scholarly journals Physical Activity Associates with Greater Antibody Persistence through 6 Months after the Second Dose of CoronaVac in Patients with Autoimmune Rheumatic Diseases

2021 ◽  
Author(s):  
Bruno Gualano ◽  
Ítalo R. Lemes ◽  
Rafael Silva ◽  
Ana Jessica Pinto ◽  
Bruna Mazzolani ◽  
...  
Keyword(s):  
Physical Activity ◽  
Rheumatic Diseases ◽  
Neutralizing Antibodies ◽  
Vigorous Physical Activity ◽  
Geometric Mean ◽  
Dose Schedule ◽  
Physically Active ◽  
Autoimmune Rheumatic Diseases ◽  
Antibody Persistence ◽  
Active Patients

Abstract This study aimed to investigate the association between physical activity and persistent anti-SARS-CoV-2 antibodies 6 months after two-dose schedule of CoronaVac in autoimmune rheumatic diseases (ARD) patients. This was a prospective cohort study within an open-label, single-arm, phase 4 vaccination trial (clinicaltrials.gov #NCT04754698), conducted at a tertiary referral hospital in Sao Paulo, Brazil. ARD patients aged ≥18 underwent a two-dose schedule of CoronaVac (Sinovac Life Sciences, China). Persistent immunogenicity 6 months after the full-course vaccination was assessed using seroconversion rates of total anti-SARS-CoV-2 S1/S2 IgG, geometric mean titers of anti-S1/S2 IgG (GMT), and frequency of positive neutralizing antibodies (NAb). Physical activity was assessed trough questionnaire (active being defined as ≥150 min/week of moderate-to-vigorous physical activity). Physically active (n=421) and inactive (n=327) ARD patients were similar for most characteristics; however, active patients were significantly younger (p<0.001), had less chronic inflammatory arthritis (p<0.001) and less frequently used biologic agents (p<0.001) than inactive ones. Six months after full-course vaccination, being male (p<0.001), use of prednisone (p<0.01) and biologics (p<0.001) were associated with poor immunogenicity, while being physically active was associated with better humoral response (p<0.01). Adjusted point estimates from logistic regression models indicated greater odds of seroconversion rates (OR: 1.5 [95%CI: 1.1 to 2.1]) and NAb positivity (OR: 1.5 [95%CI: 1.0 to 2.1]) in physically active patients and approximately 43% greater GMT (42.8% [95%CI: 11.9 to 82.2]) than inactive ones. In conclusion, among immunocompromised patients, being physically active was associated with an increment in antibody persistence through 6 months after a full-course of an inactivated SARS-CoV-2 vaccine.

scholarly journals Physical activity associates with enhanced immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases

2021 ◽  
Author(s):  
Bruno Gualano ◽  
Italo Lemes ◽  
Rafael Silva ◽  
Ana Pinto ◽  
Bruna Mazzolani ◽  
...  
Keyword(s):  
Physical Activity ◽  
Rheumatic Diseases ◽  
Geometric Mean ◽  
Neutralizing Antibody ◽  
Active Lifestyle ◽  
Physically Active ◽  
Autoimmune Rheumatic Diseases ◽  
Vaccine Schedule ◽  
Vaccine Immunogenicity ◽  
Dose Vaccine

