scholarly journals Bibliometric Analysis of Research Trends And Characteristics of Drug-Induced Gingival Overgrowth

Author(s):  
Ruonan Zhang ◽  
Jie Wu ◽  
Xiaoxiao Wang ◽  
Jiangyuan Song

Abstract Objectives: Drug-induced gingival overgrowth (DIGO) is a common adverse drug reaction generally caused by the cyclosporine, phenytoin and nifedipine which belong to the category of immunosuppressant, anticonvulsant and calcium channel blocker respectively. The objective of the bibliometric analysis was to depict main citation characteristics and analyze research trend in the field of DIGO.Methods: An exhaustive search was performed in the Scopus database for the bibliometric list of DIGO in the syntax. The information related to the number of citations, drugs related to DIGO, study topic and design, authorship, year of publication, journal, contributing institution, country of origin and department was extracted.Results: A total of 399 papers on DIGO were retrieved. The total number of citations and that after removal of self-citations is 7814 and 7314, respectively. The mean number of citations is 19.6, with a range of 0 to 608. Article (76.9%) and review (19.5%) are the main paper types. A remarkable increasing trend in the number of citations is observed since 1994. Cyclosporine (45%) is the most common used drug which has close relation with DIGO, followed by nifedipine, phenytoin (both are 18%), amlodipine (7%). Review (28%) constitutes the most design in the study of DIGO. According to the top 20 keywords, the risk factors and pathogenesis of DIGO have been the hot area of research for several years.Conclusions: The bibliometric study is the first of its kind to identify the top-cited articles and their main characteristics and research trend of DIGO. Risk factors and pathogenesis is the hotspot of research in the field of DIGO. More high level of scientific evidence on DIGO, such as systematic reviews and randomized controlled trials, are encouraged to serve as good helper to reduce the incidence and severity of DIGO.

2021 ◽  
Vol 12 ◽  
Author(s):  
Natalia Rodriguez Novo ◽  
Maria Mercedes Novo Muñoz ◽  
Leticia Cuellar-Pompa ◽  
Jose Angel Rodriguez Gomez

Aim: Despite the increase in international research in art therapy, few studies have been developed with a bibliometric approach which describe the situation regarding this area of knowledge. Thus, the aim of this study is to describe and contextualize international scientific production in the visual arts modality in the context of artistic therapies, to offer a broader and more in-depth vision of the structure of this area of knowledge through of a bibliometric analysis of the publications indexed in the core collection of the Web of Science.Methods: This is a retrospective, exploratory and descriptive, cross-sectional study to analyze the bibliographic data retrieved from the databases of the core collection. The analysis parameters included the data corresponding to the production according to type of document, country, journal, and institution. In addition, the main lines of research were located and classified and the subject matter of the most cited articles in each of them was summarized. Four periods were selected, between 1994 and 2020, to facilitate the thematic analysis and offer an evolutionary perspective of art therapy research.Results: A total of 563 works were published, in 250 journals, in the 63 years between 1958, when the first document was published, and April 2021. The annual growth rate was 7.3% with a mean average of 8.7 publications per year, and 83.13% of the published works were articles. A total of 1,269 authors from 56 countries were counted. The mean number of citations per document was 5.6 and the mean number of citations per document and year was 0.6. The main research domains were psychology and/or rehabilitation and the highest production on this topic was concentrated in only three journals. In general, a high degree of variability was observed in the study topics and numerous theoretical and methodological articles. The most used visual arts modalities were in the main drawing, painting and photography.Conclusion: This work did not find previous existence of any bibliometric analysis on the international scientific production in art therapy. In general terms, there has been a substantial growth in the number of publications on the subject over the last decade. However, this research area does not appear to have peaked, but, on the contrary, is still growing and progressing despite its long history in clinical practice.


BMJ Open ◽  
2017 ◽  
Vol 7 (11) ◽  
pp. e014715 ◽  
Author(s):  
Luke Nelson Allen ◽  
Nicholas Fox ◽  
Alissa Ambrose

ObjectivesLow-income and lower middle-income countries (LLMICs) bear a disproportionate burden of non-communicable diseases (NCDs). WHO has repeatedly called for more research on poverty and NCDs in these settings, but the current situation remains unquantified. We aimed to assess research output on poverty and NCD risk factors from these countries in relation to upper middle-income and high-income countries.DesignBibliometric analysis of primary research published between 1 January 1990 and 4 May 2017. We searched 13 databases, combining terms for poverty and NCD behavioural risk factors (tobacco, alcohol, diet and physical activity). Independent dual review was used to screen titles, abstracts and full papers. Two-tailed t-testing and multiple linear regression analyses were used to compare differences in means.Outcomes(1) Proportion of lead authors affiliated with institutions based in high and upper middle-income countries vs LLMICs. (2) Mean number of citations for publications from each region. (3) Mean journal impact factor for studies from each region.ResultsNinety-one (67%) of the 136 included studies were led by scientists affiliated with LLMIC-based institutions. These authors represented 17/83 LLMICs (20%), and their studies garnered 4.8 fewer citations per paper than studies led by high-income and upper middle-income-affiliated authors; however, this finding was non-significant (P=0.67). Papers led by authors based in high-income and upper middle-income countries were published in journals with a mean impact factor 3.1 points higher than those from LLMICs (4.9 vs 1.7) adjusting for year of publication and number of citations (P<0.001).ConclusionsMost poverty and NCD risk factor research is led by authors from a small number of LLMICs. These studies are being published in relatively low-impact journals, and the vast majority of LLMICs are not producing any research in this area that is vital to their social and economic development. The paucity of domestic evidence must be addressed to inform global policy.


