scholarly journals Radiological changes of serial CT examinations in patients recovering from coronavirus disease 2019 (COVID-19)

2020 ◽  
Author(s):  
Qian Xu ◽  
Lin Shi ◽  
Mengshuang Li ◽  
Lina Dong ◽  
Lulu Cai ◽  
...  
Keyword(s):  
Early Stage ◽  
Ground Glass Opacity ◽  
Ct Imaging ◽  
Imaging Characteristics ◽  
Third Stage ◽  
Three Stages ◽  
Common Sign ◽  
Different Characteristics ◽  
Progressive Stage ◽  
Pulmonary Ct

Abstract Purpose: To find the pulmonary CT imaging characteristics in patients recovering from coronavirus disease 2019 (COVID-19).Method: Twenty patients with confirmed COVID-19 were enrolled. We analyzed the changes of four pulmonary CT imaging manifestations (ground glass opacity, consolidation, crazy paving sign and cord/band sign) in patients during hospitalization. The disease course was divided into four stages: early stage (0-4 days), progressive stage (5-8 days), peak stage (9-13 days) and absorption stage (≥14 days).Results: There were 12 male and 8 female with an average age of 45±16 years. In the first three stages, GGO was the most common sign on CT imaging. Then, the proportion of GGO decreased in the absorption stage compared with the first three stages (P<0.05). The proportion of crazy paving sign peaked in the progressive stage and then declined, with statistical difference between the progressive stage and the absorption stage (P<0.05). Cord/band sign was increasing from the early stage to the absorption stage, and statistical differences were found between the early stage and the peak stage (P<0.05), as well as the absorption stage and the first three stages (P<0.05). No statistical differences of consolidation proportion were found among the four stages.Conclusions: CT imaging showed different characteristics during the four stages. The proportion of cord/band sign significantly increased in the third stage, which might be an indicator of COVID-19 improvement.

scholarly journals CT Imaging Features During Disease Progression of 2019 Novel Coronavirus (COVID-19) Pneumonia

2020 ◽  
Vol 17 (4) ◽  
Author(s):  
Nan Yu ◽  
Yong Yu ◽  
Shubo Cai ◽  
Cong Shen ◽  
Youmin Guo
Keyword(s):  
Disease Progression ◽  
Symptom Onset ◽  
Early Stage ◽  
Ground Glass Opacity ◽  
Ct Imaging ◽  
Imaging Features ◽  
Imaging Characteristics ◽  
Novel Coronavirus ◽  
Stage 1

Objectives: To describe the characteristics of computed tomography (CT) in patients with 2019 novel coronavirus (COVID-19) pneumonia and their changes during disease progression. Patients and Methods: A total of 96 chest CT scans of 61 pneumonia patients associated with COVID-19 were reviewed to identify CT features associated with the time of symptom onset and the evolution of disease. Results: The initial CTs of 61 patients were obtained during 1 to 11 days after the onset. The main CT pattern of initial CT obtained during 1 - 3 days after the symptom onset was single (7/23, 35%) or multiple ground-glass opacity (GGO, 8/23, 35%). At 4 - 7 days after the symptom onset, the main imaging features were crazy paving GGO mixed with partial consolidation pattern (15/32, 47%). At 8 - 11 days after the symptom onset, the CT images showed consolidation pattern (3/6, 50%). A total of 35 follow up CTs were collected. The mean interval time between each follow up CT was 3 ± 2 days. The CT patterns also changed with the evolution of the disease: the features of GGO manifested at the early stage (1 - 3d). The crazy paving GGO pattern, consolidation pattern and mixed with partial consolidation pattern were found 4 to 14 days after the onset. In the absorption stage (15 - 24d), both density and extent of lesions were reduced. Conclusion: The CT imaging features are associated with the time of symptom onset and evolution of disease. Understanding the imaging characteristics of each stage is very helpful for understanding the development of disease.

