Feasibility Study of Deep Learning Based Radiation Sensitivity Prediction Model Using Gene Expression Profiling

2021 ◽  
Author(s):  
Euidam Kim ◽  
Yoonsun Chung
Keyword(s):  
Neural Network ◽  
Gene Expression ◽  
Deep Learning ◽  
Prediction Model ◽  
Relative Error ◽  
Absorbed Dose ◽  
Absolute Error ◽  
Radiation Sensitivity ◽  
Learning Technology

Abstract Since radiation sensitivity prediction can be used in various field, we investigate the feasibility of an in vitro radiation sensitivity prediction model using a deep neural network. A microarray of the National Cancer Institute-60 tumor cell lines and clonogenic surviving fraction at an absorbed dose of 2 Gy values are used to predict radiation sensitivity. The prediction model is based on convolutional neural network and 6-fold cross-validation approach is applied to validate the model. Of the 174 samples, 170 (97.7%) samples show less than 10% and 4 (2.30%) show more than 10% of relative error, respectively. Through an additional validation, model accurately predict 172 out of 174 samples, representing a prediction accuracy of 98.85% under the criteria of absolute error < 0.01 or the relative error < 10%. This results demonstrate that in vitro radiation sensitivity prediction from gene expression can be carried out with the deep learning technology.

scholarly journals Deep Learning Approach in DOA Estimation: A Systematic Literature Review

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Shengguo Ge ◽  
Kuo Li ◽  
Siti Nurulain Binti Mohd Rum
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Deep Neural Network ◽  
Array Signal Processing ◽  
Mean Squared Error ◽  
Doa Estimation ◽  
Absolute Error ◽  
Future Research ◽  
Great Success ◽  
Learning Technology

In array signal processing, the direction of arrival (DOA) of the signal source has drawn broad research interests with its wide applications in fields such as sonar, radar, communications, medical detection, and electronic countermeasures. In recent years, the application of deep learning (DL) to DOA estimation has achieved great success. This study provides a systematic review of research on DOA estimation using deep neural network methods. We manually selected twenty-five papers related to this research from five prominent databases (SpringerLink, IEEE Xplore, ScienceDirect, Scopus, and Google Scholar) for exploration. Six questions describing the overall trend of DOA estimation using deep learning are put forward. Then, we answered these questions by reviewing the literature. This review is helpful for researchers in this field because it provides more specific and comprehensive information needed for future research. Specifically, we first analyzed the background of the selected papers, including the type of publication, the number of citations, and the country of origin. Then, the DL technology used in DOA estimation is systematically analyzed, including the purpose of using DL in DOA estimation, various DL models (convolutional neural network, deep neural network, and combination network), and various DOA estimation schemes. Finally, various evaluation criteria (root-mean-squared error, accuracy, and mean absolute error) are used to evaluate the DL technology in DOA estimation, and various factors (signal-to-noise ratio, number of snapshots, number of antennas, and number of signal sources) affecting DOA estimation are analyzed. Based on our findings, we believe that deep learning can perform DOA estimation well, and there is still room for improvement in deep learning technology. In this study, the factors affecting DOA estimation can be used as the direction for researchers to conduct in-depth research.

scholarly journals Design and Implementation of Intelligent Inspection and Alarm Flight System for Epidemic Prevention

Drones ◽  
2021 ◽  
Vol 5 (3) ◽  
pp. 68
Author(s):  
Jiwei Fan ◽  
Xiaogang Yang ◽  
Ruitao Lu ◽  
Xueli Xie ◽  
Weipeng Li
Keyword(s):  
Deep Learning ◽  
Autonomous Navigation ◽  
Detection Method ◽  
Active Role ◽  
Absolute Error ◽  
Face Mask ◽  
Learning Technology ◽  
Flight System ◽  
Crowd Density ◽  
The Mean

Unmanned aerial vehicles (UAV) and related technologies have played an active role in the prevention and control of novel coronaviruses at home and abroad, especially in epidemic prevention, surveillance, and elimination. However, the existing UAVs have a single function, limited processing capacity, and poor interaction. To overcome these shortcomings, we designed an intelligent anti-epidemic patrol detection and warning flight system, which integrates UAV autonomous navigation, deep learning, intelligent voice, and other technologies. Based on the convolution neural network and deep learning technology, the system possesses a crowd density detection method and a face mask detection method, which can detect the position of dense crowds. Intelligent voice alarm technology was used to achieve an intelligent alarm system for abnormal situations, such as crowd-gathering areas and people without masks, and to carry out intelligent dissemination of epidemic prevention policies, which provides a powerful technical means for epidemic prevention and delaying their spread. To verify the superiority and feasibility of the system, high-precision online analysis was carried out for the crowd in the inspection area, and pedestrians’ faces were detected on the ground to identify whether they were wearing a mask. The experimental results show that the mean absolute error (MAE) of the crowd density detection was less than 8.4, and the mean average precision (mAP) of face mask detection was 61.42%. The system can provide convenient and accurate evaluation information for decision-makers and meets the requirements of real-time and accurate detection.

