The preventive effect of dexmedetomidine on adverse reactions induced by uterotonics in cesarean section: a meta-analysis
Abstract Background: To evaluate the preventive effect of dexmedetomidine(DEX) on adverse reactions induced by uterotonics used in cesarean section. Methods: Randomized controlled trials(RCTs) comparing dexmedetomidine with placebo on preventing the side effects of uterotonics in cesarean section were searched in PubMed, The Cochrane Library, and CNKI. Results: Fifteen articles with 1174 patients were included in this study. Compared with placebo, DEX significantly reduced the incidence of adverse drug reactions, such as nausea, vomiting, facial flushing, chest distress, hypertension and tachycardia ([OR = 0.12, 95% CI (0.09, 0.17), P < 0.00001], [OR = 0.12, 95% CI (0.09, 0.18), P < 0.00001], [OR = 0.21, 95% CI (0.16, 0.29), P < 0.00001], [OR = 0.19,95%CI (0.12,0.30), P < 0.00001], [OR=0.09, 95%CI (0.05,0.14), P < 0.00001], [OR=0.04, 95%CI (0.02,0.07), P < 0.00001]),which were induced by uterotonics used in cesarean section. Conclusion: Dexmedetomidine can prevent adverse reactions including nausea, vomiting, facial flushing, chest distress, hypertension and tachycardia caused by uterotonics used in cesarean section.