Dynamic Imaging Changes of COVID-19 Pneumonia at Different Stages

2021 ◽  
Vol 17 ◽  
Author(s):  
Xiao-Yan Lv ◽  
Wei-Hong Xing ◽  
Xi Ma ◽  
Li-Hong Xing ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Early Stage ◽  
Disease Onset ◽  
Ground Glass Opacity ◽  
Dynamic Imaging ◽  
Ct Scans ◽  
Ground Glass ◽  
Early Improvement ◽  
Imaging Characteristics ◽  
Progressive Stage

Purpose: To investigate the Computed Tomography (CT) imaging characteristics and dynamic changes of COVID-19 pneumonia at different stages. Methods: Forty-six patients infected with COVID-19 who had chest CT scans were enrolled, and CT scans were performed 4-6 times with an interval of 2-5 days. Results: At the early stage (n=25), ground glass opacity was presented in 11 patients (11/25 or 44.0%) and ground glass opacity mixed with consolidation in 13 (13/25 or 52.0%) in the lung CT images. At the progressive stage (n=38), ground glass opacity was presented in only one patient (1/38 or 2.6%) and ground glass opacity mixed with consolidation in 33 (33/38 or 86.8%). In the early improvement stage (n=38), the imaging presentation was ground glass opacity alone in three patients (3/38 or 7.9%) and ground glass opacity mixed with consolidation in 34 (34/38 or 89.5%). In the late improvement (absorption) stage (n=33), the primary imaging presentation was ground glass presentation in eight patients (8/33 or 24.2%) and ground glass opacity mixed with consolidation in 23 (23/33 or 69.7%). The lesion reached the peak at 4-16 days after disease onset, and 26 (26/38 or 68.4%) patients reached the disease peak within ten days. Starting from 6 to 20 days after onset, the disease began to be improved, with 30 (30/38 or 78.9%) patients being improved within 15 days. Conclusion: COVID-19 pneumonia will progress to the peak stage at a mediate time of seven days and enter the improvement stage at twelve days. Computed tomography imaging of the pulmonary lesion has a common pattern from disease onset to improvement and recovery and provides important information for evaluation of the disease course and treatment effect.

The Accommodation Reflex (Pupillary) studied in the same Patients during the Three Stages of General Paralysis [Ze réxe accommodateur étudié chez les mêmes malades aux trois périodes de la paralysie générale]. (Rev. de Psychiat., No. 6, Juin, 1902.) Marandon de Montyel

1903 ◽  
Vol 49 (204) ◽  
pp. 177-178
Author(s):  
H. J. Macevoy
Keyword(s):  
Early Stage ◽  
Rapid Evolution ◽  
Motor Power ◽  
General Paralysis ◽  
Second Stage ◽  
The Third ◽  
Third Stage ◽  
Three Stages ◽  
Two Stages ◽  
Two Sides

Dr. de Montyel gives the results of his investigations on the sixth of the reflexes which he undertook to study in general paralysis. The discrepancies noticed in the conclusions of many other observers are attributed to their studying patients in various stages; in all researches of this nature it is indispensable to follow the only method susceptible of furnishing data which may be compared with one another,—that is, following up and examining the same patients from the onset to the termination of the disease. Out of 104 cases of general paralysis this method was satisfactorily carried out in the case of thirty only, the others having succumbed either in the first or second stage; 680 satisfactory observations were made, and the results of these are carefully tabulated. The following are some of the author's general conclusions:—Accommodation is more often abnormal than normal in general paralysis; exaggeration of the reflex is rare; diminution is twenty-four times more frequent—abolition being slightly more common than simple diminution. The reaction is nearly always equal on the two sides; in a few rare cases one finds normal accommodation on one side and abolition on the other. In the early stage only does one find normal accommodation more frequent than abnormal; but in the second, and more so in the third stage, abnormality is the rule. Abolition is commoner in the late stage. In more than a third of the remissions there was abnormality. Certain differences in the accommodation reflex are found in the various forms of the disease; it is more often and more profoundly altered with conditions of excitement. As regards the ætiology the reflex was always found abnormal in traumatic general paralysis; next in frequency (i. e. after abnormality of reflex) comes the alcoholic form. Alteration of the reflex is common with cases at the extreme ages of incidence of the disease (after fifty and below thirty). Accommodation was more often and more profoundly affected in the first two stages of general paralysis in proportion to the impairment of motor power. The investigation of the accommodation reflex on account of its frequent and early alterations may be helpful in the diagnosis of doubtful cases, but it affords no indication as to the slow or rapid evolution of the disease. H. J. Macevoy.

scholarly journals Clinical manifestations, CT features and outcome of 39 patients with COVID-19: retrospective case analysis

