The Effects of Injected Vitamin D on Prognosis of Patients with Urosepsis

2018 ◽  
Vol 50 (05) ◽  
pp. 383-388
Author(s):  
Abolfazl Jokar ◽  
Koorosh Ahmadi ◽  
Ali Taherinia ◽  
Farshideh Didgar ◽  
Fatemeh Kazemi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Uric Acid ◽  
Standard Treatment ◽  
Vital Signs ◽  
Control Group ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Calcium Phosphorus ◽  
The Difference ◽  
And Control

AbstractThe aim of this study was to evaluate the effect of prescribing vitamin D on improving the symptoms of patients diagnosed with urosepsis. The participants were randomly divided into two equal groups (each consisting of 50 patients). The patients in the first group received standard treatment with 300 000 units of injected vitamin with a volume of 1 cc. As for the patients in the second group, they received standard treatment along with 1 cc normal saline injected to them as placebo. Vital signs of the patients were checked every 6 h, while their CBC, EXR, CRP, creatinine, urea, and uric acid were checked 0, 24, 48, and 72 h following the interventions. Calcium, phosphorus, and vitamin D levels were measured 72 h following injection of the medicine. A significant difference was observed between the two groups in terms of the number of WBC’s in 24th, 48th, and 72nd hours. A similarly significant difference was reported between the case and control group in terms of the average BUN within 24th, 48th, and 72nd hours. The difference observed between the two groups in terms of average Cr within the 0th, 24th, 48th, and 72nd hours and in terms of days of hospitalization was also significant. Considering these results and keeping in mind the fact that no particular side effects were reported as a result of utilizing muscular injections of vitamin D and the easy and cheap use of this medicine, it can be used in auxiliary treatment of patients with urosepsis.

scholarly journals Role of Vitamin D in Near Sightedness

2020 ◽  
Vol 36 (2) ◽  
Author(s):  
Yasir Iqbal Malik ◽  
Aqsa Malik ◽  
Rabbia Shabbir ◽  
Atteaya Zaman ◽  
Sohail Zia ◽  
...  
Keyword(s):  
Vitamin D ◽  
Sampling Technique ◽  
Control Group ◽  
Mean Values ◽  
Group I ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Azad Kashmir ◽  
And Control

Purpose: To determine the levels of Vitamin D in children with myopia and to compare them with age matched controls. Study Design:  Case control study. Place and Duration of Study:  The study was conducted in Naseer Memorial Hospital, Dadhyal Azad Kashmir from March 2016 to March 2017. Material and Methods:  Two hundred patients were selected using convenient sampling technique and were divided two groups (group I Myopic and group II control). Myopia was labeled if after subjective refraction a Spherical Equivalent (SE) of −0.50 diopters (D) or more was found. Vitamin D levels were measured by radioimmunoassay technique with Diasorin SR® kit following the user’s manual. Vitamin D levels less than 20 ng/ml were considered Vitamin D deficient following the standards of American academy of pediatrics. The collected data was entered in the statistical package for social sciences (SPSS) version 21 for analysis. Independent t–test was used to determine the significant difference of means between controls and patients. P-values less than 0.05 were considered significant. Results:  Mean age of controls and myopes were 10.65 ± 3.9 and 10.20 ± 2.5 years respectively. Vitamin D levels in myopic children were found to be 14.95 ± 3.75 ng/ml and there was no significant difference in mean values of Vitamin D levels in myopic and control group. Conclusion:  We found no difference in Vitamin D levels of myopic and non myopic children and concluded that Vitamin D has no role in development or progression of myopia.

scholarly journals The Impact of Vitamin D Supplementation as an Adjuvant Therapy on the Abundance of Treg Cells in Patients with Atopic Dermatitis

2021 ◽  
Author(s):  
Payam Payandeh ◽  
Maryam Rastin ◽  
Farzaneh Iravani ◽  
Maryam Khoshkhui ◽  
pouran Layegh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Immune System ◽  
Treg Cells ◽  
Control Group ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
And Control ◽  
The Impact ◽  
Experimental Group

