Socioeconomic Status and Metabolic Syndrome in Southwest Iran: Results from Hoveyzeh Cohort Study(HCS)

Abstract BackgroundSocioeconomic status (SES) is a strong predictor of morbidity and premature mortality, especially non-communicable diseases (NCDs). However, the effect of these factors on Metabolic Syndrome (MetS) is not yet clear. This study is to assess the relationship between socioeconomic indicators and MetS.MethodsIn this prospective cohort study, 10009 people aged 35-70 years enrolled from May 2016 to August 2018. MetS was determined based on the standard national cholesterol education program (NCEP) - adult treatment panel III (ATP III) or NCEP-ATP III criteria. Demographics and socioeconomic data were gathered face to face by trained interviews. Also, lab, anthropometrics, and blood pressure measurements were assayed for participants. Logistic regression was used to estimate the association between SES and MetS, with adjustment of potential confounding variables. ResultsThe overall prevalence of MetS in participants was 39.1%. The crude odds ratios for all the assessed variables were statistically significant (p<0.05). After adjustment for age, sex, physical activity, smoking, and alcohol use as potential confounders, the results indicated significant direct independent associations between skill level (p=0.006) and Townsend index (p=0.002) with MetS, while no significant associations were seen between educational level and wealth status with MetS. ConclusionThe results of our study showed that SES is related to MetS. Among four assessed SES indicators, skilled levels and Townsend score had a stronger association with MetS. We recommend considering people’s SES when interventional programs are planning and conducting on MetS in each community.

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Association Between Age at Menarche and Metabolic Syndrome in Southwest Iran: A Population-Based Case Control Study

10.21203/rs.3.rs-712759/v1 ◽

2021 ◽

Author(s):

Bahman Cheraghian ◽

Nader Saki ◽

Zahra Rahimi ◽

Sara Sarvandian ◽

Seyed Jalal Hashemi ◽

...

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

Rural Women ◽

Case Control Study ◽

Case Control ◽

Age At Menarche ◽

Case Group ◽

Southwest Iran ◽

Menarche Age ◽

Control Study

Abstract Background: Age at menarche (AAM) affects women's health outcomes and could be a risk factor for some diseases such as Metabolic Syndrome (MetS). We assessed the association between age at menarche and metabolic syndrome components (obesity, hypertension, type 2 diabetes and cardiovascular disease) in women aged 35 to 70 years in Hoveyzeh, southwest Iran.Methods: This is a case-control study conducted on 5830 women 35 to 70 years in Hoveyzeh cohort study (HCS), a part of the PERSIAN cohort study, between 2016 to 2018. The case group were women with MetS while the controls were women without MetS. Metabolic syndrome is determined based on standard NCEP-ATP III criteria. Demographic, socioeconomic and reproductive history data were gathered face to face by trained interviews. Also, lab, anthropometrics and blood pressure measurements were assayed for participants. Multiple Logistic Regression was used to estimate the association between age at menarche and metabolic syndrome, with adjustment for potential confounding variables.Results: The overall mean age at menarche was 12.60 ± 1.76 years old. Urban and rural women differed in their age at menarche (at age 12.58±1.71 and 12.63±1.83 years, respectively). Comparison of the four menarche age groups (≤10, 11-12, 13-14, 15-16 years) was statistically different showed between age at menarche and MetS. The odds of having metabolic syndrome for groups with menarche age of 13-14 years and 16-15 years, compared to women with a menstrual age ≤10 years, decreased by 21% and 20%, respectively. Conclusion: The present study showed the effect of age at menarche on odds of having MetS in women 35-70 years.

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Thyroid function and metabolic syndrome: results from the population-based LifeLines Cohort study

Endocrine Abstracts ◽

10.1530/endoabs.49.oc9.1 ◽

2017 ◽

Author(s):

Bruce Wolffenbuttel ◽

Hanneke Wouters ◽

Sandra Slagter ◽

Waateringe Robert van ◽

Vliet-Ostaptchouk Jana van ◽

...