Abstract Immunocompromised individuals show lower vaccine immunogenicity, which may be modulated by physical activity. This prospective cohort study within a phase-4 vaccination trial investigated whether physical activity is associated with enhanced immunogenicity of Coronavac (SARS-CoV-2 inactivated vaccine) in patients with autoimmune rheumatic diseases (ARD) (n=898) and non-ARD (n=197) individuals without pre-existing immunogenicity to SARS-CoV-2 after receiving a two-dose vaccine schedule. Seroconversion rates of total anti-SARS-CoV-2 S1/S2 IgG (SC), geometric mean titers of anti-S1/S2 IgG (GMT), factor-increase in GMT (FI-GMT), frequency of neutralizing antibody (NAb), and median neutralizing activity were assessed. After controlling for covariates, active patients (≥150 min/week) exhibited greater SC (OR: 1.4 [95%CI: 1.1-2.0]), GMT (32% [95%CI: 8.8-60) and FI-GMT (33% [95%CI: 9.6-63%]) vs. inactive. Cluster analysis (physical activity/sedentary status) revealed greater GMT (43.0% [95% CI: 11.0-84.0%) and FI-GMT (48.0% [95%CI: 14.0-92.0%]) in active/non-sedentary (≥150 min/week/<8h/day) vs. inactive/sedentary (<150 min/week/>8h/day) ARD. A dose-response was observed, with greater benefits for ≥350 min/week of physical activity (OR: 1.6 [95%CI: 1.1-2.4]; 41% [95%CI: 10-80%]; 35% [95%CI: 4.3-74], for SC, GMT, and FI-GMT, respectively). Greater SC (OR: 9.9 [95%CI: 1.1-89.0]) and GMT (26% [95%CI: 2.2-56.0%]) were observed in active vs. inactive non-ARD. A physically active lifestyle may enhance SARS-CoV-2 vaccine immunogenicity, a finding of particular clinical relevance for immunocompromised individuals.

scholarly journals Profiles of Loneliness and Social Isolation in Physically Active and Inactive Older Adults in Rural England

2021 ◽  
Vol 18 (8) ◽  
pp. 3971
Author(s):  
Jolanthe de Koning ◽  
Suzanne H. Richards ◽  
Grace E. R. Wood ◽  
Afroditi Stathi
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Social Isolation ◽  
Physical Environment ◽  
Vigorous Physical Activity ◽  
Social Contact ◽  
Physical Activity Behaviour ◽  
Rural Setting ◽  
Structured Interviews ◽  
Physically Active

Objective: Loneliness and social isolation are associated with higher risk of morbidity and mortality and physical inactivity in older age. This study explored the socioecological context in which both physically active and inactive older adults experience loneliness and/or social isolation in a UK rural setting. Design: A mixed-methods design employed semi structured interviews and accelerometer-measured moderate-to-vigorous physical activity (MVPA). Interviews explored the personal, social and environmental factors influencing engagement with physical activities, guided by an adapted-socioecological model of physical activity behaviour. Findings: Twenty-four older adults (MeanAge = 73 (5.8 SD); 12 women) were interviewed. Transcripts were thematically analysed and seven profiles of physical activity, social isolation and loneliness were identified. The high-MVPA group had established PA habits, reported several sources of social contact and evaluated their physical environment as activity friendly. The low MVPA group had diverse experiences of past engagement in social activities. Similar to the high MVPA, they reported a range of sources of social contact but they did not perceive the physical environment as activity friendly. Conclusions: Loneliness and/or social isolation was reported by both physically active and inactive older adults. There is wide diversity and complexity in types and intensity of PA, loneliness and social isolation profiles and personal, social and environmental contexts.

scholarly journals Evidence-Based Overview of Accelerometer-Measured Physical Activity during School Recess: An Updated Systematic Review

2021 ◽  
Vol 18 (2) ◽  
pp. 578
Author(s):  
Sergio Pulido Sánchez ◽  
Damián Iglesias Gallego
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
School Environment ◽  
Vigorous Physical Activity ◽  
Extraction Process ◽  
Intervention Programs ◽  
World Health ◽  
After School ◽  
Cross Sectional ◽  
Physically Active

