scholarly journals How do outcome-based competitive relationships shape future risky cooperation?

2021 ◽  
Author(s):  
Zhenliang Liu ◽  
Yansong Li
Keyword(s):  
Interpersonal Trust ◽  
Negative Impact ◽  
Cooperative Behavior ◽  
Dependent Manner ◽  
Relational Context ◽  
Competitive Outcome ◽  
Outcome Feedback ◽  
Personal Costs ◽  
To Receive ◽  
Insight Into

Abstract There is growing evidence that cooperative behavior between individuals is regulated by their experience of previous interactions with others. However, it is unclear how a relationship that stems from the evaluation of outcomes from competitive interactions can affect subsequent cooperation between these individuals. To address this issue, we examined how participants cooperated with a partner having just competed with them. While competing, participants (N = 164) were randomly assigned to receive one of four types of outcome feedback regarding their performance (win vs. loss vs. uncertain vs. control). We found that both the experience of loss and of uncertainty as competitive outcomes exerted a negative impact on the extent to which participants then engaged in mutually cooperative behavior toward their opponents. Moreover, these effects operated in a context-dependent manner: they were only found when we manipulated the relational context to imply a high potential for incurring personal costs rather than imply no risk for incurring personal costs and mutual gains. Finally, our mediation analysis further revealed that the effect of the loss outcome was mediated by the intention of participants to cooperate and their level of interpersonal trust, while the effect of uncertain competitive outcome was mediated only by the extent to which participants intended to cooperate. This suggests the presence of distinct psychological processes underlying the effects of these two types of competitive outcome. Taken together, these finding offer novel insight into how risky cooperation may cascade from previous exposure to competitive settings.

Children selectively favor leaders and prosocial agents in an economic exchange

2019 ◽  
Author(s):  
Francesco Margoni ◽  
Elena Nava ◽  
Luca Surian
Keyword(s):  
Interpersonal Trust ◽  
Cooperative Behavior ◽  
Dictator Game ◽  
Trust Game ◽  
School Age Children ◽  
Antisocial Behaviors ◽  
Indirect Reciprocity ◽  
Trading Partners ◽  
Child Friendly ◽  
Neutral Agent

Most cooperative interactions involve the expectation of mutual reciprocation and are based on interpersonal trust. Thus, understanding when and how humans acquire interpersonal trust can help unveiling the origins and development of children’s cooperative behavior. Here, we investigated whether prior socio-moral information about trading partners modulates the choice of preschool- (4-5 years) and school-age children (7-8 years) to share their own goods in a child-friendly version of the Trust Game. In this game, the trustee partner can repay the child’s initial investment or keep everything and betray the trustor. In two studies, we addressed whether trust is modulated by trustees exhibiting prosocial versus antisocial behaviors (Study 1, ‘helpers and hinderers’), or respect-based versus fear-based power (Study 2, ‘leaders and bullies’). Preschoolers trusted the leader more than the bully, and trusted the hinderer less than a neutral agent, but did not yet trust the helper more than the hinderer. The tendency to trust helpers more than hinderers increased with age as a result of the increased propensity to trust the prosocial agent. In Study 3, a group of preschoolers played the Dictator Game, a measure of pure generosity, with the same agents used for Study 1. Sharing rates were reliably lower than in Study 1, suggesting that the rates of investment in the trust game cannot be due solely to altruistic or indirect reciprocity motives. Overall, these findings indicate that, by age five, children understand complex cooperative exchanges and start relying on socio-moral information when deciding whom to trust.

scholarly journals Control of microtubule dynamics using an optogenetic microtubule plus end–F-actin cross-linker

2017 ◽  
Vol 217 (2) ◽  
pp. 779-793 ◽  
Author(s):  
Rebecca C. Adikes ◽  
Ryan A. Hallett ◽  
Brian F. Saway ◽  
Brian Kuhlman ◽  
Kevin C. Slep
Keyword(s):  
Blue Light ◽  
Actin Binding ◽  
Cross Linking ◽  
Dependent Manner ◽  
Exclusion Zone ◽  
Actin Networks ◽  
Drosophila Melanogaster S2 Cells ◽  
Actin Binding Domain ◽  
Specific Factors ◽  
Insight Into

We developed a novel optogenetic tool, SxIP–improved light-inducible dimer (iLID), to facilitate the reversible recruitment of factors to microtubule (MT) plus ends in an end-binding protein–dependent manner using blue light. We show that SxIP-iLID can track MT plus ends and recruit tgRFP-SspB upon blue light activation. We used this system to investigate the effects of cross-linking MT plus ends and F-actin in Drosophila melanogaster S2 cells to gain insight into spectraplakin function and mechanism. We show that SxIP-iLID can be used to temporally recruit an F-actin binding domain to MT plus ends and cross-link the MT and F-actin networks. Cross-linking decreases MT growth velocities and generates a peripheral MT exclusion zone. SxIP-iLID facilitates the general recruitment of specific factors to MT plus ends with temporal control enabling researchers to systematically regulate MT plus end dynamics and probe MT plus end function in many biological processes.

