scholarly journals Epidemiological features and risk factors for acquiring Hepatitis B, Hepatitis C and syphilis in HIV-infected patients in Shaanxi Province, northwest China

2019 ◽  
Author(s):  
Chao Zhang ◽  
Wenhui Chang
Keyword(s):  
Risk Factors ◽  
Hiv Infection ◽  
Treponema Pallidum ◽  
Northwest China ◽  
Cd4 T Cell ◽  
Shaanxi Province ◽  
Syphilis Infection ◽  
Epidemiological Features ◽  
Homosexual Transmission ◽  
Cd4 T Cell Count

Abstract Background HIV-infected patients are at higher risk for co-infection with Hepatitis B virus (HBV), Hepatitis C virus (HCV), and Treponema pallidum (TP), the agent causing syphilis, than the general population. The prevalence of HBV, HCV, and syphilis had geographic differences and varied from region to region among HIV-infected patients. The aim of this study was to investigate the epidemiological features and risk factors of HBV, HCV, and syphilis infection in HIV-infected individuals in Shaanxi Province, northwest China. Methods A retrospective study was conducted with HIV-infected patients from June 2011 to June 2016 in Shaanxi Province. Sociodemographic data was captured from the national HIV/AIDS information system in China. Serological tests and analysis of CD4+ T-cell count levels were performed using standard procedures. Besides, the HIV infection time and age were presumed by CD4+ T-cell count levels. Results The average time from HIV infection to diagnosis was (4.7±2.4) years, and the HIV infection time ≥3 years accounted for 66.8%. Of the discovery routes, voluntary counseling & testing (VCT) only accounted for 20.7%. Among 1018 HIV-infected patients, the prevalence of HBV, HCV, and syphilis was 11.0%, 11.1%, and 26.0%, respectively. HBV-HCV, HCV-syphilis, HBV-syphilis, and HBV-HCV-syphilis co-infection was 1.7%, 2.2%, 2.6%, and 0.1%, respectively. The rate of ineffective vaccination against HBV was as high as 30.2% in HIV-infected patients. Ethnicity (OR=29.257, 95%CI: 11.243-76.133) and HIV transmission routes (OR=149.368, 95%CI: 16.590-1 344.861) were the risk factors of HCV infection in HIV-infected patients. In the HIV-infected patients with the antibody of Treponema pallidum, the rate of homosexual transmission was so higher but heterosexual transmission is lower (OR=0.548 95% CI: 0.382-0.786), suggesting that homosexual transmission might be a risk factor for HIV-syphilis co-infection. Conclusion The HIV-infected patients in Shaanxi Province had the characteristics of low active detection rate and late diagnosis. In addition, a high prevalence of HBV, HCV, and syphilis co-infection could be observed, and like HIV infection, they might not understand their HBV, HCV and syphilis infection status. At last, the high rate of ineffective vaccination against HBV suggests a need for improved vaccination services.

scholarly journals Epidemiological features and risk factors for acquiring Hepatitis B, Hepatitis C and syphilis in HIV-infected patients in Shaanxi Province, northwest China

2019 ◽  
Author(s):  
Chao Zhang ◽  
Wenhui Chang
Keyword(s):  
Risk Factors ◽  
Hiv Infection ◽  
Treponema Pallidum ◽  
Northwest China ◽  
Cd4 T Cell ◽  
Shaanxi Province ◽  
Syphilis Infection ◽  
Epidemiological Features ◽  
Homosexual Transmission ◽  
Cd4 T Cell Count

