Efficacy of Ninjin’yoeito for Preoperative Anemia, Fatigue, and Anxiety in Patients with Gynecological Disease: an Open-Label, Single-Center, Randomized Phase-II Trial.

Abstract Background: Preoperative anemia affects perioperative outcomes and often causes fatigue and psychological disorders. Therefore, anemia should be treated before a patient undergoes surgery. Ninjin’yoeito (NYT), a Japanese Kampo medicine composed of ginseng and Japanese angelica root with the other 10 herbs, is administered for anemia, fatigue and anxiety; however, there are a few reports that have prospectively examined the effects of NYT before surgery for gynecological diseases. Hence, we tended to investigate its efficacy and safety.Methods: In this open-label randomized trial, women with gynecological diseases accompanied by preoperative anemia (defined as <11.0 g/dL Hemoglobin [Hb]) were randomly assigned (1:1) into the iron supplementation and NYT groups. Patients of the iron supplementation group and the NYT group received 100 mg/day iron supplementation with and without NYT (7.5 g/day) for at least 10 days before surgery. The primary endpoint was improvement in Hb levels before and after treatment, and Cancer Fatigue Scale (CFS) and Visual Analogue Scale for Anxiety (VAS-A) scores between groups. Statistical analyses were performed with Wilcoxon signed rank test, Wilcoxon rank sum test, and Fisher’s exact test as appropriate.Results: 40 patients were enrolled of whom 30 patients were finally analyzed after allocating 15 to each group. There was no difference in the characteristics between both groups. Hb significantly increased in both groups (iron supplementation group, 9.9 ± 0.8 g/dL vs. 11.9 ± 1.6 g/dL; NYT group, 9.8 ± 1.0 g/dL vs. 12.0 ± 1.0 g/dL); the difference in the elevations in Hb between both groups was statistically insignificant (P = 0.72). Contrarily, CFS (17.9 ± 10.2 vs. 8.1 ± 5.2) and VAS-A (56 mm (50–70) vs. 23 mm (6–48)) scores were significantly decreased only in the NYT group and these changes were greater in the NYT group (∆CFS, P = 0.015; ∆VAS-A, P = 0.014). Liver dysfunction occurred in one patient of the NYT group.Conclusions: For treating preoperative anemia in women with gynecological conditions, NYT administration along with iron supplementation safely and efficiently improved the preoperative anemia, fatigue and anxiety.Trial registration: jRCT1051190012 (28/April/2019, retrospectively registered).

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The Degree of Subjective Complaints of Students Practice in Mechanical Technology Laboratories

International Research Journal of Engineering IT & Scientific Research ◽

10.21744/irjeis.v4i1.599 ◽

2018 ◽

Vol 4 (1) ◽

pp. 22

Author(s):

I Ketut Widana

Keyword(s):

Engineering Students ◽

Standing Position ◽

Statistical Test ◽

Rank Test ◽

Cross Sectional ◽

Signed Rank ◽

Before And After ◽

Signed Rank Test ◽

The Difference ◽

Paired T Test

The working practice of the engineering students is part of the learning process that is irreducible and indispensable. The composition of lecturing between theoretical and practical one is 40% to 60%. With this condition, the students spend more time at the laboratory. Generally, the students perform in the laboratory work by standing position. The design of research is observational cross-sectional. The method applied is observation, interview and measuring. The subjects of research are practicing students amounting to 21 students. Referring to the analysis of statistical test or Wilcoxon signed ranks test, the difference of effect of work position is significant, namely p < 0.05 towards musculoskeletal disorders (MSDs) before and after working. The quantity of the average complaint after working is score 44.62 ± 9.47. The result of Wilcoxon signed rank test shows that there is significant different effects of standing work position, namely p < 0.05 towards fatigue generally before and after working. The degree of the working pulse is on the average of 110.78 ± 17.80 bpm (beats per minutes) which can be categorized into the medium workload. Using paired t-test, the result is p < 0.05.