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

Thyroid Function ◽

Population Based

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2453-PUB: Changes in Metabolic Syndrome and Diabetes Risk: A Nationwide Longitudinal Cohort Study

Diabetes ◽

10.2337/db19-2453-pub ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 2453-PUB

Author(s):

MIN-KYUNG LEE ◽

HYUK-SANG KWON ◽

KI-HO SONG ◽

JAE HYUK LEE

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

Diabetes Risk ◽

Longitudinal Cohort Study ◽

Longitudinal Cohort

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Prevalence of metabolic syndrome in never treated mood disordered patientss

Clinical & Investigative Medicine ◽

10.25011/cim.v30i4.2875 ◽

2007 ◽

Vol 30 (4) ◽

pp. 95

Author(s):

Valerie Taylor ◽

Glenda M. MacQueen

Keyword(s):

Metabolic Syndrome ◽

Mood Disorders ◽

Population Attributable Risk ◽

Disease Process ◽

Visceral Obesity ◽

Premature Mortality ◽

Overweight And Obesity ◽

The Metabolic Syndrome ◽

Increased Risk ◽

Bipolar Patients

Bipolar disorder and major depression are life-shortening illnesses. Unnatural causes such as suicide and accidents account for only a portion of this premature mortality1 Research is beginning to identify that mood disordered patients have a higher incidence of metabolic syndrome, an illness characterized by dyslipidemia, impaired glucose tolerance, hypertension and obesity.2 Metabolic syndrome is associated with an increased risk for a variety of physical illnesses. Hypothesis: Never treated patients with mood disorders have preexisting elevations in the prevalence of the component variables of metabolic syndrome. Central obesity will be especially elevated, predicting increased premature mortality. Methods: We assessed never treated patients with mood disorders for metabolic syndrome and its component variables. Patients were assessed at baseline and followed up at 6-month intervals. All psychiatric pharmacotherapy was documented. Body mass index (BMI) was also obtained and the percentage of deaths attributable to overweight and obesity was calculated using the population attributable risk (PAR). [PAR= ∑[P (RR-1)/RR] Results: Prior to the initiation of treatment, patients did not differ from population norms with respect to metabolic syndrome or BMI. At 2-year follow-up, BMI had increased for unipolar patients 2.02 points and 1.92 points for bipolar patients. (p < .001) This increase in BMI predicted an increase in mortality of 19.4%. Conclusion: An increase in visceral obesity is often the first component of metabolic syndrome to appear and may indicate the initiation of this disease process prematurely in this group. The increase in BMI places patients with mood disorders at risk for premature mortality and indicates a need for early intervention. References 1.Osby U, Brandt L, Correia N, Ekbom A & Sparen P. Excess mortability in bipolar and Unipolar disorder rin Sweden. Archives of General Psychiatry, 2001;58: 844-850 2.Toalson P, Saeeduddin A, Hardy T & Kabinoff G. The metabolic syndrome in patients with severe mental illness. Journal of Clinical Psychiatry, 2004; 6(4): 152-158

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Association between polymorphism at IGF-1 rs35767 gene locus and long-term decline in renal function: a Japanese retrospective longitudinal cohort study

BMC Nephrology ◽

10.1186/s12882-021-02408-9 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Kosuke Honda ◽

Satoru Kuriyama ◽

Kimiyoshi Ichida ◽

Tomoko Nakano ◽

Naoki Sugano ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Renal Function ◽

Uric Acid ◽

Cohort Study ◽

Serum Uric Acid Level ◽

Human Growth ◽

Longitudinal Cohort Study ◽

Longitudinal Cohort

Abstract Background Insulin-like growth factor-1 (IGF-1) acts on glucose and protein metabolism and human growth and also influences blood pressure and renal function. This study investigated whether the single-nucleotide polymorphism of IGF-1, rs35767, plays a role in metabolic syndrome indicators, including blood pressure, glucose metabolism, uric acid levels, and renal function. Methods In this retrospective longitudinal cohort study, blood samples from 1506 Japanese individuals were collected and used for genotyping for variant rs35767: T > C in the IGF-1 upstream promoter. Data were analyzed to identify associations between IGF-1 genotypes and patient biochemical parameters, including the components of metabolic syndrome and the long-term change in renal function. Results The cohort rs35767 genotypes included 650 CC carriers (43.2%), 687 TC carriers (45.6%), and 169 TT carriers (11.2%). Multiple regression analysis revealed no association between IGF-1 genotype and blood pressure, glycated hemoglobin level, and serum uric acid level. However, in females, blood pressure was negatively correlated with the TT genotype. Longitudinal observation revealed that the decline in eGFR over 10 years was greater in TT (− 18.51 ± 1.04 mL/min/1.73m2) than in CC carriers (− 16.38 ± 0.52 mL/min/1.73m2; P < 0.05). Conclusion The present study suggests that renal function declines faster in individuals with the TT genotype at the IGF-1 rs35767 locus than in those with the CC genotype, suggesting that the TT genotype is associated with the long-term chronological decline in renal function.

