scholarly journals Age- and gender-dependent association of SLC11A1 polymorphisms with tuberculosis susceptibility

2021 ◽  
Author(s):  
Yuhe Wang ◽  
Zhongtao Wang ◽  
Xue He ◽  
Li Wang ◽  
Mei Bai ◽  
...  
Keyword(s):  
Unconditional Logistic Regression ◽  
Age And Gender ◽  
Genotype Frequencies ◽  
Important Health ◽  
And Gender ◽  
Important Health Issue ◽  
Regression Adjustment ◽  
Stratified Analysis ◽  
First Time ◽  
The Relationship

Abstract Background: Tuberculosis (TB) is an important health issue in our world. It is reported that various factors may effect on its pathogenesis. In this current study, we aimed to investigate the association between SLC11A1 polymorphism and the risk of TB among 510 TB patients and 508 healthy controls.Methods: Agena MassARRAY platform was conducted for genotyping. Odds ratios (ORs) and 95% confidence intervals (CIs) were analyzed through unconditional logistic regression adjustment confound factors, such as age and gender.Results: The results suggested that the allele and genotype frequencies of polymorphisms in SLC11A1 were not observed associated with TB risk. Subsequently, stratified analysis by age and gender confirmed that rs7608307 “A/A” and “C/T-T/T” genotypes were related with increased TB risk in age ≤ 41 group (p = 0.021) and males (p = 0.013), respectively. Besides, rs13062 “A/A” genotype was reduced TB risk in age > 41 group (p = 0.043). In addition, we observed that the “C/C” genotype of rs4674301 was noteworthy correlated with increased TB risk in females (p = 0.043). Conclusion: Our results demonstrated the relationship between SLC11A1 polymorphism and TB risk and confirmed for the first time that the correlation was restricted to age and gender in northwest Chinese population.

scholarly journals Fc receptor-like 1, 3, and 6 variants are associated with rheumatoid arthritis risk in the Chinese Han population

2021 ◽  
Vol 43 (1) ◽  
Author(s):  
Yonghui Yang ◽  
Dandan Li ◽  
Chunjuan He ◽  
Linna Peng ◽  
Shishi Xing ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chinese Han Population ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Rheumatoid Arthritis Risk ◽  
Age And Gender ◽  
Han Population ◽  
Genotype Frequencies ◽  
And Gender ◽  
The Relationship

Abstract Background Rheumatoid arthritis (RA) is the most common autoimmune system diseases in our world. More studies in recent years have shown that FCRL gene polymorphisms is closely related to autoimmune diseases. It is suggested that genetic factors play a crucial role in the pathogenesis of this disease. In this study, we aimed to investigate the relationship between FCRL1 rs2050568, FCRL3 rs2317230 and FCRL6 rs58240276 polymorphisms and RA risk in the Chinese Han population. 506 with RA patients and 509 healthy controls were recruited in this study, and the single nucleotide polymorphisms (SNPs) was successfully genotyped using the Agena MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (95% CIs) after adjusting for age and gender were conducted to assess these SNPs polymorphisms and RA risk. The multifactor dimensionality reduction (MDR) method was conducted to analyze SNP-SNP interaction. Results Our results revealed that there no significant association was observed between the allele and genotype frequencies among these SNPs and RA risk (all p > 0.05). Straified analysis by age and gender, the results confirmed that FCRL1 rs2050568 T/T genotype enhanced the risk of RA in females (p = 0.014). The G/T - T/T genotype of FCRL3 rs2317230 was correlated with a decreased RA risk in males (p = 0.021). We also observed that the C/T-T/T genotype of FCRL6 rs58240276 was increased the risk of RA in the group at age >  54 years (p = 0.016). In addition, FCRL1 rs2050568-TT, FCRL6 rs58240276-TT and FCRL1 rs2050568-TT, FCRL3 rs2317230-TT, FCRL6 rs58240276-TT are the best models for multi-site MDR analysis (p < 0.05), and the two best models mentioned above and classes RA have the most significant correlation. Conclusions Our study demonstrated that FCRL1 rs2050568, FCRL3 rs2317230, and FCRL6 rs58240276 polymorphisms were correlated with RA susceptibility in the Chinese Han population.