Abstract BackgroundAtopic dermatitis (AD) is a chronic, inflammatory, and severely Pruritus cutaneous disease that has an immunologic base. The most common treatments are topical steroids, which bring many adverse side effects. Vitamin D can adjust the immune system; therefore, in this study, we investigated the effect of vitamin D on the abundance of Treg cells in AD patients. MethodsIn this interventional study, 40 subjects who completed the intervention were enrolled, including 20 AD patients (as the experimental group) and 20 healthy subjects (as the control group). Accordingly, the subjects whose vitamin D levels was less than 30 ng/ml were assigned to receive vitamin D (1000 IU) daily for a 2-month duration. The severity of AD was evaluated based on SCORAD (Scoring Atopic Dermatitis) and the amount of CD4+CD25+Foxp3+Treg cells was also assessed using Flow cytometry. ResultsAverage serum level of vitamin D before performing the treatment in the experimental (14/90±4/5) and control groups (15/95±5/0) was lower than that of after the treatment (experimental group 24/60±5/2 and control group 23/60±7/3) (P<0.001). As well, there was a significant difference between the average scores of SCORAD after the vitamin D intervention (P<0.001). The amount of Treg cells significantly increased in the experimental group (P=0.002, Diff=0.35) after performing the intervention.Conclusionit was found that besides conventional medicines, Vitamin D can be adjusted as an effective complementary therapy by modulating the immune system.Trial registration: IRCT20150716023235N13, Registered 11 Feb 2018, https://www.irct.ir

The Association of Serum Vitamin D Levels with Pseudoexfoliation Glaucoma/Syndrome

2019 ◽  
Vol 19 (2) ◽  
pp. 166-170 ◽  
Author(s):  
Seyhan Dikci ◽  
Emrah Öztürk ◽  
Penpe G. Fırat ◽  
Turgut Yılmaz ◽  
Mehmet Ç. Taşkapan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Glaucoma Surgery ◽  
Control Group ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
The Mean ◽  
And Control ◽  
Glaucoma Group

Objective: To investigate whether serum vitamin D levels have an effect on pseudoexfoliation (PEX) glaucoma/syndrome development and on the control of glaucoma in these cases. </P><P> Method: A total of 31 cases with PEX glaucoma, 34 cases with the PEX syndrome and 43 control subjects of similar age and sex were included in the study. Vitamin D levels were compared between the groups and also between the cases where glaucoma surgery was performed or not. Results: PEX glaucoma group consisted of 17 males and 14 females, PEX syndrome group of 27 males and 7 females, and the control group of 27 males and 16 females. The mean age was 70.9±8.9 years, 72.1±7.3 years, and 67.9±9.1 years in PEX glaucoma, syndrome and control group, respectively. Mean vitamin D levels were 9.4±7.7 ng/mL, 7.9±6,1 ng/mL, 11.5±14.2 ng/mL in PEX glaucoma, syndrome and control group, respectively (p>0.05). The mean serum vitamin D level was 8.04±4.7 ng/mL in those who underwent glaucoma surgery and 10.1±8.7 ng/mL in those who didn't undergo glaucoma surgery in PEX glaucoma group (p>0.05). No difference was found between the PEX glaucoma subgroups in terms of the mean deviation when classified according to vitamin D levels (<10 ng/mL, ≥10 ng/mL) (p>0.05). Conclusion: Although we found no statistically significant difference between the PEX syndrome/ glaucoma, and control group in terms of serum vitamin D levels, serum vitamin D levels were lower in PEX syndrome and glaucoma group than control group. Our results indicate that serum vitamin D levels have no effect on the development of PEX glaucoma/syndrome or the control of the disorder in cases with PEX glaucoma. However, these results need to be supported with further studies on a larger number of patients and with longer follow-up.

scholarly journals THE EFFECT OF VITAMIN D LEVELS ON INFLAMMATION IN PATIENTS WITH CHRONIC RENAL FAILURE

2020 ◽  
Vol 15 (4) ◽  
pp. 166-178
Author(s):  
Nilüfer Bulut ◽  
Mehmet Çağatay Taşkapan ◽  
Hülya Taşkapan
Keyword(s):  
Vitamin D ◽  
Renal Failure ◽  
High Sensitivity ◽  
Control Group ◽  
Reactive Protein ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Hs Crp ◽  
And Control ◽  
The Relationship

