scholarly journals Physical activity and 4-year changes in body weight in 52,498 non-obese people: The Lifelines Cohort

2020 ◽  
Author(s):  
Oyuntugs Byambasukh ◽  
Petra Vinke ◽  
Daan Kromhout ◽  
Gerjan Navis ◽  
Eva Corpeleijn

Abstract Objectives: We investigated associations between daily-life physical activity (PA) and prospective weight gain in non-obese people. We also examined whether these associations were independent of other lifestyle factors and changes in muscle mass and whether they were age-dependent and changed over a person’s life course. Methods: The data were extracted from the Lifelines cohort study (N=52,498; 43.5% men) and excluded obese individuals (BMI>30kg/m 2 ). We used the validated SQUASH questionnaire to estimate moderate-to-vigorous (MVPA; MET≥4), moderate (MPA; MET between 4 and 6.5) and vigorous PA (VPA; MET≥6.5) within non-occupational (commuting and leisure) and occupational domains. Body weight was objectively measured and changes were standardized to a 4-year period. Separate analyses, adjusted for age, educational level, diet, smoking, alcohol consumption and changes in creatinine excretion (a marker of muscle mass), were performed for men and women. Results: The average weight gain was +0.45±0.03 kg in women. Relative to each reference groups (No-MVPA, No-MPA and No-VPA), non-occupational MVPA (Beta (95%CI): -0.34 kg (-0.56;-0.13)), MPA (-0.32 kg (-0.54;-0.10)) and VPA (-0.30 kg (-0.43;-0.18)) were associated with less gain in body weight in women after adjusting for potential confounders, described above. These associations were dose-dependent when physically active individuals were divided in tertiles. Beta-coefficients (95%CI) for the lowest, middle, and highest MVPA tertiles relative to the ‘No-MVPA’ were, respectively, -0.24 (-0.47;-0.02), -0.31 (-0.53;-0.08), and -0.38 (-0.61;-0.16) kg. The average weight gain in men was +0.13±0.03 kg, and only non-occupational VPA was associated with less body weight gain. Beta-coefficients (95%CI) for the VPA tertiles relative to the ‘No-VPA’ group were, respectively, -0.25 (-0.42;-0.09), -0.19 (-0.38;-0.01) and -0.20 (-0.38;-0.02) kg. However, after adjusting for potential confounders, the association was no longer significant in men. The potential benefits of non-occupational PA were age-stratified and mainly observed in younger adults (men: <35 years; women: <55 years). Moreover, occupational MVPA was not associated with favourable changes in body weight in males and females. Conclusion: Higher non-occupational MVPA, MPA, and VPA were associated with less weight gain in women <55 years. In younger men (<35 years), only non-occupational VPA was associated with less weight gain.

2020 ◽  
Author(s):  
Oyuntugs Byambasukh ◽  
Petra Vinke ◽  
Daan Kromhout ◽  
Gerjan Navis ◽  
Eva Corpeleijn

