scholarly journals COVID-19: An In-Silico Analysis on Potential Therapeutic Uses of Trikadu as Immune System Boosters

2021 ◽  
Author(s):  
Rukaiya Hasani Khasamwala ◽  
Ranjani S ◽  
S Hemalatha
Keyword(s):  
Immune System ◽  
Antioxidant Properties ◽  
In Silico Analysis ◽  
Preventive Measure ◽  
Zingiber Officinale ◽  
Herbal Remedies ◽  
Piper Nigrum ◽  
Alternative Medicines ◽  
Therapeutic Uses ◽  
Autodock 4.0

Abstract Corona virus pandemic outbreak also known as COVID-19 has created an imbalance in this World. With the vaccines still in the trials, Scientists have adopted the use of natural or alternative medicines which are consumed mostly as dietary supplements to boost the immune system using herbal remedies. India is famous for traditional medicinal formulations which includes, ‘Trikadu’ –A combination of three acrids namely Zingiber officinale, Piper nigrum and Piper longum which has antioxidant properties that boost our immune system hence acting as a strong preventive measure. In this study AutoDock 4.0 was used to study interaction between the phytocompounds of Trikadu with RNA Dependant polymerase protein and Enveloped protein of the virus. Analysis of the results showed that Coumarin, Coumaperine and Bisdemethoxycurcumin showed strong bonding interactions with both the proteins. We can conclude that Trikadu are the potential molecules which can be incorporated in the diet to boost the immune system as a preventive measure against the virus.

scholarly journals Network pharmacology of AYUSH recommended immune-boosting medicinal plants against COVID-19

2020 ◽  
Author(s):  
Pukar Khanal ◽  
Taaza Duyu ◽  
Yadu Nandan Dey ◽  
B M Patil ◽  
Iasmail Pasha ◽  
...  
Keyword(s):  
Immune System ◽  
Preventive Measure ◽  
Zingiber Officinale ◽  
Piper Nigrum ◽  
Network Pharmacology ◽  
Multiple Infections ◽  
Nf Kappa B ◽  
Protein Protein Interaction ◽  
Novel Coronavirus ◽  
Immune Booster

Abstract Background: The Ministry of AYUSH recommended the use of a decoction of the mixture of Ocimum tenuiflorum, Cinnamomum verum, Piper nigrum, Zingiber officinale, and Vitis vinifera as a preventive measure to boost immunity and to inhibit the severity of infection caused by a novel coronavirus (COVID-19). Objective: The present study aimed to identify the probable modulated pathways via AYUSH recommended formulation as an immune booster against COVID-19.Materials and methods: Reported phytoconstituents of all the plants were retrieved from the ChEBI database, and their targets were predicted using DIGEP-Pred. STRING database and Cytoscape were used to predict the protein-protein interaction and construct the network interaction respectively. Likewise, MolSoft and admetSAR2.0 were used to predict the druglikeness score and ADMET profile of phytoconstituents. Results: The study identified the modulation of HIF-1, p53, PI3K-Akt, MAPK, cAMP, Ras, Wnt, NF-kappa B, IL-17, TNF, and cGMP-PKG signaling pathways to boost the immune system. Further, multiple pathways were also identified which are involved in the regulation of pathogenesis of the multiple infections and non-infectious diseases due to the lower immune system.Conclusion: Results indicated that the recommended herbal formulation not only modulated the pathways related to boost the immune system but also modulated the multiple pathways that are contributing in the progression of multiple disease pathogenesis which would add the beneficial effect in the special subjects like patients from hypertension and diabetes in which 4-hydroxychloroquine therapeutic approach cannot be made. The study provides the scientific documentation of the role of the Ayurvedic formulation to combat COVID-19.

scholarly journals A Review on Efficacy of Siddha Medicinal Herbs as Antiviral Drugs against COVID-19

2021 ◽  
Vol 12 (1) ◽  
pp. 1-6
Author(s):  
Muralidass S D ◽  
Shree Devi M S
Keyword(s):  
Infectious Disease ◽  
Nigella Sativa ◽  
Curcuma Longa ◽  
Antioxidant Properties ◽  
Herbal Medicines ◽  
Zingiber Officinale ◽  
World Health ◽  
Tinospora Cordifolia ◽  
Piper Nigrum ◽  
Ocimum Sanctum

