The Effect of Vitamin D Deficiency on the Homeostasis Model Assessment-Insulin Resistance: Using the Propensity Score Matching

Hyperandrogenic state in females is accompanied with metabolic syndrome, insulin resistance and vascular pathologies. A total of 67%–85% of hyperandrogenic women suffer also from vitamin D deficiency. We aimed to check a potential interplay between hyperandrogenism and vitamin D deficiency in producing insulin resistance and effects on coronary resistance arteries. Adolescent female rats were divided into four groups, 11–12 animals in each. Transdermal testosterone-treated and vehicle-treated animals were kept either on vitamin D-deficient or on vitamin D-supplemented diet for 8 weeks. Plasma sexual steroid, insulin, leptin and vitamin D plasma levels were measured, and oral glucose tolerance test was performed. In coronary arterioles, insulin receptor and vitamin D receptor expressions were tested by immunohistochemistry, and insulin-induced relaxation was measured in vitro on isolated coronary resistance artery segments. Testosterone impaired glucose tolerance, and it diminished insulin relaxation but did not affect the expression of insulin and vitamin D receptors in vascular tissue. Vitamin D deficiency elevated postprandial insulin levels and homeostatic model assessment insulin resistance. It also diminished insulin-induced coronary arteriole relaxation, while it raised the expression of vitamin D and insulin receptors in the endothelial and medial layers. Our conclusion is that both hyperandrogenism and vitamin D deficiency reduce sensitivity of coronary vascular tissue to insulin, but they do it with different mechanisms.

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Effect of high-dose vitamin D supplementation in combination with weight loss diet on glucose homeostasis, insulin resistance, and matrix metalloproteinases in obese subjects with vitamin D deficiency: a double-blind, placebo-controlled, randomized clinical trial

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2018-0773 ◽

2020 ◽

Vol 45 (10) ◽

pp. 1092-1098

Author(s):

Soodabeh Aliashrafi ◽

Mehrangiz Ebrahimi-Mameghani ◽

Mohammad Asghari Jafarabadi ◽

Lida Lotfi-Dizaji ◽

Elnaz Vaghef-Mehrabany ◽

...

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Weight Loss ◽

Matrix Metalloproteinases ◽

Vitamin D Deficiency ◽

Glucose Homeostasis ◽

Vitamin D Supplementation ◽

High Dose ◽

Model Assessment ◽

Obese Subjects

As there is limited and inconsistent evidence in potential role of vitamin D on insulin resistance and matrix metalloproteinases, this study aimed to examine the effect of vitamin D supplementation on glucose homeostasis, insulin resistance, and matrix metalloproteinases in obese subjects with vitamin D deficiency. A total of 44 participants with serum 25-hydroxyvitamin D (25(OH)D) level ≤ 50 nmol/L and body mass index (BMI) 30–40 kg/m2 were randomly allocated into receiving weight reduction diet with either 50 000 IU vitamin D3 pearl (n = 22) or placebo (n = 22) once weekly for 12 weeks. Primary outcomes were changes in fasting serum glucose (FSG), homeostasis model assessment of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), and matrix metalloproteinases (MMPs). Secondary outcomes were changes in weight, BMI, 25(OH)D, calcium, phosphorous and parathyroid hormone (PTH). Sun exposure and dietary intakes were also assessed. Serum levels of 25(OH)D3 increased significantly with a simultaneous decrease in serum concentration of PTH in the vitamin D group. Weight, BMI, FSG, and MMP-9 decreased significantly in both groups, and there were significant differences in changes in weight, serum 25(OH)D3, PTH, and MMP-9 levels between the groups. Within- and between-groups analysis revealed no significant differences in serum calcium, phosphorous, serum insulin, HOMA-IR, QUICKI, and MMP-2 after intervention. Our results indicated that improvement in vitamin D status resulted in greater reductions in weight and MMP-9 during weight loss. These preliminary results are sufficient to warrant a bigger study group.

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Body composition and metabolic profile in adults with vitamin D deficiency

Revista de Nutrição ◽

10.1590/1678-98652017000400002 ◽

2017 ◽

Vol 30 (4) ◽

pp. 419-430 ◽

Cited By ~ 6

Author(s):

Liane Murari ROCHA ◽

Daniela Cristina da Silva BALDAN ◽

Aglécio Luiz SOUZA ◽

Elinton Adami CHAIM ◽

Elizabeth João PAVIN ◽

...