Abstract Objectives: We investigated associations between daily-life physical activity (PA) and prospective weight gain in non-obese people. We also examined whether these associations were independent of other lifestyle factors and changes in muscle mass and whether they were age-dependent and changed over a person’s life course.Methods: The data were extracted from the Lifelines cohort study (N=52,498; 43.5% men) and excluded obese individuals (BMI>30kg/m2). We used the validated SQUASH questionnaire to estimate moderate-to-vigorous (MVPA; MET≥4), moderate (MPA; MET between 4 and 6.5) and vigorous PA (VPA; MET≥6.5) within non-occupational (commuting and leisure) and occupational domains. Body weight was objectively measured and changes were standardized to a 4-year period. Separate analyses, adjusted for age, educational level, diet, smoking, alcohol consumption and changes in creatinine excretion (a marker of muscle mass), were performed for men and women.Results: The average weight gain was +0.45±0.03 kg in women. Relative to each reference groups (No-MVPA, No-MPA and No-VPA), non-occupational MVPA (Beta (95%CI): -0.34 kg (-0.56;-0.13)), MPA (-0.32 kg (-0.54;-0.10)) and VPA (-0.30 kg (-0.43;-0.18)) were associated with less gain in body weight in women after adjusting for potential confounders, described above. These associations were dose-dependent when physically active individuals were divided in tertiles. Beta-coefficients (95%CI) for the lowest, middle, and highest MVPA tertiles relative to the ‘No-MVPA’ were, respectively, -0.24 (-0.47;-0.02), -0.31 (-0.53;-0.08), and -0.38 (-0.61;-0.16) kg. The average weight gain in men was +0.13±0.03 kg, and only non-occupational VPA was associated with less body weight gain. Beta-coefficients (95%CI) for the VPA tertiles relative to the ‘No-VPA’ group were, respectively, -0.25 (-0.42;-0.09), -0.19 (-0.38;-0.01) and -0.20 (-0.38;-0.02) kg. However, after adjusting for potential confounders, the association was no longer significant in men. The potential benefits of non-occupational PA were age-stratified and mainly observed in younger adults (men: <35 years; women: <55 years). Moreover, occupational MVPA was not associated with favourable changes in body weight in males and females.Conclusion: Higher non-occupational MVPA, MPA, and VPA were associated with less weight gain in women <55 years. In younger men (<35 years), only non-occupational VPA was associated with less weight gain.


2020 ◽  
Author(s):  
Oyuntugs Byambasukh ◽  
Petra Vinke ◽  
Daan Kromhout ◽  
Gerjan Navis ◽  
Eva Corpeleijn

Abstract Objectives: We investigated associations between leisure-time physical activity (LTPA) at different intensities (moderate and vigorous or moderate-to-vigorous) and prospective weight gain in non-obese people. We also examined whether these associations were independent of other lifestyle factors and changes in muscle mass and whether they were age-dependent and changed over a person’s life course.Methods: The data were extracted from the Lifelines cohort study (N=52,498; 43.5% men) and excluded obese individuals (BMI>30kg/m2). We used the validated SQUASH questionnaire to estimate moderate-to-vigorous (MVPA; MET≥4), moderate (MPA; MET between 4 and 6.5) and vigorous PA (VPA; MET≥6.5). Body weight was objectively measured, and changes were standardized to a 4-year period. Separate analyses, adjusted for age, educational level, diet, smoking, alcohol consumption and changes in creatinine excretion (a marker of muscle mass), were performed for men and women.Results: The average weight gain was +0.45±0.03 kg in women. Relative to each reference groups (No-MVPA, No-MPA and No-VPA), MVPA (Beta (95%CI): -0.34 kg (-0.56;-0.13)), MPA (-0.32 kg (-0.54;-0.10)) and VPA (-0.30 kg (-0.43;-0.18)) were associated with less gain in body weight in women after adjusting for potential confounders, described above. These associations were dose-dependent when physically active individuals were divided in tertiles. Beta-coefficients (95%CI) for the lowest, middle, and highest MVPA tertiles relative to the ‘No-MVPA’ were, respectively, -0.24 (-0.47;-0.02), -0.31 (-0.53;-0.08), and -0.38 (-0.61;-0.16) kg. The average weight gain in men was +0.13±0.03 kg, and only VPA, not MPA was associated with less body weight gain. Beta-coefficients (95%CI) for the VPA tertiles relative to the ‘No-VPA’ group were, respectively, -0.25 (-0.42;-0.09), -0.19 (-0.38;-0.01) and -0.20 (-0.38;-0.02) kg. However, after adjusting for potential confounders, the association was no longer significant in men. The potential benefits of leisure-time PA were age-stratified and mainly observed in younger adults (men: <35 years; women: <55 years). Moreover, occupational MVPA was not associated with favourable changes in body weight in males and females.Conclusion: Higher leisure-time MVPA, MPA, and VPA were associated with less weight gain in women <55 years. In younger men (<35 years), only VPA was associated with less weight gain.


