scholarly journals Identifying essential proteins in dynamic protein networks based on an improved h-index algorithm

2020 ◽  
Author(s):  
Caiyan Dai ◽  
HE Ju ◽  
HU Kongfa ◽  
DING Youwei
Keyword(s):  
Cellular Networks ◽  
Theoretical Basis ◽  
Protein Networks ◽  
Cellular Functions ◽  
H Index ◽  
Essential Proteins ◽  
Protein Components ◽  
Coefficient Method ◽  
Over Time

Abstract Background : The essential proteins in protein networks play an important role in complex cellular functions and in protein evolution. Therefore, the identification of essential proteins in a network can help to explain the structure, function, and dynamics of basic cellular networks. The existing dynamic protein networks regard the protein components as the same at all time points; however, the role of proteins can vary over time. Results: To improve the accuracy of identifying essential proteins, an improved h -index algorithm based on the attenuation coefficient method is proposed in this paper. This method incorporates previously neglected node information to improve the accuracy of the essential protein search. It can ensure the accuracy of the found proteins while identifying more essential proteins. Conclusions: The described experiments show that this method is more effective than other similar methods in identifying essential proteins in dynamic protein networks. This study can better explain the mechanism of life activities and provide theoretical basis for the research and development of targeted drugs.

scholarly journals Identifying essential proteins in dynamic protein networks based on an improved h-index algorithm

2020 ◽  
Author(s):  
Caiyan Dai ◽  
HE Ju ◽  
HU Kongfa ◽  
DING Youwei
Keyword(s):  
Cellular Networks ◽  
Attenuation Coefficient ◽  
Protein Networks ◽  
Cellular Functions ◽  
H Index ◽  
Essential Proteins ◽  
Essential Protein ◽  
Protein Components ◽  
Coefficient Method

Abstract Background: The essential proteins in protein networks play an important role in complex cellular functions and in protein evolution. Therefore, the identification of essential proteins in a network can help to explain the structure, function, and dynamics of basic cellular networks. The existing dynamic protein networks regard the protein components as the same at all time points; however, the role of proteins can vary over time. Methods: To improve the accuracy of identifying essential proteins, an improved h-index algorithm based on the attenuation coefficient method is proposed in this paper. This method incorporates previously neglected node information to improve the accuracy of the essential protein search. Based on choosing the appropriate attenuation coefficient, the values, such as monotonicity, SN, SP, PPV and NPV of different essential protein search algorithms are tested.Results: The experimental results show that, the algorithm proposed in this paper can ensure the accuracy of the found proteins while identifying more essential proteins.Conclusions: The described experiments show that this method is more effective than other similar methods in identifying essential proteins in dynamic protein networks. This study can better explain the mechanism of life activities and provide theoretical basis for the research and development of targeted drugs.

scholarly journals Searching essential proteins in dynamic protein networks based on an improved H-index algorithm

2019 ◽  
Author(s):  
Caiyan Dai ◽  
HE Ju ◽  
HU Kongfa ◽  
DING Youwei
Keyword(s):  
Structure Function ◽  
Cellular Networks ◽  
Attenuation Coefficient ◽  
Protein Networks ◽  
Cellular Functions ◽  
H Index ◽  
Essential Proteins ◽  
Essential Protein ◽  
Coefficient Method

Abstract The essential proteins in protein networks play an important role in complex cellular functions and their evolution. Therefore, searching essential proteins in protein networks can help to explain the structure, function and dynamics of basic cellular networks. The existing dynamic protein network regards the protein situation at all times as the same, but in fact, the role of proteins varies at different times. In order to improve the accuracy of essential protein searching, an improved H-index algorithm based on attenuation coefficient method is proposed in this paper, which incorporates the neglected node information into consideration to improve the accuracy of essential protein searching. The experiments show that the essential proteins found on the basis of this model are more effective than other similar methods.

