The Change of Visual Acuity Correlated with Choroidal Thickness in Diabetic Retinopathy
Abstract Background To probe the change of macular choroidal thickness (MCT) in diabetic retinopathy (DR) by using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods A retrospective research was conducted among 136 eyes. Patients’ mean age was 57.34±9.42 years. 67 eyes were suffered from diabetic retinopathy (DR) without macular edema (ME), 69 eyes with ME and age matched 64 healthy eyes were as control. The choriocapillaris and the medium vascular layers (Sattler’s layer) were defined as the choroidal inner layer, and the large vessel layer (Haller’s layer) was defined as the choroidal outer layer. Results The whole, inner and out layers of choroid in macular area of the eyes with DR were significantly thinner compared to that of control (P<0.001). The whole and out choroidal layers in DR with ME were significantly thinner than that in DR without ME (P<0.001). The best-corrected visual acuity (BCVA, LogMar) was 0.41±0.37and 0.70±0.45 for DR without ME and DR with ME, respectively. Univariate linear regression analysis showed a positive correlation between MCT and BCVA in either DR with or without ME groups (P=0.023,P=0.006). A stepwise multiple linear regression analysis demonstrated that the elucidative variables strong association with MCT were BCVA and central macular thickness (CMT) in DR eyes. Conclusion In the eyes with DR, MCT was thinner compared to that of healthy control and this change was more substantial in ME eyes. MCT had a positive correction with BCVA. Our results indicate that the pathological change occurred in choroidal layer of the eyes with DR and this change correlated with impairment of BCVA.