scholarly journals Presepsin as a predictor of severe sepsis in urinary tract infection

2021 ◽  
Author(s):  
Yoshitaka Sekine ◽  
Kazuhiko Kotani ◽  
Daisuke Oka ◽  
Hiroshi Nakayama ◽  
Yoshiyuki Miyazawa ◽  
...  
Keyword(s):  
Septic Shock ◽  
Risk Factor ◽  
Severe Sepsis ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Roc Curve ◽  
Independent Risk Factor ◽  
Good Marker ◽  
Significant Difference ◽  
Tract Infections

Abstract Background Recently, presepsin is reported to be a biomarker for early diagnosis of sepsis and evaluation of prognosis in septic patients, but there are few reports about urinary-tract infections. The objective of this study is to evaluate whether presepsin is a recent marker for detecting severe sepsis, and whether it can predict the therapeutic course in UTI when compared with procalcitonin (PCT) and C-reactive protein (CRP), already used markers.Methods From April 2014 to December 2016, a total of 50 patients, who were admitted into Gunma university hospital with urinary-tract infections, were enrolled in this study. Vital signs, presepsin, PCT, CRP, white blood cell (WBC), causative diseases of urinary-tract infections and other data were evaluated at the enrollment, third and fifth days. The patients were divided into two groups; with (n=11) or without (n=39) septic shock at the enrollment day, and with (n=7) or without (n=43) sepsis at the fifth day, respectively. Presepsin was evaluated for systemic inflammatory response syndrome (SIRS) or septic shock. Results Concerning the enrollment day, there was no significant difference of presepsin between SIRS and non-SIRS groups (p=0.276). The median presepsin (pg/mL) was significantly higher in the septic shock group (p<0.001). Multivariate logistic regression analysis showed presepsin (≧ 500 pg/ml) was an independent risk factor associated with septic shock (p=0.007). ROC curve for diagnosing septic shock indicated an area under the curve (AUC) at 0.881 for presepsin (vs. 0.690, 0.583 and 0.527 for PCT, CRP and WBC, respectively). Concerning the 5th day after admission, the median presepsin of the enrollment day was significantly higher in SIRS groups than non-SIRS groups (p=0.006). On the other hand, PCT (≥ 2 ng/ml) of the enrollment day was an independent risk factor associated with SIRS. ROC curve for diagnosing sepsis at the fifth day indicated an AUC at 0.837 for PCT (vs. 0.817, 0.811 and 0.802 for presepsin, CRP and WBC, respectively).Conclusions This study shows that presepsin may be a good marker for diagnosis of severe patients who need vasopressor therapy at the data of admission, and PCT may be a good marker for predicting hard-to-treat cases in UTI.

scholarly journals Presepsin as a predictor of septic shock in patients with urinary tract infection

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yoshitaka Sekine ◽  
Kazuhiko Kotani ◽  
Daisuke Oka ◽  
Hiroshi Nakayama ◽  
Yoshiyuki Miyazawa ◽  
...  
Keyword(s):  
Septic Shock ◽  
Risk Factor ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Roc Curve ◽  
Independent Risk Factor ◽  
Multivariate Logistic Regression Analysis ◽  
University Hospital ◽  
Significant Difference ◽  
Tract Infections

Abstract Background Recently, presepsin has been reported to be a useful biomarker for early diagnosis of sepsis and evaluation of prognosis in septic patients. However, few reports have evaluated its usefulness in patients with urinary tract infections (UTI). This study aimed to evaluate whether presepsin could be a valuable marker for detecting severe sepsis, and whether it could predict the therapeutic course in patients with UTI compared with markers already used: procalcitonin (PCT) and C-reactive protein (CRP). Methods From April 2014 to December 2016, a total of 50 patients with urinary tract infections admitted to Gunma university hospital were enrolled in this study. Vital signs, presepsin, PCT, CRP, white blood cell (WBC) count, causative agents of urinary-tract infections, and other data were evaluated on the enrollment, third, and fifth days. The patients were divided into two groups: with (n = 11) or without (n = 39) septic shock on the enrollment day, and with (n = 7) or without (n = 43) sepsis on the fifth day, respectively. Presepsin was evaluated as a biomarker for systemic inflammatory response syndrome (SIRS) or septic shock. Results Regarding the enrollment day, there was no significant difference of presepsin between the SIRS and non-SIRS groups (p = 0.276). The median value of presepsin (pg/mL) was significantly higher in the septic shock group (p < 0.001). Multivariate logistic regression analysis showed that presepsin (≥ 500 pg/ml) was an independent risk factor for septic shock (p = 0.007). ROC curve for diagnosing septic shock indicated an area under the curve (AUC) of 0.881 for presepsin (vs. 0.690, 0.583, and 0.527 for PCT, CRP and WBC, respectively). Regarding the 5th day after admission, the median presepsin value on the enrollment day was significantly higher in the SIRS groups than in the non-SIRS groups (p = 0.006). On the other hand, PCT (≥ 2 ng/ml) on the enrollment day was an independent risk factor for SIRS. ROC curve for diagnosing sepsis on the fifth day indicated an AUC of 0.837 for PCT (vs. 0.817, 0.811, and 0.802 for presepsin, CRP, and WBC, respectively). Conclusions This study showed that presepsin may be a good marker for diagnosing septic shock based on admission data in patients with UTI.

scholarly journals Vitamin D Deficiency Is an Independent Risk Factor for Urinary Tract Infections After Renal Transplants

Medicine ◽  
2015 ◽  
Vol 94 (9) ◽  
pp. e594 ◽  
Author(s):  
Young Eun Kwon ◽  
Hyunwook Kim ◽  
Hyung Jung Oh ◽  
Jung Tak Park ◽  
Seung Hyeok Han ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Urinary Tract ◽  
Vitamin D Deficiency ◽  
Urinary Tract Infections ◽  
Independent Risk Factor ◽  
Renal Transplants ◽  
Tract Infections