In a very short time, the Coronavirus disease (COVID-19) caused by the SARS-CoV-2 virus, has become a global pandemic. It has infected about 29,155,581 patients and brought forth death rate about 926,544 among 216 countries as recorded by World Health Organization on 15th September 2020. At present, there is no specific and direct treatment or vaccine for this infectious disease. No therapeutic options available to cure the infection in till date which increases the mortality rate across the countries. Currently there is no antiviral treatments have been approved, several approaches have been proposed in western medicine, Chinese medicine, CAM, AYUSH and other systems. Siddha Herbal medicines are achieving high attention because of the extensive therapeutics like potent anti-microbial, immunomodulatory, anti-inflammatory, and antioxidant properties. Ministry of AYUSH, Govt. of India recommended 12 Siddha herbals (Inji – Zingiber officinale, Thulasi – Ocimum sanctum, Milaku – Piper nigrum, Karunjeeragam – Nigella sativa, Keezhanelli – Phyllanthus niruri, Adhimathuram – Glycyrrhiza glabra, Vellaippoondu – Allium sativum, Citramutti – Sida cardifolia, Seenthil – Tinospora cordifolia, Manjal – Curcuma longa, Elumitchai – Citrus lemon and Vembu – Azadirachta indica) for the prevention by enhancing immunity as well as for the management of this infectious disease in its recent official publication ‘Guidelines for Siddha Practitioners for COVID 19’. This is the common advisory and the anti-viral activity of these herbals against COVID 19 is not established yet. The current situation demands proper herbal drug utilization to prepare the population immunity to fight against the infection. The present review spotlight on the literature review and the review of pharmacological actions of these herbals.

scholarly journals Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 530
Author(s):  
Oliviero Bruni ◽  
Luigi Ferini-Strambi ◽  
Elena Giacomoni ◽  
Paolo Pellegrino
Keyword(s):  
Gaba Receptors ◽  
Herbal Medicines ◽  
Well Being ◽  
Herbal Remedies ◽  
Gamma Aminobutyric Acid ◽  
Systematic Analysis ◽  
Inhibitory Neurotransmitter ◽  
Alternative Medicines ◽  
Molecular Components ◽  
The Brain

Sleep is an essential component of physical and emotional well-being, and lack, or disruption, of sleep due to insomnia is a highly prevalent problem. The interest in complementary and alternative medicines for treating or preventing insomnia has increased recently. Centuries-old herbal treatments, popular for their safety and effectiveness, include valerian, passionflower, lemon balm, lavender, and Californian poppy. These herbal medicines have been shown to reduce sleep latency and increase subjective and objective measures of sleep quality. Research into their molecular components revealed that their sedative and sleep-promoting properties rely on interactions with various neurotransmitter systems in the brain. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter that plays a major role in controlling different vigilance states. GABA receptors are the targets of many pharmacological treatments for insomnia, such as benzodiazepines. Here, we perform a systematic analysis of studies assessing the mechanisms of action of various herbal medicines on different subtypes of GABA receptors in the context of sleep control. Currently available evidence suggests that herbal extracts may exert some of their hypnotic and anxiolytic activity through interacting with GABA receptors and modulating GABAergic signaling in the brain, but their mechanism of action in the treatment of insomnia is not completely understood.

scholarly journals In Silico Bioactive Peptide Prediction from The Enzymatic Hydrolysates of Edible Seaweed Rubisco Large Chain

2021 ◽  
Vol 21 (12) ◽  
pp. 615-625
Author(s):  
Ayse Kose
Keyword(s):  
In Silico ◽  
Bioactive Peptides ◽  
Antioxidant Properties ◽  
In Silico Analysis ◽  
Bioactive Peptide ◽  
Bioactive Substances ◽  
Edible Seaweed ◽  
Ic50 Values ◽  
Peptide Prediction ◽  
Ancient Food

Seaweeds are one of the ancient food supplements on Earth. Especially Asian countries use seaweeds as the fundamental ingredient in their cuisine. Seaweeds are photosynthetic organisms living in aquatic ecosystems and in the coastal territories. Seaweeds out of farm areas are frequently observed as coastal wastes. However, seaweeds are outstanding sources for bioactive substances and investigation bioactive properties of seaweed RuBisCO has never been done. RuBisCO is the most abundant protein on Earth but a vast amount of RuBisCO goes through waste. In this study, bioactive peptide prediction of frequently consumed seaweed RuBisCO proteins were analyzed in silico to identify possible bioactive peptides as substitute or support for grain, meat, and dairy based bioactive peptides. A huge portion of peptides were di-, tri- peptides with IC50 values less than 300 µM according to the comparison of BIOPEP database. Including gastric digestion, more than half of the peptides showed DDP-IV and ACE inhibitory activity followed by antioxidant properties. Also, novel antiinflammatory and anti-cancer peptides were found through in silico analysis.