2020 ◽  
Author(s):  
Haohao Lu ◽  
Chuansheng Zheng ◽  
Qiaoxia Tong ◽  
Jin Tian
Keyword(s):  
Early Stage ◽  
Clinical Manifestations ◽  
Ground Glass Opacity ◽  
Ground Glass ◽  
Rt Pcr ◽  
Retrospective Case ◽  
Recovery Stage ◽  
Discharged Patients ◽  
D Dimer ◽  
Pulmonary Ct

Abstract 1. BackgroundTo explore the manifestations and evolution of the pulmonary CT in COVID-19, and to analyze the causes and countermeasures of “Recurrent positive” in discharged patients.2. MethodsData of 39 patients with COVID-19 were collected. RT-PCR was positive at admission.From onset to discharge, pulmonary CT was performed regularly.During the treatment,Blood-RT,CRP and D-dimer were detected.3.ResultFrom the onset to 14 days, the lesions in pulmonary CT increased significantly.After treatment, pulmonary CT before discharge showed that some patients' lesions were completely absorbed, and some residual strip like lesions or ground glass opacity with reduced density.Two weeks after discharge, there were 2 patients with new ground glass opacity.There were 20 patients with D-dimer increased.4.ConclusionIn the early stage of COVID-19, the pulmonary CT has the characteristic manifestations, which is helpful for early diagnosis.In the middle stage, pulmonary lesions changed rapidly.In the recovery stage, some of the patients remained strip like lesions.It is necessary to pay attention to the possibility of pulmonary fibrosis after recovery.The discharge standard of COVID-19 needs to be more strict to avoid “Recurrent positive”,the discharged patients should continue to be observed.D-dimer was increased in some patients, it is safe to use heparin in anticoagulation without contraindications.

The Coherence of Mary Barton: Romance, Realism, and Utopia

2015 ◽  
Vol 5 (3) ◽  
pp. 185-200
Author(s):  
Robert Z. Birdwell
Keyword(s):  
Thomas Carlyle ◽  
The Novel ◽  
Second Stage ◽  
The Third ◽  
Third Stage ◽  
Three Stages ◽  
Mode Of Production

Critics have argued that Elizabeth Gaskell's first novel, Mary Barton (1848), is split by a conflict between the modes of realism and romance. But the conflict does not render the novel incoherent, because Gaskell surpasses both modes through a utopian narrative that breaks with the conflict of form and gives coherence to the whole novel. Gaskell not only depicts what Thomas Carlyle called the ‘Condition of England’ in her work but also develops, through three stages, the utopia that will redeem this condition. The first stage is romantic nostalgia, a backward glance at Eden from the countryside surrounding Manchester. The second stage occurs in Manchester, as Gaskell mixes romance with a realistic mode, tracing a utopian drive toward death. The third stage is the utopian break with romantic and realistic accounts of the Condition of England and with the inadequate preceding conceptions of utopia. This third stage transforms narrative modes and figures a new mode of production.

scholarly journals Chest computed tomography imaging features in patients with coronavirus disease 2019 (COVID-19)

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110106
Author(s):  
Hoda Salah Darwish ◽  
Mohamed Yasser Habash ◽  
Waleed Yasser Habash
Keyword(s):  
Computed Tomography ◽  
Intermediate Phase ◽  
Early Stage ◽  
Lower Lobe ◽  
Ground Glass Opacity ◽  
Intermediate Stage ◽  
Mediastinal Lymphadenopathy ◽  
Imaging Features ◽  
Stage Disease ◽  
Bilateral Lesions

Objective To analyze computed tomography (CT) features of symptomatic patients with coronavirus disease 2019 (COVID-19). Methods Ninety-five symptomatic patients with COVID-19 confirmed by reverse-transcription polymerase chain reaction from 1 May to 14 July 2020 were retrospectively enrolled. Follow-up CT findings and their distributions were analyzed and compared from symptom onset to late-stage disease. Results Among all patients, 15.8% had unilateral lung disease and 84.2% had bilateral disease with slight right lower lobe predilection (47.4%). Regarding lesion density, 49.4% of patients had pure ground glass opacity (GGO) and 50.5% had GGO with consolidation. Typical early-stage patterns were bilateral lesions in 73.6% of patients, diffuse lesions (41.0%), and GGO (65.2%). Pleural effusion occurred in 13.6% and mediastinal lymphadenopathy in 11.5%. During intermediate-stage disease, 47.4% of patients showed GGO as the disease progressed; however, consolidation was the predominant finding (52.6%). Conclusion COVID-19 pneumonia manifested on lung CT scans with bilateral, peripheral, and right lower lobe predominance and was characterized by diffuse bilateral GGO progressing to or coexisting with consolidation within 1 to 3 weeks. The most frequent CT lesion in the early, intermediate, and late phases was GGO. Consolidation appeared in the intermediate phase and gradually increased, ending with reticular and lung fibrosis-like patterns.

