scholarly journals Serum Total Protein, Albumin, Globulin, and Prealbumin in Acne Patients

2020 ◽  
Author(s):  
Hao Jiang ◽  
Changyi Li ◽  
bin wei ◽  
Qiang Wang ◽  
Qinggao Wang ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Total Protein ◽  
Serum Levels ◽  
Control Group ◽  
Healthy Controls ◽  
Serum Globulin ◽  
Serum Total Protein ◽  
Protein Levels ◽  
Healthy Control ◽  
Age And Sex

Abstract Background/Objectives: This study was designed to investigate serum protein levels in acne patients.Method: Acne patients (n=362) and healthy volunteers (n=272) were matched in terms of both age and sex. Serum levels were measured.Results: Among the 362 acne patients and 272 age- and sex-matched healthy controls, serum albumin levels in female acne patients were lower than in the healthy controls (P < 0.05), serum albumin levels in male acne patients were lower than in the healthy controls (P < 0.01). Additionally, serum globulin and total protein levels were significantly lower in acne patients than in the healthy control group (P < 0.01). Serum levels of prealbumin were significantly lower in female acne patients than in the control group (P < 0.05). Finally, the severity of female and male acne patients was negatively correlated with serum total protein, albumin, globulin, and prealbumin levels. Conclusions: The results of this study suggested that acne patients are potentially accompanied with protein malnutrition.

scholarly journals Serum Levels of Total Protein, Albumin and Globulin in Woman with Hyperemesis Gravidarum

1970 ◽  
Vol 19 (1) ◽  
pp. 58-60
Author(s):  
JA Begum ◽  
R Sultana ◽  
S Naher
Keyword(s):  
Pregnant Women ◽  
Total Protein ◽  
Hyperemesis Gravidarum ◽  
Serum Levels ◽  
First Trimester ◽  
Normal Pregnancy ◽  
Control Group ◽  
Serum Globulin ◽  
Serum Total Protein ◽  
Nulliparous Women

Background: Hyperemesis gravidarum is a severe type of vomiting in pregnancy which has significant effect on the health of mother and fetus. During this period various metabolic and endocrine changes occur in maternal body. Objectives: The present study has been designed to observe the serum total protein, albumin and globulin in women with hyperemesis gravidarum. Method: For this purpose 6o women with age ranging from 20 to 40 years were selected. The women with hyperemesis gravidarum were taken as case and Non pregnant nulliparous women & normal pregnant women during the first trimester of normal pregnancy were taken as control group. Each group consisted of 20 women. The total protein and albumin levels were measured in all study populations against the blank at wavelength of 530 nm and 620 nm in a colorimeter. Results: The serum total protein and albumin levels were significantly (p < 0.001) higher in hyperemesis gravidarum and normal pregnant women during first trimester compared to control non pregnant nulliparous women. Conclusion: Therefore the result of the present study reveals that higher levels of total protein, albumin and globulin in hyperemesis gravidarum in comparison to non pregnant nulliparous & normal pregnant women due to increase thyroid hormones and also increases thyroxine - binding globulins. Key words: Serum Total Protein; Serum Albumin; Serum Globulin; Hyperemesis Gravidarum DOI: 10.3329/jdmc.v19i1.6254 J Dhaka Med Coll. 2010; 19(1) : 58-60.

scholarly journals Serum albumin and total protein level as plausible marker for diagnosis of protein energy malnutrition in children under age 5 years

2020 ◽  
Vol 7 (8) ◽  
pp. 1758
Author(s):  
Saroj Sanjeev Gupta ◽  
Pranav Sanjeev Gupta
Keyword(s):  
Serum Albumin ◽  
Total Protein ◽  
Protein Energy Malnutrition ◽  
Venous Blood ◽  
Bromocresol Green ◽  
Control Group ◽  
Case Group ◽  
Healthy Controls ◽  
Serum Total Protein ◽  
Protein Energy