scholarly journals Medicinal Plants Used by Traditional Healers in Algeria: A Multiregional Ethnobotanical Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Khadidja Belhouala ◽  
Bachir Benarba
Keyword(s):  
Medicinal Plants ◽  
Zingiber Officinale ◽  
Traditional Healers ◽  
Bioactive Molecules ◽  
Ethnobotanical Study ◽  
Medicinal Species ◽  
Face To Face ◽  
New Therapeutic Approaches ◽  
Informant Consensus ◽  
Therapeutic Uses

Traditional medicine is the cornerstone that boosts scientific research to explore new therapeutic approaches. The study aimed to assess the traditional knowledge and use of medicinal plants to treat various ailments by Algerian traditional healers. Forty traditional healers were face-to-face interviewed in three different Algerian areas (West, Kabylia, and Sahara). The data collected were analyzed using quantitative indices such as fidelity level (FL) and informant consensus factor (FIC). A total of 167 species belonging to 70 families were recorded. Lamiaceae (13%), Asteraceae (13%), Apiaceae (7%), and Rosaceae and Fabaceae (5% each) were the most cited families. The survey revealed that leaves were the most used parts of the plants (29%). Furthermore, decoction (35%), raw (24%), and infusion (19%) were the common modes for the remedies’ preparation. Here, 15% of the total species were newly reported as medicinal plants. Besides, it was reported for the first time a total of 47 new therapeutic uses for 20 known plant species. Of 17 ailments categories, cancer was presented by 44 species, showing the highest FIC of 0.46. Marrubium vulgare L., Artemisia herba-alba Asso., Zingiber officinale Roscoe., and Juniperus phoenicea L. recorded the maximum fidelity value of 100%. Therefore, our study reveals strong ethnomedicinal knowledge shared by local populations living in the three regions studied. The medicinal species with a high FL could be promising candidates for identifying new bioactive molecules.

scholarly journals Kajian Tumbuhan Obat yang Banyak Digunakan untuk Aprodisiaka oleh Beberapa Etnis Indonesia

2019 ◽  
Vol 29 (1) ◽  
pp. 51-64 ◽  
Author(s):  
Fauzi Fauzi ◽  
Harto Widodo ◽  
Sari Haryanti
Keyword(s):  
Ethnic Groups ◽  
Zingiber Officinale ◽  
Imperata Cylindrica ◽  
Sexual Disorders ◽  
Piper Nigrum ◽  
Eurycoma Longifolia ◽  
Zingiber Officinale Roscoe ◽  
Areca Catechu ◽  
Eurycoma Longifolia Jack ◽  
L 14

Abstract Sexual disorders in men can cause depression, stress, unable to have children so thatit disrupts family harmony. To overcome this problem, various ethnic groups from generation to generation utilize the plants around them. Any substance that arousing sexual desire or libido is known as aphrodisiac. This article aims to find out the types of plants and plants that are often used by various ethnic groups in Indonesia for aphrodisiacs. Data were obtained from Data Management Laboratory of NIHRD Republic of Indonesia. The method was carried out through literature review with searches from various references and analysis of data from community-based ethnomedicine and medicinal plant sexploration activities in Indonesiain 2012, 2015, and 2017. Based on data analysis, it was identified 204 types of plants used for aphrodisiacs included in 78 families. There are five families of plants that are widely used, namely Zingiberaceae, Euphorbiaceae, Arecaceae, Fabaceae, and Rubiaceae. The type of plant that is often used isImperata cylindrica (L.) Raeusch. (19 ethnicities), Zingiber officinale Roscoe. (used in 17 ethnicities) Areca catechu L. (14 ethnicitiies), Eurycoma longifolia Jack. (10 ethnicities), and Piper nigrum L. (9 ethnicities). Based on literature studies, plants that have been carried out pre-clinical testing as aphrodisiacs are Zingiber officinale Roscoe., Eurycoma longifolia Jack, and Piper nigrum Abstrak Gangguan seksual pada pria dapat menyebabkan depresi, stres, dan tidak dapat memiliki keturunan sehingga mengganggu keharmonisan rumah tangga. Untuk mengatasai masalah tersebut, berbagai etnis di Indonesia secara turun temurun memanfaatkan tumbuhan di sekitar mereka. Suatu bahan yang memiliki efek membangkitkan gairah seksual atau libido dikenal dengan sebutan aprodisiaka. Artikel ini bertujuan untuk mengetahui golongan famili dan jenis tumbuhan yang sering digunakan berbagai etnis di Indonesia untuk aprodisiaka. Data diperoleh dari Laboratorium Manajeman Data, Badan Penelitian dan Pengembangan Kesehatan RI. Metode dilakukan melalui tinjauan literatur dengan penelusuran dari berbagai referensi dan analisis data hasil kegiatan eksplorasi pengetahuan lokal etnomedisin dan tumbuhan obat berbasis komunitas di Indonesia yang dilaksanakan pada tahun 2012, 2015, dan 2017. Berdasarkan analisis data, teridentifikasi 204 jenis tumbuhan yang dimanfaatkan untuk aprodisiaka yang termasuk ke dalam 78 famili. Terdapat lima famili tumbuhan yang banyak digunakan, yaitu Zingiberaceae, Euphorbiaceae, Arecaceae, Fabaceae, dan Rubiaceae. Jenis tumbuhan yang sering digunakan adalah Imperata cylindrica (L.) Raeusch. (digunakan oleh 19 etnis), Zingiber officinale Roscoe. (17 etnis), Areca catechu L.(14 etnis), Eurycoma longifolia Jack. (10 etnis), dan Piper nigrum L. (9 etnis). Berdasarkan studi literatur, tumbuhan yang sudah dilakukan uji praklinik sebagai aprodisiaka adalah Zingiber officinale Roscoe, Eurycoma longifolia Jack, dan Piper nigrum L.

