scholarly journals Incidence, bacteriological profile and antibiotic sensitivity pattern of neonatal sepsis in a tertiary health facility in Abuja, North-central Nigeria.

2021 ◽  
Author(s):  
Olutunde Oluyinka ◽  
Kareem I. Airede ◽  
Kudi E. Olateju ◽  
Obaro K. Stephen ◽  
Nosakhare Izevbigie ◽  
...  
Keyword(s):  
Blood Culture ◽  
Incidence Rate ◽  
Neonatal Sepsis ◽  
White Cell Count ◽  
Antibiotic Sensitivity ◽  
Signs And Symptoms ◽  
Special Care Unit ◽  
Bacteriological Profile ◽  
Sensitivity Pattern ◽  
Pseudomonas Luteola

Abstract Background: Neonatal sepsis is commonly caused by bacteria in the first 28 days of life. Due to diagnostic limitations in developing settings, prompt laboratory identification of causative organisms is usually a challenge. To prevent mortality, clear knowledge of bacteria and their antibiotic sensitivity patterns are important for prompt empirical treatment. Methods: This prospective study enrolled 339 newborns with signs and symptoms suggestive of neonatal sepsis out of 645 that were admitted into the special care unit of the University of Teaching Hospital during the study period. Socio-demographic and clinical profiles of the newborns were obtained using a questionnaire and blood culture was done from every enrolled newborn (339 newborns) using BACTEC 9050. The bacteriological profile and antibiotic sensitivity pattern of newborns with confirmed neonatal sepsis were documented. Results: A total of 339 newborn were admitted for probable sepsis out of a total admission of 645 newborns during the study period based on clinical features and initial laboratory work-up. Forty-six of the 645 newborns (46/645) had culture proven sepsis resulting in a neonatal sepsis incidence rate of 71.3 (95%CI 50.7-91.9) per 1000 admitted newborns. Seventeen of the 46 confirmed sepsis cases were among the 1322 newborns delivered within the study facility during the study period giving an in-hospital neonatal sepsis incidence rate of 12.9 (95% CI 6.7-19.0) per 1000 live births. Amongst the 46 babies with positive blood culture, 27/46 (58.7%) had normal white cell count while the remaining 19/46 (41.3%) had abnormal results. Fifty-two (52) counts of bacteria categorized into 11 bacteria species were isolated from the 46 positive blood cultures. Enterococcus spp and streptococcus species were the commonest gram-positive while Escherichia coli and Pseudomonas luteola were the commonest gram-negative bacteria isolates. Imipenem, amoxicillin/clavulanic acid, Vancomycin, and ofloxacin had the widest coverage of bacteria isolated from newborn with sepsis. Conclusion: Neonatal sepsis is still prevalent in our environment and compared to previous documented isolates and sensitivity pattern, the bacteria causes, and their antibiotic sensitivity patterns appears to be changing.

scholarly journals Incidence, bacteriological profile and antibiotic sensitivity pattern of neonatal sepsis in a tertiary health facility in Abuja, North-central Nigeria.

2020 ◽  
Author(s):  
Olutunde Oluyinka ◽  
Kareem I. Airede ◽  
Kudi E. Olateju ◽  
Obaro K. Stephen ◽  
Nosakhare Izevbigie ◽  
...  
Keyword(s):  
Blood Culture ◽  
Incidence Rate ◽  
Clinical Features ◽  
Neonatal Sepsis ◽  
Antibiotic Sensitivity ◽  
Vibrio Fluvialis ◽  
Bacteriological Profile ◽  
Sensitivity Pattern ◽  
Enterococcus Spp ◽  
Staphylococcus Spp