Background: The circulating concentration of transport protein, traditionally albumin, has been used to define protein deficiency. However, few studies have been conducted to see if there is any correlation between serum total protein and albumin levels in children with PEM. Hence the study was planned to estimate serum total protein, serum albumin levels in children with PEM and healthy controls.Methods: All the children were divided in two groups. Case Group A consist of 250 children with protein energy malnutrition and control Group B consist of healthy 250 children. Venous blood of amount 3 ml was collected with full aseptic precautions. The blood was collected in the EDTA vacutainer and test tube. Serum total protein was estimated by Biuret method, serum albumin was estimated by Bromocresol green dye method (BCG dye).Results: When the mean serum levels of albumin levels and the total protein levels were measured in the controls as well as case groups, there was decrease in levels in case group as compared to control group. This difference of decrease when evaluated statistically it was found to be statistically significant. When the albumin/globulin ratio was calculated in both the groups, it was found to be statistically lower in case group as compared to control group. PEM children have low serum total protein and albumin levels as compared to healthy controls (p<0.001), this is probably due to decreased intake of proteins and reduced biosynthesis. PEM children have lower hemoglobin levels as compared to healthy controls; this is probably due to deficiency of iron and other micronutrients, which is often found in a child with malnutrition.Conclusions: Early diagnosis and prompt management of PEM and its complications can prevent development of permanent physical and mental retardation.

scholarly journals Shortened platelet half-life in multiple myeloma

Blood ◽  
1986 ◽  
Vol 68 (2) ◽  
pp. 514-520
Author(s):  
E Fritz ◽  
H Ludwig ◽  
W Scheithauer ◽  
H Sinzinger
Keyword(s):  
Multiple Myeloma ◽  
Half Life ◽  
Serum Levels ◽  
Statistical Correlation ◽  
Control Group ◽  
Healthy Controls ◽  
Platelet Factor ◽  
Healthy Control

Various defects in platelet function have been reported as being associated with multiple myeloma. In 30 myeloma patients and 15 healthy controls, we investigated platelet survival using in vitro labeling of autologous platelets with 111indium-oxine and measuring the in vivo kinetics of the radioisotope. Significantly shortened platelet half- life in patients averaged 73 hours, while platelet half-life in the healthy controls averaged 107 hours. In myeloma patients, serum levels of thromboxane B2, beta-thromboglobulin, and platelet factor 4 were significantly elevated; aggregation indices were within the pathological range; platelet counts and spleen-liver indices, however, were comparable to those of the healthy control group. No statistical correlation was found between platelet half-life and paraprotein concentrations. Our findings suggest an initial--so far unexplained-- intravascular process of platelet activation and consumption that finally manifests in shortened platelet half-life. It seems that overt thrombocytopenia develops only when the compensatory capacity of the bone marrow finally becomes exhausted. Further studies should be able to elucidate the pathophysiologic processes involved.

The effect of β-hydroxy-β-methylbutyrate (HMB) on selected parameters of humoral immunity in calves

2014 ◽  
Vol 17 (2) ◽  
pp. 357-359 ◽  
Author(s):  
R. Wójcik ◽  
J. Małaczewska ◽  
A.K. Siwicki ◽  
J. Miciński ◽  
G. Zwierzchowski
Keyword(s):  
Humoral Immunity ◽  
Total Protein ◽  
Experimental Period ◽  
Lysozyme Activity ◽  
Control Group ◽  
Serum Total Protein ◽  
Immunological Parameters ◽  
Protein Levels ◽  
Ceruloplasmin Activity ◽  
Experimental Group

Abstract The objective of this study was to evaluate the effect of HMB on selected parameters of the humoral immunity in calves. The experiment was performed on 14 calves aged 30 ± 2 days, divided into two equal groups of control (group K) and experimental (group H) animals. The feed administered to the experimental calves was supplemented with HMB at 40 mg/kg BW, whereas the control calves were administered standard farm-made feed without supplementation. Blood was sampled from the jugular vein immediately before the experiment (day 0) and on experimental days 15, 30 and 60 to determine the following immunological parameters: total protein levels, gammaglobulin levels, lysozyme activity and ceruloplasmin activity. An analysis of the results obtained revealed a significant increase (p < 0.05; p < 0.01; p < 0.001 respectively) in gammaglobulin levels and lysozyme activity throughout the entire experimental period, an increase (p < 0.05; p < 0.01 respectively) in ceruloplasmin activity on experimental days 15 and 30, but no changes in serum total protein levels of calves administered HMB as compared to those found in the control group

scholarly journals Alterations in Serum Protein Levels in Patients with Cushing’s Syndrome before and after Successful Treatment