scholarly journals Zanjabeel (Zingiber officinale Roscoe.): An Evidence-Based Review of Anti-nociceptive, Anti-inflammatory, Antioxidant, and Antimicrobial Properties

2021 ◽  
pp. 26-35
Author(s):  
Fatima Khan ◽  
Mohd Nayab ◽  
Abdul Nasir Ansari
Keyword(s):  
Therapeutic Potential ◽  
Antioxidant Properties ◽  
Plant Secondary Metabolites ◽  
Zingiber Officinale ◽  
Extensive Study ◽  
The Body ◽  
Wide Range ◽  
Zingiber Officinale Roscoe ◽  
Medicinal Properties ◽  
Anti Inflammatory

Ginger has been appreciated for over 2500-3000 years in many parts of the world due to its numerous scientific properties. The ginger plant (Zingiber officinale Roscoe) belongs to the Zingiberaceae family. It is a known food and flavoring ingredient reputed for its wide range of medicinal properties that have been widely used in Chinese, Ayurvedic, and Unāni Tibb worldwide, since antiquity. Ginger has long been used to cure a variety of ailments, including diarrhea, stomach discomfort, indigestion, and nausea. It is a versatile herb with phenomenal phytotherapeutic and medicinal properties. Active ingredients available in ginger such as 6-gingerol, 6-shogaol, 6-paradol, and zingerone are responsible for upgrading enzyme actions and balancing circulation through rejuvenating the body with physical re-strengthening. Gingerols, the key phenolic plant secondary metabolites responsible for its distinct flavor and health benefits, are found in the rhizome of ginger Extensive study has been undertaken over the last two decades to uncover bioactive ingredients and the therapeutic potential of ginger. This review considers ginger's chemical composition and the most recent study findings on its possible health advantages, such as analgesic, anti-inflammatory, antibacterial, and antioxidant properties due to its phytochemistry. Overall, clinical trials are needed to confirm these prospective various health advantages of ginger in human subjects and the most efficacious dosage, based on the current body of scientific literature.

Complementary and alternative medicine in rheumatology

2011 ◽  
pp. 599-608
Author(s):  
Alan J. Hakim ◽  
Gavin P.R. Clunie ◽  
Inam Haq
Keyword(s):  
Rheumatic Disease ◽  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Chronic Diseases ◽  
Herbal Remedies ◽  
Complementary And Alternative Medicines ◽  
Alternative Medicines ◽  
Hands On ◽  
Cam Use ◽  
Complementary And Alternative

Introduction 600 Herbal remedies (phytotherapy) 602 Physical and ‘hands-on’ therapies 604 Homeopathy 605 Other complementary and alternative medicines 606 The popularity of complementary and alternative medicine (CAM) among people with chronic diseases including arthritis is widely recognized.1 Up to one-third of arthritis sufferers have received CAM from CAM practitioners and CAM use prevalence has been reported at between 30–100% of patients with rheumatic disease....

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