  
Oya Uygur Bayramicli ◽  
A. Melih Ozel ◽  
Fehime Aksungar ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Relationship Of

scholarly journals SERUM MAGNESIUM LEVEL IN DIABETIC RETINOPATHY - A CROSS SECTIONAL STUDY

2019 ◽  
Vol 3 (5) ◽  
Author(s):  
Dr. I. Vijayapriya ◽  
Dr. Prakash. S ◽  
Dr. S. Hemadharshini
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Serum Magnesium ◽  
Study Groups ◽  
Control Group ◽  
P Value ◽  
Cross Sectional ◽  
The Difference ◽  
And Control

Background: Among different complications of diabetes, ddiabetic retinopathy is one of the leading causes of blindness in the world. Increase in the frequency of lower serum magnesium levels have been reported among patients with diabetes. Materials and methods: A total of 120 subjects were included in this study and divided into 3 groups. The study groups consisted of 40 patients that are type 2 diabetes with retinopathy and 40 patients with type 2 diabetes without retinopathy and control group consisted of 40 healthy subjects respectively. Both cases and controls were subjected to estimation of biochemical parameters. Results: Among the study population, (80) 66.67% participants were cases and another (40) 33.33% participants were controls. Among the people who had mild NPDR, the median Mg was 1.90 (IQR 1.80, 2.00). It was 1.90 (1.70, 2.00), 1.75 (1.67, 1.92), 1.8 (1.69, 2.0) and 2.10 (1.90, 2.20) among people with DM retinopathy moderate NPDR, severe NPDR, Proliferative retinopathy and no retinopathy respectively. The difference in the Mg across DM retinopathy was statistically significant (P Value 0.008). The difference between the values among both the case and control groups for certain parameters such as SBP, FBG, PPBG, HbA1c, Magnesium, Urea, and Creatinine were found to be statistically significant. Conclusion: Serum magnesium levels were significantly lower in patients with diabetic retinopathy compared to diabetics without complications and control group. Keywords:  Diabetes mellitus, Diabetic retinopathy, Magnesium

PENERAPAN BIRTH BALL DENGAN TEKNIK PELVIC ROCKING TERHADAP LAMA PERSALINAN PADA KALA I FASE AKTIF

2021 ◽  
Vol 4 (1) ◽  
pp. 70-76
Author(s):  
Diah Evawanna Anuhgera ◽  
Nikmah Jalilah Ritonga ◽  
Riris Sitorus ◽  
Juni Mariati Simarmata
Keyword(s):  
Active Phase ◽  
Control Group ◽  
P Value ◽  
Control Groups ◽  
Midwifery Care ◽  
Quasi Experimental ◽  
Review Study ◽  
The Difference ◽  
And Control ◽  
Measured Duration

A comfortable childbirth is the dream of mothers. Faster delivery progress can lead to quality midwifery care. Birth ball is a tool that can be used by mothers to position the pelvis properly, especially applied the pelvic rocking technique. This review study aimed to evaluate the evidence regarding the effect of using birth ball with pelvic rocking in duration of labor in kala I active phase. This study followed a quasi experimental research design with posttest control group design.The sample consisted of 12 treatment people dan 12 controls with the purposive sampling.Partograph was measured duration of labor in kala I active phase. The difference in duration of labor for the treatment and control group were tested with Mann Whitney. There was a difference in the effect of  using a birth ball with pelvic rocking technique in length of labor in kala I active phase in the treatment and control groups with p-value 0.001. The use of birth ball with pelvic rocking technique is evidence to speed the duration of labor in kala I active phase. Birth ball with pelvic rocking are recommended to be use an alternative to speed the duration of labor in kala I active phase in midwifery services

scholarly journals Effect of the Use Lethal Ovitrap to Population Aedes sp

2017 ◽  
Vol 1 (1) ◽  
pp. 20
Author(s):  
Tri Ramadhani ◽  
Bondan Fajar Wahyudi
Keyword(s):  
Population Control ◽  
Total Sample ◽  
Control Group ◽  
P Value ◽  
Before And After ◽  
Quasi Experimental ◽  
The Mean ◽  
The Difference ◽  
And Control ◽  
Experimental Group

<p><em>Dengue vector control has been done in various ways, however, has not been able to obtain optimal </em><em>results. Ovirap use to determine the presence of Aedes sp in a region is often done, but the application </em><em>of lethal ovitrap for population control Aedes sp still rarely done. This study was aimed to assess the </em><em>effect of LO applications on populations of Aedes sp. </em></p><p><em></em><em>This research includes quasi experimental design with a pretest-posttest control group without </em><em>randomization. Research sites in dengue in endemic areas in Banyumas district, with a total sample of </em><em>100 homes in each treatment and control areas. Insecticides used on ovistrip is cypermethrin at a dose </em><em>of 12.5 mg ai/strip. Populations of Aedes sp measured each week for three weeks prior to the </em><em>intervention and twelve weeks during the intervention. The mean density of Aedes sp compared before </em><em>and after intervention and between treatment and control areas.</em><br /><em>The study showed the difference of mosquito densities before and after the intervention in the </em><em>experimental group was 0,07 ( p-value 0.044), whereas the control group was 0.037 (p-value 0.341). </em><em>LO use with the addition of insecticide active ingredient cypermetrin on ovistrip impact on the decline </em><em>density of Aedes sp.</em></p>

scholarly journals Pengaruh Pajanan Sinar Ultraviolet B Bersumber dari Sinar Matahari terhadap Konsentrasi Vitamin D (25(OH)D) dan Hormon Paratiroit pada Perempuan Usia Lanjut Indonesia