2017 ◽  
Vol 8 (2) ◽  
pp. 97-103
Author(s):  
Murtala Muhammada ◽  
Abubakar Ahmed ◽  
Gold Kafilah Lola ◽  
Usman Mikail Usman ◽  
Nader Ale Ebrahim

Abstract The purpose of this research is to assess the universal scientific trends and examine the patterns in the intellectual research published on trade liberalization over a period of 35 years (1980-2015). The data were collected from a leading indexing and abstracting database Thomson Reuters Web of Science. The Kruskal-Walis test, ANOVA and Pearson’s correlation were employed in analyzing the retrieved data. Based on the citation trend of first 100 highly cited published articles with the least number of authors are found to have received the highest number of citations. Our result shows that there is actual statistical significance (p˂ 0.001) between the total citations attracted by articles published by 1 author and those published by 3 and 4 authors. The word trade liberalization has become dominant and consistent in the field of the study. These research trend and interest could provide focus to researchers for future research.


2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Haslina Taib ◽  
◽  
Muhammad Haziq Mohd Radzwan ◽  
Muhammad Annurdin Sabaruddin ◽  
Wan Majdiah Wan Mohamad ◽  
...  

Gingival overgrowth (GO) or enlargement is an unwanted effect occurring on the gingiva that commonly associated with medications. Hypertension is a global burden systemic conditions and showed high prevalent and more patients are taking antihypertensive drugs. Objective: This study aimed to assess the prevalence of drug-induced gingival overgrowth (DIGO) and its associated risk factors among hypertensive patients attending Hospital Universiti Sains Malaysia, Kelantan, Malaysia. Methods: A total of 42 patients with the mean age of 57.1 (SD=9.3) years had participated in this cross-sectional study. They were recruited if they had consumed anti-hypertensive agents for at least 6 months. Demographic data and oral hygiene status were recorded and the presence of DIGO was assessed based on clinical index for gingival overgrowth. Data were analyzed using SPSS version 24.0 with p< 0.05 is considered statistically significant. Results: Majority of patients were taking calcium channel blockers (CCB) (81.0%) with amlodipine reported as the most common antihypertensive prescribed (47.6%). About 52% presented with DIGO and among them 55.9% were in those on CCB by which 9.5% presented with clinically significant enlargement. Except for gingivitis, oral hygiene status and demographic data were not significant risk factors for DIGO (p > 0.05). Conclusion: We found that DIGO is prevalent among hypertensive patients on CCB and its occurrence is coexists with gingivitis. Therefore, periodontal assessment is recommended among these patients for early detection and management of drug-induced gingival overgrowth.


2000 ◽  
Vol 27 (4) ◽  
pp. 217-223 ◽  
Author(s):  
R. A. Seymour ◽  
J. S. Ellis ◽  
J. M. Thomason

2014 ◽  
Vol 6 (1) ◽  
pp. 6-10
Author(s):  
Nur Agustin ◽  
Hayuni Rahmah ◽  
Nani Nurhaeni

