scholarly journals Clinical course and features of critical patients with COVID-19: a single-center, retrospective study from Wuhan Huoshenshan Hospital

2020 ◽  
Author(s):  
Huisi He ◽  
Zhichao Jin ◽  
Yibin Ren ◽  
Junxue Wang ◽  
Wen Wen ◽  
...  
Keyword(s):  
Troponin I ◽  
Clinical Course ◽  
Virus Disease ◽  
Case Fatality ◽  
Epidemiological Data ◽  
Health Concern ◽  
Fatality Rate ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Critical Patients

Abstract Background and Aims: The coronavirus pandemic has become a growing public health concern worldwide, and there are insufficient epidemiological data on critical illness. We sought to investigate the clinical course and features of critical patients with Corona Virus Disease 2019 (COVID-19).Method: The data on 94 critical patients from 8th February through 16th March 2020, including demographic and clinical information, were obtained from the intensive care unit (ICU) of Wuhan Huoshenshan Hospital. A cross-sectional survey and comparisons of key biomarkers between survivors and nonsurvivors were performed.Results: Over the study period, 42 nonsurvivors and 52 survivors were included. The overall case fatality rate for critical patients with COVID-19 was approximately 45%. The average age was 69.17±9.55 years, and the majority had underlying health problems such as hypertension (56[60%]) and diabetes (18[19%]). The median length of ICU stay was 8 days (IQR 4, 13). Compared with survivors, nonsurvivors were more likely to develop sepsis (42[100%] vs. 34[65%]), acute respiratory distress syndrome (40[95%] vs. 28[54%]) and organ dysfunction. In addition, the dynamic changes in some biomarkers were significantly different between the two groups. The trajectories of temperature revealed that the group with a high temperature on admission that steadily declined had the highest percentage of deaths (93.33%).Conclusion: Patients aged 60 years or older with many concomitant diseases were at highest risk, and the fatality rate started to increase with age. Lymphocyte, platelet, C-reactive protein and hypersensitivity troponin I were revealed to have potential as prognostic factors, whereas some other biomarkers, such as hepatic enzymes, may not offer additional information. Moreover, patients with high temperatures on admission should receive extra care.

scholarly journals Clinical course and features of critical patients with COVID-19: a single- center, retrospective study from Wuhan Huoshenshan Hospital

2020 ◽  
Author(s):  
Huisi He ◽  
Zhichao Jin ◽  
Yibin Ren ◽  
Junxue Wang ◽  
Wen Wen ◽  
...  
Keyword(s):  
Troponin I ◽  
Clinical Course ◽  
Virus Disease ◽  
Case Fatality ◽  
Epidemiological Data ◽  
Health Concern ◽  
Fatality Rate ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Critical Patients

Abstract Background : The coronavirus pandemic has become a growing public health concern worldwide, and there are insufficient epidemiological data on critical illness. Objective: To investigate the clinical course and features of critical patients with Corona Virus Disease 2019 ( COVID-19 ). Methods: The data on 94 consecutive critical patients from 8 th February through 16 th March 2020, including demographic and clinical information, were obtained from the intensive care unit (ICU) of Wuhan Huoshenshan Hospital. A cross-sectional survey and comparisons of key biomarkers between survivors and nonsurvivors were performed. Results: Over the study period, 42 nonsurvivors and 52 survivors were included. The overall case fatality rate for critical patients with COVID-19 was approximately 45%. The average age was 69.17±9.55 years, and the majority had underlying health problems such as hypertension (56[60%]) and diabetes (18[19%]). The median length of ICU stay was 8 days (IQR 4, 13). Compared with survivors, nonsurvivors were more likely to develop sepsis (42[100%] vs. 34[65%]), acute respiratory distress syndrome (40[95%] vs. 28[54%]) and organ dysfunction. In addition, the dynamic changes in some biomarkers were significantly different between the two groups. The trajectories of temperature revealed that the group with a high temperature on admission that steadily declined had the highest percentage of deaths (93.33%). Conclusions: Patients aged 60 years or older with many concomitant diseases were at highest risk, and the fatality rate started to increase with age. Lymphocyte, platelet, C-reactive protein and hypersensitivity troponin I were revealed to have potential as prognostic factors, whereas some other biomarkers, such as hepatic enzymes, may not offer additional information. Moreover, patients with high temperatures on admission should receive extra care.

