Helicobacter pylori: A Cause of Community-Acquired Pediatric Septic Shock: A Cross Sectional Study

Abstract Background: Blood culture negative sepsis is a diagnostic challenge to both clinicians and microbiologists. We aimed to investigate blood culture negative cases of community-acquired sepsis among children admitted at pediatric intensive care unit of Cairo University Specialized Children Hospital, Egypt. Methodology: Our cross-sectional study was carried out over a period of six months. Electrical cardiometry was used to assess the patients’ status. For blood culture negative samples, broad range bacterial and fungal PCR amplification and sequencing were performed. Results: Among 43 patients, 9 samples were positive to pan bacterial 16srRNA gene, while five samples (20,22,23,24,25) were identified as Helicobacter pylori positive with the following sequence accession numbers respectively (KT198991.1, JQ323580.1, APEL01000010.1, APEL01000010.1, CP007603.1). Patients H pylori positive higher C reactive protein, longer duration of ventilation, higher stroke volume variation and pre-ejection period (P value= 0.005, 0.005, 0.043 & 0.043) Conclusion: Detection of Helicobacter pylori in community acquired septic children alarms the necessity to conduct epidemiological studies on populations of septic shock in countries with high prevalence of H. pylori such as Egypt.

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A descriptive cross-sectional study of helicobacter pylori infection in non-ulcer dyspepsia patients in a tertiary care teaching hospital In the Eastern part of Nepal

Journal of Nobel Medical College ◽

10.3126/jonmc.v5i2.16309 ◽

2016 ◽

Vol 5 (2) ◽

pp. 10-16

Author(s):

Rishab Shrestha ◽

Gaurav Chhetri ◽

Arbind Deo ◽

Rabindra Nath Das

Keyword(s):

Helicobacter Pylori ◽

Teaching Hospital ◽

Tertiary Care ◽

Cross Sectional Study ◽

Helicobacter Pylori Infection ◽

P Value ◽

Sectional Study ◽

Cross Sectional ◽

Non Ulcer Dyspepsia ◽

H Pylori

Background In Gastroenterology practice, worldwide, the most common cause of dyspepsia is functional. Functional or non-ulcer dyspepsia is established by gastroduodenoscopy which rules out structural disorders in dyspeptic patients. Helicobacter pylori, a gram-negative bacterium in gastric mucosa is associated with non-ulcer dyspepsia, chronic gastritis, gastriculcer and cancer. Worldwide prevalence of Helicobacter pylori infection is higher but its association with non-ulcer dyspepsia is less clear.Material and Methods The aim of this study was to see the prevalence of H. pylori infection in non-ulcer dyspepsia. A cross-sectional study of 340 patients presented at Nobel Teaching Hospital in one year with dyspeptic symptoms underwent clerking, physical examination, gastroduodenoscopy and RUT. Symptomatic patients without any structural lesions were designated as functional dyspepsia. RUT when turned red indicated positive for H. pylori infection.Result Out of 340 patients, 180 (52.9%) were female and 160(47.1%) were male. Mean age of male and female patients was 35.88 ± 11.8 and 38.11 ± 11.7 respectively. Amongst all participants 150 (44.11%) were housewives and 69(20.3%) were students. Endoscopic findings showed gastritis 205(60.29%) and duodenitis 15(4.42%). RUT was found positive in 62% of gastritis and 86.7% of duodenitis patients (p value=0.001).Conclusion High prevalence of H pylori infection in present study may be one of the causative factors in producing symptomatic non-ulcer dyspepsia. Hence, early detection and complete eradication of H.pylori infection is mandatory. It will reduce usage of PPIs and also improve quality of life.Journal of Nobel Medical College Vol.5(2) 2016; 10-16

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Seroprevalence of Helicobacter pylori infection among children of low socioeconomic level in São Paulo

Sao Paulo Medical Journal ◽

10.1590/s1516-31802010000400002 ◽

2010 ◽

Vol 128 (4) ◽

pp. 187-191 ◽

Cited By ~ 13

Author(s):

Aurea Cristina Portorreal Miranda ◽

Rodrigo Strehl Machado ◽

Edina Mariko Koga da Silva ◽

Elisabete Kawakami

Keyword(s):