Interest in analyzing physically active behaviors during school recesses has grown in recent years as the school environment has consolidated (recess, physical education classes, lunch-time, before and after school) as a crucial space to bring these levels towards those recommended through intervention programs and improvements in the school environment. Unfortunately, in most of these studies, children do not achieve the 60 min a day of moderate to vigorous physical activity (MVPA) recommended by the World Health Organization. The aim of this systematic review is to analyze the cross-sectional, longitudinal, and intervention studies objectively measured with accelerometers that have emerged in recent years to determine the amount of MVPA of children at recess. This systematic review followed the PRISMA guidelines. The extraction process for the studies included in this systematic review yielded a total of 43 articles. The studies were classified according to the methodological nature of the research: cross-sectional (n = 34), longitudinal (n = 3) and quasi-experimental (n = 6). The results of the studies confirm that during the recess period younger children are physically more active than older ones and that in general, boys are more physically active than girls. In addition, the data show that the school contributes to more than 40% of the total MVPA. The intervention programs led to an increase in MVPA of up to 5%. Providing schools with equipment and facilities shows that intervention programs are beneficial for raising children’s levels of physical activity.

Abstract P234: Associations of Clinical Characteristics and Health-related Behaviors With Physical Activity Levels in Stage B Heart Failure Patients

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Maira Tristao Parra ◽  
Meredith A Pung ◽  
Kathleen Wilson ◽  
Christopher Pruitt ◽  
Barry H Greenberg ◽  
...  
Keyword(s):  
Physical Activity ◽  
Heart Failure ◽  
Clinical Characteristics ◽  
Well Being ◽  
Physically Active ◽  
Heart Failure Patients ◽  
Health Related Behaviors ◽  
Health Related ◽  
Active Patients

Hypothesis: insufficiently active heart failure patients will report poorer QoL, more fatigue and depressive mood compared to active patients. Aims: To characterize clinical characteristics and health-related behaviors according to physical activity (PA). Also, to explore predicting factors of quality of life (QoL). Methods: Cross-sectional analysis of a cohort of Stage B HF patients. PA classification was set as active, moderately active or insufficiently active, according to the LTEQ questionnaire. For QoL, the SF-36 questionnaire was used. ANOVAS, Chi-Square tests or likelihood ratios and unadjusted multiple regression models were calculated. Significance was set at p ≤ 0.05. Results: In this cohort, 277 HF patients completed the PA questionnaire. The prevalence of active patients was higher than moderately active and insufficiently active (53.3% vs 15.2% and 29.6%), respectively. Younger age (p = 0.044), lower waist circumference (WC) (p = 0.002), and lower waist-to-hip ratio (p = 0.046) were associated with being active. The prevalence of Type II diabetes mellitus (T2DM) in the active groups was significantly lower (p = 0.001). Physically active groups had cases of mild LV enlargement (1.4% and 7.5%, respectively), while no cases were observed among insufficiently active patients (p = 0.017). PA was positively associated with less fatigue (p= 0.002), more vigor (p = 0.001), more self-efficacy (p < 0.001), and better quality of life (p = 0.002). Patients who were less physically active had more inflammation (CRP, p = 0.015; IL-6, p <0.001; TNF-α: p = 0.033, and IL-1ra, p = 0.001). WC (β =-0.16, p = 0.008), glucose (β =-0.12, p < 0.001) and fatigue (β = - 0.39, p < 0.001) predicted general health perception (R 2 = 0.449). For physical functioning (high scores reflects performing PA without limitations due to health), WC (β = - 0.28, p = 0.001), sleep (β = - 1.50, p = 0.003) and fatigue (β = - 0.32, p = 0.018) were significant predictors (R 2 = 0.422); while age (β = 0.36, p <0.001) physical activity (β = 0.051, p = 0.055), sleep (β = 0.50, p =0.046), fatigue (β = -0.37, p <0.001) and depression (β = -1.12, p <0.001) predicted emotional well-being (R 2 = 0.696). Conclusion: Physically active heart failure patients had a better anthropometric profile and lower prevalence of T2DM. In this cohort, PA was not a significant predictor for general and physical functioning, but it remained relevant for predicting emotional well-being.

