scholarly journals Age-and-Sex Specific Profile of Temporal Fasting Plasma Glucose Variability in a Routine Health Screening Population

2020 ◽  
Author(s):  
Agyei Helena Lartey ◽  
Xiaona Li ◽  
Zhongqi Li ◽  
Qun Zhang ◽  
Jianming Wang
Keyword(s):  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Chinese Population ◽  
Health Screening ◽  
Health Examination ◽  
Age And Gender ◽  
Fasting Plasma ◽  
And Gender ◽  
Age And Sex ◽  
Specific Profile

Abstract BackgroundFasting plasma glucose (FPG) variability is an important predictor of mortality, mainly in patients with a poor glycemic control. This study aims to explore the temporal age-and-sex specific profile of temporal FPG variability in a routine health screening Chinese population and to guide the prevention and control of diabetes for targeted public health intervention.MethodsWe used the general linear model to compare differences of temporal FPG values between gender and across age groups of 101886 Nanjing residents who took part in the routine physical health examination at the Health Management Center, the First Affiliated Hospital of Nanjing Medical University in 2018. Variability of FPG caused by time, age and gender independently or in combination was analyzed.ResultsThe participants included 57455(56.4%) males and 44431(43.6%) females, with the mean age of 42.8±15.0 years. The average FPG level was 5.5±1.1 mmol/L. The monthly variation contributed 22% of the overall FPG variability. A significant main effect for age group was observed (F=7.39, P <0.05), with a good fitting effect (Eta-squared =0.15). Variability of FPG showed gender differences by comparing the percentage differences of coefficient of variation which was higher in males than females. There were significant interaction effects of month*age*gender and day*age*gender.ConclusionsTemporal variability of FPG is obvious in the general Chinese population, which is affected by both age and gender. To avoid complications associated with FPG variability such as hypoglycemia, interventions should be directed at females and males at specific ages for optimal control of FPG variability and reducing the risk of diabetes and cardiovascular outcomes

scholarly journals Age- and sex-specific profiles of temporal fasting plasma glucose variability in a population undergoing routine health screening

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Agyei Helena Lartey ◽  
Xiaona Li ◽  
Zhongqi Li ◽  
Qun Zhang ◽  
Jianming Wang
Keyword(s):  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Chinese Population ◽  
Age Groups ◽  
Health Screening ◽  
Health Examination ◽  
Cross Sectional ◽  
Fasting Plasma ◽  
Percentage Difference ◽  
Age And Sex

Abstract Background Fasting plasma glucose (FPG) variability is a significant predictor of mortality, especially in patients with poor glycemic control. This study aimed to explore the temporal age- and sex-specific profiles of temporal FPG variability in a Chinese population undergoing routine health screening and to guide the development of targeted public health interventions for the prevention and control of diabetes. Methods In this cross-sectional study, we used a general linear model to compare differences in temporal FPG values between sexes and across age groups in 101,886 Nanjing residents who underwent a routine physical health examination at the Health Management Center, the First Affiliated Hospital of Nanjing Medical University, in 2018. The variability of FPG as a function of time, age, and sex, independently and in combination, was analyzed. Results The participants included 57,455 (56.4%) males and 44,431 (43.6%) females, with a mean ± SD age of 42.8 ± 15.0 years. The average ± SD FPG level was 5.5 ± 1.1 mmol/L. The monthly variation contributed to 22% of the overall FPG variability. A significant main effect for the age group was observed (F = 7.39, P < 0.05), with an excellent fitting effect (Eta-squared =0.15). The variability of FPG showed sex differences in the percentage difference of the coefficient of variation, which was 34.1% higher in males than females. There were significant interaction effects for month*age*sex and day*age*sex. Conclusions Temporal variability in FPG is evident in the general Chinese population and is affected by both age and sex. To avoid complications associated with FPG variability, interventions should be directed at females and males at specific ages for optimal control of FPG variability and to reduce the risk of diabetes and cardiovascular events.

scholarly journals Reversion From Pre–Diabetes Mellitus to Normoglycemia and Risk of Cardiovascular Disease and All‐Cause Mortality in a Chinese Population: A Prospective Cohort Study

2021 ◽  
Vol 10 (3) ◽  
Author(s):  
Xiaoxue Liu ◽  
Shouling Wu ◽  
Qiaofeng Song ◽  
Xizhu Wang
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Chinese Population ◽  
Cox Proportional Hazards ◽  
Unique Identifier ◽  
Fasting Plasma ◽  
All Cause Mortality