Abstract Background: Neonatal sepsis is commonly caused by bacteria in the first 28 days of life. If prompt management is not instituted, it could lead to death within hours of onset. Due to diagnostic limitation in developing settings, prompt laboratory identification of causative organism is usually a challenge. To prevent mortality, clear knowledge of bacteria and their antibiotics sensitivity pattern is important for prompt empirical treatment. Methods: This prospective and cross-sectional study enrolled 339 newborns and were admitted for probable sepsis to the special care unit of the university of Abuja Teaching Hospital. Socio-demographic profile and Blood culture was done from every enrolled newborn using BACTEC 9050. The pattern of the clinical features, incidence, bacteriological profile and antibiotic sensitivity pattern of newborns with confirmed neonatal sepsis were documented. Results: A total of 645 newborn were admitted for probable sepsis during the study period based on clinical features and initial laboratory work-up. Forty-six of the 645 newborns (46/645) had laboratory confirmed sepsis based on blood culture resulting in a neonatal sepsis incidence rate of 71.3 (95%CI 50.7-91.9) per 1000 admitted newborn. Seventeen of the 46 confirmed sepsis cases were among the 1322 newborns delivered within the study facility during the study period giving an in-hospital neonatal sepsis incidence rate of 12.9 (95% CI 6.7-19.0) per 1000 live birth. Amongst the 46 babies with positive blood culture, 27/46 (58.7%) had normal white cell count while the remaining 19/46 (41.3%) had abnormal results. In all, 52 counts of bacteria categorized into 11 bacteria species were isolated from the 46 positive blood cultures. Enterococcus spp and streptococcus species were the commonest gram-positive while Escherichia coli and Chryseomonas luteola were the commonest gram-negative bacteria isolates. Imipenem (all bacterial isolates except Vibrio fluvialis), Augmentin (Streptococcus spp, Staphylococcus spp, Escherichia spp, Enterococcus spp, Klebsiella spp, Moraxella catarrhalis, Acinetobacter baumannii), Vancomycin (Streptococcus spp, Staphylococcus spp, Escherichia spp, Enterococcus spp), and Ofloxacin (all except Vibrio fluvialis and Citrobacter freundii) had the widest coverage of bacteria isolated from newborn with sepsis. Conclusion: Sepsis in newborn is still prevalent in our environment and compared to previous documented isolates and sensitivity pattern, the bacteria causes, and their antibiotic sensitivity patterns appears to be changing.

scholarly journals To Study Bacteriological Profile and Antibiotic Sensitivity Pattern in Cases of Neonatal Sepsis

2015 ◽  
Vol 2 (1) ◽  
pp. 20
Author(s):  
Sagar Sonawane ◽  
M. K. Tolani ◽  
Milind Suryawanshi ◽  
Priyanka Patil
Keyword(s):  
Blood Culture ◽  
Neonatal Sepsis ◽  
Neonatal Intensive Care ◽  
Late Onset ◽  
Antibiotic Sensitivity ◽  
Automated Method ◽  
Bacteriological Profile ◽  
Late Onset Sepsis ◽  
Sensitivity Pattern ◽  
Sepsis Screen

<strong>Objective:</strong> To study the bacteriological profile and sensitivity pattern in cases of Neonatal sepsis at 12 bedded Neonatal Intensive Care Unit (NICU). <strong>Methods:</strong> This was a prospective study of neonates admitted to our NICU from Jan 2010 to Oct 2011 with diagnosis of neonatal sepsis or those who developed sepsis later during their stay in NICU. All newborns diagnosed as a case of neonatal sepsis, based on clinical features with positive sepsis screen and/or positive blood culture, were included in our study. Blood Culture&amp;Sensitivity was done with conventional non-automated method using Herley's Broth. <strong>Results:</strong> Out of 55 cases blood culture was positive in 27 (49.09%) cases. Klebsiella Pneumoniae 15 (55.55%) was the most common organism isolated in both early and late onset sepsis showed sensitivity to collistin in 86.6% of cases followed by sensitivity to imipenam-cilastin in 46.67% cases. Only 20% Klebsiella isolates were sensitive to drugs like Ampicillin-sulbactum, Amikacin, Tazobactum, cefpime and for other antibiotics like Meropenam, Piperacillin-tazobactum, Vancomycin it was less than 20%. Other organisms isolated were Staph. aureus, E. Coli, Pseudomonas, Enterobactor, Acinetobactor and candida species. <strong>Conclusion:</strong> Gram negative organisms are most common cause of early as well as late onset sepsis and there is alarming degree of antibiotic resistance to commonly used antibiotics.

scholarly journals Clinical and Bacteriological Profile of Early Onset Neonatal Sepsis Admitted in NICU of Tertiary Hospital in Biratnagar

2018 ◽  
Vol 3 (1) ◽  
pp. 370-376
Author(s):  
Arun Giri ◽  
Vijay Kumar Sah ◽  
Bikash Sharma Poudel ◽  
Niraj Niraula ◽  
Raju Sedai
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Blood Culture ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Coagulase Negative Staphylococcus ◽  
Sensitivity Pattern ◽  
Clinical Signs And Symptoms