scholarly journals Detection and Severity Evaluation of Combined Rail Defects Using Deep Learning

Vibration ◽  
2021 ◽  
Vol 4 (2) ◽  
pp. 341-356
Author(s):  
Jessada Sresakoolchai ◽  
Sakdirat Kaewunruen
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Deep Learning ◽  
Mean Absolute Error ◽  
Absolute Error ◽  
Machine Learning Techniques ◽  
Rolling Stock ◽  
Raw Data ◽  
Learning Techniques ◽  
Combined Defects

Various techniques have been developed to detect railway defects. One of the popular techniques is machine learning. This unprecedented study applies deep learning, which is a branch of machine learning techniques, to detect and evaluate the severity of rail combined defects. The combined defects in the study are settlement and dipped joint. Features used to detect and evaluate the severity of combined defects are axle box accelerations simulated using a verified rolling stock dynamic behavior simulation called D-Track. A total of 1650 simulations are run to generate numerical data. Deep learning techniques used in the study are deep neural network (DNN), convolutional neural network (CNN), and recurrent neural network (RNN). Simulated data are used in two ways: simplified data and raw data. Simplified data are used to develop the DNN model, while raw data are used to develop the CNN and RNN model. For simplified data, features are extracted from raw data, which are the weight of rolling stock, the speed of rolling stock, and three peak and bottom accelerations from two wheels of rolling stock. In total, there are 14 features used as simplified data for developing the DNN model. For raw data, time-domain accelerations are used directly to develop the CNN and RNN models without processing and data extraction. Hyperparameter tuning is performed to ensure that the performance of each model is optimized. Grid search is used for performing hyperparameter tuning. To detect the combined defects, the study proposes two approaches. The first approach uses one model to detect settlement and dipped joint, and the second approach uses two models to detect settlement and dipped joint separately. The results show that the CNN models of both approaches provide the same accuracy of 99%, so one model is good enough to detect settlement and dipped joint. To evaluate the severity of the combined defects, the study applies classification and regression concepts. Classification is used to evaluate the severity by categorizing defects into light, medium, and severe classes, and regression is used to estimate the size of defects. From the study, the CNN model is suitable for evaluating dipped joint severity with an accuracy of 84% and mean absolute error (MAE) of 1.25 mm, and the RNN model is suitable for evaluating settlement severity with an accuracy of 99% and mean absolute error (MAE) of 1.58 mm.

scholarly journals Methodology for comprehensive cell-level analysis of wound healing experiments using deep learning in MATLAB

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Jan Oldenburg ◽  
Lisa Maletzki ◽  
Anne Strohbach ◽  
Paul Bellé ◽  
Stefan Siewert ◽  
...  
Keyword(s):  
Wound Healing ◽  
Deep Learning ◽  
Cell Density ◽  
Relative Error ◽  
Medical Image Analysis ◽  
Learning Algorithms ◽  
Cell Velocity ◽  
Population Scale ◽  
Conventional Methods

Abstract Background Endothelial healing after deployment of cardiovascular devices is particularly important in the context of clinical outcome. It is therefore of great interest to develop tools for a precise prediction of endothelial growth after injury in the process of implant deployment. For experimental investigation of re-endothelialization in vitro cell migration assays are routinely used. However, semi-automatic analyses of live cell images are often based on gray value distributions and are as such limited by image quality and user dependence. The rise of deep learning algorithms offers promising opportunities for application in medical image analysis. Here, we present an intelligent cell detection (iCD) approach for comprehensive assay analysis to obtain essential characteristics on cell and population scale. Results In an in vitro wound healing assay, we compared conventional analysis methods with our iCD approach. Therefore we determined cell density and cell velocity on cell scale and the movement of the cell layer as well as the gap closure between two cell monolayers on population scale. Our data demonstrate that cell density analysis based on deep learning algorithms is superior to an adaptive threshold method regarding robustness against image distortion. In addition, results on cell scale obtained with iCD are in agreement with manually velocity detection, while conventional methods, such as Cell Image Velocimetry (CIV), underestimate cell velocity by a factor of 0.5. Further, we found that iCD analysis of the monolayer movement gave results just as well as manual freehand detection, while conventional methods again shows more frayed leading edge detection compared to manual detection. Analysis of monolayer edge protrusion by ICD also produced results, which are close to manual estimation with an relative error of 11.7%. In comparison, the conventional Canny method gave a relative error of 76.4%. Conclusion The results of our experiments indicate that deep learning algorithms such as our iCD have the ability to outperform conventional methods in the field of wound healing analysis. The combined analysis on cell and population scale using iCD is very well suited for timesaving and high quality wound healing analysis enabling the research community to gain detailed understanding of endothelial movement.