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Utilization of Technology to Improve Efficiency in Investigational Drug Management Processes

Journal of Pharmacy Technology ◽

10.1177/8755122519900049 ◽

2020 ◽

Vol 36 (2) ◽

pp. 84-90

Author(s):

Dinesh Pal Mudaranthakam ◽

Colin Cernik ◽

Leslie Curtis ◽

Blake Griffith ◽

Jinxiang Hu ◽

...

Keyword(s):

Inventory Management ◽

Processing Time ◽

Study Drug ◽

Rank Test ◽

Investigational Drug ◽

Utilization Of Technology ◽

Signed Rank ◽

Before And After ◽

Signed Rank Test ◽

The Difference

Background: Background: An investigational pharmacy is responsible for all tasks related to receiving, storing, and dispensing of any investigational drugs. Traditional methods of inventory and protocol tracking on paper binders are very tedious and could be error-prone. Objective: To evaluate the utilization of the IDS to efficiently manage the inventory within an investigational Pharmacy. We hypothesize that the IDS will reduce the drug processing time. Methods: Our pharmacy tracked the drug processing time before and after using the IDS including the receiving, dispensing, and inventory. As part of the receiving the study drug pharmacists tracked the time it took a pharmacist to complete the tasks of logging the study drug before and after the implementation of the IDS system. In addition, the pharmacy also timed the process for drug dispensing and a full investigational drug inventory check. Wilcoxon signed-rank test was used to compare the difference in the meantime of total processing before and after the IDS. Results: Utilization of the IDS system showed significant reduction in processing time, and improvement of efficiency in inventory management. Additionally, the usability survey of the IDS demonstrated that the IDS system helped pharmacists capture data consistently across every clinical trial. Conclusion: Our results demonstrates how technology helps pharmacists to focus on their actual day to day medication-related tasks rather than worrying about other operational aspects. Informatics team continues to further enhance the features such as monitor portal, and features related to finance – generation of invoices, billing reconciliation, etc.

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Effect of Sertraline on Uremic Pruritus Improvement in ESRD Patients

International Journal of Nephrology ◽

10.1155/2012/363901 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 23

Author(s):

Mansor Shakiba ◽

Hoshang Sanadgol ◽

Hamid Reza Azmoude ◽

Mohamad Ali Mashhadi ◽

Hassan Sharifi

Keyword(s):

Clinical Trial ◽

Rank Test ◽

Uremic Pruritus ◽

Signed Rank ◽

Wilcoxon Signed Rank Test ◽

Before And After ◽

Signed Rank Test ◽

The Difference ◽

Chronic Pruritus ◽

Esrd Patients

Background. Although uremic pruritus is a common and upsetting problem of chronic kidney disease, there is no approved treatment for it. This study was undertaken to find the efficiency of sertraline as a possible treatment for uremic pruritus.Methods. 19 ESRD patients under hemodialysis with severe chronic pruritus were randomly selected to participate in this before-after clinical trial. Before and after starting treatment with sertraline, a detailed pruritus history was obtained and pruritus graded by the 30-item inventory of pruritus that patients based on priorities grade allocated to 3 classes. Subjects were treated with sertraline 50 mg oral daily for four months, with monthly assessments of pruritus symptoms.Results. Before treatment with sertraline, the grade of pruritus in 9 (47.4%) patients was moderate and severe in 10 (52.6%) patients. After treatment, grade of pruritus in 11 (57.8%) patients was weak, 6 (31.5%) have moderate and only 2 (10.7%) patients have severe pruritus. Of 10 patients with severe pruritus, 5 (50%) patients experiencing weak pruritus, and 4 (40%) patients have moderate pruritus after treatment. Based on Wilcoxon signed-rank test, the difference between the grade of pruritus before and after treatment with sertraline was significant (P=0.001).Conclusions. Although no definitive recommendation can be made regarding treatment of uremic pruritus, we found an increased antipruritic effect of sertraline in ESRD patients.

