scholarly journals Pregnancy Complications in Venezuelan Women With Malaria

2020 ◽  
Author(s):  
Mariestefany Romero ◽  
Elizabeth Leiba ◽  
Fhabián Stevens Carrión-Nessi ◽  
Diana Carolina Freitas-DeNobrega ◽  
Ángel Gamardo ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Clinical Laboratory ◽  
Negative Impact ◽  
Severe Anaemia ◽  
University Hospital ◽  
Third Trimester ◽  
Malaria Burden ◽  
High Prevalence ◽  
Symptoms And Signs

Abstract BackgroundPregnant women are particularly vulnerable to malaria infections, increasing the risk of maternal-foetal complications, mainly in areas of high endemicity. However, few studies of malaria in pregnancy (MiP) have been carried out in Latin America, a region with low endemicity and transmission of both, Plasmodium falciparum and P. vivax. Despite the high malaria burden in Venezuela in the last years, no recent studies of MiP have been conducted. Hence, epidemiological and clinical characteristics of pregnant women with malaria in Venezuela are described herein.MethodsA retrospective study in pregnant women attending to the “Ruíz y Páez” University Hospital Complex, Bolívar state, Venezuela between February and October, 2019 was carried out. Epidemiological, clinical, and laboratory information was analysed.ResultsThirty-seven out of 52 pregnant women analysed, were infected with P. vivax. Age ranged between 15 and 39 years, and adolescent pregnancies were common. Malaria infection was diagnosed mainly during the third trimester of pregnancy (63.4%). The distribution of symptoms and signs as well as clinical laboratory values was similar among Plasmodium spp. Although uncomplicated malaria was most frequent, 30% (13/52) had severe anaemia. A high proportion of studied women (44%) presented at least one complication during the pregnancy or delivery. Spontaneous abortion was recorded in four women, and three foetal deaths were observed. Six women had preterm delivery without any further complication.ConclusionsA high prevalence of maternal and foetal complications was found in the studied population, highlighting the requirement for a careful medical follow up during the prenatal check-ups, aimed to reduce the negative impact of malaria in the new-born and mother.

scholarly journals Malaria in pregnancy complications in Southern Venezuela

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Mariestéfany Romero ◽  
Elízabeth Leiba ◽  
Fhabián S. Carrión-Nessi ◽  
Diana C. Freitas-De Nobrega ◽  
Serris Kaid-Bay ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Clinical Laboratory ◽  
Negative Impact ◽  
Severe Anaemia ◽  
Malaria In Pregnancy ◽  
University Hospital ◽  
Mosquito Net ◽  
Malaria Burden ◽  
Fetal Complications ◽  
In Pregnancy

Abstract Background Pregnant women are particularly vulnerable to malaria infections, increasing the risk of maternal–fetal complications, mainly in high-endemicity areas. However, few studies of malaria in pregnancy (MiP) have been carried out in Latin America, a region with low endemicity and transmission of both, Plasmodium falciparum and Plasmodium vivax. Despite the high malaria burden in Venezuela in the last years, no recent studies of MiP have been conducted. Hence, epidemiological and clinical characteristics of pregnant women with malaria in southern Venezuela are described herein. Methods A retrospective study in pregnant women attending at the “Ruíz y Páez” University Hospital Complex, Bolivar state, Venezuela, was carried out between February and October, 2019. Epidemiological, clinical, and laboratory information was analysed. Results Thirty-seven out of 52 pregnant women analysed were infected with P. vivax. Age ranged between 15 and 39 years, and adolescent pregnancies were common. Malaria infection was diagnosed mainly during the third trimester of pregnancy (63.4%). The distribution of symptoms and signs as well as clinical laboratory values was similar among Plasmodium spp. Although uncomplicated malaria was most frequent, 30% (13/52) had severe anaemia. A high proportion of studied women (44%) presented at least one complication during the pregnancy or delivery. Spontaneous abortion was recorded in four women, and three fetal deaths were observed. Six women had preterm delivery without any further complication. Conclusions A high prevalence of maternal–fetal complications was found in the studied population, highlighting the requirement for a careful medical follow up during the prenatal check-ups, which should include routinary malaria tests. Preventive measures as distribution of insecticide-treated mosquito net for pregnant women at risk should also be implemented. Those measures can help to reduce the negative impact of malaria on the newborn and mother.

scholarly journals PREDICTORS OF POOR PROGNOSIS IN PREGNANT WOMEN WITH COVID-19: A PROSPECTIVE COHORT STUDY IN THE MATERNITY MOTHER AND CHILD UNIVERSITY HOSPITAL OF CASABLANCA MOROCCO