scholarly journals No Self Without Salience: Affective and Self-relevance Ratings of 552 Emotionally Valenced and Neutral Dutch Words

2021 ◽  
Author(s):  
Lora I. Dimitrova ◽  
Eline M. Vissia ◽  
Hanneke Geugies ◽  
Hedwig Hofstetter ◽  
Sima Chalavi ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Emotional Valence ◽  
Age And Gender ◽  
Gender And Age ◽  
Main Effect ◽  
Emotional Salience ◽  
And Gender ◽  
The Relationship

AbstractIt is unknown how self-relevance is dependent on emotional salience. Emotional salience encompasses an individual's degree of attraction or aversion to emotionally-valenced information. The current study investigated the interconnection between self and salience through the evaluation of emotional valence and self-relevance. 56 native Dutch participants completed a questionnaire assessing valence, intensity, and self-relevance of 552 Dutch nouns and verbs. One-way repeated-measures ANCOVA investigated the relationship between valence and self, age and gender. Repeated-measures ANCOVA also tested the relationship between valence and self with intensity ratings and effects of gender and age. Results showed a significant main effect of valence for self-relevant words. Intensity analyses showed a main effect of valence but not of self-relevance. There were no significant effects of gender and age. The most important finding presents that self-relevance is dependent on valence. These findings concerning the relationship between self and salience opens avenues to study an individual's self-definition.

scholarly journals Comparing Executive Function of Normal Children with ADHD Children

2016 ◽  
Vol 8 (3) ◽  
pp. 11
Author(s):  
Fereshteh Heydari ◽  
Shohreh Farahani
Keyword(s):  
Executive Function ◽  
Cognitive Deficits ◽  
Measurement Tool ◽  
Normal Male ◽  
Normal Children ◽  
Age And Gender ◽  
Significant Difference ◽  
Adhd Children ◽  
And Gender ◽  
First Time

<p>This study was conducted to compare with the executive function of ADHD versus normal male and female children. To obtain this objective, 30 ADHD children referring a private psychological center for the first time who had taken no medication for this disorder, and 30 normal children from one of the schools of District 14 in Tehran were selected randomly who were of the same age and gender of ADHD children. Wisconsin test was used as a measurement tool. Results showed that there is a significant difference between the average scores of the executive function of normal and ADHD children as well as average scores of the executive function of normal boys and ADHD children at the 0.01 level. In addition, there was a significant difference between the average scores of the executive function of normal girls and ADHD girls at the 0.05 level according to which null hypothesis is rejected. Therefore, ADHD children are of lower executive and cognitive function compared to normal children and have extensive cognitive deficits. Therefore, they require medications along with special training and rehabilitation.</p>

Focus on Text Messages: A Review of Studies in French

2015 ◽  
pp. 1037-1050
Author(s):  
Olga Volckaert-Legrier ◽  
Antonine Goumi ◽  
Alain Bert-Erboul ◽  
Josie Bernicot
Keyword(s):  
Text Message ◽  
Text Messages ◽  
French Language ◽  
Age And Gender ◽  
Future Studies ◽  
Linguistic Markers ◽  
Production Processes ◽  
Language Research ◽  
And Gender ◽  
The Relationship

The study of text messages has given rise to a number of French language research topics. First, databases of natural text messages have been created in multiple Francophone countries in an effort to link the texters' characteristics with the linguistic markers of the text messages. Many studies have focused on textisms (changes in spelling as compared to the traditional written code), creating repertoires of spelling processes and classifying them into typologies. With regard to linguistic aspects, a few studies have analyzed vocabulary and syntax. Sociolinguistic aspects have also been studied, taking into account the relationship among textisms, age, and gender. To address the question of whether text message writing is a threat to spelling, several studies have analyzed the link between text message writing and traditional writing. Finally, a number of studies have focused on the production processes of text message writing. Future studies will need to take into account the dialogical and conversational aspects of text messages.