Keyword(s):

Vitamin D ◽

Body Composition ◽

Vitamin D Deficiency ◽

Lean Mass ◽

Metabolic Profile ◽

The Body ◽

Impedance Method ◽

Model Assessment ◽

Homeostasis Model Assessment ◽

Vitamin D Levels

ABSTRACT Objective: To investigate the body composition and metabolic profile in individuals in terms of different concentrations of serum vitamin D, ranging from deficiency to sufficiency. Methods: A cross-sectional study of 106 adults of both genders, who were divided into three groups according to vitamin D levels: deficiency: <20ng/mL; insufficiency: 20-29.9ng/mL; and sufficiency: 30-100ng/mL. Anthropometric evaluation included weight, height, and body circumferences. Fat mass and lean mass were assessed using the Tetrapolar bioelectrical impedance method. Clinical and biochemical evaluations were also carried out. Insulin resistance was estimated using the Homeostasis Model Assessment Insulin index. Results: The analysis showed that the main alterations in individuals in the vitamin D deficiency group were higher triglycerides, very low density lipoprotein - cholesterol, fasting blood glucose, insulin, glycated hemoglobin, body mass index, body fat percentage, lean mass percentage, waist circumference, and Homeostasis Model Assessment Insulin than those of the vitamin D sufficient group (p<0.05). Conclusion: It was found that vitamin D deficiency causes important body composition and metabolic changes, which may lead to diseases such as diabetes Mellitus and metabolic syndrome.

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Vitamin D Supplementation Does Not Impact Insulin Resistance in Black and White Children

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2015-3687 ◽

2016 ◽

Vol 101 (4) ◽

pp. 1710-1718 ◽

Cited By ~ 15

Author(s):

Ashley J. Ferira ◽

Emma M. Laing ◽

Dorothy B. Hausman ◽

Daniel B. Hall ◽

George P. McCabe ◽

...

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Dose Response ◽

Fasting Glucose ◽

Vitamin D Supplementation ◽

Model Assessment ◽

Homeostasis Model Assessment ◽

White Children ◽

Black And White ◽

Surrogate Measure

Abstract Context: Vitamin D supplementation trials with diabetes-related outcomes have been conducted almost exclusively in adults and provide equivocal findings. Objective: The objective of this study was to determine the dose-response of vitamin D supplementation on fasting glucose, insulin, and a surrogate measure of insulin resistance in white and black children aged 9–13 years, who participated in the Georgia, Purdue, and Indiana University (or GAPI) trial: a 12-week multisite, randomized, triple-masked, dose-response, placebo-controlled vitamin D trial. Design: Black and white children in the early stages of puberty (N = 323, 50% male, 51% black) were equally randomized to receive vitamin D3 (0, 400, 1000, 2000, or 4000 IU/day) for 12 weeks. Fasting serum 25-hydroxyvitamin D (25(OH)D), glucose and insulin were assessed at baseline and weeks 6 and 12. Homeostasis model assessment of insulin resistance was used as a surrogate measure of insulin resistance. Statistical analyses were conducted as intent-to-treat using a mixed effects model. Results: Baseline serum 25(OH)D was inversely associated with insulin (r = −0.140, P = 0.017) and homeostasis model assessment of insulin resistance (r = −0.146, P = 0.012) after adjusting for race, sex, age, pubertal maturation, fat mass, and body mass index. Glucose, insulin, and insulin resistance increased (F > 5.79, P < .003) over the 12 weeks, despite vitamin D dose-dependent increases in serum 25(OH)D. Conclusions: Despite significant baseline inverse relationships between serum 25(OH)D and measures of insulin resistance, vitamin D supplementation had no impact on fasting glucose, insulin, or a surrogate measure of insulin resistance over 12 weeks in apparently healthy children.

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The influence of puberty on vitamin D status in obese children and the possible relation between vitamin D deficiency and insulin resistance

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2014-0033 ◽

2015 ◽

Vol 28 (1-2) ◽

Cited By ~ 8

Author(s):

Sonsoles Gutiérrez Medina ◽

Teresa Gavela-Pérez ◽

María Nieves Domínguez-Garrido ◽

Elisa Gutiérrez-Moreno ◽

Adela Rovira ◽

...