Children’s Heart Rates during Physical Education Lessons: A Review

1996 ◽  
Vol 8 (3) ◽  
pp. 215-233 ◽  
Author(s):  
Gareth Stratton
Keyword(s):  
Physical Activity ◽  
Heart Rate ◽  
Physical Education ◽  
Vigorous Physical Activity ◽  
Moderate Physical Activity ◽  
Physical Educators ◽  
Vigorous Activity ◽  
Education Curriculum ◽  
Maximum Heart Rate ◽  
Physically Active

Physical educators have purported to teach children to be physically active and to promote their fitness. To achieve these goals, children should regularly experience moderate-to-vigorous physical activity (MVPA) during physical education lessons. For the purposes of this review, moderate physical activity is that which elicits a heart rate of 50% of maximum heart rate reserve (MHRR), moderate-to-vigorous activity elicits 60% of MHRR, and vigorous activity elicits 75% of MHRR. Duration criteria were set at 50% of lesson time or 20 min. The majority of lessons described in previous reports failed to achieve these criteria, although problems were noted in method and analyses of data. Lessons with physical activity as a direct goal have been successful in increasing MVPA. A greater focus on physical activity is required in the planning and delivery of physical education lessons if the physical activity and fitness goals of the physical education curriculum are to be met.

Can a Multicomponent-Overnight Camp Increase Physical Activity Among Danish Children? A Retrospective Cross-Sectional Study

2020 ◽  
pp. 1-7
Author(s):  
Dorthe Dalstrup Jakobsen ◽  
Jasper Schipperijn ◽  
Jens Meldgaard Bruun
Keyword(s):  
Physical Activity ◽  
Physical Activity Level ◽  
Vigorous Physical Activity ◽  
Cross Sectional Study ◽  
Activity Level ◽  
Cross Sectional ◽  
Physically Active ◽  
And Behavior ◽  
Children’S Physical Activity

Background: In Denmark, most children are not sufficiently physically active and only a few interventions have been found to increase long-term physical activity among overweight and obese children. The aim of our study was to investigate if children are physically active in correspondence to Danish recommendations after attending a multicomponent-overnight camp. Methods: A questionnaire was developed to estimate children’s physical activity level and behavior and investigate how transport, economy, availability, time, motivation, and knowledge about physical activity affect children’s physical activity level and behavior. Results: In this study, 60.9% of the children did vigorous physical activity (VPA) minimum 30 minutes 3 times per week up to 3 years after camp. Most children were physically active at a sports club (44.3%) and only 5.7% of the children did not participate in physical activity. Parental physical activity and child motivation toward physical activity were significantly (P < .05) associated with children doing VPA. Conclusion: Our findings suggest that 60.9% of children who attended camp engage in VPA after camp, which compared with a recent Danish study, is more frequent than children who did not attend camp. Further investigations are needed to determine the long-term health effects in children attending interventions such as multicomponent-overnight camps.

scholarly journals Association between Family Structure and Physical Activity of Chinese Adolescents

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Lijuan Wang ◽  
Jing Qi
Keyword(s):  
Physical Activity ◽  
Family Structure ◽  
Family Environment ◽  
Vigorous Physical Activity ◽  
Single Parent ◽  
Chinese Adolescents ◽  
Physically Active ◽  
Biological Parents ◽  
Significant Difference

Background. This study examines the association between family structure and moderate-to-vigorous physical activity (MVPA) of adolescents in China.Methods. The participants included 612 adolescents (317 boys and 295 girls) from Shanghai with ages ranging from 10 to 16 years. Accelerometers were used to measure the duration of MVPA of adolescents, and questionnaires on family structure were completed by the parents of these adolescents.Results. Findings suggested that family structure significantly increased the likelihood of adolescents engaging in physical activity (PA) and explained 6% of MPVA variance. Adolescents living in single-parent households and step families were more physically active than those living in two-parent homes and with biological parents, respectively. However, adolescents residing with grandparents were less active than those living with neither grandparent. No significant difference was found in MVPA time between adolescents living with one sibling and those without siblings.Conclusion. Family environment may be considered in the development of PA interventions and policies, and adolescents living with their grandparents may be targeted in PA promotion.