scholarly journals Developing an Individual Glucose Prediction Model Using Recurrent Neural Network

Sensors ◽  
2020 ◽  
Vol 20 (22) ◽  
pp. 6460
Author(s):  
Dae-Yeon Kim ◽  
Dong-Sik Choi ◽  
Jaeyun Kim ◽  
Sung Wan Chun ◽  
Hyo-Wook Gil ◽  
...  
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Prediction Model ◽  
Glucose Level ◽  
Recurrent Neural Network ◽  
Learning Algorithm ◽  
Percentage Error ◽  
Glucose Prediction

In this study, we propose a personalized glucose prediction model using deep learning for hospitalized patients who experience Type-2 diabetes. We aim for our model to assist the medical personnel who check the blood glucose and control the amount of insulin doses. Herein, we employed a deep learning algorithm, especially a recurrent neural network (RNN), that consists of a sequence processing layer and a classification layer for the glucose prediction. We tested a simple RNN, gated recurrent unit (GRU), and long-short term memory (LSTM) and varied the architectures to determine the one with the best performance. For that, we collected data for a week using a continuous glucose monitoring device. Type-2 inpatients are usually experiencing bad health conditions and have a high variability of glucose level. However, there are few studies on the Type-2 glucose prediction model while many studies performed on Type-1 glucose prediction. This work has a contribution in that the proposed model exhibits a comparative performance to previous works on Type-1 patients. For 20 in-hospital patients, we achieved an average root mean squared error (RMSE) of 21.5 and an Mean absolute percentage error (MAPE) of 11.1%. The GRU with a single RNN layer and two dense layers was found to be sufficient to predict the glucose level. Moreover, to build a personalized model, at most, 50% of data are required for training.

scholarly journals Research on GDP Forecast Analysis Combining BP Neural Network and ARIMA Model

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Shaobo Lu
Keyword(s):  
Neural Network ◽  
Time Series ◽  
Prediction Model ◽  
Error Correction ◽  
Relative Error ◽  
Bp Neural Network ◽  
Arima Model ◽  
Forecast Model ◽  
Price Prediction ◽  
The Neural Network

Based on the BP neural network and the ARIMA model, this paper predicts the nonlinear residual of GDP and adds the predicted values of the two models to obtain the final predicted value of the model. First, the focus is on the ARMA model in the univariate time series. However, in real life, forecasts are often affected by many factors, so the following introduces the ARIMAX model in the multivariate time series. In the prediction process, the network structure and various parameters of the neural network are not given in a systematic way, so the operation of the neural network is affected by many factors. Each forecasting method has its scope of application and also has its own weaknesses caused by the characteristics of its own model. Secondly, this paper proposes an effective combination method according to the GDP characteristics and builds an improved algorithm BP neural network price prediction model, the research on the combination of GDP prediction model is currently mostly focused on the weighted form, and this article proposes another combination, namely, error correction. According to the price characteristics, we determine the appropriate number of hidden layer nodes and build a BP neural network price prediction model based on the improved algorithm. Validation of examples shows that the error-corrected GDP forecast model is also better than the weighted GDP forecast model, which shows that error correction is also a better combination of forecasting methods. The forecast results of BP neural network have lower errors and monthly prices. The relative error of prediction is about 2.5%. Through comparison with the prediction results of the ARIMA model, in the daily price prediction, the relative error of the BP neural network prediction is 1.5%, which is lower than the relative error of the ARIMA model of 2%.

scholarly journals Deep Learning Based Proarrhythmia Analysis Using Field Potentials Recorded from Human Pluripotent Stem Cells Derived Cardiomyocytes

