IVF Outcome With High Level of AMH: Focus on Pcos Versus Non-pcos
Abstract Background: To investigate whether high AMH level in PCOS patients resulted in different IVF outcomes compared to non-PCOS patients.Methods: A cross-sectional observational study involving 238 women undergoing IVF who have AMH level > 4 ng/ml. Participants then grouped into PCOS and non-PCOS cohorts. Results: The median AMH was significantly higher in the PCOS group (7.59 [4.61] ng/ml vs 5.91 [2.22] ng/ml) (U = 4087, p < 0.001). The PCOS group required less gonadotropin but yielded more oocytes after stimulation. Significantly more participants from PCOS group (41.5% [n=39]) developed hyper-response to ovarian stimulation compared to the non-PCOS group (26.4% [n=38]) (OR = 1.978, 95% CI: 1.138 – 3.488; p = 0.015).Conclusion: Women with PCOS and high AMH levels have a higher risk of hyper-response after ovarian stimulation than their non-PCOS cohorts.