Helicobacter Pylori ◽

Cross Sectional Study ◽

Sao Paulo ◽

Helicobacter Pylori Infection ◽

Socioeconomic Level ◽

São Paulo ◽

Sectional Study ◽

Cross Sectional ◽

Low Socioeconomic ◽

H Pylori

CONTEXT AND OBJECTIVE: Helicobacter pylori infection is mainly acquired during childhood, and is associated with significant morbidity in adults. The aim here was to evaluate the seroprevalence and risk factors of H. pylori infection among children of low socioeconomic level attended at a public hospital in São Paulo, Brazil. DESIGN AND SETTING: Cross-sectional study, among patients attended at an outpatient clinic. METHODS: 326 children were evaluated (150 boys and 176 girls; mean age 6.82 ± 4.07 years) in a cross-sectional study. Patients with chronic diseases or previous H. pylori treatment, and those whose participation was not permitted by the adult responsible for the child, were excluded. The adults answered a demographic questionnaire and blood samples were collected. The serological test used was Cobas Core II, a second-generation test. Titers > 5 U/ml were considered positive. RESULTS: H. pylori infection was diagnosed in 116 children (35.6%). Infected children were older than uninfected children (7.77 ± 4.08 years versus 5.59 ± 3.86 years; p < 0.0001). The seroprevalence increased from 20.8% among children aged two to four years, to 58.3% among those older than 12 years. There were no significant relationships between seropositivity and gender, color, breastfeeding, number of people in the home, number of rooms, bed sharing, living in a shantytown, maternal educational level, family income or nutritional status. In multivariate analysis, the only variable significantly associated with H. pylori seropositivity was age. CONCLUSION: Infection had intermediate prevalence in the study population, and age was associated with higher prevalence.

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PREVALENCE OF HELICOBACTER PYLORI TEN YEARS AGO COMPARED TO THE CURRENT PREVALENCE IN PATIENTS UNDERGOING UPPER ENDOSCOPY

ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) ◽

10.1590/0102-6720201600030006 ◽

2016 ◽

Vol 29 (3) ◽

pp. 151-154 ◽

Cited By ~ 6

Author(s):

Sandra FRUGIS ◽

Nicolau Gregori CZECZKO ◽

Osvaldo MALAFAIA ◽

Artur Adolfo PARADA ◽

Paula Bechara POLETTI ◽

...

Keyword(s):

Helicobacter Pylori ◽

Cross Sectional Study ◽

World Population ◽

Upper Endoscopy ◽

Sectional Study ◽

Cross Sectional ◽

Current Prevalence ◽

Number Of Patients ◽

Two Samples ◽

H Pylori

ABSTRACT Background: Helicobacter pylori has been extensively studied since 1982 it is estimated that 50% of the world population is affected. The literature lacks studies that show the change of its prevalence in the same population over time. Aim: To compare the prevalence of H. pylori in 10 years interval in a population that was submitted to upper endoscopy in the same endoscopy service. Method: Observational, retrospective and cross-sectional study comparing the prevalence of H. pylori in two samples with 10 years apart (2004 and 2014) who underwent endoscopy with biopsy and urease. Patients were studied in three consecutive months of 2004, compared to three consecutive months of 2014. The total number of patients was 2536, and 1406 in 2004 and 1130 in 2014. Results: There were positive for H. pylori in 17 % of the sample as a whole. There was a significant decrease in the prevalence from 19.3% in 2004 to 14.1% in 2014 (p<0.005). Conclusion: There was a 5.2% reduction in the prevalence of H. pylori comparing two periods of three consecutive months with 10 years apart in two equivalent population samples.

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Helicobacter pylori Infection and Predictors Risk Factors among Patients undergoing Gastro-duodenal Fibroscopy in Yaoundé, Cameroon

European Journal of Medical and Health Sciences ◽

10.24018/ejmed.2021.3.4.920 ◽

2021 ◽

Vol 3 (4) ◽

pp. 28-32

Author(s):

Abel Fils Nkoth ◽

Christian Ngounouh Taheu ◽

Angele Clarisse Okono Kabeyene ◽

Sandra Germaine Gueuma Tchoumbou ◽

Jean Paul Chedjou ◽

...

