scholarly journals Development an Immune-Associated LncRNA Prognostic Index for Papillary Thyroid Cancer

2020 ◽  
Author(s):  
Min Mao ◽  
Rong-zhi Huang ◽  
Zhu Yu ◽  
Jie Zheng ◽  
Hai-qi Liang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Correlation Analysis ◽  
Papillary Thyroid Cancer ◽  
Pearson Correlation ◽  
Prognostic Index ◽  
Gene Set Enrichment Analysis ◽  
Papillary Thyroid ◽  
Immune System Development ◽  
Pearson Correlation Analysis ◽  
The Impact

Abstract BACKGROUND: Papillary thyroid cancer (PTC) is the most common pathological type of thyroid cancer and its incidence is still on the rise worldwide. Our study aimed to provide an understanding of papillary thyroid cancer in immunological aspects and prompt its clinical diagnosis and treatment.METHODS: We obtained RNA-FPKM data and clinical data of papillary thyroid cancer (PTC) samples from the TCGA data portal. Immune-related genes (IRGs) were selected from Molecular Signatures Database v7.0. The immune-related lncRNAs were identified by constructing DELs-IRGs co-expression networks. Cox regression and Kaplan-Meier methods were used to construct immune-related lncRNAs prognosis index (IRLPI) and analyze the impact of IRLPI on overall survival. Gene Set Enrichment Analysis (GSEA) was performed by clusterProfiler R package to explore the potential molecular mechanism in TCGA dataset. The relationship between immune cell types and IRLPI were explored by using Pearson correlation analysis.RESULTS: A total of 478 primary PTC samples were collected for the analysis. 162 immune-related lncRNAs were identified in immune-lncRNAs co-expression network. And 7 lncRNAs were extracted to develop the IRLPI. Patients with high-IRLPI showed poor survival probability (P =0.00052) and IRLPI was identified as an independent prognostic factor (HR: 2.329, 95%CI: 1.481-2.664, p =2.54e-4). ROC curve declared a promising prognosis ability of IRLPI. PCA proved that IRLPI reflected different immune environment and biological processes. GSEA indicated that immune system development is the main different biological process between high- and low-IRLPI group. Furthermore, IRLPI was proved that it related with multiple immune cells and immune responses by Pearson correlation analysis.CONCLUSION: Our results showed that immune-related lncRNAs prognosis index (IRLPI) could serve as a potential prognostic model in papillary thyroid cancer and play an important role in the immunotherapies and surveillance of PTC.

The Impact of Customer Service, Insurance and Luggage Delivery Towards Logistics Customer Satisfaction in Pandemic Situation

2021 ◽  
Vol 12 (3) ◽  
pp. 4999-5004
Author(s):  
Mohd Fathi Abu Yaziz Et. al.
Keyword(s):  
Customer Satisfaction ◽  
Correlation Analysis ◽  
Customer Service ◽  
Business Model ◽  
Quantitative Method ◽  
Pearson Correlation ◽  
Logistics Industry ◽  
Pearson Correlation Analysis ◽  
Customer Services ◽  
The Impact

As the pandemic of Covid 19 has directly affected the business industry, the business model has changed, including the logistics industry, especially the courier company. Courier company has benefited the most during this pandemic situation as the e-commerce business flourished. Enhanced service by courier company is crucial as stiff competition in the industry. Therefore, this study explores the impact of customer service, insurance, and luggage delivery on logistics customer satisfaction. A quantitative method was employed to analyse the effects of enhanced services of customer services, insurance, and luggage delivery towards logistics customer satisfaction, where 384 responses were collected from respondents identified as active users of courier services for the last 12 months. IBM SPSS was used to analyse the response collected using descriptive, reliability and Pearson Correlation analysis. As a result, it is justifiable that customer service, insurance, and luggage delivery positively impact logistics customer satisfactio

scholarly journals Impact of lymph node metastases identified on central neck dissection (CND) on the recurrence of papillary thyroid cancer: potential role of BRAFV600E mutation in defining CND

2012 ◽  
Vol 20 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Ali S Alzahrani ◽  
Mingzhao Xing
Keyword(s):  
Thyroid Cancer ◽  
Neck Dissection ◽  
Papillary Thyroid Cancer ◽  
Tertiary Care ◽  
Disease Recurrence ◽  
Central Neck Dissection ◽  
Central Neck ◽  
Papillary Thyroid ◽  
Cervical Lymph Nodes ◽  
The Impact