2000 ◽  
Vol 85 (9) ◽  
pp. 3309-3312
Author(s):  
P. Putignano ◽  
G. A. Kaltsas ◽  
M. Korbonits ◽  
P. J. Jenkins ◽  
J. P. Monson ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Serum Protein ◽  
Cushing’S Syndrome ◽  
Successful Treatment ◽  
Total Protein ◽  
Cushing's Syndrome ◽  
Reference Ranges ◽  
Serum Globulin ◽  
Protein Levels ◽  
Albumin To Globulin Ratio

Abstract Alteration in serum protein concentration is used commonly in clinical practice as a nonspecific indicator of underlying disease or to monitor disease activity. Although hypercortisolemia may affect protein metabolism directly or indirectly, data regarding alterations of levels of serum protein in a large series of patients with Cushing’s syndrome (CS) have been lacking. We have now evaluated, retrospectively, the levels of circulating serum albumin, globulins, total proteins, and the albumin to globulin ratio in 99 patients with endogenous CS before, immediately after, and 3, 6, and 12 months following successful treatment. Subjects with concomitant infections or other chronic diseases were excluded from the analysis. Although mean serum albumin and total protein levels were within the normal reference ranges, in general, they gradually increased after treatment with maximal values being reached at 12 months after normalization of hypercortisolemia (P &lt; 0.0001 for both); there were no significant changes in serum globulin levels or in the albumin to globulin ratio. Patients with CS as a whole showed a weak but significant negative correlation between serum albumin and 0900 h cortisol level (r = −0.303; P = 0.0035). In conclusion, our data suggest that CS is associated with a small but significant reduction in circulating serum protein levels, which are restored following treatment of hypercortisolemia, although these changes occur within the reference range. Thus, extreme alterations in serum total protein or albumin levels in patients with CS should alert physicians to the presence of concomitant pathology, and additional specific investigation should be undertaken to elucidate the cause.

The Influence of Valproic Acid and Carbamazepine Treatment on Serum Biotin and Zinc Levels and on Biotinidase Activity

2011 ◽  
Vol 26 (12) ◽  
pp. 1522-1524 ◽  
Author(s):  
Manuel Castro-Gago ◽  
Laura Pérez-Gay ◽  
Carmen Gómez-Lado ◽  
Daisy E. Castiñeiras-Ramos ◽  
Santiago Otero-Martínez ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Enzyme Activity ◽  
Serum Levels ◽  
Normal Serum ◽  
Control Group ◽  
Healthy Controls ◽  
Normal Range ◽  
Zinc Levels ◽  
Biotinidase Activity ◽  
Age And Sex

We determined the serum concentration of biotin, zinc, antiepileptic drugs, and biotinidase enzyme activity in 20 children treated with valproic acid, in 10 children treated with carbamazepine, and in 75 age- and sex-matched healthy controls. There were no significant differences in the serum levels of biotin, and biotinidase enzyme activity between the patients treated with valproic acid, the patients treated with carbamazepine, and the control group. Zinc serum levels were lower in the patients treated with valproic acid and with carbamazepine than in the control group, but within the normal range. Hair loss was observed in 3 patients treated with valproic acid, with normal serum levels of biotin, zinc, and biotinidase activity, and the alopecia disappeared with the oral administration of biotin (10 mg/d) in 3 months. These results suggest that the treatment with valproic acid does not alter the serum levels of biotin, zinc, and biotinidase enzyme activity.

Increased serum G72 protein levels in patients with schizophrenia: a potential candidate biomarker

2016 ◽  
Vol 29 (2) ◽  
pp. 80-86 ◽  
Author(s):  
Esra Soydaş Akyol ◽  
Yakup Albayrak ◽  
Nurkan Aksoy ◽  
Başak Şahin ◽  
Murat Beyazyüz ◽  
...  
Keyword(s):  
Pilot Study ◽  
Healthy Control Group ◽  
Control Group ◽  
Potential Candidate ◽  
Healthy Controls ◽  
Operating Characteristics ◽  
Protein Levels ◽  
Schizophrenia Group ◽  
Healthy Control ◽  
The Mean