Background It is unclear whether reversion from pre–diabetes mellitus to normoglycemia reduces cardiovascular disease (CVD) and all‐cause mortality risk in a Chinese population. We aimed to fill this research gap. Methods and Results The current study included 14 231 Chinese participants (mean age, 58.08 years) who were free from myocardial infarction and stroke at the time of survey participation (2006–2007 and 2008–2009). Participants were divided into 3 categories according to the 2‐year changes in pre–diabetes mellitus, defined by fasting plasma glucose: those with progression to diabetes mellitus, those with reversion from pre–diabetes mellitus to normoglycemia, and those with persistent pre–diabetes mellitus. Cox proportional hazards models were used to calculate hazard ratios (HRs) and their 95% CIs for CVD and all‐cause mortality. After a median follow‐up period of 8.75 years, a total of 879 CVD events (including 180 myocardial infarction events and 713 stroke events) and 941 all‐cause mortality events were recorded. After adjustment for confounding factors, reversion from pre–diabetes mellitus to normoglycemia was associated with decreased risks of CVD (HR, 0.78; 95% CI, 0.64–0.96), myocardial infarction (HR, 0.62; 95% CI, 0.40–0.97), stroke (HR, 0.79; 95% CI, 0.63–0.98), and all‐cause mortality (HR, 0.82; 95% CI, 0.68–0.99) compared with progression to diabetes mellitus. Conclusions Reversion from fasting plasma glucose–defined pre–diabetes mellitus to normoglycemia was associated with a reduction in the future risk of CVD and all‐cause mortality in a Chinese population. Registration URL: https://www.chictr.org ; Unique identifier: ChiCTRTNC‐11001489.

scholarly journals A Five-year Follow-up Study of Fasting Plasma Glucose Levels in 3,604 Subjects Undergoing Health Screening.

2001 ◽  
Vol 28 (4) ◽  
pp. 429-433
Author(s):  
Hidetaka HORIE ◽  
Yoko SHIBATA ◽  
Shinji MITSUHASHI ◽  
Fumitoshi OHNO ◽  
Seiki SHIINO ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Health Screening ◽  
Glucose Levels ◽  
Follow Up Study ◽  
Fasting Plasma

scholarly journals Global 11 beta-hydroxysteroid dehydrogenase activity assessed by the circulating cortisol to cortisone ratio is associated with features of metabolic syndrome

2020 ◽  
Author(s):  
La-or Chailurkit ◽  
Wichai Aekplakorn ◽  
Nitchawat Paiyabhroma ◽  
Boonsong Ongphiphadhanakul
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
High Blood Pressure ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Serum Cortisol ◽  
Health Examination ◽  
Causative Role ◽  
Fasting Plasma ◽  
Liquid Chromatography Tandem Mass

Abstract Background 11 Beta-hydroxysteroid dehydrogenases (11HSD) are enzymes involved in the interconversion of cortisol and cortisone. There are two isoenzymes of 11HSD, 11HSD1 and 11HSD2. A causative role of 11HSD, particularly 11HSD1, in metabolic syndrome is well established in experimental animals. However, its role in human metabolic syndrome is less clear. We examined the influence of global 11HSD activity on metabolic syndrome in the general population, using the circulating cortisol:cortisone ratio as an index of global 11HSD activity.Methods A subsample of 269 sera randomly selected from the Thai National Health Examination Survey IV samples was analyzed for serum cortisol and cortisone levels by liquid chromatography-tandem mass spectrometry.Results There was no association between serum cortisol and age. However, circulating cortisone was negatively correlated with age (r = −0.12, p < 0.001), and the serum cortisol:cortisone ratio was positively associated with age (r = 0.03, P < 0.001). No association was found between serum cortisol:cortisone ratio and BMI or serum lipids. Multivariate analyses showed that the serum cortisol:cortisone ratio was associated with high blood pressure (P < 0.05) independent of age, BMI and sex. In subjects without hypertension, the serum cortisol to cortisone ratio was associated with mean systolic blood pressure after controlling for age, BMI and sex. The cortisol:cortisone ratio was not significantly different between subjects with and without diabetes. After excluding the 16 subjects with diabetes, it was found that the serum cortisol:cortisone ratio was positively associated with fasting plasma glucose independent of age, BMI and sex (P < 0.01).Conclusions The global index of 11HSD activity, assessed by the circulating cortisol:cortisone ratio, was related to high blood pressure and fasting plasma glucose. Modulation of 11HSD may help treat hypertension and diabetes but probably not other features of metabolic syndrome.

scholarly journals Age- and sex-related changes in fasting plasma glucose and lipoprotein in cynomolgus monkeys

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Feng Yue ◽  
Guodong Zhang ◽  
Rongping Tang ◽  
Zhouquan Zhang ◽  
Liqiong Teng ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Cynomolgus Monkeys ◽  
Fasting Plasma ◽  
Age And Sex
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