scholarly journals Propiedades psicométricas de la Escala de Interacción en las Clases Dirigidas (EICD)

2016 ◽  
Vol 12 (3) ◽  
pp. 840 ◽  
Author(s):  
Adrián Pastor-Barceló ◽  
Vicente Prado-Gascó ◽  
Pilar Bustillo-Casero
Keyword(s):  
Design Methodology ◽  
Scientific Literature ◽  
Small Sample ◽  
Improve Quality ◽  
Validity And Reliability ◽  
Final Version ◽  
First Time ◽  
To Receive ◽  
Insight Into

Purpose: This research focuses on the construction and validation of a scale designed to assess the quality of the supervised classes: Interaction on Supervised Classes Scale (ISCS).Design/methodology/approach: This is a descriptive correlational study. For the construction of the scale three phases were performed in which different experts assessed the adequacy of the items. Finally, the psychometric properties of the final version were studied in a sample of 314 consumers (69.1% women) aged between 18 and 77 with an average of 39.33 years (SD=12.25).Findings: The scale presents adequate validity and reliability, being a useful tool for measuring the interaction in Supervised Classes.Research limitations/implications: The sampling, non-probabilistic or convenience, have taken the sample of a unique sports facility and the small sample size.Practical implications: The ISCS allows managers to receive better feedback, allowing them to obtain deeper insight into the quality and satisfaction of the service. According to its results, the managers may implement different strategies to improve quality in a key service within sports centers.Originality/value: For the first time the interaction between customers and between customers and employees is evaluated both inside and outside the center, a topic that had not yet been studied in the scientific literature. The scale can be applied to any type of directed activity, and will allow a greater understanding of the quality of service.

Market Influence Analytics in a Digital Ecosystem

2012 ◽  
Vol 2 (4) ◽  
pp. 42-53 ◽  
Author(s):  
Vandana Ahuja
Keyword(s):  
Negative Impact ◽  
Information Age ◽  
Product Positioning ◽  
Careful Evaluation ◽  
Digital Ecosystem ◽  
New Business ◽  
Marketing Intelligence ◽  
Micro Level ◽  
Viral Proliferation ◽  
Insight Into

The internet provides opportunities for marketing which extend from the micro level of electronic contacts to the macro level of new business opportunities. As the democratisation of consumer expression leads to a viral proliferation of information online, the new age communication ecosystem has prompted the need for a careful evaluation of the potential of what is being called Consumer Generated internet content, creating new challenges for Marketing Intelligence. These offerings of the Information age have garnered adequate potential to engineer business transformations. Consumer Generated Media (CGM) comprises the content generated by consumers within online venues such as Internet forums, Blogs, Wikis, discussion lists, etc. Leveraging CGM and channelizing it appropriately has become critical for organisations for understanding and managing market performance, product positioning, and driving brand reputations. The biggest challenge in front of organizations now is to harvest CGM to help marketers gain insight into the online market conversations taking place. Efforts are on by marketing in organizations to track the volume, origin, flow, and trajectory of the conversations in real time as they evolve, study the domain of Individual Internet Worth and map the scope, reach and influence of the same on topics that might have a positive or negative impact on a company’s products, promotions, and reputation.

scholarly journals The Acceptability of Text Messaging to Help African American Women Manage Anxiety and Depression: Cross-Sectional Survey Study

10.2196/15801 ◽  
2020 ◽  
Vol 7 (2) ◽  
pp. e15801 ◽  
Author(s):  
Terika McCall ◽  
Todd A Schwartz ◽  
Saif Khairat
Keyword(s):  
Mental Health ◽  
Health Care ◽  
African American ◽  
Mental Health Care ◽  
African American Women ◽  
Text Messaging ◽  
Anxiety And Depression ◽  
American Women ◽  
To Receive ◽  
Insight Into

