scholarly journals Airway Obstruction as the Primary Manifestation of Infantile Thyroid Hemangioma: A Case Report and Literature Review

2020 ◽  
Author(s):  
Yujian Liang ◽  
Ronghui Pu ◽  
Xueqiong Huang ◽  
Suping Li ◽  
Yingqian Chen ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Airway Obstruction ◽  
Thyroid Nodules ◽  
Histopathological Examination ◽  
Combined Treatment ◽  
Capillary Hemangioma ◽  
Normal Thyroid Function ◽  
Cavernous Hemangiomas ◽  
Parenchyma Enhancement ◽  
Oral Propranolol

Abstract Background: Thyroid hemangioma mostly occurs in adults and is extremely rare in infants. So far, only four pediatric cases of thyroid hemangioma have been reported, one of which has only been clinically diagnosed. Most of the reported cases are of cavernous hemangiomas; capillary hemangioma cases are very rare. To date, there are no reports on capillary thyroid hemangioma in an infant. Therefore, here we present the case of an infant with a primary capillary hemangioma of the thyroid gland, and discuss its treatment and follow-up.Case Presentation: A 2-month-old infant with normal thyroid function presented with airway obstruction as the primary manifestation of thyroid hemangioma. The main symptoms were laryngeal wheezing and dyspnea. Ultrasonography revealed hypoechoic lesions at the lower pole of the bilateral thyroid. Computed tomography revealed enlargement of the thyroid gland, inhomogeneous parenchyma enhancement, and multiple thyroid nodules. However, these imaging modalities were unable to provide an exact diagnosis and the nature of the tumor remained unknown prior to an operation. Therefore, a postoperative histopathological examination was undertaken, which revealed capillary thyroid hemangioma. The symptoms significantly improved by a combined treatment involving surgery and oral propranolol (2 mg/kg per day).Conclusion: When a well-defined capsulate mass is detected on the medical image, the possibility of primary thyroid hemangioma must be considered.

scholarly journals Airway Obstruction as the Primary Manifestation of Infantile Thyroid Hemangioma: A Case Report and Literature Review

2020 ◽  
Author(s):  
Yujian Liang ◽  
Ronghui Pu ◽  
Xueqiong Huang ◽  
Suping Li ◽  
Yingqian Chen ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Airway Obstruction ◽  
Histopathological Examination ◽  
Combined Treatment ◽  
Capillary Hemangioma ◽  
Case Presentation ◽  
Normal Thyroid Function ◽  
Cavernous Hemangiomas ◽  
Parenchyma Enhancement

Abstract Background: Thyroid hemangioma mostly occurs in adults and is extremely rare in infants. So far, only four pediatric cases of thyroid hemangioma have been reported, one of which has only been clinically diagnosed. Most of the reported cases are of cavernous hemangiomas; capillary hemangioma cases are very rare. To date, there are no reports on capillary thyroid hemangioma in an infant. Therefore, here we present the case of an infant with a primary capillary hemangioma of the thyroid gland, and discuss its treatment and follow-up. Case Presentation: A 2-month-old infant with normal thyroid function presented with airway obstruction as the primary manifestation of thyroid hemangioma. The main symptoms were laryngeal wheezing and dyspnea. Ultrasonography revealed hypoechoic lesions at the lower pole of the bilateral thyroid. Computed tomography revealed enlargement of the thyroid gland, inhomogeneous parenchyma enhancement, and multiple thyroid nodules. However, these imaging modalities were unable to provide an exact diagnosis and the nature of the tumor remained unknown prior to an operation. Therefore, a postoperative histopathological examination was undertaken, which revealed capillary thyroid hemangioma. The symptoms significantly improved by a combined treatment involving surgery and oral propranolol (2 mg/kg per day). Conclusion: When a well-defined capsulate mass is detected on the medical image, the possibility of primary thyroid hemangioma must be considered.

scholarly journals Airway obstruction as the primary manifestation of infantile thyroid hemangioma

2020 ◽  
Vol 46 (1) ◽  
Author(s):  
Yujian Liang ◽  
Ronghui Pu ◽  
Xueqiong Huang ◽  
Suping Li ◽  
Yingqian Chen ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Airway Obstruction ◽  
Histopathological Examination ◽  
Combined Treatment ◽  
Capillary Hemangioma ◽  
Case Presentation ◽  
Normal Thyroid Function ◽  
Cavernous Hemangiomas ◽  
Parenchyma Enhancement