Penyalahgunaan obat dan narkotika merupakan masalah yang serius di kalangan remaja. Hal ini menyebabkan tingginya risiko terjadi AIDS pada kelompok ini. Masa pertumbuhan dan perkembangan remaja dimana kondisi psikologisnya belum stabil untuk menemukan jati dirinya mendukung terjadinya kasus AIDS. Penelitian ini dilakukan untuk mendapatkan gambaran tentang pengetahuan, sikap, dan penilaian remaja terhadap AIDS. Data dianalisa dengan menghitung nilai mean (rata-rata) dari pernyataan yang dikelompokkan dalam variable pengetahuan, sikap, dan penilaian. Kemudian berdasarkan skala penilaian yang sudah ditetapkan, hasil perhitungan nilai mean dikelompokkan untuk menilai level/tingkatannya. Penelitian dilakukan di empat SMU di wilayah Jakarta Utara yang ditentukan secara acak untuk mendapatkan responden sebanyak 160 orang. Dari data yang ada didapatkan nilai mean 2,694 untuk variable pengetahuan yang dilihat dari skala menunjukkan berada pada tingkat sangat baik. Sedang nilai mean untuk variable sikap didapatkan 3,327 dan variable penilaian dengan mean 3,516, sesuai skala yang ditetapkan menggambarkan berada pada tingkat baik. Hasil penelitian ini kurang mendukung fenomena yang ada sekarang ini, yaitu bahwa kejadian kasus AIDS cenderung terjadi peningkatan, padahal secara kognitif sudah menunjukkan tingginya pemahaman, sikap, dan penilaian remaja terhadap AIDS. Maka untuk menindaklanjuti penelitian ini diharapkan aka nada penelitian lebih lanjut untuk mengidentifikasi faktor-faktor yang mempengaruhi remaja dalam kaitannya dengan perilaku menyimpang dan peningkatan kasus AIDS. Drug abused and narcotics are the big problem that occurs in adolescent group. Its cause of high risk the incidence of AIDS cases in this group. Growth and development period in adolescent that are still unstable psychologically to find out their self-identity support in increasing the incidence of AIDS. The purpose of this study is to describe the knowledge, attitude, and value of adolescent toward AIDS. This study uses means of the knowledge, attitude, and value statement variables to analyze the data. Based on the score scale, the mean is used to assess level of value. This study is conducted in four senior high school in North Jakarta District . Random sampling is used in this study to choose 160 students as respondent. The result of this study indicated that the mean of knowledge variable is 2,694 and this shows a very good level. Furthermore, the mean of attitude and value variables that describes a high of incidence of AIDS in adolescent group. In fact, this study cognitively indicated a high level of knowledge, attitude, and value variables in adolescent group due to AIDS. It needs to identify the risk factors that affect the adolescent in relation to behavior and increase of AIDS cases.


2019 ◽  
Author(s):  
Danilo Carmona ◽  
Pablo Jaque ◽  
Esteban Vöhringer-Martinez

<div><div><div><p>Peroxides play a central role in many chemical and biological pro- cesses such as the Fenton reaction. The relevance of these compounds lies in the low stability of the O–O bond which upon dissociation results in radical species able to initiate various chemical or biological processes. In this work, a set of 64 DFT functional-basis set combinations has been validated in terms of their capability to describe bond dissociation energies (BDE) for the O–O bond in a database of 14 ROOH peroxides for which experimental values ofBDE are available. Moreover, the electronic contributions to the BDE were obtained for four of the peroxides and the anion H2O2− at the CBS limit at CCSD(T) level with Dunning’s basis sets up to triple–ζ quality provid- ing a reference value for the hydrogen peroxide anion as a model. Almost all the functionals considered here yielded mean absolute deviations around 5.0 kcal mol−1. The smallest values were observed for the ωB97 family and the Minnesota M11 functional with a marked basis set dependence. Despite the mean deviation, order relations among BDE experimental values of peroxides were also considered. The ωB97 family was able to reproduce the relations correctly whereas other functionals presented a marked dependence on the chemical nature of the R group. Interestingly, M11 functional did not show a very good agreement with the established order despite its good performance in the mean error. The obtained results support the use of similar validation strategies for proper prediction of BDE or other molecular properties by DF Tmethods in subsequent related studies.</p></div></div></div>


Author(s):  
V. Dodokhov ◽  
N. Pavlova ◽  
T. Rumyantseva ◽  
L. Kalashnikova

The article presents the genetic characteristic of the Chukchi reindeer breed. The object of the study was of the Chukchi reindeer. In recent years, the number of reindeer of the Chukchi breed has declined sharply. Reduced reindeer numbers could lead to biodiversity loss. The Chukchi breed of deer has good meat qualities, has high germination viability and is adapted in adverse tundra conditions of Yakutia. Herding of the Chukchi breed of deer in Yakutia are engaged only in the Nizhnekolymsky district. There are four generic communities and the largest of which is the agricultural production cooperative of nomadic tribal community «Turvaurgin», which was chosen to assess the genetic processes of breed using microsatellite markers: Rt6, BMS1788, Rt 30, Rt1, Rt9, FCB193, Rt7, BMS745, C 143, Rt24, OheQ, C217, C32, NVHRT16, T40, C276. It was found that microsatellite markers have a wide range of alleles and generally have a high informative value for identifying of genetic differences between animals and groups of animal. The number of identified alleles is one of the indicators of the genetic diversity of the population. The total number of detected alleles was 127. The Chukchi breed of deer is characterized by a high level of heterozygosity, and the random crossing system prevails over inbreeding in the population. On average, there were 7.9 alleles (Na) per locus, and the mean number of effective alleles (Ne) was 4.1. The index of fixation averaged 0.001. The polymorphism index (PIC) ranged from 0.217 to 0.946, with an average of 0.695.


Sign in / Sign up

Export Citation Format

Share Document