Author(s):  
Oyuntugs Byambasukh ◽  
Petra Vinke ◽  
Daan Kromhout ◽  
Gerjan Navis ◽  
Eva Corpeleijn

Abstract Objectives We investigated associations between leisure-time physical activity (LTPA) at different intensities (moderate and vigorous or moderate-to-vigorous) and prospective weight gain in non-obese people. We also examined whether these associations were independent of other lifestyle factors and changes in muscle mass and whether they were age-dependent and changed over a person’s life course. Methods The data were extracted from the Lifelines cohort study (N = 52,498; 43.5% men) and excluded obese individuals (BMI > 30 kg/m2). We used the validated SQUASH questionnaire to estimate moderate-to-vigorous (MVPA; MET≥4), moderate (MPA; MET between 4 and 6.5) and vigorous PA (VPA; MET≥6.5). Body weight was objectively measured, and changes were standardized to a 4-year period. Separate analyses, adjusted for age, educational level, diet, smoking, alcohol consumption and changes in creatinine excretion (a marker of muscle mass), were performed for men and women. Results The average weight gain was + 0.45 ± 0.03 kg in women. Relative to each reference groups (No-MVPA, No-MPA and No-VPA), MVPA (Beta (95%CI): − 0.34 kg (− 0.56;-0.13)), MPA (− 0.32 kg (− 0.54;-0.10)) and VPA (− 0.30 kg (− 0.43;-0.18)) were associated with less gain in body weight in women after adjusting for potential confounders, described above. These associations were dose-dependent when physically active individuals were divided in tertiles. Beta-coefficients (95%CI) for the lowest, middle, and highest MVPA tertiles relative to the ‘No-MVPA’ were, respectively, − 0.24 (− 0.47;-0.02), − 0.31 (− 0.53;-0.08), and − 0.38 (− 0.61;-0.16) kg. The average weight gain in men was + 0.13 ± 0.03 kg, and only VPA, not MPA was associated with less body weight gain. Beta-coefficients (95%CI) for the VPA tertiles relative to the ‘No-VPA’ group were, respectively, − 0.25 (− 0.42;-0.09), − 0.19 (− 0.38;-0.01) and − 0.20 (− 0.38;-0.02) kg. However, after adjusting for potential confounders, the association was no longer significant in men. The potential benefits of leisure-time PA were age-stratified and mainly observed in younger adults (men < 35 years) or stronger with younger age (women < 55 years). Conclusion Higher leisure-time MVPA, MPA, and VPA were associated with less weight gain in women < 55 years. In younger men (< 35 years), only VPA was associated with less weight gain.


2020 ◽  
Vol 3 (1) ◽  
pp. 8-15
Author(s):  
Rahmat Anwar ◽  
Umbang Arif Rokhayati

This study aims to determine the palatability of Balinese cattle to the silage of banana shoe stems. The study was conducted in March to April 2019 in Dambalo Village, Tomilito Subdistrict, North Gorontalo Regency. The research site had a capacity of 50 cattle but this study used 20 cows which were divided into 2 groups. The first group as control was given 15 kg of elephant grass and then added 1 kg / head / day of fresh banana feed and the second group was given 15 kg of elephant grass and 1 kg / head / day of banana shoe silage feed treatment. While processing data using the t test. The results showed that banana shoe stem silage feed was significantly different (P 0.05) to the value of palatability or preferred by Balinese cattle. Whereas the value of body weight gain is higher in cattle given banana silage feed compared to Balinese cattle which are fed fresh banana stems, where the average weight gain of Bali cattle is 42 to 57 grams / head / day. The conclusion is that the treatment of banana shoe stem fermentation was significantly different (P 0.05) to the palatability of Balinese cattle.