Abstract Background HIV-infected patients are at higher risk for co-infection with Hepatitis B virus (HBV), Hepatitis C virus (HCV), and Treponema pallidum (TP), the agent causing syphilis, than the general population. The prevalence of HBV, HCV, and syphilis had geographic differences and varied from region to region among HIV-infected patients. The aim of this study was to investigate the epidemiological features and risk factors of HBV, HCV, and syphilis infection in HIV-infected individuals in Shaanxi Province, northwest China. Methods A retrospective study was conducted with HIV-infected patients from June 2011 to June 2016 in Shaanxi Province. Sociodemographic data was captured from the national HIV/AIDS information system in China. Serological tests and analysis of CD4+ T-cell count levels were performed using standard procedures. Besides, the HIV infection time and age were presumed by CD4+ T-cell count levels. Results The average time from HIV infection to diagnosis was (4.7±2.4) years, and the HIV infection time ≥3 years accounted for 66.8%. Of the discovery routes, voluntary counseling & testing (VCT) only accounted for 20.7%. Among 1018 HIV-infected patients, the prevalence of HBV, HCV, and syphilis was 11.0%, 11.1%, and 26.0%, respectively. HBV-HCV, HCV-syphilis, HBV-syphilis, and HBV-HCV-syphilis co-infection was 1.7%, 2.2%, 2.6%, and 0.1%, respectively. The rate of ineffective vaccination against HBV was as high as 30.2% in HIV-infected patients. Ethnicity (OR=29.257, 95%CI: 11.243-76.133) and HIV transmission routes (OR=149.368, 95%CI: 16.590-1 344.861) were the risk factors of HCV infection in HIV-infected patients. In the HIV-infected patients with the antibody of Treponema pallidum, the rate of homosexual transmission was so higher but heterosexual transmission is lower (OR=0.548 95% CI: 0.382-0.786), suggesting that homosexual transmission might be a risk factor for HIV-syphilis co-infection. Conclusion The HIV-infected patients in Shaanxi Province had the characteristics of low active detection rate and late diagnosis. In addition, a high prevalence of HBV, HCV, and syphilis co-infection could be observed, and like HIV infection, they might not understand their HBV, HCV and syphilis infection status. At last, the high rate of ineffective vaccination against HBV suggests a need for improved vaccination services.

scholarly journals 321. Low Volumetric Bone Density at Proximal Femur in HIV-Infected Men and Its Risk Factors: Comparison with Community-Dwelling Non-Infected Men

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S170-S170
Author(s):  
Jung Ho Kim ◽  
Namki Hong ◽  
Woon Ji Lee ◽  
Hye Seong ◽  
Jin young Ahn ◽  
...  
Keyword(s):  
Risk Factors ◽  
T Cell ◽  
Hiv Infection ◽  
Protease Inhibitor ◽  
Cell Count ◽  
Community Dwelling ◽  
Cd4 T Cell ◽  
Total Hip ◽  
Tertiary Center ◽  
Cd4 T Cell Count

Abstract Background Individuals with HIV infection is at increased risk of low area bone mineral density (BMD) and fracture. However, data regarding volumetric BMD (vBMD) of central bone determined by quantitative computed tomography (QCT) which can distinguish the cortical and trabecular bone component are limited. Methods From November 2017 to October 2018, we measured spine and hip vBMD in HIV-infected men aged 30 years or older at the tertiary center. QCT data were compared with 1:2 matched control by age- and body mass index (BMI) sampled from a community-based healthy individual cohort. HIV-specific risk factors for low total hip vBMD as a primary outcome were identified using multivariate linear regression models. Results A total of 83 HIV-infected men and 166 control were analyzed (mean age 47.4 vs. 47.0 year; BMI 23.3 vs. 23.7 kg/m2; P > 0.05). In HIV-infected men, vBMD of trochanter, intertrochanter and total hip was significantly lower than that of non-infected men. (198 ± 31 vs. 213 ± 32; 339 ± 50 vs. 356 ± 47; 280 ± 41 vs. 296 ± 41 mg/cc; all P < 0.05) Association between HIV infection and lower total hip vBMD remained robust (Adjusted β -14.4; P = 0.013) after adjustment for age, diabetes, smoking, and vitamin D status. In HIV cohort, low CD4 T-cell count at initial diagnosis (< 200 vs. ≥200 cells/μL; Adjusted β = −6.7, P = 0.015) and use of protease inhibitor (vs. integrase inhibitor; Adjusted β = −29.9, P = 0.029) were negatively associated with total hip vBMD, after adjustment for age, BMI, and duration of HIV infection, whereas tenofovir disoproxil fumarate use was not. (Adjusted β −12.1, P = 0.280) In HIV-infected men with low tertile total hip vBMD, the levels of β-crosslaps (0.42 ± 0.23 vs. 0.30 ± 0.16 ng/mL; P = 0.012) and osteocalcin (22.10 ± 8.65 vs. 16.57 ± 6.04 ng/mL; P = 0.001) were higher than those with middle-upper tertile total hip vBMD. Conclusion HIV-infected men had lower hip vBMD compared with age- and BMI-matched non-infected men. Low baseline CD4 T-cell count and protease inhibitor use were independent risk factors for lower total hip vBMD. High born turnover was attributable to the negative effect on born health of HIV-infected men. Disclosures All authors: No reported disclosures.