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Effects of a periodized functional strength training program (FST) on Functional Movement Screen (FMS) in physical education students

Physical Education of Students ◽

10.15561/20755279.2020.0306 ◽

2020 ◽

Vol 24 (3) ◽

pp. 162-167

Author(s):

Michał Sawczyn

Keyword(s):

Physical Education ◽

Strength Training ◽

Statistical Significance ◽

Rank Test ◽

Training Intervention ◽

Control Group ◽

Before And After ◽

Signed Rank Test ◽

The Difference ◽

Experimental Group

Background and Study Aim: To examine the effects of periodized functional strength training (FST) on FMS scores of sport university students with higher risk of injury. Material and Methods: Thirty three participants (age 21.6±1.3 years, height 177.8±6.9 m, mass 80.4±7.7 kg) with FMS total score ≤ 14 were selected from eighty two volunteered students of University of Physical Education and Sport in Gdańsk and randomly assigned to experimental group (n=16) and control group (n=17). The FMS test was conducted one week before and one week after the 12 week training intervention. The experimental group participated in FST program through 12 weeks. The control group did not engaged in any additional physical activity than planned in their course of study. The collected data were analysed using Statistica 13.3 pl (StatSoft Inc). Wilcoxon signed rank test was used to establish the statistical significance of the difference between FMS total scores within each group and Mann Whitney U test between groups before and after the 12 week training intervention. Results: 45 % of volunteers in the first FMS testing showed total scores ≤14. The experimental group that participated in FST program changed significantly FMS total scores after 12 weeks (p<0.05). There were also significant differences in FMS total score between groups after the experiment (p<0.05). Conclusions: There is a need for injury prevention programs for students of University of Physical Education and Sport in Gdańsk. It is clear from this study that FST is effective in improving FMS total score in students with cut off score ≤14.

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Comparison of tendency and accuracy in predicted post-operative refraction and recommended IOL power between IOL Master and VERION before and after optimizing IOL-constant in the VERION

10.21203/rs.2.21267/v1 ◽

2020 ◽

Author(s):

Takeshi Teshigawara ◽

Akira Meguro ◽

Nobuhisa Mizuki

Keyword(s):

Mean Absolute Error ◽

Anterior Chamber Depth ◽

Absolute Error ◽

Rank Test ◽

K Value ◽

Signed Rank ◽

Before And After ◽

Signed Rank Test ◽

Iol Power ◽

The Difference

Abstract Background: We assessed the accuracy and tendency of the VERION image-guided system (Alcon) and the intra-ocular lens (IOL) Master 700 (Zeiss), by comparing mean refractive shift (MRS) of predicted post-operative refraction (PPR), mean absolute error (MAE) of PPR, recommended IOL power (RIP) and K-value before and after optimizing the IOL-constant in VERION, to show the importance of optimization.Methods: This retrospective study involved 72 eyes. K-value was measured with both biometers. Axial length (AL) and anterior chamber depth (ACD) measured by the IOL Master were applied to the VERION because it cannot measure these variables. The User group for Laser Interference Biometry (ULIB) IOL-constant for the IOL Master was applied to the VERION before optimizing the IOL constant, since no such official measure was established for it. MRS of PPR, MAE of PPR, RIP and K-value as measured by both biometers were compared before and after optimizing the IOL-constant in the VERION. Finally, correlations between the MRS, MAE, RIP, and K-value were analyzed in the VERION. The Wilcoxon signed-rank test was used for analysis.Results: Compared to the IOL Master, K-value was significantly higher in the VERION. Prior to optimization, MRS of PPR showed a significant myopic shift in the VERION, and MAE of PPR was significantly higher. Additionally, RIP in the VERION was significantly lower. After optimization, there were no significant differences in the MRS of PPR and RIP between the VERION and IOL Master. MAE of PPR in the IOL Master was significantly higher than in the VERION. No significant correlations were found between MRS and MAE of PPR and RIP with K-value in the VERION. Conclusions: Before optimization, the VERION was less reliable in MRS, MAE and RIP than the IOL Master. However, after optimization, the difference in MRS and RIP between the two devices became insignificant. This study indicates that optimization of IOL-constant in the VERION is vital. After optimization, the VERION is more accurate in PPR than the IOL Master.