1959 ◽  
Vol 37 (1) ◽  
pp. 763-774
Author(s):  
Dorothy S. Dow ◽  
C. E. Allen

Rate of body weight gain of both the young chick and the young rat was markedly inhibited following ingestion of amounts of thyroxine which were greatly in excess of physiological requirements. The rate of body weight gain of the young rat was also markedly inhibited in alloxan diabetes. The administration of insulin partly or largely prevented the observed effect on body weight in both conditions. The administration of thyroxine caused a reduction of rat skeletal muscle mass which was partially prevented when insulin was given concurrently with thyroxine.Reduced body weight gain and muscle mass in the rat were accompanied by marked increases in the muscle DNA and nuclei concentration. Nuclear diameter and the amount of DNA per nucleus remained unchanged. RNA concentration of the muscle was not reduced. The beneficial effect of insulin administration on body weight and muscle mass was accompanied by a preventive effect against changes in muscle DNA and nuclei concentration. However, since the DNA content of muscle bundles remained relatively unchanged and since muscle bundle weights changed proportionately with body weight it would appear that DNA content does not reflect change in muscle mass.The effectiveness of insulin in the thyroxine-treated animal appears to be due to an improved utilization of energy. A hypoglycemic action of thyroxine implies an antagonism between the two hormones in their mechanism of action. The relationship between the two hormones is not direct since the administration of insulin does not affect the increased plasma protein-bound iodine levels resulting from thyroxine treatment.


1999 ◽  
Vol 2 (1a) ◽  
pp. 87-96 ◽  
Author(s):  
Anthony Kafatos ◽  
Yannis Manios ◽  
Irini Markatji ◽  
Ismene Giachetti ◽  
Maria Daniel Vaz de Almeida ◽  
...  

AbstractIntroductionAlthough the benefits of physical activity regarding body-weight gain and health in general are now widely accepted, physical activity levels remain low among citizens in the western world. This could be attributed to certain attitudes and beliefs about physical activity. Identifying and understanding these parameters would be the first step in an attempt to increase the levels of physical activity in populations generally characterized as having a sedentary lifestyle.ObjectiveThe aim of the present study was to identify the attitudes and beliefs regarding physical activity, body weight and health in a nationally representative sample in the EU and in particular to explore the demographic and national (cultural) influences on attitudes towards physical activity.DesignIn each member state of the EU, approximately 1000 adults aged 15 years and over, were selected to complete an interviewer-assisted face-to-face questionnaire. Overall, a sample of 15 239 individuals in the EU participated in the study. Subject selection was quota-controlled to ensure samples in each country were nationally representative.ResultsOn a European level wide variations were observed regarding the levels, beliefs and attitudes towards physical activity. More positive beliefs were observed among Finns, while less positive beliefs were observed among southern Europeans. A similar pattern was observed for attitudes, with the Portuguese having the highest percentage feeling that they do not need to be more physically active than they already are. However, most southern Europeans felt that a campaign would encourage them to become more active than they already are. On a demographic level, the youngest, more educated and most physically active subjects had more positive attitudes and beliefs towards physical activity and the health benefits derived from it; while for the overweight, beliefs and attitudes toward physical activity were related primarily to the benefits related to weight control.ConclusionsLower levels of physical activity, an unwillingness to become active among non-participants and confusion regarding the weight gain benefits and general health benefits of exercise were reported more frequently among southern Europeans and older and less educated subjects. The Finns scored highest in all these parameters, possibly due to the programmes implemented and the beliefs and behaviour changes observed in this country during the last few years. The actions taken in Finland and their benefits could be employed appropriately in the other European states.