It is suggested that a number of environmental and genetic factors trigger the formation of progressive kidney damage and complications. One of these factors is inflammation, it occurs as a result of a series of mechanisms included within a number of cytokines. Vitamin-D, IL-6, PCT and hs-CRP are also valuable biomarkers in terms of mortality in dialysis patients in this sense. Vitamin D deficiency is common in patients with chronic kidney disease (CKD) and is associated with inflammation. In recent years, some randomized controlled trials have revealed the effect of Vitamin D on inflammation in CKD patients, but the results are conflicting. The aim of this study is to investigate the relationship between Vitamin D, high-sensitivity C Reactive Protein (hs-CRP), procalcitonin and IL-6, and to evaluate the relation of Vitamin D levels with inflammation in PD patients, HD patients and controls. This study was carried on with 40 patients receiving on hemodialysis treatment, 40 patients receiving peritoneal treatment with renal failure disease and with a control group consisting of 40 healthy individuals. Vitamin D levels were measured by HPLC, PCT and IL-6 levels were measured by chemiluminescent method, hs-CRP is measured by nephelometric method. For Vitamin D, there was no differences between the groups. For PCT, there was a significant difference between all groups. For IL-6, while there was no difference between peritoneal and hemodialysis groups, a significant difference was determined between the peritoneal dialysis and control groups. For hs-CRP, there was a significant difference among all groups. While correlation was found between serum PCT levels with IL-6 and hs-CRP, no correlations were found between serum PCT with Vitamin D levels. Although a correlation was found between serum IL-6 levels and hs-CRP, no correlation was detected between serum IL-6 and Vitamin D levels. No correlations were detected between Vitamin D andPCT, IL-6 and hs-CRP.

Effects of Mindfulness-Based Psychoeducation on the Internalized Stigmatization Level of Patients With Schizophrenia

2018 ◽  
Vol 29 (7) ◽  
pp. 496-503 ◽  
Author(s):  
Emine Yılmaz ◽  
Funda Kavak
Keyword(s):  
Health Centers ◽  
Control Group ◽  
Community Mental Health Centers ◽  
Control Groups ◽  
Face To Face ◽  
Significant Difference ◽  
The Difference ◽  
Mental Health Centers ◽  
And Control ◽  
Experimental Group

The aim of this study was to determine the effects of mindfulness-based psychoeducation on internalized stigma in patients with schizophrenia. The patients were recruited from the community mental health centers. This quasiexperimental study was conducted using pretests and posttests with a control group. The participants were 69 patients with schizophrenia; 34 were part of the experimental group and 35 were part of the control group. The patients in the experimental group participated 2 days a week for 6 weeks in a total of 12 sessions which were given in the form of face-to-face group training. The difference between the scale mean posttest scores of the patients in the experimental and control groups was found to be statistically significant ( p < .05). In the intragroup comparisons, a significant difference was found between the stigma mean scores in the experimental group ( p < .05). It was concluded that mindfulness-based psychoeducation was effective in reducing stigma in patients with schizophrenia.

scholarly journals Thoracic periaortic adipose tissue is increased in patients with subclinical hypothyroidism

2015 ◽  
Vol 172 (5) ◽  
pp. 553-559
Author(s):  
Ömer Akyürek ◽  
Duran Efe ◽  
Zeynettin Kaya
Keyword(s):  
Adipose Tissue ◽  
Subclinical Hypothyroidism ◽  
Smoking Status ◽  
Control Group ◽  
Laboratory Findings ◽  
Significant Difference ◽  
Sh Group ◽  
The Difference ◽  
And Control ◽  
Tsh Levels