scholarly journals Clinical Course and Features of Critical Patients with COVID-19: A Single- Center, Retrospective Study from Wuhan Huoshenshan Hospital

2020 ◽  
Author(s):  
Huisi He ◽  
Zhichao Jin ◽  
Yibin Ren ◽  
Junxue Wang ◽  
Shuzhen Chen ◽  
...  
Keyword(s):  
Clinical Course ◽  
Virus Disease ◽  
Case Fatality ◽  
Clinical Information ◽  
The Elderly ◽  
Health Concern ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Additional Information ◽  
Critical Patients

Abstract Background: Nationally, the indicators tracking the coronavirus pandemic has remained stable. However, it’s still a public health concern and it’s worth providing more front-line data on critical illness. We aim to investigate the clinical course and features of critical patients with Corona Virus Disease 2019 (COVID-19).Methods: The data on 124 consecutive critical patients from 8th February through April 16th 2020, including demographic and clinical information, were obtained from the intensive care unit (ICU) of Wuhan Huoshenshan Hospital. A cross-sectional survey and comparisons of key biomarkers between survivors and nonsurvivors were performed.Results: Over the study period, 57 nonsurvivors and 67 survivors were included. The overall case-fatality rate for critical patients with COVID-19 was approximately 46%. The overall average age was 69.89±11.03 years, and the majority had underlying health problems such as hypertension (63[51%]) and diabetes (27[22%]). Compared with survivors, nonsurvivors were more likely to develop sepsis (57[100%] vs. 34[51%]), acute respiratory distress syndrome (52[91%] vs. 21[38%]) and organ dysfunction. Besides, the dynamic changes in some biomarkers (i.e. WBC, TLC, CRP, PLT) were significantly different between the two groups. The trajectories of temperature revealed that the group with a high temperature on admission that steadily declined had the highest percentage of deaths (84.21%).Conclusions: The elderly with many concomitant diseases were at the highest risk. Lymphocyte, platelet, C-reactive protein and temperature were revealed to have potential as prognostic factors, whereas some other biomarkers, such as hepatic enzymes, may not offer additional information. Moreover, patients with high temperatures on admission should receive extra care.

scholarly journals Repeated Leftover Serosurvey of SARS-CoV-2 IgG Antibodies in Greece, May to August 2020

Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 504
Author(s):  
Zacharoula Bogogiannidou ◽  
Matthaios Speletas ◽  
Alexandros Vontas ◽  
Dimitrios J. Nikoulis ◽  
Katerina Dadouli ◽  
...  
Keyword(s):  
Urban Areas ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Cumulative Effect ◽  
Age Group ◽  
Fatality Rate ◽  
Igg Antibodies ◽  
Serum Samples ◽  
Cross Sectional Survey ◽  
Cross Sectional

A serosurvey of IgG antibodies against SARS-CoV-2 was conducted in Greece between May and August 2020. It was designed as a cross-sectional survey and was repeated at monthly intervals. The leftover sampling methodology was used and a geographically stratified sampling plan was applied. Of 20,110 serum samples collected, 89 (0.44%) were found to be positive for anti-SARS-CoV-2 antibodies, with higher seroprevalence (0.35%) observed in May 2020. The highest seroprevalence was primarily observed in the “30–49” year age group. Females presented higher seroprevalence compared to males in May 2020 (females: 0.58% VS males: 0.10%). This difference reversed during the study period and males presented a higher proportion in August 2020 (females: 0.12% VS males: 0.58%). Differences in the rate of seropositivity between urban areas and the rest of the country were also observed during the study period. The four-month infection fatality rate (IFR) was estimated to be 0.47%, while the respective case fatality rate (CFR) was at 1.89%. Our findings confirm low seroprevalence of COVID-19 in Greece during the study period. The young adults are presented as the most affected age group. The loss of the cumulative effect of seropositivity in a proportion of previous SARS-CoV-2 infections was indicated.

scholarly journals Mortality due to primary brain tumours in China and detection rate in people with suspected symptoms: a nationally representative cross-sectional survey