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A Positive Association of Overactivated Immunity with Metabolic Syndrome Risk and Mitigation of Its Association by a Plant-Based Diet and Physical Activity in a Large Cohort Study

Nutrients ◽

10.3390/nu13072308 ◽

2021 ◽

Vol 13 (7) ◽

pp. 2308

Author(s):

Sunmin Park ◽

Ting Zhang

Keyword(s):

Physical Activity ◽

Metabolic Syndrome ◽

Cohort Study ◽

Large Scale ◽

Smoking Status ◽

Characteristic Curve ◽

Daily Intake ◽

Positive Association ◽

Cell Counts ◽

High Hba1c

The association between immunity and metabolic syndrome (MetS) has been studied, but its interaction with lifestyles remains unclear. We studied their association and interactions with lifestyles in 40,768 adults aged over 40 years from a large-scale, hospital-based cohort study collected during 2010–2013. White blood cell counts (WBC) and serum C-reactive protein concentrations (CRP) were used as indexes of immune status. The participants were categorized into four groups by the cutoff points of 6.2 × 109/L WBC(L-WBC) and <0.5 mg/dL CRP(L-CRP): L-WBC+L-CRP(n = 25,604), H-WBC+L-CRP(n = 13,880), L-WBC+H-CRP(n = 464), and H-WBC+H-CRP(n = 820). The participants in the H-WBC+L-CRP were younger and had higher numbers of males than the L-WBC+L-CRP. MetS risk was higher by 1.75- and 1.86-fold in the H-WBC+L-CRP and H-WBC+H-CRP, respectively, than the L-WBC+L-CRP. MetS components, including plasma glucose and triglyceride concentrations, and SBP were elevated in H-WBC+L-CRP and H-WBC+H-CRP compared with L-WBC+L-CR+P. The risk of hyperglycemia and high HbA1c was the highest in the H-WBC+H-CRP among all groups. Areas of WBC counts and serum CRP concentrations were 0.637 and 0.672, respectively, in the receiver operating characteristic curve. Daily intake of energy, carbohydrate, protein, and fat was not significantly different in the groups based on WBC counts and CRP. However, a plant-based diet (PBD), physical activity, and non-smoking were related to lowering WBC counts and CRP, but a Western-style diet was linked to elevating CRP. A high PBD intake and smoking status interacted with immunity to influence MetS risk: a low PBD and current smoking were associated with a higher MetS risk in the H-WBC+H-CRP. In conclusion, overactivated immunity determined by CRP and WBC was associated with MetS risk. Behavior modification with PBD and physical activity might be related to immunity regulation.

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The effects of weight fluctuation on the components of metabolic syndrome: a 16-year prospective cohort study in South Korea

Archives of Public Health ◽

10.1186/s13690-021-00539-x ◽

2021 ◽

Vol 79 (1) ◽

Author(s):

Young Ran Chin ◽

Eun Sun So

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

Prospective Cohort Study ◽

Abdominal Obesity ◽

Prospective Cohort ◽

Weight Control ◽

Normal Weight ◽

Health Concern ◽

Care Providers ◽

Weight Fluctuation

Abstract Background Weight fluctuation (WF) is highly prevalent in parallel with the high prevalence of intentional or unintentional dieting. The health risks of frequent WF for metabolic syndrome (MS) have become a public health concern, especially for health care providers who supervise dieting as an intervention to prevent obesity-related morbidity or to improve health, as well as for the general population for whom dieting is of interest. The aim of this study was to investigate the long-term effect of WF on the risk of MS in Koreans. Methods This study analyzed secondary data from the Korean Genome and Epidemiology Study, a 16-year prospective cohort study, on 8150 individuals using time-dependent Cox regression. Results WF did not increase the risk of MS in either normal-weight or obese subjects. In an analysis of the components of MS, greater WF significantly increased the risk of abdominal obesity (HR = 1.05, 95% CI = 1.02–1.07, p < 0.001) in normal-weight individuals. However, WF did not increase the risk of hyperglycemia, low high-density lipoprotein cholesterol levels, elevated blood pressure, or raised fasting glucose in normal-weight individuals, and it did not influence any of the components of MS in obese individuals. Conclusion Since WF was found to be a risk factor for abdominal obesity, which is the most reliable predictor of MS, it should be considered when addressing weight control. Further studies on cut-off points for the degree of weight loss in a certain period need to be conducted to help clinicians provide guidance on appropriate weight control.

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