FP867VITAMIN D DEFICIENCY IS AN INDEPENDENT RISK FACTOR FOR URINARY TRACT INFECTIONS AFTER RENAL TRANSPLANTS

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii367-iii367
Author(s):  
In Mee Han ◽  
Geun Woo Ryu ◽  
Jong Hyun Jhee ◽  
Hyung Woo Kim ◽  
Sul A Lee ◽  
...  
Keyword(s):  
Risk Factor ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Independent Risk Factor ◽  
Renal Transplants ◽  
Tract Infections

scholarly journals Oral D mannose in the prevention and treatment of recurrent urinary tract infections: A review

2021 ◽  
Vol 33 (1) ◽  
Author(s):  
Daniele Porru ◽  
Annalisa De Silvestri ◽  
Edda Buffa ◽  
Catherine Klersy ◽  
Barbara Gardella ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Antibiotic Prophylaxis ◽  
Urinary Tract Infections ◽  
Resistant Bacteria ◽  
Control Groups ◽  
Recurrent Utis ◽  
Recurrent Urinary Tract Infections ◽  
Long Term Treatment ◽  
Significant Difference ◽  
Tract Infections

The results of several studies reveal that antibiotics may promote treatment resistance by causing alterations in the intestinal flora. The development of a gut reservoir of resistant bacteria promotes the development of UTIs through autoinfection. This review aims to address clinical reliability, efficacy and safety of long-term treatment with oral D mannose for the prevention of Recurrent Urinary Tract Infections (RUTI) in females. A comprehensive MEDLINE, Embase, Scopus and Cochrane search was performed for English language reports published before December 2018 using the term “recurrent urinary tract infections and D mannose” was carried out. We searched Medline, Embase, Scopus and the Cochrane Register of Controlled Trials from January 2010 to December 2018. Eligible studies did not include non-oral therapy, local (vaginal) treatment in women with recurrent UTIs. We identified eligible original articles. A few limitations of the review are the heterogeneity of the available studies, their different rational and aim, the assumption of D mannose for prophylaxis or treatment of recurrent UTIs. Oral D mannose performs well in the prevention of UTIs recurrences, significant improvement of urinary symptoms was observed, the disease- free time was longer in the groups of patients under prophylaxis with D mannose in comparison with control groups (no treatment, antibiotic prophylaxis, prophylaxis with Proanthocyanidin (PAC) etc. The review has limitations, as the studies are heterogeneous, the meta-analysis requires classifications that can also be arbitrary. Furthermore, single-arm studies are not included. Some of the authors found this evidence inconclusive, which results as a limitation of the study. D mannose prolonged the recurrence-free interval of recurrent UTIs, thus reducing the prolonged or cyclical use of antibiotics, improving clinical symptoms, with a significant difference between treatment and control groups (no treatment, antibiotic prophylaxis, prophylaxis with Proanthocyanidin). However, most clinical trials used an association of different substances commingled with D mannose, dosages and regimens of D mannose were different. For this reason, the evidence of the efficacy of D mannose remains low.

Intestinal microbiome as a risk factor for urinary tract infections in children

2018 ◽  
Vol 37 (10) ◽  
pp. 1881-1891 ◽  
Author(s):  
Niko Paalanne ◽  
Aleksi Husso ◽  
Jarmo Salo ◽  
Oskari Pieviläinen ◽  
Mysore V. Tejesvi ◽  
...  
Keyword(s):  
Risk Factor ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Intestinal Microbiome ◽  
Tract Infections

High incidence of urinary tract infections after photoselective laser vaporisation of the prostate: a risk factor analysis of 665 patients

2019 ◽  
Vol 38 (7) ◽  
pp. 1787-1794
Author(s):  
Kathrin Bausch ◽  
Jürg Motzer ◽  
Jan A. Roth ◽  
Marc Dangel ◽  
Hans-Helge Seifert ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Risk Factor ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Risk Factor Analysis ◽  
High Incidence ◽  
Tract Infections ◽  
Laser Vaporisation

scholarly journals Prevention of Recurrent Urinary Tract Infections in Postmenopausal Women

2014 ◽  
pp. 55-60
Author(s):  
Darrell Fernando ◽  
Budi I Santoso
Keyword(s):  
Systematic Review ◽  
Urinary Tract ◽  
Postmenopausal Women ◽  
Urinary Tract Infections ◽  
Antimicrobial Prophylaxis ◽  
Prophylaxis Group ◽  
Research Article ◽  
Recurrent Urinary Tract Infections ◽  
Significant Difference ◽  
Tract Infections

Objective: To determine the most effective and applicable methods to reduce recurrence of urinary tract infections in postmenopausal women. Method: A search was conducted on Pubmed, NEJM, BMJ, and Google. After screening and selection, six articles were considered useful; comprising of two original research articles, one systematic review, and three society guidelines. Result: Society guidelines recommended continuous antimicrobial prophylaxis, with postcoital antimicrobial prophylaxis as an alternative. The first research article found similar results in continous antimicrobial prophylaxis group and intermittent antimicrobial prophylaxis group. The second research article found no significant difference in cranberry and trimethoprim group. The systematic review revealed vaginal estrogens are effective in preventing recurrent UTI, but the type of estrogen is less clear. Oral estrogens are not effective. Conclusion: Prevention of recurrent urinary tract infections in postmenopausal women include risk factor identification, non-antimicrobial prophylaxis with cranberry and vaginal estrogen preparations, and antimicrobial prophylaxis (continuous or intermittent). Keywords: postmenopausal, prevention, recurrent urinary tract infection.

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