Abstract Background Thyroid hemangioma mostly occurs in adults and is extremely rare in infants. So far, only four pediatric cases of thyroid hemangioma have been reported, one of which has only been clinically diagnosed. Most of the reported cases are of cavernous hemangiomas; capillary hemangioma cases are very rare. To date, there are no reports on capillary thyroid hemangioma in an infant. Therefore, here we present the case of an infant with a primary capillary hemangioma of the thyroid gland, and discuss its treatment and follow-up. Case presentation A2-month-old infant with normal thyroid function presented with airway obstruction as the primary manifestation of thyroid hemangioma. The main symptoms were laryngeal wheezing and dyspnea. Ultrasonography revealed hypoechoic lesions at the lower pole of the bilateral thyroid. Computed tomography revealed enlargement of the thyroid gland, inhomogeneous parenchyma enhancement, and multiple thyroid nodules. However, these imaging modalities were unable to provide an exact diagnosis and the nature of the mass remained unknown prior to an operation. Therefore, a postoperative histopathological examination was undertaken, which revealed capillary thyroid hemangioma. The symptoms significantly improved by a combined treatment involving surgery and oral propranolol. Conclusion When a well-defined capsulate mass is detected on the medical image, the possibility of primary thyroid hemangioma must be considered.

Compensated 131I-therapy of solitary autonomous thyroid nodules: effect on thyroid size and early hypothyroidism

1986 ◽  
Vol 113 (2) ◽  
pp. 226-232 ◽  
Author(s):  
Laszlo Hegedüs ◽  
Dagmar Veiergang ◽  
Steen Karstrup ◽  
Jens Mølholm Hansen
Keyword(s):  
Thyroid Gland ◽  
Thyroid Function ◽  
Thyroid Nodules ◽  
Thyroid Volume ◽  
131I Therapy ◽  
Important Place ◽  
Gland Volume ◽  
Thyroid Gland Volume ◽  
One Year ◽  
Hyperthyroid Patients

Abstract. Thyroid function and thyroid gland volume, ultrasonically determined, were investigated in 27 hyperthyroid patients with solitary autonomous thyroid nodules before and during one year after 131I-treatment. Total thyroid volume decreased gradually from 40.9 ± 3.5 ml (mean ± sem) before treatment to 23.9 ± 1.8 ml (P < 0.001) at 3 months after 131I-treatment. No further change was observed. All but two patients received only one dose of 131I, and in spite of a significant decrease also of the non-adenoma side of the gland, none became hypothyroid. We conclude that 131I-therapy has an important place in the treatment of solitary autonomous thyroid nodules since all our patients became euthyroid within 3 months, only 2 of 27 patients needed more than one dose of 131I, no cases of hypothyroidism occurred, and thyroid volume was substantially decreased.

scholarly journals Effects of electrochemotherapy with cisplatin and peritumoral IL-12 gene electrotransfer on canine mast cell tumors: a histopathologic and immunohistochemical study

2017 ◽  
Vol 51 (3) ◽  
pp. 286-294 ◽  
Author(s):  
Claudia Salvadori ◽  
Tanja Svara ◽  
Guido Rocchigiani ◽  
Francesca Millanta ◽  
Darja Pavlin ◽  
...  
Keyword(s):  
Mast Cell ◽  
T Lymphocytes ◽  
Mhc Class Ii ◽  
Cellular Response ◽  
Histopathological Examination ◽  
Combined Treatment ◽  
Gene Electrotransfer ◽  
Neoplastic Cells ◽  
Ki 67 ◽  
Mast Cell Tumors