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Analisis Pengaruh Stock Split Terhadap Volume Perdagangan, Harga Saham, dan Abnormal Return pada Perusahaan yang Terdaftar di BEI Periode 2017 - 2018

Jurnal Manajemen Bisnis dan Kewirausahaan ◽

10.24912/jmbk.v4i1.6805 ◽

2020 ◽

Vol 4 (1) ◽

pp. 84

Author(s):

Agus Amanda Tanoyo

Keyword(s):

Stock Prices ◽

Trading Volume ◽

Stock Exchange ◽

Abnormal Returns ◽

Rank Test ◽

Volume Activity ◽

Stock Split ◽

Before And After ◽

Signed Rank Test ◽

The Difference

This study aims to determine the difference in the trading volume activity, stock prices and abnormal returns before and after the announcement of a stock split. The population of this study are all companies listed in Indonesia Stock Exchange that take corporate action in the form of stock split at period 2017-2018. Sampling using purposive sampling. Based on the sampling criteria predetermined number of samples acquired 24 stocks. The analytical method used is the analysis Wilcoxon Signed Rank Test with the observation period (event window) is 14 days. The results showed that there were differences in the trading volume activity and stock prices before and after the announcement of stock split, while the last hypothesis showed that there were no differences in abnormal returns before and after the announcement of stock split.

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Pengaruh Pelatihan terhadap Peningkatan Pengetahuan Kader Posyandu tentang Deteksi Dini TBC Anak di Kelurahan Tanjung Mas Semarang

ABDIMASKU : JURNAL PENGABDIAN MASYARAKAT ◽

10.33633/ja.v4i3.188 ◽

2021 ◽

Vol 4 (3) ◽

pp. 222

Author(s):

Eti Rimawati ◽

Sri Handayani ◽

Catur Yuantari

Keyword(s):

Early Detection ◽

Junior High School ◽

Rank Test ◽

P Value ◽

Test Analysis ◽

Signed Rank ◽

Before And After ◽

Signed Rank Test ◽

The Difference ◽

Tuberculosis In Children

Introduction: Symptoms of tuberculosis in children that are not specific require early detection efforts. One of the efforts to carry out early detection is to monitor children's growth and development in posyandu activities. Posyandu cadres have an important role in this. The purpose of this training activity is to increase the knowledge of posyandu cadres in early detection of tuberculosis in children. Method: The target of the training was 21 posyandu cadres who were selected by purposive sampling. Training activities as a form of community service are carried out with the stages of giving a pretest, presentation of material and case and posttest questions. The Wilcoxon Signed Rank Test analysis is used to determine differences in knowledge before and after training.Result Recommendation: All cadres were female, with the lowest education was junior high school (9.8%), the youngest was 38 years old and the oldest was 65 years old. The results of the difference test showed that there was a difference between before and after training (p value 0.0006), indicating that the training method was effective in increasing the knowledge of the cadres

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PENAMBAHAN LATIHAN CORE STABILITY PADA PROGRAM PELATIHAN ATLET DAYUNG UNTUK PENINGKATAN KECEPATAN MENDAYUNG

Sport and Fitness Journal ◽

10.24843/spj.2017.v05.i03.p06 ◽

2017 ◽

Author(s):

Dyno Aryo Christanto ◽

N. Adiputra ◽

S. Indra Lesmana ◽

Dw P. Sutjana ◽

Made Muliarta ◽

...

Keyword(s):