scholarly journals Missing in Action: Sex and Gender in Substance Use Research

2020 ◽  
Vol 17 (7) ◽  
pp. 2352 ◽  
Author(s):  
Lorraine Greaves
Keyword(s):  
Substance Use ◽  
Health Issue ◽  
Sex And Gender ◽  
Gender Diverse ◽  
Global Health Issue ◽  
Important Health ◽  
Gender Based ◽  
And Gender ◽  
Missing In Action ◽  
Important Health Issue

Substance use and misuse is a significant global health issue that requires a sex- and gender-based analysis. Substance use patterns and trends are gendered: that is, women and men, girls and boys, and gender-diverse people often exhibit different rates of use of substances, reasons for use, modes of administration, and effects of use. Sex-specific effects and responses to substances are also important, with various substances affecting females and males differentially. Nevertheless, much research and practice in responding to substance use and misuse remains gender blind, ignoring the impacts of sex and gender on this important health issue. This special issue identifies how various aspects of sex and gender matter in substance use, illustrates the application of sex- and gender-based analyses to a range of substances, populations and settings, and assists in progressing sex and gender science in relation to substance use.

Effects of Feature Variations on Attributions for Schematic Faces

1993 ◽  
Vol 73 (1) ◽  
pp. 275-288 ◽  
Author(s):  
Stuart J. McKelvie
Keyword(s):  
Age And Gender ◽  
Short Nose ◽  
Folk Wisdom ◽  
Perceived Age ◽  
Six Dimensions ◽  
Individual Features ◽  
And Gender ◽  
The Relationship

31 subjects classified 16 schematic faces on six dimensions. Attractiveness was generally associated with widely separated eyes, a short nose, and high feature placement. When features were considered in combination, faces with low placement were judged attractive, although the effect was mitigated by a narrow mouth. Previous findings concerning perceived age and gender were partially replicated, but folk wisdom linking intelligence to low placement (high forehead) was refuted. It is suggested that the relationship between individual features and attributions is nonlinear and interactive, and that researchers should investigate these hypotheses by exercising finer control over feature variations.

The Relationship of Human Saphenous Vein Smooth Muscle Contractile Responses to Donor Age and Gender

1995 ◽  
Vol 29 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Kelvin G. M. Brockbank ◽  
Mark G. Davies ◽  
Shirley M. Fields ◽  
Per-Otto Hagen
Keyword(s):  
Smooth Muscle ◽  
Saphenous Vein ◽  
Donor Age ◽  
Human Saphenous Vein ◽  
Age And Gender ◽  
Contractile Responses ◽  
And Gender ◽  
Relationship Of ◽  
The Relationship ◽  
Muscle Contractile

scholarly journals Pneumonia: Does Age or Gender Relate to the Presence of an SLP Dysphagia Consultation?

Geriatrics ◽  
2020 ◽  
Vol 5 (3) ◽  
pp. 51
Author(s):  
Christopher Bolinger ◽  
James Dembowski ◽  
Kimberly Mory
Keyword(s):  
Geriatric Patients ◽  
Care Setting ◽  
Gender Disparities ◽  
Age And Gender ◽  
Speech Language Pathologist ◽  
Hospital Policies ◽  
And Gender ◽  
Relationship Of ◽  
The Relationship

A retrospective study of 1489 hospital records examined the relationship of speech-language pathologist (SLP) consults for dysphagia to age and gender in pneumonia patients from an acute care setting. Age and gender disparities exist in healthcare. The research sought to determine if disparities existed in the presence/absence of SLP dysphagia consults related to age and gender. Results suggested SLPs were consulted on a greater percentage of geriatric patients overall; however, there were differences in the number of consults for each pneumonia type. More males and geriatric patients were seen than females and non-geriatric adults, respectively. Results may be used to address local hospital policies and protocols and thus increase quality of care by improving morbidity and mortality outcomes of geriatric patients with pneumonia.

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