AbstractBackgroundThe study was aimed to characterize tumor response after combined treatment employing electrochemotherapy with IL-12 gene electrotransfer in dogs with spontaneous mast cell tumors (MCT).Materials and methodsEleven dogs with eleven MCTswere included in the study. Histological changes were investigated in biopsy specimens collected before the treatment (T0), and 4 (T1) and 8 weeks (T2) later. Cellular infiltrates were characterized immunohistochemically by using anti CD3, CD20, Foxp3 (Treg), CD68 and anti MHC-class II antibodies. Proliferation and anti-apoptotic activity of neoplastic cells were assessed using anti Ki-67 and Bcl-2 antibodies. Angiogenetic processes were investigated immunohistochemically by using anti Factor VIII and anti CD31 antibodies and micro vessel density quantification.ResultsHistopathological examination of samples at T0confirmed the diagnosis and the presence of scanty infiltrates consisted mainly of T-lymphocytes and macrophages. At T1and T2neoplastic cells were drastically reduced in 7/11 cases, small clusters of neoplastic cells were detected in 3/11 cases and 1/11 cases neoplastic cells were still evident. Proliferation activity of neoplastic cells was significantly reduced at T1and T2and expression of anti-apoptotic protein at T1. Microvessel density was drastically reduced in all samples after treatment. The number of T-lymphocytes increased at T1, although not significant, while Treg were significant higher at T1and macrophages at T2.ConclusionsThe combined electrochemotherapy and IL-12 gene electrotransfer effectively induced a cellular response against neoplastic cells characterized mainly by the recruitment of T-lymphocytes and macrophages and a fibrotic proliferation with reduction of microvessels.

Treatment of Infantile Subglottic Hemangioma with Radioactive Gold Grain

1978 ◽  
Vol 87 (1) ◽  
pp. 18-21 ◽  
Author(s):  
Bruce Benjamin
Keyword(s):  
Radiation Therapy ◽  
Thyroid Gland ◽  
Mortality Rate ◽  
Airway Obstruction ◽  
Active Treatment ◽  
Malignant Change ◽  
Conventional Radiotherapy ◽  
Life Threatening

Congenital subglottic hemangioma causes life-threatening airway obstruction during the first few months of life. The mortality rate of recognized and untreated cases justifies active treatment, and although radiation therapy is currently most favored, it carries a risk of inducing malignant change in the thyroid gland later in life. A series of 11 patients with laryngeal hemangiomata is reported, conventional radiotherapy was utilized in the first seven patients, and placement of a radioactive gold grain directly into the lesion was used in the last four patients. This technique offers maximal tumor dose with minimal thyroid gland irradiation compared to treatment by conventional radiotherapy, and its successful use in these four patients is reported as worthy of further trial.

scholarly journals Posttraumatic thoracic epidural capillary hemangioma – A rare case report

2020 ◽  
Vol 11 ◽  
pp. 179 ◽  
Author(s):  
G. Sudhir ◽  
Vignesh Jayabalan ◽  
T. H. Manohar ◽  
Saikrishna Gadde ◽  
Venkatesh Kumar ◽  
...  
Keyword(s):  
Epidural Space ◽  
Lower Limb ◽  
Histopathological Examination ◽  
Cord Compression ◽  
Capillary Hemangioma ◽  
Vascular Lesions ◽  
Surgical Removal ◽  
En Bloc ◽  
Limb Weakness ◽  
Thoracic Epidural

Background: Capillary hemangiomas are benign vascular lesions commonly seen in subcutaneous tissues. The most common site of origin is from the vertebral body, and only a few cases of isolated lesions in thoracic epidural space, especially after trauma, have been reported in the literature. Case Description: We report a case of 63-year-old male with progressive bilateral lower limb weakness and exaggerated lower limb deep tendon reflexes without bowel and bladder involvement. His history revealed T7 fracture with paraparesis which was treated surgically, and implants were removed a year later. MRI showed an epidural lesion from T6-T8 extending into the right T7-8 foramen which showed hypointensity on T1, hyperintensity on T2, and homogenous enhancement in contrast images with severe cord compression. Laminectomy was done and the lesion was removed en bloc. Histopathological examination revealed it to be capillary hemangioma. The neurology came back to normal after 3 months. Conclusion: Although capillary hemangiomas are rare lesions, it has to be considered in the differential diagnosis of epidural space-occupying lesions which require early surgical removal to prevent a progressive and permanent neurological deficit.

scholarly journals Microcalcifications without a thyroid nodule as the sole sign of papillary thyroid carcinoma

2021 ◽  
Vol 2021 ◽  
Author(s):  
Stamatina Ioakim ◽  
Vasilis Constantinides ◽  
Meropi Toumba ◽  
Theodoros Lyssiotis ◽  
Angelos Kyriacou
Keyword(s):  
High Risk ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Gland ◽  
Thyroid Carcinoma ◽  
Histopathological Examination ◽  
Needle Aspiration ◽  
List Type ◽  
Papillary Thyroid ◽  
Resected Tissue ◽  
Current Guidelines