Background The rates of mental illness among African American women are comparable with the general population; however, they significantly underutilize mental health services compared with their white counterparts. Previous studies revealed that interventions delivered via text messaging are effective and can be used to increase access to services and resources. More insight into whether or not this modality is acceptable for use to deliver mental health care to help African American women manage anxiety and depression is needed. Objective This exploratory study aimed to gain insight into the acceptability of using text messaging to help African American women manage anxiety and depression. Methods A self-administered Web-based survey was launched in June 2018 and closed in August 2018. Eligible participants were African American women (18 years or older) who reside in the United States. Participants were recruited through convenience sampling (eg, email sent via listservs and social media posts). Respondents were provided an anonymous link to the questionnaire. The survey consisted of 53 questions on the following subjects: sociodemographic characteristics, attitudes toward seeking professional psychological help, mobile phone use, and acceptability of using a mobile phone to receive mental health care. Results The results of this exploratory study (N=101) showed that fewer than half of respondents endorsed the use of text messaging to communicate with a professional to receive help to manage anxiety (49/101, 48.5%) and depression (43/101, 42.6%). Approximately 51.4% (52/101) agreed that having the option to use text messaging to communicate with a professional if they are dealing with anxiety would be helpful. Similarly, 48.5% (49/101) agreed that having the option to use text messaging to communicate with a professional if they are dealing with depression would be helpful. Among participants who agreed that text messaging would be helpful, more than 80% noted being comfortable with its use to receive help for managing anxiety (approximately 86%, 45/52) and depression (approximately 82%, 40/49; highly significant positive association, all P<.001). More than 50% of respondents (56/101, 55.4%) indicated having concerns about using text messaging. No statistically significant associations were found between age and agreement with the use of text messaging to communicate with a professional to receive help for managing anxiety (P=.26) or depression (P=.27). Conclusions The use of text messaging was not highly endorsed by African American women as an acceptable mode of communication with a professional to help them manage anxiety or depression. Concerns around privacy, confidentiality, and the impersonal feel of communicating about sensitive issues via text messages must be addressed for this modality to be a viable option. The findings of this study demonstrated the need for further research into the use of mobile technology to provide this population with more accessible and convenient options for mental health care.

scholarly journals Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

2013 ◽  
Vol 210 (9) ◽  
pp. 1695-1710 ◽  
Author(s):  
Tyler R. Simpson ◽  
Fubin Li ◽  
Welby Montalvo-Ortiz ◽  
Manuel A. Sepulveda ◽  
Katharina Bergerhoff ◽  
...  
Keyword(s):  
T Cells ◽  
Cytotoxic T Lymphocyte ◽  
Tumor Regression ◽  
Cell Activity ◽  
Dependent Manner ◽  
Antitumor Effector ◽  
Tumor Environment ◽  
In Trans ◽  
Immunomodulatory Therapies ◽  
Insight Into

Treatment with monoclonal antibody specific for cytotoxic T lymphocyte–associated antigen 4 (CTLA-4), an inhibitory receptor expressed by T lymphocytes, has emerged as an effective therapy for the treatment of metastatic melanoma. Although subject to debate, current models favor a mechanism of activity involving blockade of the inhibitory activity of CTLA-4 on both effector (T eff) and regulatory (T reg) T cells, resulting in enhanced antitumor effector T cell activity capable of inducing tumor regression. We demonstrate, however, that the activity of anti–CTLA-4 antibody on the T reg cell compartment is mediated via selective depletion of T reg cells within tumor lesions. Importantly, T reg cell depletion is dependent on the presence of Fcγ receptor–expressing macrophages within the tumor microenvironment, indicating that T reg cells are depleted in trans in a context-dependent manner. Our results reveal further mechanistic insight into the activity of anti-CTLA-4–based cancer immunotherapy, and illustrate the importance of specific features of the local tumor environment on the final outcome of antibody-based immunomodulatory therapies.

Carousel fraud in terms of price manipulation

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Cecília Olexová ◽  
Milan Husťák ◽  
František Sudzina
Keyword(s):  
Tax Evasion ◽  
Design Methodology ◽  
Negative Impact ◽  
Point Of View ◽  
Legal Cases ◽  
Content Type ◽  
Price Manipulation ◽  
Legal Texts ◽  
Tax Fraud ◽  
Insight Into

Purpose The purpose of this paper is to analyse the effects of carousel fraud on the average price of goods, as one of the negative economic aspects of carousel fraud. Design/methodology/approach This paper is primarily based on the description of selected legal cases and the modus operandi of carousel fraud, the analysis of legal texts (legislation and judgments of courts) and the discussion, from the point of view of price manipulation. Findings The results of the analysis specify the negative impact of carousel fraud in the form of the distortion of reported average prices and suggest that the authorities should monitor usual or fair prices to detect cases where there is a risk of carousel fraud. Originality/value This paper brings new insight into the issue of carousel frauds by understanding the principle of carousel fraud, the motives for it, and the possibilities for detecting this type of tax fraud, which is necessary to prevent tax evasion and to preserve a state’s income.