La trasmissione della conoscenza e la funzione della scrittura

GRUPPI ◽  
2009 ◽  
pp. 61-68
Author(s):  
Flavio Nosč ◽  
Silvia Anfilocchi
Keyword(s):  
Theoretical Basis ◽  
Oral Tradition ◽  
Oral Communication ◽  
Oral Transmission ◽  
Online Journals ◽  
Written Form ◽  
Broad Dimension ◽  
Historical Moment ◽  
Over Time

- After reflection upon the role of narcissism - of the pupil as well as of the teacher - as an obstacle to knowledge, we are now reflecting upon the function of writing and its relationship with the oral transmission of psychotherapeutic "knowledge", in that oral learning has always played an important role. It is observed that oral transmission is nurtured by a dialogic context made of emotional confirmation and disconfirmation and takes advantage of the richness of the context, while writing needs to build a sort of dialog with that which is absent. Furthermore, we are now living in a historical moment in which web communica- tion also exists, and although it is in written form, it may be that it has such peculiarities of simultaneity and such a broad dimension that it is closer to oral tradition, and online journals themselves undoubtedly play an important role. The group feels it needs to keep identity and possibility of change together, so as to create a strong theoretical basis, with elements of stability which can be passed on. This theoretical basis can be split up but should remain in contact with the transmission of experience. The group also feels that behind the apparent dichotomy between online writing and traditional writing there is the idea of a culture that is changing over time, and that through this change it is building a tradition in which the group can recognize itself. It is necessary to keep the space devoted to the COIRAG Journal, a space in which a more pondered and processed exchange can be fostered, where the understanding of-and not only the description of-events has its own room. What we need is a space that can collect the consolidated aspects and the strong theoretical core of our reality, and that can build the identity with which we present ourselves to the exterior. .Parole chiave: conoscenza, apprendimento, formazione, comunicazione orale, comunicazione scritta, rivista. .Key words: knowledge, learning, training, oral communication, written communication, magazine.

scholarly journals Functional Aspects of Seminal Plasma in Bird Reproduction

2020 ◽  
Vol 21 (16) ◽  
pp. 5664
Author(s):  
Julian Santiago-Moreno ◽  
Elisabeth Blesbois
Keyword(s):  
Seminal Plasma ◽  
Ion Homeostasis ◽  
Sperm Concentration ◽  
Cellular Functions ◽  
Functional Aspects ◽  
Reproductive Techniques ◽  
Sperm Survival ◽  
Protein Components ◽  
And Function

This review provides an updated overview of the seminal plasma composition, and the role of metabolic and protein components on the sperm function of avian species. In addition, the implication of seminal plasma on assisted reproductive techniques of birds was discussed. The semen of birds usually has exceptionally high sperm concentration with relatively little seminal plasma, but this contributes to very fast changes in sperm metabolism and function. The biochemical characteristics and physiological roles of the various seminal plasma components in birds (carbohydrates, lipids, amino acids, hormones, and proteins) are poorly understood. Seminal plasma content of proteins has an action on most cellular functions: metabolism, immunity, oxido-reduction regulation, proteolysis, apoptosis, ion homeostasis, and antimicrobial defenses. The variable amount of many proteins is related to a different fertility capacity of poultry sperm. The role of seminal plasma on semen conservation (chilling and freezing) remains largely a matter of speculation, as both inhibitory and stimulating effects have been found. Whereas the presence of seminal plasma did not seem to affect the sperm survival after freezing–thawing, DNA fragmentation is lower in the absence of seminal plasma. The molecular basis of the influence of seminal plasma on sperm cryo-resistance was also discussed in the present review.

scholarly journals The Mitochondrial-Associated Endoplasmic Reticulum Membrane and Its Role in Diabetic Nephropathy

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Lihua Ni ◽  
Cheng Yuan
Keyword(s):  
Endoplasmic Reticulum ◽  
Diabetic Nephropathy ◽  
Theoretical Basis ◽  
Drug Research ◽  
Endoplasmic Reticulum Membrane ◽  
Outer Mitochondrial Membrane ◽  
Cellular Functions ◽  
Wide Range ◽  
Targeted Drug

The mitochondrial-associated endoplasmic reticulum membrane (MAM) is located between the outer mitochondrial membrane and the endoplasmic reticulum membrane. The MAM is involved in a wide range of cellular functions, including calcium signaling, the division and fusion of mitochondria, endoplasmic reticulum stress, and the synthesis and transport of lipids. Recent studies have discovered that the MAM is involved in the pathogenesis of diabetic nephropathy (DN). In this article, we summarize the structure, function and role of the MAM in DN. We hope this study will provide clues and a theoretical basis for mechanistic and targeted drug research on DN.