The impact of metastasized cervical lymph nodes (CLN) identified on central neck dissection (CND) on the recurrence/persistence of papillary thyroid cancer (PTC) and the extent of CND needed to reduce recurrence/persistence have not been firmly established. To assess the impact of CLN metastasis andBRAFmutation on the recurrence/persistence of PTC and the potential ofBRAFmutation in assisting CND. Analyses of 379 consecutive patients with PTC who underwent thyroidectomy with (n=243) or without CND (n=136) at a tertiary-care academic hospital during the period 2001–2010 for their clinicopathological outcomes andBRAFmutation status. Increasingly aggressive tumor characteristics were found as the extent of CND was advanced following conventional risk criteria from non-CND to limited CND to formal CND. Disease recurrence/persistence rate also sharply rose from 4.7% to 15.7% and 40.5% in these CND settings respectively (P<0.0001). CLN metastasis rate rose from 18.0 to 77.3% from limited CND to formal CND (P<0.0001). An increasing rate ofBRAFmutation was also found from less to more extensive CND. A strong association of CLN metastasis andBRAFmutation with disease recurrence/persistence was revealed on Kaplan–Meier analysis andBRAFmutation strongly predicted CLN metastasis. CLN metastases found on CND are closely associated with disease recurrence/persistence of PTC, which are both strongly predicted byBRAFmutation. Current selection of PTC patients for CND is appropriate but higher extent of the procedure, once selected, is needed to reduce disease recurrence, which may be defined by combination use of preoperativeBRAFmutation testing and conventional risk factors of PTC.

scholarly journals Service management and guest satisfaction for the hotel industry in Abeokuta, Nigeria

2021 ◽  
pp. 52-69
Author(s):  
Edwin Chigozie-Nwokorie
Keyword(s):  
Standard Deviation ◽  
Correlation Analysis ◽  
Service Management ◽  
Pearson Correlation ◽  
Hotel Industry ◽  
Southwest Nigeria ◽  
Guest Satisfaction ◽  
Pearson Correlation Analysis ◽  
The Impact ◽  
The Relationship

This study investigates the impact of service management on guest satisfaction in the hotel industry in five medium hotels in Abeokuta, Southwest Nigeria. A sample size of 154 was selected for the study, in which 102 usable responses were analyzed in inferential statistics for means and standard deviation. Pearson correlation, Analysis of Variance, and Ordinary List Squares were compared to measure relationships between variables through the formulated hypotheses for the study. Findings revealed a significant relationship between sufficient service management and guest satisfaction, while the relationship between guest goodwill and service management in the study area is not statistically significant. The study recommends the essentiality for the employer to provide adequate motivation to enhance workforce dedication to facilitate guest satisfaction.

Downregulation of miR-519d-3p is Associated with Poor Outcomes and Facilitates Tumor Progression in Papillary Thyroid Cancer by Regulating FOXQ1

2021 ◽  
Vol 53 (09) ◽  
pp. 625-632
Author(s):  
Pihong Li ◽  
Xiaoyu Pan ◽  
Zhouci Zheng ◽  
Yihan Sun ◽  
Yifan Han ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Tumor Progression ◽  
Papillary Thyroid Cancer ◽  
Cox Regression ◽  
Biological Effects ◽  
Pearson Correlation ◽  
Progression Free Survival ◽  
Luciferase Reporter ◽  
Migration And Invasion ◽  
Papillary Thyroid

AbstractMicroRNA-519d-3p (miR-519d-3p) has emerged as a tumor suppressor in several human cancers. But whether miR-519d-3p is involved in papillary thyroid cancer (PTC) remains elusive. In this study, we investigated the potential relevance of miR-miR-519d-3p in PTC. A retrospective study of 119 PTCs was carried out. The RT-qPCR analysis was used to measure the expression of miR-519d-3p and FOXQ1 in PTC tissues and cells. Chi-square test, Kaplan–Meier curve analysis, and multivariate Cox regression analyses were performed to assess the clinical and prognostic value of miR-519d-3p in PTC. Then cellular experiments were used to explore its biological effects on PTC cells. Finally, the Pearson correlation coefficient, dual-luciferase reporter assay, and rescue experiments were used to analyze the association between miR-519d-3p and FOXQ1. miR-519d-3p was significantly downregulated in PTC tissues and cell lines. The decreased expression of miR-519d-3p was associated with reduced overall survival and progression-free survival of patients. The proliferative, migratory, and invasive abilities of cells were blocked or elevated after upregulation or downregulation of miR-519d-3p, while FOXQ1 reversed these cellular behaviors caused after upregulation or knockdown of miR-519d-3p. In conclusion, miR-519d-3p was downregulated in PTC and associated with OS and PFS of patients. MiR-519d-3p may be a tumor-inhibiting miRNA in PTC, and that miR-519d-3p/FOXQ1 axis mediated PTC tumor progression from cell proliferation, migration, and invasion in PTC cells.