Summary Our objective is to demonstrate the importance of considering microcalcifications even without evidence of nodules as a potential sign of malignancy. Current guidelines, such as those of the British Thyroid Association, acknowledge the clinical significance of microcalcifications only when found within nodules. In this case, they are considered a suspicious feature, classifying the nodules as U5 (i.e. high risk) where fine-needle aspiration biopsy (FNAB) is warranted, following the high likelihood of cancer in these nodules. In addition, there is a dearth of evidence of ultrasound scan (USS) detection of microcalcifications in the thyroid gland outside of nodules, along with their associated clinical implications. Yet, this clinical manifestation is not so infrequent considering that we do encounter patients in the clinic showing these findings upon ultrasound examination. Three patients who presented to our clinic with thyroid-related symptoms were shown to have areas of microcalcifications without a nodule upon sonographic evaluation of their thyroid gland. These incidentally detected hyperechoic foci were later confirmed to correspond to areas of papillary thyroid carcinoma (PTC) on histopathological examination of resected tissue following thyroidectomy. Four more cases were identified with sonographic evidence of microcalcifications without nodules and given their clinical and other sonographic characteristics were managed with active surveillance instead. Learning points Echogenic foci known as microcalcifications may be visible without apparent association to nodular structures. Microcalcifications without nodules may not be an infrequent finding. Microcalcifications are frequently indicative of malignancy within the thyroid gland even without a clearly delineated nodule. Empirically, the usual guidelines for the management of thyroid nodules can be applied to the management of microcalcifications not confined to a nodule, but such a finding per se should be classified as a ‘high-risk’ sign.

scholarly journals Effect of oral propranolol on periocular infantile capillary hemangioma: Outcomes based on extent of involvement

2021 ◽  
Vol 28 (1) ◽  
pp. 6
Author(s):  
Swathi Kaliki ◽  
KavyaM Bejjanki ◽  
Kahkashan Akhtar ◽  
ArushiP Gupta
Keyword(s):  
Capillary Hemangioma ◽  
Oral Propranolol

scholarly journals Equine Carcinoma Hemithyroidectomy

2021 ◽  
Vol 49 ◽  
Author(s):  
Alessandra Mayer Coelho ◽  
Brenda Valeria dos Santos Oliveira ◽  
Diana Villa Verde Salazar ◽  
Karin Elisabeth Rodrigues Borba ◽  
Lais Maria Gomes ◽  
...  
Keyword(s):  
Weight Loss ◽  
Weight Gain ◽  
Thyroid Gland ◽  
Thyroid Carcinoma ◽  
Ultrasound Examination ◽  
Histopathological Examination ◽  
Thyroid Tissue ◽  
Parathyroid Glands ◽  
Common Finding ◽  
Significant Weight Loss