The Role of microRNAs in the Viral Infections

2019 ◽  
Vol 24 (39) ◽  
pp. 4659-4667 ◽  
Author(s):  
Mona Fani ◽  
Milad Zandi ◽  
Majid Rezayi ◽  
Nastaran Khodadad ◽  
Hadis Langari ◽  
...  
Keyword(s):  
Viral Infections ◽  
Rna Viruses ◽  
Regulation Of Gene Expression ◽  
Molecular Structures ◽  
Main Function ◽  
Cellular Functions ◽  
Viral Genes ◽  
Non Coding Rnas ◽  
Post Transcriptional Regulation

MicroRNAs (miRNAs) are non-coding RNAs with 19 to 24 nucleotides which are evolutionally conserved. MicroRNAs play a regulatory role in many cellular functions such as immune mechanisms, apoptosis, and tumorigenesis. The main function of miRNAs is the post-transcriptional regulation of gene expression via mRNA degradation or inhibition of translation. In fact, many of them act as an oncogene or tumor suppressor. These molecular structures participate in many physiological and pathological processes of the cell. The virus can also produce them for developing its pathogenic processes. It was initially thought that viruses without nuclear replication cycle such as Poxviridae and RNA viruses can not code miRNA, but recently, it has been proven that RNA viruses can also produce miRNA. The aim of this articles is to describe viral miRNAs biogenesis and their effects on cellular and viral genes.

Raza, ciencia, sociedad

2015 ◽  
Vol 2 (4) ◽  
Author(s):  
Peter Wade
Keyword(s):  
Cultural Discourse ◽  
Human Biology ◽  
Science And Society ◽  
Race Science ◽  
And Behavior ◽  
Over Time

<p class="p1"><span class="s1"><strong>Resumen </strong></span>| En este trabajo quiero presentar una cronología convencional del concepto raza que marca un movimiento en el cual raza cambia de ser una idea basada en la cultura y el medio ambiente, a ser algo biológico, inflexible y determinante, para luego volver a ser una noción que habla de la cultura<span class="s2"><strong>.</strong></span>Resumo cómo la idea de raza ha cambiado a través del tiempo, mirando necesariamente el rol que ha desempeñado la ciencia, y enfocando los diferentes discursos de índole <em>natural-cultural </em>sobre los cuerpos, el medio ambiente y el comportamiento, en los cuales las dimensiones culturales y naturales siempre coexisten<span class="s2"><strong>.</strong></span>“La naturaleza” no puede ser entendida solamente como “la biología” y ni la naturaleza ni la biología necesariamente implican sólo el determinismo, la fijeza y la inmutabilidad Estar abiertos a la coexistencia de la cultura y la naturaleza y a la mutabilidad de la naturaleza nos permite ver mejor el ámbito de acción del pensamiento racial.</p><p class="p1"><strong><em>Race, Science and Society</em></strong></p><p class="p1"> </p><p class="p2"><span class="s1"><strong>Abstract </strong></span>| In this article I present and critique a standard chronology of race as, first, a concept rooted in culture and environment, and later in human biology and determinism, and finally back to culture alone<span class="s2"><strong><em>.</em></strong></span>I will outline changing understandings of race over time, with some attention to the role of science, broadly understood, and on the continuing but changing character of race as a natural-cultural discourse about organic bodies, environments and behavior, in which both cultural and natural dimensions always co-exist<span class="s2"><strong><em>.</em></strong></span>“Nature” is not to be understood simply as “biology,” and neither nature nor biology necessarily imply the fixity and determination that they are often assumed nowadays to involve<span class="s2"><strong><em>.</em></strong></span>Being open to the co-existence of culture and nature and the mutability of the latter allows us to better comprehend the whole range of action of racial thinking.</p>

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