An Examination of Multilevel Factors That May Explain Gender Differences in Children’s Physical Activity

2013 ◽  
Vol 10 (7) ◽  
pp. 982-992 ◽  
Author(s):  
Noe C. Crespo ◽  
Kirsten Corder ◽  
Simon Marshall ◽  
Gregory J. Norman ◽  
Kevin Patrick ◽  
...  
Keyword(s):  
Physical Activity ◽  
Gender Differences ◽  
Linear Regression ◽  
Vigorous Physical Activity ◽  
Parent Support ◽  
Cross Sectional ◽  
Physically Active ◽  
Several Variables ◽  
Sectional Analysis ◽  
Children’S Physical Activity

Background:Girls are less physically active than boys, yet no single study has examined the factors that may explain gender differences in children’s physical activity (PA).Methods:This study was a cross-sectional analysis of data from 116 caregivers and their children aged 5–8 years who participated in the MOVE study. Caregivers reported various factors that may relate to children’s PA (eg, encouragement for child PA and PA equipment at home). Child PA was measured by 7-day accelerometry. Linear regression tested for the variance in moderate-to-vigorous physical activity (MVPA) explained by gender and several variables. Gender and ethnicity interactions were examined.Results:Caregivers were mostly female (97%), mean age 38 ± 6 years, mean BMI 28 ± 6 (kg/m2). Child’s mean age was 8.1 ± 0.7, 54% were female and 40% were overweight/obese. Girls were less physically active than boys (54.1 ± 19.7 vs. 65.2 ± 28.0 daily minutes of MVPA, respectively). Among girls, more days of PE/week was associated with greater MVPA. Among boys, greater parent support for PA, greater parent modeling for PA, and greater number of PA equipment in the home were associated with greater MVPA.Conclusions:This study supports that boys and girls have different correlates for MVPA, which may partly explain gender differences in PA.

Associations Between Neighborhood Safety, Availability of Recreational Facilities, and Adolescent Physical Activity Among Canadian Youth

2010 ◽  
Vol 7 (4) ◽  
pp. 442-450 ◽  
Author(s):  
Marianne Nichol ◽  
Ian Janssen ◽  
William Pickett
Keyword(s):  
Physical Activity ◽  
Vigorous Physical Activity ◽  
Geographical Information ◽  
Neighborhood Safety ◽  
Recreational Facilities ◽  
Physically Active ◽  
Perceived Safety ◽  
Adolescent Physical Activity ◽  
Group Perceptions ◽  
Perceptions Of Safety

Background:The safety of neighborhoods and availability of parks and facilities may influence adolescent physical activity independently or interactively.Methods:9114 Canadians in grades 6 to 10 completed the 2006 Health Behavior in School-Aged Children Survey. The outcome of interest was students’ self-reported participation in moderate-to-vigorous physical activity outside of school. A composite scale based on questions measuring student perceptions of safety was used to capture individual perceptions of safety. In addition, schools were grouped into quintiles based on the mean of the perceived safety scale, used as a proxy for peer perceptions. The number of parks and recreational facilities within 5 km of schools was abstracted from a geographical information system.Results:Moderate gradients in physical activity were observed according to individual and group perceptions of safety. Boys and girls with the highest perceptions of safety were 1.31 (95% CI: 1.17−1.45) and 1.45 (1.26−1.65) times more likely to be physically active, respectively, than those with the lowest perceptions. Compared with those who perceived the neighborhood as least safe, elementary students in higher quintiles were 1.31, 1.39, 1.37, and 1.56 times more likely to be physically active (Ptrend = 0.012). Increased numbers of recreational features were not related to physical activity irrespective of neighborhood safety.Conclusions:Individual and group perceptions of neighborhood safety were modestly associated with adolescents’ physical activity.

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