ObjectiveTo evaluate thoracic periaortic adipose tissue (TAT) volume in patients with subclinical hypothyroidism (SH) in comparison with controls and in relation to cardiovascular risk factors.MethodsThe study population consisted of 28 newly diagnosed SH patients (mean (s.d.) age: 37.3 (±11.4) years, 85.7% were females) and 37 healthy volunteers (mean (s.d.) age: 35.3 (±10.7) years, 81.5% were females). Comparisons between patient and control groups used demographic characteristics, anthropometrics, and laboratory findings. All participants underwent thoracic radiographic assessment in the supine position, using an eight-slice multidetector computed tomography scanner and TAT volume was measured.ResultsThe TAT volume was determined to be 27.2 (±12.7) cm3 in the SH group and 16.3 (±8.1) cm3 in the control group, and the difference was statistically significant (P<0.001). In addition, TSH levels were significantly higher in the patient group compared with the control group (P<0.001). A significant correlation was also found between TSH levels and TAT volume (r=0.572; P<0.001). In SH patients, no significant difference was noted in TAT levels with respect to sex (P=0.383) or concomitant smoking status (P=0.426).ConclusionsOur findings indicate that SH patients have significantly higher TAT values than controls and that increased TAT levels correlate with increased TSH levels.

Vitamin D levels in patients with childhood cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e20000-e20000
Author(s):  
Nurdan Tacyildiz ◽  
Gulsah oktay Tanyildiz ◽  
Deniz Tekin ◽  
Can Ates ◽  
Handan Dincaslan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Inverse Correlation ◽  
Control Group ◽  
Healthy Children ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Patient Groups ◽  
Cell Growth And Differentiation ◽  
Age Range ◽  
Nonparametric Correlation

e20000 Background: There is increasing interest in the possible association between cancer incidence and vitamin D through its role as a regulator of cell growth and differentiation. Although there are several studies related cancer risk and prognosis of cancer, related vit D levels in adult patients there are only few recent studies in pediatric patients. Methods: Between 2010 and 2011, D Vit levels of 45 patients (25 boys, 20 girls; age range: 6 months-17 years, median: 11 years) have been compared to D Vit levels of 22 healthy children with similar age group. Patient groups were leukemias, lymphomas, bone tumors, retinoblastoma (RB), and other tumors. Kruskal-Wallis and Spearman nonparametric correlations test of SPSS has been used for statistics. Results: Although there was no statistically significant difference for vit D levels between control group (range: 7.2-22.8; median: 14.75 ng/ml) and patients (range: 5.5-40.2; median: 16.0 ng/ml),difference between patients groups were significant (Table). Patients with RB have statistically lower level of Vit D than leukemia (p:0.016) and lymphoma groups ( p: 0.047). “Other tumors group” has lower vit D levels than leukemia group (p: 0.024). Since RB and other tumors group have younger age than other patients, Spearsman’s nonparametric correlation has been performed to exclude age effect on the results and no statistically significant correlation between D vit levels and age (p: 0.779) was found, although there was an inverse correlation between age and vit D levels in patient group (p: 0.03). Conclusions: According to our preliminary results, most of the patients and healthy children have low level of Vit D. Especially patients with RB have statistically significant lower level of Vit D than other malignancies which can be subject to future studies for confirmation of our results. In addition, etiologic studies related RB may have a new area. [Table: see text]

scholarly journals Plasma Calcium Levels in Pregnant Asian Women

1976 ◽  
Vol 13 (1-6) ◽  
pp. 339-344 ◽  
Author(s):  
Nina Polanska ◽  
R. A. Dale ◽  
M. R. Wills
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Dietary Intake ◽  
Total Protein ◽  
Plasma Calcium ◽  
Asian Women ◽  
Control Group ◽  
Calcium Phosphorus ◽  
And Control ◽  
Endogenous Synthesis

Plasma calcium, phosphorus, alkaline phosphatase, total protein, and albumin were measured during pregnancy in a group of Asian women living in the south of England and in a control group. The Asian women had slightly lower mean plasma calcium concentrations than the control group. Exposure of Asian women to sunshine appeared to be low, and it was inferred that they probably had little endogenous synthesis of cholecalciferol as a result. Both Asian and control subjects ingested similarly low amounts of vitamin D. The Asian women consumed greater amounts of phytate and vegetable fibres than the controls, and it is suggested that these substances may reduce absorption of insoluble lipids (including cholecalciferol) and calcium in a setting where the dietary intake and endogenous synthesis of vitamin D are already borderline for the subjects' requirements.