2021 ◽  
Vol 9 (10) ◽  
pp. 735-741
Author(s):  
Lamrissi A. ◽  
◽  
Midyani H. ◽  
Khalloufi C. ◽  
Jalal M. ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Death Rate ◽  
Poor Prognosis ◽  
First Trimester ◽  
University Hospital ◽  
Maternity Unit ◽  
Second Trimester ◽  
Third Trimester ◽  
High Prevalence ◽  
Mother And Child

Objective: We aim to study the clinicalcharacteristics, the evolution of COVID-19 on pregnant women and survival factors. Study design: Its a prospective cohortstudy in a large tertiary maternity unit within the Mother and Child University Hospital Ibn Rochd of Casablanca with an average annual birth of over 6950 births. We prospectively collected and analyzed data for a cohort of 40 pregnant patients tested positive for COVID-19 between January 2020 and December 2020 inclusive to assess the effect of COVID-19 on pregnancy. Results: Forty pregnant patients testedpositive for COVID-19, 36 patients gave birth and 4 patients died pregnant. The severity of the symptoms ranged from mild in 20/40 (50%) of the patients, moderate in 7/40 (17,5%), and severe in 13/40 (32,5%). Thirteen of our patients were admitted to invasive care units, six were in their third trimester, and seven in their second trimester nine were intubated and ventilated prior to delivery and three of them required Extracorporeal membrane oxygenation. Among these patients intubated only two survived. Most common comorbidities were gestational diabetes 4/40 (10 %), asthma 4/40 (10 %), preeclampsia 7/40 (17,5%). Of the 40 pregnant patients 31 (77,5%) were in their third trimester, 8 (20%) women in their second trimester, and one in her first trimester. Of the 36 patients who delivered, 12/36 (33,3 %) were preterm delivered by elective C-sections. The death rate was 17,5% (7/40). Conclusion: COVID-19 is associated with high prevalence of preterm birth, caesarean section, and a high mortality rate.

scholarly journals Feasibility of a Birth-cohort In Pakistan: Evidence For Better Lives Study

2021 ◽  
Author(s):  
Yasmeen Anwer ◽  
Fahad Abbasi ◽  
Ariba Dar ◽  
Abdullah Hafeez ◽  
Assad Hafeez ◽  
...  
Keyword(s):  
Mental Health ◽  
Pregnant Women ◽  
Birth Cohort ◽  
Partner Violence ◽  
Postnatal Period ◽  
Practice Change ◽  
Birth Cohort Study ◽  
Third Trimester ◽  
Resource Poor

Abstract BackgroundEvidence for Better Lives Study (EBLS) is an endeavour to establish a global birth cohort with participants from resource poor settings across the globe. It aims to investigate mediators and moderators of child development and wellbeing; it envisages informing policy and practice change to promote child health and wellbeing globally. Pakistan is one of the resource poor settings taking part in this global birth cohort; we report the feasibility of establishing such a birth cohort in Pakistan.MethodFrom March 2019 to July 2019, 153 third trimester pregnant women were identified, using community health worker registers, and approached for baseline demographics and a number of maternal wellbeing, mental health, support related information and stress related biomarkers in a peri-urban area of Islamabad Capital Territory. From October 2019 to December 2019, we re-contacted and followed 121 between 8-24 weeks postnatal period. All interviews were done after consent and data was collected electronically. Results150 (98%) third trimester pregnant women consented and were interviewed, 111 (74%) provided bio-samples and 121 (80.6%) were followed up postnatally. Their mean age and years of schooling was 27.29 (5.18) and 7.77 (4.79) respectively. Majority (82.3%) of the participants were housewives. Nearly a tenth were first time mothers while 63% of women reported current pregnancy to have been unplanned. Overall wellbeing and mental health were reported to be poor (WHO-5 mean scores 49.41 (32.20) & PHQ-9 mean scores 8.23 (7.0)). About 22% of women reported four or more adverse childhood experiences; 12.2% reported intimate partner violence during their current pregnancy. During the postnatal follow up visits, 58% of the women reported breastfeeding their infants. ConclusionThe study demonstrated Pakistan site could identify, approach, interview and follow up women and children postnatally, with a high response rates for both the follow up visits and bio-samples. Thus, a larger scale pregnancy birth cohort study in Pakistan is feasible to conduct.