scholarly journals Epidemiological Features and Risk Factors for Acquiring Hepatitis B, Hepatitis C, and Syphilis in HIV-Infected Patients in Shaanxi Province, Northwest China

2020 ◽  
Vol 17 (6) ◽  
pp. 1990
Author(s):  
Chao Zhang ◽  
Qiang Ren ◽  
Wenhui Chang
Keyword(s):  
Risk Factors ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Hiv Transmission ◽  
Treponema Pallidum ◽  
Northwest China ◽  
High Rate ◽  
Shaanxi Province ◽  
Heterosexual Transmission ◽  
Hiv Positive

Human immunodeficiency virus (HIV)-infected patients are at a higher risk for co-infection with Hepatitis B virus (HBV), Hepatitis C virus (HCV), and Treponema pallidum (TP; the agent causing syphilis) than the general population. The prevalence of HBV, HCV, and syphilis has geographic differences and varies from region to region among HIV-positive individuals. A retrospective study was carried out on HIV-positive individuals between June 2011 and June 2016 in Shaanxi Province. Univariate and multivariate logistic regression analyses using stepwise regression analysis regarding risk factors for HIV–HBV, HIV–HCV, and HIV–syphilis co-infection. HBV–HCV, HCV–syphilis, HBV–syphilis, and HBV–HCV–syphilis co-infection rates were 1.7%, 2.2%, 2.6%, and 0.1%, respectively. The rate of ineffective hepatitis B vaccine immunization was as high as 30.2% among HIV-positive individuals. Ethnicity (OR = 31.030, 95% CI: 11.643–82.694) and HIV transmission routes (OR = 134.024, 95% CI: 14.328–1253.653) were the risk factors for HCV infection in HIV-positive individuals. Among the HIV-positive individuals with the antibodies of TP, the rate of homosexual transmission was also higher, but heterosexual transmission was lower (OR = 0.549 95% CI: 0.382–0.789) The HIV-infected patients in Shaanxi Province had the characteristics of low active detection rate and late diagnosis. The high rate of ineffective vaccination against HBV suggests a need for improved vaccination services.

The Effect of Antiretroviral Therapy on IL-6, IL-1β, TNF-α, IFN-γ Levels and their Relationship with HIV-RNA and CD4+ T Cells in HIV Patients

2020 ◽  
Vol 18 (5) ◽  
pp. 354-361
Author(s):  
Gülay Okay ◽  
Meliha Meric Koc ◽  
Eray Metin Guler ◽  
Ayşegül Yabaci ◽  
Abdürrahim Kocyigit ◽  
...  
Keyword(s):  
T Cell ◽  
Hiv Infection ◽  
Cell Count ◽  
Cd4 T Cell ◽  
Positive Correlation ◽  
Hiv Rna ◽  
Tnf Α ◽  
Cytokine Levels ◽  
Ifn Γ ◽  
Cd4 T Cell Count

Background: Serum cytokine levels over the course of HIV infection usually increase with immunosuppression and decrease after antiretroviral treatment (ART). Objectives: The aim of the study is to compare cytokine levels between HIV-infected patients (HIP) and controls and investigate the relationship between CD4+T cell count, HIV-RNA levels, and cytokine levels. Methods: The study subjects comprised ART-naive HIP (n=30) with no comorbidities and age-and sex-matched healthy controls. We measured levels of IL-6, IL-1β, TNF-α, and IFN-γ in serum samples of HIP at the beginning and at month 6 of ART and in controls. Results: The mean age of the study subjects was 38.7 ±10.3 years, with men making up 86.7% of the study subjects (n=26). IL-6, IL-1β, and TNF-α levels were significantly higher in both ART-naive (p<0.001, p=0.002, p=0.001) and ART-experienced HIP (p<0.001) than controls. The IFN-γ level was lower in both ART-naive and ART-experienced HIP compared to controls (p=0.082 and p=0.002). There was a positive correlation between the CD4+T cell count and serum concentration of IFN- γ(r=0.320, p<0.05). While the serum IFN-γ concentration showed a negative correlation with the HIVRNA level(r=-0.412, p<0.001), the serum IL-1β, IL-6, and TNF-α concentrations showed a positive correlation with the HIV-RNA level (r=0.349, p<0.001; r:0.54, p<0.001; r:0.438, p<0.00). Conclusions: Although serum concentrations of IL-6, IL-1β and TNF-α showed a significant decrease after ART, they were still significantly higher than the controls. IFN-γ responded differently to ART compared to the other cytokines, indicating that it may play a distinct and important role in the pathogenesis of HIV infection.