Keyword(s):

Risk Factors ◽

Helicobacter Pylori ◽

Alcohol Consumption ◽

Cross Sectional Study ◽

P Value ◽

African Countries ◽

Cross Sectional ◽

Level Of Education ◽

Regional Group ◽

H Pylori

Background: Helicobacter pylori (H. pylori) infection affects more than half people worldwide particularly in African countries such as Cameroon. This study aimed to investigate the prevalence of H. pylori infection and predictors risk factors among patients undergoing gastro-duodenal fibroscopy at the Centre Medical, la Cathédrale of Yaoundé. Methods: A facility-based descriptive cross-sectional study involving 147 patients was conducted from October 2015 to April 2016. A structured questionnaire was used to collect information on socio-demographic factors and predictors of H. pylori infection. Gastric biopsies specimens were collected from the antrum and corpus using an Olympus GIF – Q30 fully immersible gastroscope respectively. The biopsies were screened for the presence of H. pylori by targeting the glmM gene using polymerase chain reaction (PCR). Statistical analysis was performed using SPSS v. 20 with p-value<0.05 considered statistically significant. Results: The mean age was 47.19 ±16.64 years and female were more represented with 88/147 (59.8%) versus (vs.) 59/147(40.1%) for male. The overall prevalence of H. pylori infection was 50/147 (34.01%; 95% CI: 26.41% - 42.28%). The prevalence of H. pylori infection was 22/59 (37.29%) in male vs. 28/88 (31.82%) in female and this prevalence increased with age and peaked among 30-50 years. Bivariate logistic regression analysis identified that, the regional group, particularly the Centre region (OR 2.55, p= 0.007) and West region (OR 2.67, p=0.005), the level of education (OR 1.18, p=0.001), source of income (OR 0.95, p=0.004), and alcohol consumption (OR 1.41, p=0.0001) were predictors risk factors of H. pylori infection. Conclusions: Our findings indicate a relatively high prevalence of H. pylori infection in Yaoundé. Factors such as regional group, level of education, source of income, and alcohol consumption predisposed the subjects to H. pylori infection.

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Diagnosis of Helicobacter pylori infection using immunochromatography among patients attending Tamboul Hospital in Gezira State, Sudan: a cross-sectional study

F1000Research ◽

10.12688/f1000research.25237.1 ◽

2020 ◽

Vol 9 ◽

pp. 1054

Author(s):

Rawda Mohmmed Elhassan Ali Noor ◽

Wafaa Mohammed Abdalla ◽

Ahmed Bakheet Abd Alla ◽

Ahmed Ibrahim Hashim

Keyword(s):

Helicobacter Pylori ◽

Patient Group ◽

Cross Sectional Study ◽

Sectional Study ◽

Serum Antibodies ◽

Cross Sectional ◽

Major Health Problem ◽

Asymptomatic Patients ◽

Stool Antigen ◽

H Pylori

Background: Helicobacter pylori causes a major health problem worldwide; more than half of the world’s population are infected with this pathogen. The diagnosis of the infection was initially made through invasive methods, but now non-invasive methods have been developed to make diagnosis easier. This study aimed to screen the presence of H.pylori antibodies and antigen among symptomatic and asymptomatic patients at Tamboul City in Gezira State. Methods: A cross-sectional study was conducted in Tamboul city, Gezira State, Sudan between March 2016 and December 2019 to compare between antigen and antibody tests results used for diagnosis of H. pylori infection among symptomatic and asymptomatic Sudanese patients. Stool and blood samples were collected and analyzed for presence of antigen and antibodies to H. pylori using immunochromatography (ICT) cards. Results: Serum and stool samples were collected from 100 patients; 50 were symptomatic and 50 were asymptomatic. In symptomatic patients, 18/50 (36%) were men (32; 64%, women) with mean age of 16.7±24.6 years. In this group, 35/50 (70%) showed positive results for stool antigen, while 30/50 (60%) were positive for serum antibodies. In asymptomatic patients, 19/50 (38%) were men (31; 62%, women) with mean age of 16.7±20.4 years. In this group, 18/50 (36%) were positive for stool antigen and 25/50 (50%) for serum antibodies. There was a significant association between antigen results and patient group (P=0.001), but there was an insignificant association between antibodies results and patient group (P=0.317). Age group, history of infected persons in the family, blood group, and previous treatment were all not associated with H. pylori infection (P≥0.05). Conclusion: The frequency of H. pylori antigen was higher than antibodies in symptomatic patients, while the frequency of H. pylori antibodies was higher than antigen in asymptomatic patients.