scholarly journals The Impact of Age and Gender on Papillary Thyroid Cancer Survival

2012 ◽  
Vol 97 (6) ◽  
pp. E878-E887 ◽  
Author(s):  
J. Jonklaas ◽  
G. Nogueras-Gonzalez ◽  
M. Munsell ◽  
D. Litofsky ◽  
K. B. Ain ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Cancer Survival ◽  
Papillary Thyroid ◽  
Age And Gender ◽  
And Gender ◽  
The Impact

scholarly journals Impact of Extent of Surgery on Survival for Papillary Thyroid Cancer Patients Younger Than 45 Years

2015 ◽  
Vol 100 (1) ◽  
pp. 115-121 ◽  
Author(s):  
Mohamed Abdelgadir Adam ◽  
John Pura ◽  
Paolo Goffredo ◽  
Michaela A. Dinan ◽  
Terry Hyslop ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Papillary Thyroid Cancer ◽  
Extent Of Resection ◽  
Stage I ◽  
Papillary Thyroid ◽  
Cancer Data ◽  
Thyroid Lobectomy ◽  
Extent Of Surgery ◽  
The Impact

Abstract Context: Papillary thyroid cancer (PTC) patients &lt;45 years old are considered to have an excellent prognosis; however, current guidelines recommend total thyroidectomy for PTC tumors &gt;1.0 cm, regardless of age. Objective: Our objective was to examine the impact of extent of surgery on overall survival (OS) in patients &lt;45 years old with stage I PTC of 1.1 to 4.0 cm. Design, Setting, and Patients: Adult patients &lt;45 years of age undergoing surgery for stage I PTC were identified from the National Cancer Data Base (NCDB, 1998–2006) and the Surveillance, Epidemiology, and End Results dataset (SEER, 1988–2006). Main Outcome Measure: Multivariable modeling was used to compare OS for patients undergoing total thyroidectomy vs lobectomy. Results: In total, 29 522 patients in NCDB (3151 lobectomy, 26 371 total thyroidectomy) and 13 510 in SEER (1379 lobectomy, 12 131 total thyroidectomy) were included. Compared with patients undergoing lobectomy, patients having total thyroidectomy more often had extrathyroidal and lymph node disease. At 14 years, unadjusted OS was equivalent between total thyroidectomy and lobectomy in both databases. After adjustment, OS was similar for total thyroidectomy compared with lobectomy across all patients with tumors of 1.1 to 4.0 cm (NCDB: hazard ratio = 1.45 [confidence interval = 0.88–2.51], P = 0.19; SEER: 0.95 (0.70–1.29), P = 0.75) and when stratified by tumor size: 1.1 to 2.0 cm (NCDB: 1.12 [0.50–2.51], P = 0.78; SEER: 0.95 [0.56–1.62], P = 0.86) and 2.1 to 4.0 cm (NCDB: 1.93 [0.88–4.23], P = 0.10; SEER: 0.94 [0.60–1.49], P = 0.80). Conclusions: After adjusting for patient and clinical characteristics, total thyroidectomy compared with thyroid lobectomy was not associated with improved survival for patients &lt;45 years of age with stage I PTC of 1.1 to 4.0 cm. Additional clinical and pathologic factors should be considered when choosing extent of resection.

The Impact Analysis of Climate Change on the Wetland in Jianghan and Dongting Plain

2013 ◽  
Vol 864-867 ◽  
pp. 949-952
Author(s):  
Hui Li ◽  
Xue Lei Wang ◽  
Xiao Yan Wang ◽  
Liu Zhi Jiang ◽  
Ting Zhang ◽  
...  
Keyword(s):  
Climate Change ◽  
Correlation Analysis ◽  
Air Temperature ◽  
Impact Analysis ◽  
Algal Bloom ◽  
Pearson Correlation ◽  
Significant Negative Correlation ◽  
Pearson Correlation Analysis ◽  
Migratory Route ◽  
The Impact

The trend of climate change in Jianghan and Dongting Plain is obvious. The trend of climate change and its impact on the wetland were got through the unitary linear recursive analysis and Pearson correlation analysis. That the air temperature is becoming higher made the algal bloom happens earlier. The precipitation has a significant negative correlation with the exposed days of bottomland. Meanwhile, the exposed days of bottomland has a positive correlation with the air temperature. The trend of climate warming has impact on the distribution, migratory route and breed time. The biodiversity decreased in the Jianghan and Dongting Plain.

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