2008 ◽  
Vol 2 (4) ◽  
pp. 147 ◽  
Author(s):  
Siti Setiati
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Vitamin D Deficiency ◽  
Elderly Women ◽  
Calcium Supplementation ◽  
Sunlight Exposure ◽  
Ultraviolet B ◽  
Control Group ◽  
Random Allocation ◽  
And Control

Berbagai penelitian menunjukkan bahwa defisiensi vitamin D dan hiperpara-tiroidisme sekunder menimbulkan dampak serius pada kesehatan, antara lain meliputi osteoporosis, osteomalasia, kelemahan otot, jatuh dan fraktur osteoporotik. Tujuan penelitian ini adalah (1) mengetahui pengaruh pajanan UVB sinar matahari pada konsentrasi 25(OH)D dan hormon paratiroid (PTH) perempuan usia lanjut Indonesia. (2) mendapatkan saat dan lama pemajanan yang optimal. Penelitian uji klinik acak terbuka ini melibatkan 74 perempuan berusia 60 - 90 tahun yang tinggal di 4 panti werda di Jakarta dan Bekasi. Randomisasi dilakukan untuk memisahkan kelompok studi dan kontrol. Kelompok kontrol hanya mendapat kalsium 1000 mg/hari, sedang kelompok intervensi dipajankan dengan matahari selama 6 minggu. Hasil yang diukur sebelum dan sesudah 6 minggu pemajanan adalah konsentrasi 25(OH)D, PTH, dan ion kalsium. Ditemukan bahwa, waktu pemajanan yang optimal adalah 1 jam sebelum dan sesudah tengah hari. Prevalensi defisiensi vitamin D pada wanita usia lanjut adalah 35,1%. Pada kelompok terpajan, konsentrasi 25(OH)D meningkat lebih tinggi daripada yang tidak dipajan (51,8% vs 12,5%). Hasil tambahan adalahrerata asupan kalsium 248 mg/hari, dan rerata asupan vitamin D 28 IU/hari.Kata kunci: Defisiensi vitamin D, perempuan usia lanjut, hormon paratiroidAbstractMany studies showed that vitamin D deficiency and secondary hyper-parathyroidism cause serious impact on health including osteoporosis, osteomalacia, paralysis, fall, and osteoporotic fracture. This study was conducted to compare the effect of UVB from sunlight exposure in combination with calcium supplementation, and control (calcium only) on the vitamin D status and parathyroid hormone (PTH) concentration in Indonesian elderly women. This study was a randomized clinical trial in institutionalized care unit. Subjects included 74 elderly women with a mean age 71 years. Intervention was random allocation of UVB from sunlight exposure at 0.6 MED/hour noted in the UV meter on the face and both arms and calcium 1000 mg, three times per week for 6 weeks, and without treatment (calcium 1000 mg only). Main outcome measured were fasting serum levels of 25(OH) D, PTH, and calcium ion at 0 and 6 weeks in both treatment and control groups. The incidence of vitamin D deficiency in this population study was 35.1 %. In the treatment group, 25(OH) D increased from 59.1 nmol/L to 84.3 nmol/L (mean value after 6 weeks of sunlight exposure) with only a slight increase of 25(OH) D in the control group (51.8% vs 12.5%). 25(OH)D deficient levels in 15 out 16 subjects became normal after 6 weeks of sun exposure. There was no change of PTH levels in both groups. Additional results of this study are mean calcium intake of 248 mg/day and vitamin D intake of 28 IU/day.Keywords: Vitamin D deficiency, elderly women, parathyroid hormone

The Effects of Injected Vitamin D on Prognosis of Patients with Urosepsis

2018 ◽  
Vol 50 (05) ◽  
pp. 383-388
Author(s):  
Abolfazl Jokar ◽  
Koorosh Ahmadi ◽  
Ali Taherinia ◽  
Farshideh Didgar ◽  
Fatemeh Kazemi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Uric Acid ◽  
Standard Treatment ◽  
Vital Signs ◽  
Control Group ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Calcium Phosphorus ◽  
The Difference ◽  
And Control

AbstractThe aim of this study was to evaluate the effect of prescribing vitamin D on improving the symptoms of patients diagnosed with urosepsis. The participants were randomly divided into two equal groups (each consisting of 50 patients). The patients in the first group received standard treatment with 300 000 units of injected vitamin with a volume of 1 cc. As for the patients in the second group, they received standard treatment along with 1 cc normal saline injected to them as placebo. Vital signs of the patients were checked every 6 h, while their CBC, EXR, CRP, creatinine, urea, and uric acid were checked 0, 24, 48, and 72 h following the interventions. Calcium, phosphorus, and vitamin D levels were measured 72 h following injection of the medicine. A significant difference was observed between the two groups in terms of the number of WBC’s in 24th, 48th, and 72nd hours. A similarly significant difference was reported between the case and control group in terms of the average BUN within 24th, 48th, and 72nd hours. The difference observed between the two groups in terms of average Cr within the 0th, 24th, 48th, and 72nd hours and in terms of days of hospitalization was also significant. Considering these results and keeping in mind the fact that no particular side effects were reported as a result of utilizing muscular injections of vitamin D and the easy and cheap use of this medicine, it can be used in auxiliary treatment of patients with urosepsis.

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