Initial Predictors for Short-termprognosisin Anti-melanoma Differentiation-associated Protein-5 Positive Patients

2020 ◽  
Author(s):  
Qihua Yang ◽  
Tianfang Li ◽  
Xin Zhang ◽  
Kunlong Lyu ◽  
Shujun Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mortality Rate ◽  
Clinical Laboratory ◽  
Combined Treatment ◽  
Good Prognosis ◽  
High Prevalence ◽  
Short Term Mortality ◽  
Image Variables ◽  
Prognostic Risk Factors

Abstract Background: Anti-melanoma differentiation-associated protein-5 (anti-MDA5) positive patients are characterized by the high mortality rate caused by interstitial lung disease (ILD). We conducted a retrospective study to summarize the clinical features and identify the initial predictors for death in anti-MDA5 positive patients.Methods:We designed a retrospective cohort of anti-MDA5 positive patients.The demographic and clinical data recorded on first admission, as well as the outcomes during the first six months follow-up were collected. Risk factors for death were identified using multivariate analyses.Results: A total of 90 anti-MDA5 positive patients were included in this study. Eighty-one (90%) patients presentedILD on admission and 35(38.9%) patients developed rapidly progressive ILD (RP-ILD) subsequently.During the first six months of follow-up, 22 (24.4%) patients died of respiratory failure at an average time of 6.6 ± 5.9 weeks.Univariate analysis identified several factors associated with death, including demographic, clinical, laboratory and image variables. Multivariate analysis showed that total CT GGO score≥4(HR 4.8, 95%CI 1.3-17.9,P=0.020), KL-6>1600U/ml (HR3.7, 95%CI 1.5-9.1, P=0.004) and CRP>5.8mg/L (HR3.7, 95%CI 1.0-12.8, P=0.044) were poor prognostic risk factors, however initial combined treatment(HR 0.3, 95%CI 0.1-0.8, P=0.019) predicted good prognosis in anti-MDA5 positive patients.Conclusion: Anti-MDA5 positive patients demonstrated a high prevalence of ILD on admission, leading to a high short-term mortality rate. Higher total GGO score, higher levels of initial KL-6 and CRP predict poor outcome in anti-MDA5 positive patients. However, in tial intensive treatment may improve the prognosis.

scholarly journals Cystic Fibrosis with Severe Anaemia and Hypoproteinaemia

2019 ◽  
Vol 38 (2) ◽  
pp. 118-121
Author(s):  
Md Abu Bakkar Siddique ◽  
Kalimuddin Khan ◽  
Aparajita Bera ◽  
Sudipta Ghorai ◽  
Jasmine Mallik ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Respiratory Symptoms ◽  
Severe Anaemia ◽  
Initial Presentation ◽  
Elastase Level ◽  
Symptoms And Signs

The presentation of cystic fibrosis (CF) is dependent upon which organs are affected. Severe anaemia is reported to occur rarely in patients with CF. We are presenting a case of 2 months old infant admitted with anaemia, malnutrition, hypoproteinaemia and hypoalbuminaemia, without any pulmonary symptoms at the initial presentation. Abnormal sweat chlorides and low faecal elastase level confirmed the diagnosis of CF. Respiratory symptoms and signs developed later on further follow up.

scholarly journals Follow-up of Toxoplasmosis during Pregnancy: Ten-Year Experience in a University Hospital in Southern Brazil

2019 ◽  
Vol 41 (09) ◽  
pp. 539-547 ◽  
Author(s):  
Amanda Andrade Diesel ◽  
Suzana de Azevedo Zachia ◽  
Ana Lúcia Letti Müller ◽  
Amanda Vilaverde Perez ◽  
Flavio Antonio de Freitas Uberti ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Pregnant Women ◽  
Triple Therapy ◽  
Gestational Age ◽  
Congenital Toxoplasmosis ◽  
Immunoglobulin M ◽  
University Hospital ◽  
Pcr Analysis ◽  
Ultrasound Findings