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Bin Jiang ◽  
Hongmei Liu ◽  
Dongling Sun ◽  
Haixin Sun ◽  
Xiaojuan Ru ◽  
...  
Keyword(s):  
Brain Tumour ◽  
Brain Tumours ◽  
Detection Rate ◽  
Epidemiological Data ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Detection Rates ◽  
Primary Brain Tumours ◽  
Symptom Screening ◽  
Nationally Representative

Abstract Background and purpose Epidemiological data on primary brain tumours (PBTs) are lacking due to the difficulty in case ascertainment among the population. Thus, we aimed to estimate mortality due to PBTs in China nationwide and the detection rate in people with suspected symptoms. Methods A multistage, complex sampling survey regarding mortality due to PBTs in Chinese individuals was carried out by reviewing all causes of death within a year. The detection rates in people with suspected symptoms were estimated based on PBT symptom screening and neurologist reviews and compared between groups by logistic regression analysis. Results Weighted mortality due to PBT was 1.6 (0.8–3.3) per 100,000 population in Chinese individuals, 1.8 (0.7–4.6) per 100,000 population in men, and 1.5 (0.5–4.5) per 100,000 population in women. Among 14,990 people with suspected symptoms, the PBT detection rate was 306.9 (95% CI 224.7–409.3) per 100,000 population in the total population, 233.0 (95% CI 135.7–373.1) per 100,000 population in men, and 376.9 (95% CI 252.4–546.3) per 100,000 population in women. People with an unsteady gait (OR 2.46; 95% CI 1.09–5.51; P=0.029), visual anomalies (3.84; 1.88–7.85; P<0.001), and headache (2.06; 1.10–3.86; P=0.023) were more likely to have a brain tumour than those without corresponding symptoms, while people with dizziness/vertigo were less likely to have a brain tumour than those without corresponding symptoms (0.45; 0.23–0.87; P=0.017). Conclusions Mortality due to PBT in China was low, with a nationwide estimate of 21,215 (10,427–43,165) deaths attributable to PBTs annually. However, the detection rate of PBTs can be greatly improved based on symptom screening in the population.

COVID-19 and health information seeking behavior: Digital health literacy survey amongst university students in Pakistan (Preprint)

2021 ◽  
Author(s):  
Rubeena Zakar ◽  
Sarosh Iqbal ◽  
Muhammad Zakria Zakar ◽  
Florian Fischer
Keyword(s):  
Health Literacy ◽  
University Students ◽  
Information Seeking ◽  
Digital Health ◽  
Relevant Information ◽  
Health Concern ◽  
Information Seeking Behavior ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Seeking Behavior

BACKGROUND Amid to the COVID-19 pandemic, digital health literacy (DHL) has become a significant public health concern. OBJECTIVE This research aims to assess information seeking behavior, as well as the ability to find relevant information and deal with DHL among university students in Pakistan. METHODS An online-based cross-sectional survey, using a web-based interviewing technique, was conducted to collect data on DHL. Simple bivariate and multivariate linear regression was performed to assess the association of key characteristics with DHL. RESULTS The results show a high DHL related to COVID-19 in 54.3% of students. Most of the Pakistani students demonstrated ~50% DHL in all dimensions, except of reliability. Multivariate findings showed that gender, sense of coherence and importance of information were found to be significantly associated with DHL. However, a negative association was observed with students’ satisfaction with information. CONCLUSIONS This led to the conclusion that critical operational and navigations skills are essential to achieve COVID-19 DHL and cope with stress, particularly to promote both personal and community health. Focused interventions and strategies should be designed to enhance DHL amongst university students to combat the pandemic.

scholarly journals Predictors of COVID-19 Fatality: A Worldwide Analysis of the Pandemic over Time and in Latin America

2022 ◽  
Author(s):  
Dayana Rojas ◽  
Jorge Saavedra ◽  
Mariya Petrova ◽  
Yue Pan ◽  
José Szapocznik
Keyword(s):  
Latin America ◽  
Latin American ◽  
Strong Association ◽  
Case Fatality ◽  
Cross Sectional Study ◽  
Fatality Rate ◽  
Cross Sectional ◽  
The Difference ◽  
Latin American Countries ◽  
Risk Ratios