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Asymptomatic Duodenitis and Helicobacter pylori associated Dyspepsia in 2-Year-Old Chronic Malnourished Bangladeshi Slum-Dwelling Children: A Cross-Sectional Study

Journal of Tropical Pediatrics ◽

10.1093/tropej/fmaa079 ◽

2020 ◽

Author(s):

Md Shabab Hossain ◽

Subhasish Das ◽

S M Khodeza Nahar Begum ◽

M Masudur Rahman ◽

Ramendra Nath Mazumder ◽

...

Keyword(s):

Helicobacter Pylori ◽

Cross Sectional Study ◽

Upper Gastrointestinal Endoscopy ◽

Sectional Study ◽

Cross Sectional ◽

Malnourished Children ◽

Asymptomatic Children ◽

Environmental Enteric Dysfunction ◽

Dyspeptic Symptoms ◽

H Pylori

Abstract Aim There is insufficient knowledge on the * duodenal histology and Helicobacter pylori infection in malnourished Bangladeshi children. Therefore, we attempted to explore the prevalence of H. pylori infection and duodenal histopathology in 2-year-old chronic malnourished Bangladeshi slum-dwelling children and investigate their association with dyspeptic symptoms. Methods This cross-sectional study was conducted using the data of the Bangladesh Environmental Enteric Dysfunction study in an urban slum of Dhaka, Bangladesh. With a view to address the association of environmental enteric dysfunction (EED) with stunting, upper gastrointestinal endoscopy was performed on 54 chronic malnourished children {31 stunted [length-for-age Z-scores (LAZ) <−2] and 23 at risk of stunting (LAZ <−1 to −2)} aged between 12–24 months and the mucosal biopsies were subjected to histopathological examination after obtaining proper clinical history. Stool antigen for H. pylori (HpSA) was assessed to determine H. pylori status. Results In all, 83.3% (45/54) of the children had histopathological evidence of duodenitis. Chronic mild duodenitis was found to be the most prevalent form of duodenitis (53.7%) in the children. Only 8.9% (4/45) of the children with duodenitis had dyspepsia (p < 0.05). The 14.8% (8/54) of the children were found positive for H. pylori infection. Logistic regression analysis revealed children positive for HpSA had significant association with dyspepsia (OR 9.34; 95% CI 1.54–56.80). Conclusions The number of chronic malnourished children suffering from duodenitis was found to be very high. Majority of these children was asymptomatic. Children positive for HpSA had significant association with dyspeptic symptoms.

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Correlation between the Intensity of Helicobacter pylori Colonization and Severity of Gastritis

Gastroenterology Research and Practice ◽

10.1155/2017/8320496 ◽

2017 ◽

Vol 2017 ◽

pp. 1-5 ◽

Cited By ~ 5

Author(s):

Hamid Reza Ghasemi Basir ◽

Mehdi Ghobakhlou ◽

Parvin Akbari ◽

Arash Dehghan ◽

Mohamad Ali Seif Rabiei

Keyword(s):

Helicobacter Pylori ◽

Chronic Gastritis ◽

Cross Sectional Study ◽

Lymphoid Follicle ◽

Pathological Findings ◽

Sectional Study ◽

Cross Sectional ◽

H Pylori ◽

The Relationship ◽

Colonization Rates

Background. The most common cause of chronic gastritis is infection with Helicobacter pylori. Identifying the relationship between intensities of colonization and activity of gastritis helps the clinician in more effective treatment and posttreatment follow-ups. Methods. In this cross-sectional study, endoscopic gastric biopsy samples of 544 patients who complained symptoms of dyspepsia for more than three months referring to the laboratory were studied. To determine the colonization rate of H. pylori and other pathological findings, Giemsa and H&E stains were, respectively, used. Results. Among 544 subjects, 47 (8.64%) patients had no gastritis, 203 (37.32%) had mild gastritis, 278 (10.51%) suffered moderate gastritis, and 16 (2.94%) had severe gastritis. In this study, patients with mild H. pylori colonization rates had the highest level of mild activity (33.52%); in contrast, those with severe H. pylori colonization had the highest level of severe activity (43.75%). 93.96% of people with severe H. pylori colonization suffered from moderate and severe chronic gastritis. There is a significant statistical relationship between the intensity of H. pylori colonization and histopathological findings including intestinal metaplasia, atrophy, and lymphoid follicle formation. Conclusions. According to the present study, with increasing intensity of H. pylori colonization, chronicity and activity of gastritis and its complications increase.