Abstract Objective To describe a population of pregnant women diagnosed with toxoplasmosis and their respective newborns, describing the hospital protocol for treatment and follow-up. Methods Retrospective cohort of pregnant women with acute toxoplasmosis infection and risk of transplacental transmission who were sent to the Fetal Medicine Group of Hospital de Clínicas de Porto Alegre (HCPA) between - January 1, 2006 and December 31, 2016. All patients with confirmed disease were included. The diagnostic protocol and treatment were applied; a polymerase chain reaction (PCR) analysis of the amniotic fluid was used to diagnose toxoplasmosis and determine the treatment. The newborns were followed up at the pediatric outpatient clinic specializing in congenital infection. The patients who were not followed up or were not born in the HCPA were excluded. Results A total of 65 patients were confirmed to have gestational toxoplasmosis; 40 performed amniocentesis, and 6 (15%) were identified as having positive PCR in the amniotic fluid. In five of those cases, this result associated with the gestational age defined the triple therapy during pregnancy, and in one case, it defined the monotherapy (advanced gestational age). A total of 4 of these newborns were treated from birth with triple therapy for 10 months, 1 was not treated (due to maternal refusal), and 1 progressed to death within the first 54 hours of life due to complications of congenital toxoplasmosis. Of the 34 remaining cases with a negative PCR, 33 were treated with monotherapy and 1 was treated with triple therapy (ultrasound findings); of these children, 9 (26.5%) presented negative immunoglobulin G (IgG), 24 (70.6%) presented positive IgG (but none presented positive immunoglobulin M [IgM]), and 1 (2,9%) presented alterations compatible with congenital disease and started treatment with the triple therapy soon after birth. Out of the total sample of 60 patients, among the 25 who did not perform amniotic fluid PCR, 5 were treated with triple therapy (ultrasound findings/prior treatment) and 20 patients were submitted to monotherapy; only two newborns underwent treatment for congenital toxoplasmosis. Among the 65 cases of gestational toxoplasmosis, 6 (9,2%) children had a diagnosis of congenital toxoplasmosis, and 2 patients with triple therapy felt severe adverse effects of the medications. Conclusions The present study suggests that research on PCR screening of the amniotic fluid may be useful to identify patients with a higher potential for fetal complications, who may benefit from the poly-antimicrobial treatment. Patients with negative PCR results must continue to prevent fetal infection with monotherapy, without risk of fetal or maternal impairment.

scholarly journals Studies on Serum Total Cholesterol, in Second and Third Trimester of Pregnancy

1970 ◽  
Vol 1 ◽  
pp. 1-4 ◽  
Author(s):  
F Husain ◽  
SA Latif ◽  
MM Uddin
Keyword(s):  
Pregnant Women ◽  
Total Cholesterol ◽  
Serum Total Cholesterol ◽  
Reproductive Age ◽  
Control Group ◽  
Serum Concentrations ◽  
Third Trimester ◽  
Medical College ◽  
Unpaired Student

Study was carried out in the department of physiology, Mymensingh Medical College, Mymensingh, Bangladesh during the period of July 2006 to June 2007 to investigate the effect of pregnancy on serum total cholesterol. The serum concentrations of total cholesterol was measured in 100 cases of 2nd and 3rd trimester of pregnancy and in a control group of 100 cases of non pregnant women which was matched on reproductive age. Data were analyzed by computer with SPSS program using unpaired student‘t’ test. The results showed that the pregnant women had significantly higher concentrations of serum total cholesterol. Higher concentration of total cholesterol was more common in pregnant than control and reaching maximum at 3rd trimester of pregnancy. This may be a purely physiological response to pregnancy or it may be indicative of pathology in some women. These results deserve a follow up study to investigative whether the hypercholesterolemia persists after parturition. Key Words: Total cholesterol, pregnancy, parturition, hypercholesterolemia J Bangladesh Soc Physiol. 2006 Dec;(1):1-4.

Venous Insufficiency 4 Years after an Episode of Deep Vein Thrombosis: A Clinical and Plethysmographic Investigation

1998 ◽  
Vol 13 (2) ◽  
pp. 53-58
Author(s):  
M. Nordström ◽  
B. Lindblad ◽  
H. Åkesson ◽  
D. Bergqvist ◽  
T. Kjellström
Keyword(s):  
Deep Vein Thrombosis ◽  
Venous Insufficiency ◽  
Outcome Measure ◽  
Clinical Symptoms ◽  
University Hospital ◽  
Vein Thrombosis ◽  
Venous Function ◽  
Deep Vein ◽  
Symptoms And Signs

Objective: To evaluate the frequency of venous insufficiency following deep vein thrombosis (DVT). Design: Follow-up 4 years after a verified DVT. Setting: University hospital in Malmö. Patients: Eighty-seven subjects with venographically verified DVT. Main outcome measure: To compare venous function in legs, with and without previous DVT, by venous straingauge plethysmography and its correlation with clinical symptoms and signs. Results: Fifty-two per cent of patients described general discomfort from the thrombotic leg at follow-up. Active leg ulcers were found in three patients (3%); there were no signs of venous insufficiency in 33% at clinical examination. Thirty-seven patients (75%) with ≥ 1 cm difference in calf circumference between the thrombotic and contralateral leg had suffered a proximal DVT. The refilling time T90 was pathological in 67% and the muscle pump function (RV) in 55%. In the nonthrombotic leg the corresponding figures were 53% and 40%. Nevertheless a positive correlation was found between RV of the thrombotic leg and the contralateral leg ( r = 0.33) but an even stronger correlation was found for T90 ( r = 0.74). Conclusion: Venous insufficiency was found in 60% of legs 4 years after DVT but was also found in 14% of legs without previous thrombosis. This may be caused not only by effects of the thrombosis but also by the ageing process.