scholarly journals Serum levels of vitamin D, calcium, phosphorus, and oxidative parameters in healthy and diabetic people

2021 ◽  
Vol 11 (5) ◽  
pp. 238
Author(s):  
Maryam Barghi ◽  
Amir Sadeghipoor Ranjbar ◽  
Homa Moazen ◽  
Narges Eskandari-Roozbahani
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Vitamin D ◽  
Healthy People ◽  
Diabetic Patients ◽  
Fars Province ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Calcium Phosphorus ◽  
Calcium And Phosphorus

Introduction: Diabetes mellitus is a metabolic disease that is a primary public health consideration. Low Vitamin D levels are linked to type 2 diabetes (T2DM), diminished insulin release, and enhanced insulin resistance in humans and animals. Vitamin D is also involved in the regulation of calcium and phosphorus homeostasis. Oxidative stress and antioxidant imbalances are important for the progression of diabetes as well. In this endeavor, the levels of vitamin D, calcium, phosphorus, and evaluation of the oxidant- antioxidant factors of malondialdehyde (MDA) and total antioxidant capacity (TAC) in healthy and diabetic people were compared.Methods: This descriptive-analytical study was conducted in 2020 in Shiraz, Fars province, Iran. The population included 40 T2DM patients (with HbA1c equivalent 6-8) without comorbidities, 20-60 years old for both genders, and 40 healthy individuals (female and male between 20-60 years old without comorbidities). The high-performance liquid chromatography (HPLC) method was adopted for measuring Vitamin D and for measuring other levels, the colorimetric method was used. Using SPSS 22, statistical analysis was performed. The Mann- Whitney U test for quantitative data was applied. P<0.05 was deemed significant.Results: There was a statistically significant difference between the two groups when it came to the means of vitamin D and MDA. In the diabetic group, vitamin D levels were lower (p=0.001) and MDA levels were higher (p<0.001). Comparing the level of calcium and phosphorus in diabetics and healthy people revealed no significant difference. This result was also true for the TAC test.Conclusions: According to our results, the mean of vitamin D in T2DM was significantly lower than healthy people and MDA in T2DM significantly increased compared to the control group, suggesting that increasing the activity of this enzyme in the development of secondary complications in diabetic patients is a predisposing factor.Keywords: Vitamin D, Diabetes mellitus, HPLC, Oxidative stress

scholarly journals The Effects of Task-Based Language Teaching on Writing Achievement at a High School in Vietnam

2021 ◽  
Vol 04 (09) ◽  
Author(s):  
Dang Thi Thu Huong ◽  
Keyword(s):  
High School ◽  
Teaching Writing ◽  
Control Group ◽  
Writing Achievement ◽  
Significant Difference ◽  
Post Test ◽  
The Mean ◽  
The Difference ◽  
And Control ◽  
Experimental Group

The current study determines the effectiveness of using task-based language instructions in teaching writing at a high school in Thai Nguyen province. The participants consist of 92 grade 10 students from Bing Yen high school, Dinh Hoa district. The study employs a mix method research design (MMR) as the plan for the research. The results of the study reveals that the results of writing performance were reported at a low level (M=3.72). The results also confirmed that the intervention worked well for the experimental group. The mean score of the pre-test (the baseline for both groups) was M=3.72. The intervention focused on TBLT instructions. After first five weeks, the means of post-test1 were M=4.96 and M=3.83 for experimental group and control group respectively. There was a significant difference between the mean of pre-test and post-test1 for the experimental group (M=3.72 compared to M=4.96), while the control group showed a little improvement (M=3.72 compared to M=3.83) the difference was not significant. After another five weeks, the difference in the mean scores of the experimental group were far more than the mean scores of the control group, M=5.56 and M=4.45 respectively. By the end of the fifteenth week of the intervention, the mean of post-test 3 of the experimental group reached M=6.41, the mean for control group was M=5.54. The difference of the mean scores in the pre-test and post-test revealed a significant improvement in both groups. However, the experimental group showed a greater improvement, M=6.41 and M=5.54 respectively. It can infer that the uses of TBLT writing instruction improved writing achievement greatly.

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