ObjectiveThe product of the G72 gene is an activator of d-amino acid oxidase and has been suggested to play a role in the pathogenesis of schizophrenia. Increased G72 protein levels may be associated with disturbed glutamatergic transmission and increased reactive oxygen species. Only one pilot study by Lin et al. has investigated the potential role of serum G72 protein levels as a biomarker for schizophrenia. In this study, we aimed to compare serum G72 protein levels between patients with schizophrenia and healthy controls, and to retest the results of the previous pilot study.Materials and methodsIn total, 107 patients with a diagnosis of schizophrenia according to the inclusion and exclusion criteria and 60 age–sex-matched healthy controls were included in the study. The groups were compared regarding serum G72 protein levels.ResultsThe mean serum G72 protein values were 495.90±152.03 pg/ml in the schizophrenia group and 346.10±102.08 pg/ml in the healthy control group. The mean serum G72 protein level was significantly increased in the schizophrenia group compared with the healthy control group (t=−3.89, p<0.001). A receiver operating characteristics analysis was performed to compare the schizophrenia and healthy control groups. It was determined that the cut-off value was 141.51 pg/ml with a sensitivity of 0.991 and a specificity of 0.821.ConclusionWe suggest that serum G72 protein levels may represent a candidate biomarker for schizophrenia and have confirmed the results of the previous preliminary study. Additional studies with larger sample sizes and the inclusion of first episode schizophrenia patients are required to clarify the reliability and validity of serum G72 protein levels as a biomarker for schizophrenia.

scholarly journals Shortened platelet half-life in multiple myeloma

Blood ◽  
1986 ◽  
Vol 68 (2) ◽  
pp. 514-520 ◽  
Author(s):  
E Fritz ◽  
H Ludwig ◽  
W Scheithauer ◽  
H Sinzinger
Keyword(s):  
Multiple Myeloma ◽  
Half Life ◽  
Serum Levels ◽  
Statistical Correlation ◽  
Control Group ◽  
Healthy Controls ◽  
Platelet Factor ◽  
Healthy Control

Abstract Various defects in platelet function have been reported as being associated with multiple myeloma. In 30 myeloma patients and 15 healthy controls, we investigated platelet survival using in vitro labeling of autologous platelets with 111indium-oxine and measuring the in vivo kinetics of the radioisotope. Significantly shortened platelet half- life in patients averaged 73 hours, while platelet half-life in the healthy controls averaged 107 hours. In myeloma patients, serum levels of thromboxane B2, beta-thromboglobulin, and platelet factor 4 were significantly elevated; aggregation indices were within the pathological range; platelet counts and spleen-liver indices, however, were comparable to those of the healthy control group. No statistical correlation was found between platelet half-life and paraprotein concentrations. Our findings suggest an initial--so far unexplained-- intravascular process of platelet activation and consumption that finally manifests in shortened platelet half-life. It seems that overt thrombocytopenia develops only when the compensatory capacity of the bone marrow finally becomes exhausted. Further studies should be able to elucidate the pathophysiologic processes involved.

scholarly journals Circulating Total and Active Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinases-1 in Patients with Systemic Lupus Erythomatosus

2006 ◽  
Vol 2006 ◽  
pp. 1-7 ◽  
Author(s):  
Ewa Robak ◽  
Agnieszka Wierzbowska ◽  
Magdalena Chmiela ◽  
Liliana Kulczycka ◽  
Anna Sysa-Jędrejowska ◽  
...  
Keyword(s):  
Serum Levels ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Inactive Disease ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Healthy Controls ◽  
Tissue Inhibitor ◽  
Positive Correlation ◽  
Healthy Control ◽  
Metalloproteinase 9

We investigated the serum concentration of total metalloproteinase-9 (tMPP-9), active MMP-9 (aMMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in a group of 41 patients with SLE and 20 healthy controls. Serum levels of tMMP-9 and TIMP-1 were assessed by an enzyme-linked immunosorbent assay (ELISA) and aMMP-9 by fluorometric assay. The tMMP-9 level was lower in SLE patients (mean 262 ng/mL) than in healthy volunteers (mean 325 ng/mL) (P=.048). Similarly, aMMP-9 level was lower in SLE patients (mean 121 ng/mL) than in control group (mean 169 ng/mL) (P=.0355) and lower in active SLE (mean 54 ng/mL) than in inactive disease (mean 99 ng/mL) (P=.033). TIMP-1 level was also lower in SLE patients (mean 181 ng/mL) than in control group (mean 233 ng/mL) (P=.004). In SLE patients, a positive correlation was found between tMMP-9 and aMMP-9 (ρ=0.568;P=.001). We also found a positive correlation of tMMP-9 and TIMP-1 with VEGF concentrations (ρ=0.450,P=.005andρ=0.387;P=.018, resp). tMMP-9, aMMP-9, and TIMP-1 serum levels are lower in SLE patients than in healthy control group.

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