Introduction: Neonatal sepsis is one of the major causes of neonatal morbidity and mortality especially in developing countries. The clinical signs and symptoms of neonatal sepsis are non specific and blood culture report is considered gold standard for confirmation of neonatal sepsis. Organisms and their sensitivity pattern vary from place to place. The confirmation of diagnosis and management of neonatal sepsis is challenging and time consuming.Objective: The aim of this study was to find incidence of blood culture proven sepsis in suspected early onset neonatal sepsis, find out sensitivity pattern of isolated organism and to find association of risk factors and clinical signs and symptoms with blood culture proven sepsis.Methodology: Prospective study was conducted in Nobel Medical College, Biratnagar from November 2016 to November 2017. Sample size was calculated to be 300 and blood culture was sent of each neonates admitted with suspected early onset neonatal sepsis before giving neonates with first dose of antibiotics and report of 72 hours was taken into consideration.Results: Out of 300 cases of suspected early onset neonatal sepsis 70.3% presented with lethargy, followed by other symptoms like poor feeding, respiratory distress, fever, hypothermia, feeding intolerance, abnormal body movement and abdominal distension. Low birth weight neonates, preterm neonates, prolonged duration of per vaginal leaking and low platelets count were significantly associated with blood culture proven sepsis in this study. Incidence of blood culture positive sepsis in suspected early onset neonatal sepsis was 27%. Coagulase negative Staphylococcus aureus(21%) was predominant organism isolated followed by Klebsiella Pneumonia, Pseudomonas, Escherichia coli. All of the isolated Klebsiella and Pseudomonas and 86% of Escherichia coli were found to be resistant to ampicillin. All isolated Coagulase negative Staphylococcus aureus were sensitive to vancomycin.Conclusion: Coagulase negative Staphyloccus aureus was predominant organism detected but majority of organisms were gram negative organisms. High resistance to ampicillin was found and cefotaxime was also less sensitive to isolated organism. Vancomycin was found to be sensitive to all isolated Staphylococcus aureus and coagulase negative Staphylococcus aureus. Amikacin was highly sensitive among causative organisms isolated. BJHS 2018;3(1)5 : 370-376

scholarly journals Bacteriological profile and sensitivity pattern of neonatal sepsis

2017 ◽  
Vol 8 (1) ◽  
pp. 174-177
Author(s):  
Rowshan Jahan Akhter ◽  
Md Mahbubul Hoque ◽  
BH Nazma Yasmeen ◽  
MAK Azad Chowdhury
Keyword(s):  
Antibiotic Resistance ◽  
Neonatal Sepsis ◽  
Antibiotic Sensitivity ◽  
Neonatal Morbidity ◽  
Diffusion Method ◽  
Bacteriological Profile ◽  
Sensitivity Pattern ◽  
Haematological Profile ◽  
Resistance Patterns ◽  
Antibiotic Resistance Patterns

Introduction : Neonatal sepsis remains an important cause of neonatal morbidity and mortality in NICU setup and a major challenge for the neonatologists. The prevalent organisms and their antibiotic resistance patterns evolve with time and with the usage of antimicrobials.Aims and Objectives : To analyze the bacteriological profile and antibiotic resistance patterns of proven neonatal sepsis cases in Dhaka Shishu Hospital.Materials and Methods : The study was Prospective observational study. All the clinically suspected cases of Neonatal Sepsis admitted to the Neonatal word from January 2015 to December 2015 were included in the study. Clinically suspected cases of neonatal sepsis further evaluated with blood cultures and antibiotic susceptibility testing using the Kirby Bauer disc diffusion method. Data was collected for the following variables: Demographic profile, haematological profile, blood culture result and antibiotic sensitivity patterns.Results : Total 96 cases clinically suspected neonatal sepsis were included in the study. Among them 29 cases (30.21%) was culture positive septicemia. Klebsiella pneumoniae was the most common isolate accounting for 31.03% cases followed by Escherichia coli 27.59%. In Klebsiella infection most common sensitivity were Imipenum and Ciprofloxacin which were 77.78 and 33.33% respectively. In E.coli common sensitive drugs were Imipenum and Amikacin. In serratia common sensitive drugs were Imipenum, Netlmicin and Ciprofloxacin.Conclusion : K. pneumoniae was the most common pathogen. Most common sensitivity was Imipenum, Amikacin, Ciprofloxacin, Gentamicin, Netlmicin, and Ceftazidime,.Northern International Medical College Journal Vol.8(1) July 2016: 174-177

scholarly journals Clinical and bacteriological profile of neonatal sepsis with emerging resistance patterns