CD4+ T cell count, HIV-1 viral loads and demographic variables of newly identified patients with HIV infection in Wuhan, China

2013 ◽  
Vol 85 (10) ◽  
pp. 1687-1691 ◽  
Author(s):  
Man-Qing Liu ◽  
Li Tang ◽  
Wen-Hua Kong ◽  
Ze-Rong Zhu ◽  
Jin-Song Peng ◽  
...  
Keyword(s):  
T Cell ◽  
Hiv Infection ◽  
Cell Count ◽  
Demographic Variables ◽  
Cd4 T Cell ◽  
Viral Loads ◽  
Hiv 1 ◽  
Cd4 T Cell Count

scholarly journals CD4+T Cell Count Decreases by Ethnicity among Untreated Patients with HIV Infection in South Africa and Switzerland

2009 ◽  
Vol 200 (11) ◽  
pp. 1729-1735 ◽  
Author(s):  
Margaret May ◽  
Robin Wood ◽  
Landon Myer ◽  
Patrick Taffé ◽  
Andri Rauch ◽  
...  
Keyword(s):  
South Africa ◽  
T Cell ◽  
Hiv Infection ◽  
Cell Count ◽  
Cd4 T Cell ◽  
Cd4 T Cell Count

scholarly journals Assessment of syphilis infection among pregnant women and its associated risk factors at Sovu health center in Rwanda

2020 ◽  
Vol 1 (3) ◽  
Author(s):  
Augustin Nshimiyimana ◽  
Joseph Mucumbitsi ◽  
Callixte Yadufashije ◽  
Francois N. Niyonzima
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Health Center ◽  
Sexual Behaviors ◽  
Treponema Pallidum ◽  
Health Concern ◽  
Syphilis Infection ◽  
Cross Sectional ◽  
History Of ◽  
Associated Risk Factors

Syphilis in pregnant women caused by Treponema pallidum remains a major cause of reproductive morbidity and poor pregnancy outcomes in developing countries. Severe neonatal infections, stillbirths, perinatal deaths, and low birth weight babies are common among mothers with syphilis infection. The aim of the study was to assess the prevalence and risk factors associated to syphilis in pregnant women. A cross-sectional and retrospective studies were conducted among pregnant women who attended the prenatal service at the Gisovu health center. Participants were pregnant women who tested positive for syphilis based on lab results and responses collected from anonymous questionnaires completed with sexual behaviors, demographics, sexual partners, history of abortion, and knowledge about STDs. The prevalence of syphilis was 5.74%. Syphilis was associated to the history of previous abortion (P = 0.005 < 0.05), a low level of education (P = 0.049 < 0.05), and marital status (P = 0.044 < 0.05). The main associated behavioral factor was women who had sex with different partners using condom and did not acquire syphilis infection (P = 0.00 < 0.05). Syphilis is still a public health concern in patients and especially in pregnant women as shown by the findings of this study. It is very important to screen all pregnant women for syphilis and to strengthen the existing antenatal care services and health education on transmission and prevention of the disease.

scholarly journals Investigating the risk factors for seroprevalence and the correlation between CD4+ T-cell count and humoral antibody responses to Toxoplasma gondii infection amongst HIV patients in the Bamenda Health District, Cameroon

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0256947
Author(s):  
Eugene Enah Fang ◽  
Raymond Babila Nyasa ◽  
Emmanuel Menang Ndi ◽  
Denis Zofou ◽  
Tebit Emmanuel Kwenti ◽  
...  
Keyword(s):  
Risk Factors ◽  
T Cell ◽  
Toxoplasma Gondii ◽  
Cell Count ◽  
Health District ◽  
Cd4 T Cell ◽  
Igg Antibody ◽  
Hiv Patients ◽  
Significant Difference ◽  
Cd4 T Cell Count