Background: In horses, the thyroid gland is located slightly caudal to the larynx and dorsolaterally between the third and sixth tracheal ring, adjacent to the thyroid, there are four small glands called parathyroid glands. In the clinical routine of horses, thyropathies are difficult to be diagnosed, as they have a silent evolution. Thyroid neoplasia is the most common finding in horses, usually unilateral and normally present in older animals. The present study reports a case of equine thyroid carcinoma and its systemic clinical effects, which was successfully treated by means of hemitieroidectomy. Case: A 12-year-old male mixed breed horse weighing 436 kg, was admitted to the Veterinary Medical Teaching Hospital of the FZEA/USP    with the main complaint of volume increase in the right ventrolateral region of the neck, difficulty in swallowing, significant weight loss and weakness of the pelvic limbs. On inspection, there was an increase in volume in the topographic region of the thyroid gland and on palpation, there was a firm mass, with delimited edges, with a smooth, mobile surface, without increasing the temperature and without pain. The animal was sent for ultrasound examination, which revealed a delimited mass, with an apparent capsule around it, differentiated and disorganized cellularity with small hypoechoic points of liquid inside the structure, with no apparent vascularization inside the mass. These findings, associated with the anatomical location of the mass, were consistent with thyroid tissue. The clinical signs commonly observed in thyroid neoformations are respiratory stridor, decreased performance, difficulty in swallowing and suffocation. As there was a compromised diet and weight gain, as well as athletic performance, he chose to have a hemithyroidectomy. After surgery, histopathology of the tissue was performed and thyroid carcinoma was diagnosed. Postoperatively, the animal was medicated with antibiotics, anti-inflammatory and anti-tetanus serum, after 10 days the stitches were removed and the animal was discharged. Discussion: Neoplasia is the most frequent cause of progressive thyroid growth and in case of suspicion of thyroid disorders, thin needle aspiration (FNAB) is recommended and, later, histopathological examination, which is considered the gold standard for diagnosis pathologies of the thyroid gland. In the present case, no FNAB or preoperative histopathological examination was performed due to the time required to obtain the result, associated with difficulty in swallowing and significant weight loss, which required immediate removal of the mass. Considering that the ultrasound examination revealed the absence of noble structures or important vascularization very close to or adhered to the mass, its removal prior to the histopathological examination was indicated. As there was compromised feeding and weight gain, he opted for hemithyroidectomy, the recommended treatment for unilateral tumors in horses. When performing a hemithyroidectomy, it should be remembered that the parathyroid glands accompany the thyroid and are located in its posterior portion, in the pre tracheal region, with its variable final position. With this variation in topography, the identification of parathyroid glands becomes challenging and, consequently, after thyroidectomy, a portion of parathyroid glands stops operating, and this fact is marked clinically by hypocalcemia and its consequences. In this case described, in which the animal had a tumor in thyroid tissue, possibly the parathyroid functions were also altered, which probably reflected in the lameness in the pelvic limbs. It is concluded that partial hemithyroidectomy in horses is an easy procedure to perform and has favorable results in relation to prognosis and quality of life. Keywords: carcinoma, hemithyroidectomy, thyroid. Título: Hemitireoidectomia por carcinoma em equinoDescritores: carcinoma, hemitireoidectomia, tireóide. 

LONG-TERM OUTCOMES OF RADIOIODINE THERAPY FOR JUVENILE GRAVES DISEASE WITH EMPHASIS ON SUBSEQUENTLY DETECTED THYROID NODULES: A SINGLE INSTITUTION EXPERIENCE FROM JAPAN

2020 ◽  
Vol 26 (7) ◽  
pp. 729-737 ◽  
Author(s):  
Tetsuya Mizokami ◽  
Katsuhiko Hamada ◽  
Tetsushi Maruta ◽  
Kiichiro Higashi ◽  
Junichi Tajiri
Keyword(s):  
Thyroid Gland ◽  
Thyroid Nodules ◽  
Radioiodine Therapy ◽  
Antithyroid Drug ◽  
Overt Hypothyroidism ◽  
Graves Disease ◽  
Outpatient Basis ◽  
Long Term Outcomes

Objective: To investigate the long-term outcomes of radioiodine therapy (RIT) for juvenile Graves disease (GD) and the ultrasonographic changes of the thyroid gland. Methods: All of 117 juvenile patients (25 males and 92 females, aged 10 to 18 [median 16] years) who had undergone RIT for GD at our clinic between 1999 and 2018 were retrospectively reviewed. Each RIT session was delivered on an outpatient basis. The maximum 131I dose per treatment was 13.0 mCi, and the total 131I dose per patient was 3.6 to 29.8 mCi (median, 13.0 mCi). 131I administration was performed once in 89 patients, twice in 26, and three times in 2 patients. Ultrasonography of the thyroid gland was regularly performed after RIT. The duration of follow-up after the initial RIT ranged from 4 to 226 (median 95) months. Results: At the latest follow-up more than 12 months after RIT (n = 111), the patients' thyroid functions were overt hypothyroidism (91%), subclinical hypothyroidism (2%), normal (5%), or subclinical hyperthyroidism (2%). New thyroid nodules were detected in 9 patients, 4 to 17 years after initial RIT. Patients with newly detected thyroid nodules underwent RIT with lower doses of 131I and had larger residual thyroid volumes than those without nodules. None of the patients were diagnosed with thyroid cancer or other malignancies during the follow-up period. Conclusion: Over a median follow-up period of 95 months (range, 4 to 226 months), RIT was found to be effective and safe in juvenile GD. However, cumulative evidence from further studies is required to confirm the long-term safety of RIT for juvenile GD. Abbreviations: ATD = antithyroid drug; GD = Graves disease; KI = potassium iodide; LT4 = levothyroxine; MMI = methimazole; PTU = propylthiouracil; RAIU = radio-active iodine uptake; RIT = radioiodine therapy; 99mTc = technetium-99m; TSH = thyrotropin

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