scholarly journals Early CT features of COVID-19 pneumonia, association with patients’ age and duration of presenting complaint

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Reem M. EL Kady ◽  
Hosam A. Hassan ◽  
Tareef S. Daqqaq ◽  
Rania Makboul ◽  
Hanan Mosleh Ibrahim
Keyword(s):  
Pleural Effusion ◽  
Ground Glass Opacity ◽  
Ct Imaging ◽  
Older Age ◽  
Ground Glass ◽  
Imaging Features ◽  
Age Group ◽  
Patient Age ◽  
Atypical Features ◽  
Patient Âgé

Abstract Background Coronavirus disease (COVID-19) is a respiratory syndrome with a variable degree of severity. Imaging is a vital component of disease monitoring and follow-up in coronavirus pulmonary syndromes. The study of temporal changes of CT findings of COVID-19 pneumonia can help in better understanding of disease pathogenesis and prediction of disease prognosis. In this study, we aim to determine the typical and atypical CT imaging features of COVID-19 and discuss the association of typical CT imaging features with the duration of the presenting complaint and patients’ age. Results The lesions showed unilateral distribution in 20% of cases and bilateral distribution in 80% of cases. The lesions involved the lower lung lobes in 30% of cases and showed diffuse involvement in 58.2% of cases. The lesions showed peripheral distribution in 74.5% of cases. The most common pattern was multifocal ground glass opacity found in 72.7% of cases. Atypical features like cavitation and pleural effusion can occur early in the disease course. There was significant association between increased number of the lesions, bilaterality, diffuse pattern of lung involvement and older age group (≥ 50 years old) and increased duration of presenting complaint (≥ 4 days). There was significant association between crazy-paving pattern and increased duration of presenting complaint. No significant association could be detected between any CT pattern and increased patient age. Conclusion The most common CT feature of COVID-19 was multifocal ground glass opacity. Atypical features like cavitation and pleural effusion can occur early in the course of the disease. Our cases showed more extensive lesions with bilateral and diffuse patterns of distribution in the older age group and with increased duration of presenting complaint. There was a significant association between crazy-paving pattern and increased duration of presenting complaint. No significant association could be detected between any CT pattern and increased patient age.

scholarly journals Clinical characteristics and outcomes of COVID-19 long-term nucleic acid positive patients

2021 ◽  
pp. 1-10
Author(s):  
Xuan Zhu ◽  
Xinxin Zhu ◽  
Min Wang ◽  
Fang Yang ◽  
Zhibing Sun ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Clinical Characteristics ◽  
Clinical Symptoms ◽  
Control Group ◽  
Viral Shedding ◽  
Imaging Characteristics ◽  
And Gender ◽  
Acid Test ◽  
Pulmonary Ct

OBJECTIVE: This study aimed to investigate the clinical characteristics and outcomes of coronavirus disease-19 (COVID-19) long-term nucleic acid positive patients (hereinafter referred to as CLTAPs). METHODS: Patients were recruited from the Xiaogan Central Hospital between 16 January 2020 and 28 March 2020. Among the 562 cases of patients with laboratory-identified COVID-19 infection by real-time polymerase chain reaction (qtPCR), 19 cases of COVID-19 patients with more than 41 days from the first to the last time of nucleic acid test were selected as the study group, and 76 cases of age- and gender-matched COVID-19 patients were selected as the control group (hereinafter referred to as C-CLTAPs). Demographic characteristics, clinical symptoms, laboratory examination and computed tomography (CT) imaging characteristics were retrospectively analyzed. RESULTS: On admission, among the 562 cases of patients with COVID-19, there were 398 cases of ordinary COVID-19 patients, 99 cases of severe COVID-19 patients and 99 cases of critical COVID-19 patients. CLTAPs had milder clinical symptoms and longer viral shedding time in comparison to C-CLTAPs. Compared to C-CLTAPs, CLTAPs had a lower infection index at admission. CLTAPs used less oxygen therapy and a higher proportion of hydroxychloroquine treatment in comparison to C-CLTAPs. In comparison to C-CLTAPs, CLTAPs showed slower pulmonary CT progression and faster pulmonary CT absorption. CONCLUSION: In this study, out of the 562 cases, we found 19 CLTAPs. The clinical differences between CLTAPs and C-CLTAPs were compared and analyzed. We hope that these finding can provide a theoretical basis for the treatment of CLTAPs.