Background Toxoplasmosis is caused by an obligate intracellular tissue protozoan parasite, Toxoplasma gondii that infect humans and other warm-blooded animals. Transmission to humans is by eating raw or inadequately cooked infected meat or through ingestion of oocysts that cats have passed in faeces. Studies have shown life-threatening and substantial neurologic damage in immunocompromised patients; however, 80% of humans remain asymptomatic. The aim of this study was to determine the seroprevalence of Toxoplasma gondii infection in HIV positive patients and the risk factors associated with the infection, and to investigate the correlation between CD4+ T-cell count and toxoplasma specific antibodies as possible predictors of each other amongst HIV patients in the Bamenda Health District of the North West Region of Cameroon. Methods A cross-sectional study was conducted, in which 325 HIV patients were recruited for administration of questionnaire, serological diagnosis of T. gondii and measurement of CD4+ T-cell count. Bivariate and multivariate logistic regression was used to identify risk factors associated with T. gondii infection while the linear regression was used to investigate the relationship between CD4+ T-cell count and antibody levels against T. gondii. Results The findings showed that, majority (45.8%) of HIV patients suffered from chronic (IgG antibody) infection, and 6.5% from acute (IgM and IgM/IgG antibody) toxoplasma infection. The overall sero-prevalence of T. gondii infection amongst HIV patients was 50.5%. On the whole, 43 men (45.7%) and 127 women (55%) presented with anti- T. gondii antibodies; however, there was no significant difference amongst males and females who were positive to T. gondii infection (p = 0.131). Marital status (p = 0.0003), contact with garden soil (p = 0.0062), and garden ownership (p = 0.009), were factors that showed significant association with T. gondii infection. There was no significant difference (p = 0.909) between the mean CD4+ T-cell count of HIV patients negative for toxoplasma infection (502.7 cells/mL), chronically infected with T. gondii (517.7 cells/mL) and acutely infected with T. gondii (513.1 cells/mL). CD4+ T-cell count was neither a predictor of IgM antibody titer (r = 0.193, p = 0.401), nor IgG antibody titer (r = 0.149, p = 0.519) amongst HIV patients acutely infected with T. gondii. Conclusion The findings from this study underscore the need to implement preventive and control measures to fight against T. gondii infection amongst HIV patients in the Bamenda Health District.

scholarly journals Clinical characteristics and risk factors of severe infections in hospitalized adult patients with primary nephrotic syndrome

2017 ◽  
Vol 45 (6) ◽  
pp. 2139-2145 ◽  
Author(s):  
Jie Li ◽  
Qiankun Zhang ◽  
Bofeng Su
Keyword(s):  
Risk Factors ◽  
Nephrotic Syndrome ◽  
T Cell ◽  
Cell Count ◽  
Severe Infection ◽  
Adult Patients ◽  
Cd4 T Cell ◽  
Infection Group ◽  
Severe Infections ◽  
Cd4 T Cell Count

Objective Infection is a common condition in patients with nephrotic syndrome. The objective of the present study is to investigate the clinical characteristics and risk factors of infections in adult patients with primary nephrotic syndrome (PNS). Methods Medical charts of 138 consecutive patients with PNS and infections who were admitted to hospital from April 2013 to April 2016 were systematically reviewed. Results Patients were divided into three groups according to the degree of infections: mild infection group (n = 45), moderate infection group (n = 60), and severe infection group (n = 33). In the severe infection group, most patients (96.9%) had pulmonary infections with opportunistic pathogens. There were significant differences in cumulative prednisone dose, immunosuppressor use, and CD4+ T cell count among the three groups. A lower CD4+ T cell count (<300 cells/mm3) (odds ratio = 4.25 [95% confidence interval 1.680–10.98]) and higher cumulative dose of prednisone (odds ratio = 1.38 [95% confidence interval 1.05–3.26]) were risk factors for severe infections in adult patients with PNS. Conclusions CD4+ T cell count (<300 cells/mm3) and a higher cumulative dose of prednisone are important risk factors for severe infections in adult patients with PNS.

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