The Pen and the Spade: Gerrard Winstanley and the Digger Movement

2018 ◽  
Author(s):  
Renata Colwell
Keyword(s):  
Civil Wars ◽  
Negative Impact ◽  
The Bible ◽  
The Earth ◽  
Great Insight ◽  
English Society ◽  
Communal Living ◽  
Religious Sects ◽  
Gerrard Winstanley ◽  
Insight Into

In the wake of the English Civil Wars of the 1640s, increased religious tolerance gave rise to unprecedented religious radicalism. While most emerging religious sects adopted unorthodoxinterpretations of the Bible, some sects were more radical than others. The Diggers, led by Gerrard Winstanley, were unique in that their biblically inspired focus on private property’s inherent corruption drove them to establish an agricultural commune in Surrey in 1649. By setting an example for the rest of the world and encouraging others to adopt their methods, they hoped to ultimately restore the Earth to a state of ‘Common Treasury.’ Drawing on scriptural precedent and personal interpretation of the Bible, Winstanley offered an eloquent, politically charged justification for the Diggers’ program of communal living in The True Levellers Standard (1649), which became the Digger manifesto. It pointedly critiquedseventeenth-century English society, had both a positive and negative impact on the Diggers’ reception at the time, and survived the movement’s violent suppression and subsequent collapse. Today, it continues to offer great insight into the origins, development and fate of the Digger movement, while at the same time inspiring modern scholars to delve deeper into the movement’s significance, and raising questions about property and equality that remain highly relevant in this day and age. 

The Digitalization in the COVID-19 Era

2022 ◽  
pp. 284-304
Author(s):  
Inès Gharbi ◽  
Yomna Daoud ◽  
Aïda Kammoun
Keyword(s):  
Negative Impact ◽  
Practical Case ◽  
Review Of The Literature ◽  
Health Crisis ◽  
Digital Platforms ◽  
Goods And Services ◽  
Slowing Down ◽  
Education And Health ◽  
Digital Processes ◽  
Insight Into

In December 2019, a new viral pneumonia called COVID-19 appeared in Wuhan, China causing a health crisis that then turned into an economic and social crisis. Since then, entire sectors of the economy have been slowing down, forcing them to integrate innovative digital processes to mitigate the negative impact of this crisis. In this regard, the purpose of the chapter is to initiate a reflection on digitization processes based on a review of the literature to help explain the concept. This work allowed spotlighting the existing research on digitalization through practical case studies in business, education, and health systems, and how organizations perceive digitalization during the COVID-19 pandemic. The authors analyze how digital platforms can increase the survival rate of businesses in times of crisis and ensure the continuity of customers' access to the various goods and services. The purpose behind this is to serve as a basis for further empirical research for academics and improve the knowledge base by providing insight into the efforts of the sectors studied.

scholarly journals Progression from remodeling to hibernation of ribosomes in zinc-starved mycobacteria

2020 ◽  
Vol 117 (32) ◽  
pp. 19528-19537
Author(s):  
Yunlong Li ◽  
Jamie H. Corro ◽  
Christopher D. Palmer ◽  
Anil K. Ojha
Keyword(s):  
Zinc Concentration ◽  
Specific Protein ◽  
Zinc Binding ◽  
Free Form ◽  
Dependent Manner ◽  
Drug Resistant ◽  
Zinc Depletion ◽  
Cellular Zinc ◽  
Mouse Lungs ◽  
Insight Into

Zinc starvation in mycobacteria leads to remodeling of ribosomes, in which multiple ribosomal (r-) proteins containing the zinc-binding CXXC motif are replaced by their motif-free paralogues, collectively called C− r-proteins. We previously reported that the 70S C− ribosome is exclusively targeted for hibernation by mycobacterial-specific protein Y (Mpy), which binds to the decoding center and stabilizes the ribosome in an inactive and drug-resistant state. In this study, we delineate the conditions for ribosome remodeling and hibernation and provide further insight into how zinc depletion induces Mpy recruitment to C− ribosomes. Specifically, we show that ribosome hibernation in a batch culture is induced at an approximately two-fold lower cellular zinc concentration than remodeling. We further identify a growth phase in which the C− ribosome remains active, while its hibernation is inhibited by the caseinolytic protease (Clp) system in a zinc-dependent manner. The Clp protease system destabilizes a zinc-bound form of Mpy recruitment factor (Mrf), which is stabilized upon further depletion of zinc, presumably in a zinc-free form. Stabilized Mrf binds to the 30S subunit and recruits Mpy to the ribosome. Replenishment of zinc to cells harboring hibernating ribosomes restores Mrf instability and dissociates Mpy from the ribosome. Finally, we demonstrate zinc-responsive binding of Mpy to ribosomes inMycobacterium tuberculosis(Mtb) and show Mpy-dependent antibiotic tolerance of Mtb in mouse lungs. Together, we propose that ribosome hibernation is a specific and conserved response to zinc depletion in both environmental and pathogenic mycobacteria.

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