AbstractSARS-CoV-2 has infected over one hundred million people worldwide and has affected Latin America particularly severely in terms of both cases and deaths. This study aims to determine the association between SARS-CoV-2 testing and COVID-19 fatality rate worldwide over 8 months and to examine how this relationship differs between Latin America and all other countries. This cross-sectional study used March 2021 data from 169 countries. Multivariate regressions predicted COVID-19 fatality (outcome) from the number of SARS-CoV-2 tests (exposure), while controlling for other predictors. Results for March 2021 were compared to results from June 2020. Additionally, results for Latin America were also compared to all other countries except Latin American for March 2021. SARS-CoV-2 testing was associated with a significant decrease in COVID-19 fatality rate in both June 2020 and March 2021 (RR = 0.92; 95% CI 0.87–0.96 and RR = 0.86; 95% CI 0.74–1.00, respectively). SARS-CoV-2 testing was associated with a significant decrease in COVID-19 fatality rate in Latin American countries but not in all other countries (RR = 0.45; 95% CI 0.23–0.89 and RR = 0.95; 95% CI 0.82–1.11, respectively). However, the difference between the risk ratios for June 2020 and March 2021 and between the risk ratios for Latin America and all other countries were not statistically significant. Increased SARS-CoV-2 testing may be a significant predictor of lower COVID-19 case fatality rate, specifically in Latin American countries, due to the existence of a strong association, which may have driven the worldwide results.

scholarly journals Public Perceptions and Attitudes of Bangladeshi Population towards Thalassemia Prevention: A Nationwide Study

2021 ◽  
Author(s):  
Nur-E- Alam ◽  
Md Shariful Islam ◽  
Umme Suriea ◽  
Ramisa Binti Mohiuddin ◽  
Md. Muzahidul Islam ◽  
...  
Keyword(s):  
Transmitted Disease ◽  
Knowledge Score ◽  
Health Concern ◽  
P Value ◽  
Cross Sectional Survey ◽  
Chi Square ◽  
Cross Sectional ◽  
Premarital Screening ◽  
Knowledge And Attitude ◽  
Bangladeshi Population

Abstract Background: Thalassemia is one of the most common life-threatening yet preventable congenital hemoglobin disorders especially in South Asian regions like Bangladesh. It has become a rising public health concern for Bangladesh as 6-12% of the population are carriers and many of them are unaware of it. The purpose of the study is to inspect the knowledge and attitude towards thalassemia among the general people of Bangladesh. Methods: A cross-sectional survey was conducted in eight administrative regions of Bangladesh between January and October of 2020. A self-administrative close-ended questionnaire was designed to collect information about thalassemia and socio-demographic characteristics. Pearson’s chi-square (χ2) test and One-way ANOVA were performed to assess the association between the demographic variables with knowledge and practice regarding thalassemia. A p-value <0.05 was considered significant.Results: Of the 1623 participants, only 44.7% (726/1623) had heard of thalassemia. The mean knowledge of thalassemia was scored 4.75 ± 2.05 out of a total possible score of 10. Half of the participants had no idea that thalassemia was not a transfusion transmitted disease. About 73.1% knew that blood tests are a diagnosis process to determine thalassemia. The urban residing participants had the highest (5.10 ± 1.99) and participants with primary education had the lowest (3.38 ± 1.37) mean score of knowledge. Participants' knowledge score varied significantly by marital status, living pace, literacy and occupation (p< 0.05). However, about 68.2% and 85.5% of the participants showed a positive attitude towards premarital screening of themselves or their family members and donating blood to thalassemia patients, respectively. Conclusion: The study shows that there is a need to disseminate the information on thalassemia since the knowledge gap is huge among people. These findings will assist the implementation of significant steps such as educational programs, health counseling, premarital screening, campaigning, etc. to increase the awareness of thalassemia.

scholarly journals Sebaran Infeksi Leptospira Patogenik pada Tikus dan Cecurut di Daerah Pasca Banjir Kabupaten Pati dan Endemis Boyolali

2018 ◽  
pp. 173-182
Author(s):  
Zumrotus Sholichah ◽  
Rahmawati Rahmawati
Keyword(s):  
Case Fatality Rate ◽  
Endemic Area ◽  
Case Fatality ◽  
Google Earth ◽  
Transmission Risk ◽  
Random Pattern ◽  
Fatality Rate ◽  
Pathogenic Leptospira ◽  
Cross Sectional ◽  
Cross Sectional Design