2018 ◽  
Vol 5 (6) ◽  
pp. 2203 ◽  
Author(s):  
Rohitashwa Rajana ◽  
Dhan Raj Bagri ◽  
J. N. Sharma ◽  
Vijay Agrawal
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Neonatal Sepsis ◽  
Antibiotic Sensitivity ◽  
Polymyxin B ◽  
Laboratory Evaluation ◽  
Gram Positive ◽  
Gram Negative ◽  
Bacteriological Profile ◽  
Sensitivity Pattern

Background: The present study was designed to evaluate the clinical spectrum, bacteriological profile, antibiotic sensitivity pattern and mortality due to neonatal septicemia in neonates admitted in neonatal units attached to the SMS Medical College, Jaipur.Methods: In born and out born babies of postnatal age up to 28 days who were bacteriological proven cases of septicemia were subjected to history, clinical examination and laboratory evaluation and data were analyzed statistically.Results: Out of 150 cases 67.33% neonates were preterm and 77.33% were low birth weight neonates. Gram negative organisms were most common cause of septicemia (66.6%), Both the Gram negative and Gram positive organisms were sensitive to piperacillin-tazobactam, linezolid, fosfomycin, teicoplanin, polymyxin B, colistin, ofloxacin. Both the Gram negative and Gram positive organisms were resistant against cephalosporins, ampicillin, Amoxyclav, cotrimoxazole. Gram negative isolates were most sensitive to Polymyxin B (70%) and had the highest resistance to cefepime (36%). Gram-positive organisms were most sensitive to vancomycin (84%) and linezolid (82%). Highest resistance was noted from Amoxyclav (52%).Conclusions: Preterm (<37 week) and low birth weight (<2500gm) neonates are considered as major susceptible causes of neonatal sepsis. Proper hygiene and hand washing, early detection of sepsis and judicial use of antibiotics to prevent multidrug resistance is needful in our setup.

Neonatal Sepsis in a Tertiary Care Hospital in South India: Bacteriological Profile and Antibiotic Sensitivity Pattern

2010 ◽  
Vol 78 (4) ◽  
pp. 413-417 ◽  
Author(s):  
Bambala Puthattayil Zakariya ◽  
Vishnu Bhat ◽  
Belgode Narasimha Harish ◽  
Thirunavukkarasu Arun Babu ◽  
Noyal Mariya Joseph
Keyword(s):  
Neonatal Sepsis ◽  
South India ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
Care Hospital ◽  
Bacteriological Profile ◽  
Sensitivity Pattern

scholarly journals Bacteriological profile and antibiotic sensitivity pattern of blood culture isolates from tertiary care level teaching hospital of Vijayapura district

2020 ◽  
Vol 8 (11) ◽  
pp. 3974
Author(s):  
Raveendra D. Totad ◽  
Praveen Ganganahalli
Keyword(s):  
Blood Culture ◽  
Teaching Hospital ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
Blood Stream ◽  
The Body ◽  
Blood Stream Infections ◽  
Bacteriological Profile ◽  
Sensitivity Pattern ◽  
Resistance To Penicillin

Background: Blood stream infections, ranging from self-limiting bacteraemia to life threatening septicaemia, remain one of the most important cause of morbidity and mortality worldwide. Sepsis is a systemic illness caused by microbial invasion of normally sterile parts of the body. Bacteria isolated from blood stream infections are numerous and diseases related to them need urgent treatment with antimicrobial drugs. Aim was to study the bacteriological profile of positive blood cultures and to find their antibiotic sensitivity patternMethods: A retrospective analysis of positive blood culture reports was done in the microbiology laboratory of present tertiary care teaching hospital (Al-Ameen Medical College, Vijayapura) for the consecutive year 2017, 2018 and 2019.Results: Total 21% samples found positive on blood culture shows Staphylococcus aureus as most common organism followed by Klebseilla and E.Coli antibiotic sensitivity pattern shows maximum sensitive to gentamicin (92%) and vancomycin (92%) as maximum resistance to penicillin (55%). Gram-positive organisms show more resistance to penicillin and least to vancomycin whereas gram-negative organisms show more resistance to cephalosporin group of antibiotics and least resistance to ciprofloxacin/gentamicin.Conclusions: Resistance pattern of organisms to some commonly used drugs has given warning signal to clinicians to search for alternate effective antibiotics and hospital authorities to formulate antibiotic policy for rationale use of antibiotics to prevent drug resistance.

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