Assessing Weight Conservation Non-Verbally: The Problem of Conceptualization among African Children

1981 ◽  
Vol 49 (3) ◽  
pp. 851-855
Author(s):  
Bernice N. Ezeilo
Keyword(s):  
Cognitive Processes ◽  
Deaf Children ◽  
Weight Discrimination ◽  
Horizontal Movement ◽  
Clinical Method ◽  
African Children ◽  
Third Stage ◽  
Three Stages ◽  
Effective Use ◽  
World Environment

This study examined the criteria used by 138 Zambian children in their responses to Furth's non-verbal weight conservation test via posttest interviews. Thirty seven and seven tenths percent of the children responded by weight, 29% by size, 4.4% by size and weight, and 1.4% by size and shape. Others either did not respond at all or gave other nonrelevant responses. Of the conservers, 46% responded by weight while 53% responded by nonweight criteria. The remaining 1% gave nonrelevant responses. All were expected to respond by weight alone. These results raise some doubt about the validity of evidence for weight conservation among African children, based on Furth's non-verbal technique. To improve communication of the weight concept, it is recommended that this test be modified to include a pretraining in size-weight discrimination. A major obstacle to the effective use of the clinical method, by the non-indigenous, for the study of cognitive processes in Third World environment is the problem of verbal communication, so attempts are made to use non-verbal methods. One such attempt was made by Heron and Simonsson (3) who used Furth's non-verbal conservation test to study weight conservation by Zambian children. Furth (2) developed this technique for studying weight conservation of deaf children. It involves essentially three stages. The first requires practice with weights of different sizes. Second, there is practice with obviously equal and obviously unequal balls of plasticine. The third stage is the test. The two practice stages were to ensure that the children had fully understood that same weight was indicated by a horizontal movement of both hands simultaneously and that a judgment of heavier must be communicated by allowing the hand to fall sharply on the table.

scholarly journals A case study on the observability of cutting fluid flow and the associated contact mechanics in scaled rough surfaces

2021 ◽  
Vol 3 (5) ◽  
Author(s):  
Michael Müller ◽  
Lukas Stahl ◽  
Robar Arafat ◽  
Nadine Madanchi ◽  
Christoph Herrmann
Keyword(s):  
Fluid Flow ◽  
Contact Mechanics ◽  
Early Stage ◽  
Cutting Fluid ◽  
Cutting Fluids ◽  
Friction Behavior ◽  
Two Fluids ◽  
Grinding Processes ◽  
Different Characteristics ◽  
Tool Cutting

AbstractIn grinding processes, heat is generated by the contact of the grains with the workpiece. In order to reduce damages on the workpiece and the grinding tool, cutting fluids are necessary for most grinding processes. They have the tasks of cooling and lubricating the contact zone and to remove the chips from the contact area. Different types of cutting fluids perform differently regarding these tasks, which can be investigated on a laboratory scale. However, the results of those experiments are limited to certain workpieces and processes and information about the contact mechanics are not available. The experimental investigation of contact mechanics under cutting fluid influence is hardly possible. For this reason, this paper uses a measurement strategy that uses scaled topographies and has already been successfully applied to contact mechanics problems. With such a setup, it is intended that at an early stage in the development of cutting fluids, their characteristics in terms of contact mechanics can be determined very efficiently. To demonstrate this approach, two different cutting fluids were tested with the help of the associated test rig—a water miscible emulsion and a non-water miscible grinding oil. The two fluids showed fundamentally different characteristics regarding their hydrodynamic load bearing effect, their influence on the friction behavior of the contact and their fluid flow in the gap. The properties analyzed here correspond to the practical application of cutting fluids. The results underline the potential of the presented setup for an integration into the development process of cutting fluids.

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