Until March 2014 leptospirosis cases and its Case Fatality Rate increased in Pati and Boyolali. This study aims to describe distribution of infected rats and shrews in flood area in Pati and endemic area in Boyolali. Research carried out by the cross sectional design on March-April 2014. Coordinate of Leptospira infected rats and shrews were mapped using google earth with home range buffer. Data analyzed descriptively to describe distribution of infected rats and shrews. Pathogenic Leptospira sp. infected rats and shrews spread with random pattern. This results could be an explanation of higher transmission risk. of leptospirosis in the area of study

scholarly journals Epidemiology of traumatic injuries to the permanant incisors of 9-12-years-old school children in Damascus, Syria

2001 ◽  
Vol 7 (1-2) ◽  
pp. 291-301
Author(s):  
N. Al Beiruti ◽  
W. Marcenes ◽  
D. Tayfour ◽  
S. Issa
Keyword(s):  
Primary Schools ◽  
Traffic Accidents ◽  
Public Health Problem ◽  
Epidemiological Data ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Public And Private ◽  
Traumatic Injuries ◽  
The Difference ◽  
Dental Injuries

This cross-sectional survey was carried out to assess epidemiological data concerning dental injuries to the permanent incisors of Syrian children. It included 1087 children aged 9 to 12 years, of both sexes, randomly selected from public and private primary schools in Damascus. The response rate was 100%. The prevalence of traumatic injuries to the permanent incisors rose from 5.2% at the age of 9 years to 11.7% at the age of 12 years [P = 0.007]. The difference in prevalence between boys and girls was not statistically significant [P > 0.05]. The majority [59.8%] of children who had experienced injuries to the permanent incisors reported that they were not taken to the dentist for evaluation or treatment of the damage. Among those children who had experienced traumatic injuries to the teeth 93.1% presented with untreated damage. Because some injuries were minor, such as small enamel fractures, the proportion of children who needed treatment was 63.2%. There was a tendency for children with an incisal overjet greater than 5 mm to have experienced dental injuries [P = 0.06]. Children with inadequate lip covcmgc were more likely to have experienced dental injuries than those with adequate lip coverage [P = 0.000]. The most common reported cause of iniuries to the permanent incisors was violence [42.5%], followed by traffic accidents [24.1%] collisions with people or inanimate objects [16.0%] and falls [9.1%]. In conclusion, traumatic dental injury may pose a serious dental public health problem.

scholarly journals Prevalence and Associated Factors of Hypertension Among Adults living in the City of Bandundu, Republic Democratic Republic of the Congo. A Population-Based Cross-Sectional Study.

2021 ◽  
Author(s):  
Ferdinand Mukoso ◽  
Aliocha Nkodila ◽  
François Lepira ◽  
Pascal Bayauli ◽  
Yves Lubenga ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Sleep Duration ◽  
Subclinical Atherosclerosis ◽  
Statistical Significance ◽  
Epidemiological Data ◽  
Cluster Sampling ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Factors Associated

Abstract Background and aim: In limited resource settings, reliable epidemiological data generated from hypertension high risk geographical areas or people is a prerequisite for the planning of proven and effective interventions. The aim of the present survey was to assess the prevalence, awareness, control and factors associated with hypertension in adults living in the port City of Bandundu, located in the southwestern part of DRC.Methods: a cross-sectional survey using a modified WHO STEPwise questionnaire for data collection during face-to face interviews was conducted from 1st May to 30th October 2018. A multistage cluster sampling method was used and inclusion criteria were age ≥18 years and informed consent. Information on demographic parameters, behavioral lifestyles, anthropometric and blood pressure (BP) measurements was obtained. Hypertension was defined as an average of two BP ≥ 140/90 mmHg or self-reported history of antihypertensive medication use. Independent factors associated with hypertension were identified using logistic regression analysis. P<0.05 defined the level of statistical significance. Results: The prevalence of hypertension was 34,5% (Women 36,6 %). Older age (p<0.001), subclinical atherosclerosis (p= 0.021), sleep duration <8 hours (p<0.002), diabetes mellitus (p<0.001), and obesity (p= 0.009) emerged as main cardiovascular risk factors associated with hypertension.Conclusion: Hypertension was characterized by a high prevalence, low rate of awareness and suboptimal BP control, high cardiovascular risk and associated sleep duration and obesity as modifiable risk factors.

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