2008 ◽  
Vol 294 (3) ◽  
pp. R699-R710 ◽  
Author(s):  
Catherine M. Kotz ◽  
Jennifer A. Teske ◽  
Charles J. Billington

High levels of spontaneous physical activity in lean people and the nonexercise activity thermogenesis (NEAT) derived from that activity appear to protect lean people from obesity during caloric challenge, while obesity in humans is characterized by dramatically reduced spontaneous physical activity. We have similarly demonstrated that obesity-resistant rats have significantly greater spontaneous physical activity than obesity-prone rats, and that spontaneous physical activity predicts body weight gain. Although the energetic cost of activity varies between types of activity and may be regulated, individual level of spontaneous physical activity is important in determining propensity for obesity. We review the current status of knowledge about the brain mechanisms involved in controlling the level of spontaneous physical activity and the NEAT so generated. Focus is on potential neural mediators of spontaneous physical activity and NEAT, including orexin A (also known as hypocretin 1), agouti-related protein, ghrelin, and neuromedin U, in addition to brief mention of neuropeptide Y, corticotrophin releasing hormone, cholecystokinin, estrogen, leptin, and dopamine effects on spontaneous physical activity. We further review evidence that strain differences in orexin stimulation pathways for spontaneous physical activity and NEAT appear to track with the body weight phenotype, thus providing a potential mechanistic explanation for reduced activity and weight gain.


2021 ◽  
Author(s):  
Wei L Shen ◽  
Hongbin Sun ◽  
Qian Zhou ◽  
Hao Bian ◽  
Mengting Wang ◽  
...  

Mutations in the gene brain-derived neurotrophic factor (BDNF) cause obesity in humans. BDNF signaling and its expressing neurons in the hypothalamus help control feeding, energy expenditure (EE), and physical activity. However, whether the BDNF neurons interact with another EE-regulating system, the thermoregulation circuitry, remains unclear. Here, we show that BDNF neurons in the dorsomedial hypothalamus (DMH) are activated by environmental cooling and sufficient to induce body temperature increases and brown adipose tissue (BAT) thermogenesis. Conversely, blocking these neurons impairs BAT thermogenesis and cold defense, causing body weight gain and glucose intolerance. DMH BDNF neurons are therefore an important type of thermoregulatory neuron, integrating thermal afferent signals to control EE during cold defense. This reveals a critical intersection between the BDNF circuitry and the thermoregulatory system.


2015 ◽  
Vol 2 (1) ◽  
pp. 169-175
Author(s):  
Gias Uddin Ahmed ◽  
Habiba Aktar ◽  
Sudristi Chakma ◽  
Neaz Al Hasan ◽  
Mohammad Shamsuddin

Correction: On 29th April 2015 the page numbers of this article were changed from 167-173 to 169-175An investigation was conducted to determine the comparative growth study of supermale tilapia and monosex tilapia in earthen mini ponds from May-July 2012. Four treatments were considered having two replicates. For supermale tilapia treatments were named as ST1 and ST2 and for monosex tilapia were MT1 and MT2. All the fish were of same age group having mean body weight of 1.4 g. Feeding frequency in all the treatments were two times a day. Fish were fed diet at a rate of 30% of their body weight for the first thirty days that was gradually reduced to 15% for the next thirty days and 5% till the termination of the experiment. Final weight, weight gain, average daily weight gain, % weight gain and production of supermale tilapia were significantly (p<0.05) higher than those of monosex tilapia. But SGR (% day), FCR and survival rate of supermale tilapia were not significantly (p>0.05) varied. However, the result of the present study showed that the best weight gain of 124.85 g was observed in ST1 after 90 days culture period. Average weight gain (g) were 1.39, 1.16, 1.14 and 1.05, SGR (per day) were 2.17, 2.09, 2.08 and 2.04%, FCR were 2.98, 2.65, 2.84 and 2.57, survival rate were 96, 94.50, 95 and 91% and fish production were 5053.92, 8926.10, 4108.07 and 7821.41 kg/ha in ST1, ST2, MT1 and MT2 respectively. The present research findings suggested that supermale tilapia has significantly high growth potential compare to monosex tilapia under mini ponds culture condition.Res. Agric., Livest. Fish.2(1): 169-175, April 2015


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