Training Program ◽

Core Stability ◽

Rank Test ◽

P Value ◽

Signed Rank ◽

Wilcoxon Signed Rank Test ◽

Before And After ◽

Post Test ◽

Signed Rank Test ◽

The Difference

Introduction: Generally, core stability exercise as a training program is needed in almost kind of sport including paddle, analysis of movement in any kind of paddle sport such as kayak, canoe, or even rowing have been showed that the activity of core stability muscles are really needed. Purpose: purpose of this research is to know the effectivity of core stability exercise replenishment to increase sculling speed in paddle training program. Methods: This research is experimental with treatment by subject design project, involving 15 paddle athletes which divided into two groups and consists of II periods which are, Period I and Period II. In the 1st period, the athletes were given extra core stability exercise along with their normal paddling routine mean while in the 2nd period, the athletes only doing their normal paddling routine. Each period do the trial in 6 weeks, so this reseach took 12 weeks. In 1st period, the subjects were given extra core stability training 3 times a week along with their normal paddling routine where as subjects in period II only do their normal paddling routine. Results: The used of parametric paired t test is to know the difference of sculling speed before and after the trials were given. To period I pre test value is 3.80 ± 0.26 meters/second while the post test value is 4.06 ± 0.41 meters/second and the value 0.001 (p<0.05)mean while the 2nd period use Wilcoxon signed rank test to know the difference of sculling speed between before and after the trial were given resulting pre test value 3.80 ± 0.22 meters/second and post test value 3.91 ± 0.27 meters/second while the p value is 0.004 (p<0.05). After 12 weeks of sculling speed test between both period using Wilcoxon signed rank test and resulting obvions with period I value 0.26 ± 0.20 meters/second and period II value is 0.11 ± 0.12 meters/second along with p value 0.001 (p<0.05). Conclusion: Therefore, based on the result of my research test, we can concluded that the addition of core stability exercise in paddle training program is more effective to increase sculling speed.

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Argument Mapping to Improve Student's Mathematical Argumentation Skills

TEM Journal ◽

10.18421/tem93-48 ◽

2020 ◽

pp. 1208-1212

Author(s):

Nonik Indrawatiningsih ◽

Purwanto Purwanto ◽

Abdur Rahman As'ari ◽

Cholis Sa'dijah

Keyword(s):

Rank Test ◽

Mathematical Argumentation ◽

Revised Bloom's Taxonomy ◽

Signed Rank ◽

Learning Mathematics ◽

Argument Mapping ◽

Before And After ◽

Signed Rank Test ◽

The Difference ◽

Level Of Significance

This study aims at investigating the difference in students' mathematical argumentation skills before and after the implementation of argument mapping in learning mathematics. It is a quasiexperiment with a quantitative approach. The population was the students of class X Natural Sciences Program in a state senior high school in Pasuruan, East Java, Indonesia. 36 students were involved. The instrument was a mathematical argumentation skills test. Several components were established, adopted from the Revised Bloom's Taxonomy, namely identifying (C1), explaining (C2), drawing conclusions (C3), reducing/adding premises (C4), deducing (C5), and developing/constructing (C6). Students' mathematical argumentation skills were analyzed using the Wilcoxon signed-rank test at 5% level of significance (∝ = 0.05). The findings of this study indicate that students' argumentation skills after the implementation of argument mapping is better than prior treatment (p = 0.002). It can be claimed that argument mapping is effective for improving such skills.

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Dampak Pengumuman Covid-19 Terhadap Return Saham: Penelaahan Beberapa Sektor Industri

Akuntabilitas ◽

10.15408/akt.v14i2.22362 ◽

2021 ◽

Vol 14 (2) ◽

pp. 269-278

Author(s):

Leni Sari ◽

Hariman Bone

Keyword(s):

Abnormal Return ◽

Banking Sector ◽

Abnormal Returns ◽

Rank Test ◽

Telecommunication Sector ◽

First Case ◽

Before And After ◽

Signed Rank Test ◽

The Difference ◽

Return Difference

This Research is an event study that examine abnormal return difference before and after first announcement of covid-19 case in Indonesia. This Study use daily closing price data to calculate returns. We use 30 days estimation period and 20 days window period. The data collection method is purposive sampling. There are 64 companies that meet the establish criteria. Wilcoxon signed rank test and paired sample t-test were used to examine the difference in abnormal return before and after the covid-19 first case announcement in Hotel, Restaurant & Tourism, Banking and telecommunication sector. This study found that there was no difference in abnormal returns before and after the announcement of the first Covid-19 case in Hotel, Restaurant & Tourism and Banking sector. Furthermore, this study found differences in abnormal return before and after the announcement of the first covid 19 case in telecommunication sector. How to Cite:Sari, L., & Bone, H. (2021). Dampak Pengumuman Covid-19 Terhadap Return Saham: Penelaahan Beberapa Sektor Industri. Akuntabilitas: Jurnal Ilmu Akuntansi, 14(2), 269-278.

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