2018 ◽  
Author(s):  
Zeinab Golgooni ◽  
Sara Mirsadeghi ◽  
Mahdieh Soleymani Baghshah ◽  
Pedram Ataee ◽  
Hossein Baharvand ◽  
...  
Keyword(s):  
Neural Network ◽  
Stem Cells ◽  
Deep Learning ◽  
Pluripotent Stem Cells ◽  
Field Potential ◽  
Input Sequence ◽  
Patient Specific ◽  
Field Potentials ◽  
Drug Induced

AbstractAimAn early characterization of drug-induced cardiotoxicity may be possible by combining comprehensive in vitro pro-arrhythmia assay and deep learning techniques. The goal of this study was to develop a deep learning method to automatically detect irregular beating rhythm as well as abnormal waveforms of field potentials in an in vitro cardiotoxicity assay using human pluripotent stem cell (hPSC) derived cardiomyocytes and multi-electrode array (MEA) system.Methods and ResultsWe included field potential waveforms from 380 experiments which obtained by application of some cardioactive drugs on healthy and/or patient-specific induced pluripotent stem cells derived cardiomyocytes (iPSC-CM). We employed convolutional and recurrent neural networks, in order to develop a new method for automatic classification of field potential recordings without using any hand-engineered features. In the proposed method, a preparation phase was initially applied to split 60-second long recordings into a series of 5-second long windows. Thereafter, the classification phase comprising of two main steps was designed. In the first step, 5-second long windows were classified using a designated convolutional neural network (CNN). In the second step, the results of 5-second long window assessments were used as the input sequence to a recurrent neural network (RNN). The output was then compared to electrophysiologist-level arrhythmia (irregularity or abnormal waveforms) detection, resulting in 0.84 accuracy, 0.84 sensitivity, 0.85 specificity, and 0.88 precision.ConclusionA novel deep learning approach based on a two-step CNN-RNN method can be used for automated analysis of “irregularity or abnormal waveforms” in an in vitro model of cardiotoxicity experiments.

scholarly journals Flutter speed prediction by using deep learning

2021 ◽  
Vol 13 (11) ◽  
pp. 168781402110622
Author(s):  
Yi-Ren Wang ◽  
Yi-Jyun Wang
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Short Term Memory ◽  
Learning Technology ◽  
Memory Space ◽  
Flutter Speed ◽  
Aeroelastic Flutter ◽  
Speed Prediction ◽  
Computational Fluid Dynamics Cfd ◽  
Cfd Method

Deep learning technology has been widely used in various field in recent years. This study intends to use deep learning algorithms to analyze the aeroelastic phenomenon and compare the differences between Deep Neural Network (DNN) and Long Short-term Memory (LSTM) applied on the flutter speed prediction. In this present work, DNN and LSTM are used to address complex aeroelastic systems by superimposing multi-layer Artificial Neural Network. Under such an architecture, the neurons in neural network can extract features from various flight data. Instead of time-consuming high-fidelity computational fluid dynamics (CFD) method, this study uses the K method to build the aeroelastic flutter speed big data for different flight conditions. The flutter speeds for various flight conditions are predicted by the deep learning methods and verified by the K method. The detailed physical meaning of aerodynamics and aeroelasticity of the prediction results are studied. The LSTM model has a cyclic architecture, which enables it to store information and update it with the latest information at the same time. Although the training of the model is more time-consuming than DNN, this method can increase the memory space. The results of this work show that the LSTM model established in this study can provide more accurate flutter speed prediction than the DNN algorithm.

A Model Based on BP Neural Network for Audible Noise Prediction

2014 ◽  
Vol 986-987 ◽  
pp. 1356-1359
Author(s):  
You Xian Peng ◽  
Bo Tang ◽  
Hong Ying Cao ◽  
Bin Chen ◽  
Yu Li
Keyword(s):  
Neural Network ◽  
Prediction Model ◽  
Transmission Lines ◽  
Bp Neural Network ◽  
Prediction Models ◽  
Absolute Error ◽  
Research Area ◽  
Noise Prediction ◽  
Bp Network ◽  
Model Based

Audible noise prediction is a hot research area in power transmission engineering in recent years, especially come down to AC transmission lines. The conventional prediction models at present have got some problems such as big errors. In this paper, a prediction model is established based on BP network, in which the input variables are the four factors in the international common expression of power line audible noise and the noise value is the output. Take multiple measured power lines as an example, a train is made by the BP network and then the prediction model is set up in the hidden layer of the network. Using the trained model, the audible noise values are predicted. The final results show that the average absolute error in absolute terms of the values by the audible noise prediction model based on BP neural network is 1.6414 less than that predicted by the GE formula.

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