Clinical profile of women with severe anaemia in the third trimester of pregnancy

2010 ◽  
Vol 40 (2) ◽  
pp. 85-86 ◽  
Author(s):  
Sharda Patra ◽  
Manju Puri ◽  
S S Trivedi ◽  
Shikha Pasrija
Keyword(s):  
Pregnant Women ◽  
Severe Anaemia ◽  
Clinical Profile ◽  
Obstetric Complications ◽  
Third Trimester ◽  
The Third ◽  
Medical Disorder

Anaemia, the most common medical disorder associated with pregnancy, is a silent killer. Most severely anaemic pregnant women are asymptomatic and present late in the third trimester with medical and obstetric complications.

scholarly journals Indeks DMF-T dan OHIS pada Ibu Hamil

2019 ◽  
Vol 1 (1) ◽  
pp. 12-22
Author(s):  
Applonia Leo Obi
Keyword(s):  
Pregnant Women ◽  
Health Center ◽  
Sampling Technique ◽  
First Trimester ◽  
Second Trimester ◽  
Third Trimester ◽  
High Prevalence ◽  
Second Trimester Pregnancy ◽  
And Behavior ◽  
Descriptive Method

Abstract: DMF-T and OHIS index for pregnant women. Pregnancy is a physiological process that causes changes in a woman's body both physically and psychologically. During pregnancy physiological changes occur which are often accompanied by changes in attitude and behavior. The health behavior of pregnant women also has a very big influence on herself and the fetus. This research is a descriptive method. This study aims to determine the rates of DMF-T and OHIS in pregnant women at Oesapa Health Center, Kupang City. Sampling by accidental sampling technique, amounting to 97 pregnant women who visited the MCH polyclinic at the Kupang Oesapa Health Center. The results based on DMF-T figures show that the high prevalence of dental caries in the second-trimester pregnant women group (36.0%) than in the third trimester of pregnancy (28.8%) while OHIS most respondents in the second-trimester pregnancy (36, 1%) had an OHI-S index in the medium category with a ratio of trimester 3 there were 23 people (23.7%) and first trimester around 19 people (19.6%). It was concluded that the DMF-T index of pregnant women in the working area of ​​the Kupang City Oesapa health center was mostly carious and most of the pregnant women examined had caries of more than 4 teeth per person and all pregnant women who were examined for dental and oral hygiene levels showed moderate criteria. Abstrak: Indeks DMF-T dan OHIS pada Ibu Hamil. Kehamilan merupakan suatu proses fisiologis yang menimbulkan perubahan pada tubuh wanita baik fisik maupun psikis. Pada masa kehamilan terjadi perubahan fisiologis yang sering disertai dengan perubahan sikap dan perilaku. perilaku  kesehatan  ibu  hamil  juga  memiliki  pengaruh yang  sangat  besar  bagi  dirinya  sendiri  dan  janin. Penelitian ini adalah metode deskriptif. Penelitian ini bertujuan untuk mengetahui  angka DMF-T dan OHIS pada ibu hamil di Puskesmas Oesapa Kota Kupang. Pengambilan sampel dengan teknik accidental sampling, berjumlah 97 ibu hamil yang berkunjung ke poli KIA di Puskesmas Oesapa Kota Kupang. Hasil penelitian berdasarkan Angka DMF-T menunjukkan bahwa tingginya prevalensi karies gigi pada kelompok ibu hamil  trimester kehamilan kedua (36,0%) dari pada trimester kehamilan ke tiga (28,8%) sedangkan OHIS sebagian besar responden pada kehamilan trimester 2 (36,1%) memiliki indek OHI-S pada kategori sedang dengan perbandingan trimester 3 ada 23 orang (23,7%) dan trimester I sekitar 19 orang (19,6%). Disimpulkan bahwa indeks DMF-T ibu hamil diwilayah kerja puskesmas Oesapa Kota Kupang sebagian besar berkaries dan sebagian besar ibu hamil yang diperiksa mempunyai karies lebih dari 4 gigi per orang dan semua ibu hamil yang diperiksa tingkat kebersihan gigi dan mulutnya menunjukkan kriteria sedang.

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