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Helicobacter pylori: A Cause of Community-Acquired Pediatric Septic Shock: A Cross Sectional Study

10.21203/rs.2.15769/v2 ◽

2019 ◽

Author(s):

HebatAllah Algebaly ◽

Rasha Elsherif ◽

Doaa Ghaith ◽

Bassem Saad ◽

Nabil Mohsen

Keyword(s):

Septic Shock ◽

Helicobacter Pylori ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

Abstract The authors have withdrawn this preprint from Research Square

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The Association Between Helicobacter Pylori Infection and Erosive Gastroesophageal Reflux Disease; a Cross-Sectional Study

10.21203/rs.3.rs-1124716/v1 ◽

2021 ◽

Author(s):

Ramin Niknam ◽

Kamran Bagheri Lankarani ◽

Mohsen Moghadami ◽

Seyed Alireza Taghavi ◽

Leila Zahiri ◽

...

Keyword(s):

Helicobacter Pylori ◽

Gastroesophageal Reflux Disease ◽

Gastroesophageal Reflux ◽

Hiatus Hernia ◽

Reflux Disease ◽

Cross Sectional Study ◽

Helicobacter Pylori Infection ◽

Sectional Study ◽

Cross Sectional ◽

H Pylori

Abstract Background The association between H. pylori (Helicobacter pylori) infection and gastroesophageal reflux disease (GERD) is a complex and confusing subject, so we designed this study. Method In a cross-sectional study, all patients referred for endoscopy due to dyspepsia were enrolled. The diagnosis of erosive GERD was made by endoscopy. Patients with normal esophagus were selected as comparison group. Random gastric biopsies were taken from all participants to diagnose H. pylori infection. Result In total, 1916 patients were included in this study, of whom 45.6% had GERD. The mean age (SD) was 42.95 (16.32). Overall, 1442 (75.3%) patients were positive for H. pylori infection. The frequency of H. pylori infection in mild GERD patients was higher than the severe GERD, but this difference was not significant (P=0.214). Except for sociodemographic status (P < 0.001), other variables including gender, age, ethnicity, body mass index (BMI), smoking, and presence of hiatus hernia in patients had no significant association with the frequency of H. pylori infection. According to Robust Poisson regression models analysis, the association of H. pylori (PR 1.026;95%CI 0.990-1.064; P=0.158) and sociodemographic status were not significantly different between the two groups. But smoking, increased BMI, older age, presence of hiatus hernia, and peptic ulcer diseases were significantly associated with GERD compared with the non-GERD group. Conclusion In our results, there was no association between H. pylori infection and erosive GERD. Further studies are recommended, especially considering the effects of pathophysiological and other confounding factors on H. pylori and GERD.

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Risk Factor Assessment of Helicobacter pylori Infection in a Rural Community of People with Gastritis: A Community Based Cross-Sectional Study

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i20a31348 ◽

2021 ◽

pp. 56-63

Author(s):

Suresh Jaiswal ◽

Bishnu Raj Tiwari ◽

Dinesh C. Sharma

Keyword(s):

Risk Factors ◽

Cross Sectional Study ◽

Rural Setting ◽

P Value ◽

Sectional Study ◽

Significant Relation ◽

Community Based ◽

Cross Sectional ◽

Potential Risk Factors ◽

H Pylori

Aim: The purpose of this study was to detect the incidence and risk factors of H. Pylori infections in patients with gastritis. Study Design: A community-based cross-sectional study. Place and Duration of Study: Mahagadhimai-5, Province 2 in a rural setting of Nepal from November 2019 to March 2020. Methodology: Stool samples were collected from the gastritis patients and were subjected to detection of the H. pylori stool antigen following the procedures recommended by the manufacturer. A questionnaire was completed by the investigators with the cooperation of each participant for the potential risk factors as designed and completed. Results: Out of 150 participants, 82 (54.7%) were female and 68 (45.3%) were male participants. Out of 150 participants, 32.7% (49) were positive for H. pylori antigen. No significant association was seen with sex, age group while others did not show significant relation with socio-demography. Association of food habits with H. pylori antigen has significant association with smoking habits with P-value 0.049 OR 0.518 at 95% CI (0.249- 1.080) while others did not show significant relation. Conclusions: Nearly one-third of the population was infected with H. pylori in Mahagadhimai-5, Province 2. The socio-demographic profiles, socio-economic factors and lifestyle are worth taking into consideration to prevent diseases associated with H. pylori infection.

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