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Standard Deviation Score ◽

Normal Weight ◽

Model Assessment ◽

Vitamin D Status ◽

Cross Sectional ◽

Prepubertal Children ◽

Vitamin D Levels

Abstract: Puberty can affect vitamin D levels.The goal of this study was to analyze the relation between vitamin D deficiency and puberty in obese Spanish children, along with the possible interrelation between vitamin D status and degree of insulin resistance.A cross-sectional study was carried out, in which clinical and biochemical data were gathered from 120 obese and 50 normal weight children between January 2011 and January 2013.: Mean vitamin D levels were 19.5 and 31.6 ng/mL in obese pubertal and obese prepubertal children, respectively. About 75% of the obese pubertal subjects and 46% of the obese prepubertal subjects had vitamin D deficiency. Vitamin D levels were significantly lower in pubescent subjects compared with pre-pubescent subjects in summer, fall, and winter. There was no apparent relation between vitamin D levels and homeostasis model assessment index for insulin resistence (expressed in standard deviation score for sex and Tanner stage) in either puberty or pre-puberty.: Puberty may be a risk factor for the vitamin D deficiency commonly found in the obese child population. This deficiency is not associated with higher insulin resistance in obese pubertal children compared with obese prepubertal children.

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The relationship between vitamin D and insulin resistance before delivery in advanced maternal age

Reproductive Biology and Endocrinology ◽

10.1186/s12958-019-0555-y ◽

2019 ◽

Vol 17 (1) ◽

Author(s):

Beibei Dong ◽

Mengmeng Zhi ◽

Manman Han ◽

Hao Lin ◽

Hong Yu ◽

...

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Maternal Age ◽

Multivariable Analysis ◽

Advanced Maternal Age ◽

Model Assessment ◽

Gynecology And Obstetrics ◽

Vitamin D Levels

Abstract Background With the widely implementation of universal two-child policy, the number of pregnant women in advanced maternal age (AMA) will increase gradually. We aimed to assess the association of vitamin D levels and insulin resistance (IR) during the late pregnancy in AMA. Methods A total of 80 pregnant women were consecutively enrolled in the cross-sectional study before delivery from the August 2016 to June 2017 at the department of gynecology and obstetrics in the hospital of ZhongDa, affiliated to Southeast University. At delivery, serum 25(OH) D and metabolism parameters including glucose and lipid levels were measured. IR was calculated by the method of homeostasis model assessment 2(HOMA2). Results Pregnant women in AMA with vitamin D deficiency have higher fasting insulin (14.70(8.76–34.65) and 10.89(7.15–16.12), respectively, P = 0.031) and HOMA-IR indices (1.78(1.07–4.14) and 1.30(0.83–1.89), respectively, P = 0.024) than those with vitamin D non-deficiency. Serum 25(OH) D levels were inversely associated with HOMA-IR indices (r = − 0.25, P = 0.025). In multivariable analysis for adjusting confounder factors, vitamin D non-deficiency was also negatively correlated with HOMA-IR compared to vitamin D deficiency (β = − 1.289, P = 0.026). Conclusions Taken together, our findings suggest that serum 25(OH) D levels were inversely associated with HOMA-IR in AMA. Furthermore, pregnant women in AMA with vitamin D deficiency might have higher HOMA-IR levels than those with vitamin D non-deficiency. Trial registration Chinese Clinical Trial Registry (No. ChiCTR-RRC-16008714). retrospectively registered.

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The Correlation of Vitamin D Deficiency on Metabolic Syndrome in Korean Adults Using the Propensity Score Matching

Korean Journal of Family Practice ◽

10.21215/kjfp.2018.8.6.882 ◽

2018 ◽

Vol 8 (6) ◽

pp. 882-889

Author(s):

Soo-Jin Park ◽

Han-young Lee ◽

Chung-Hwan Cho ◽

Jin-Hee Lee ◽

Jae-sung Lee

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

Propensity Score ◽

Vitamin D Deficiency ◽

Propensity Score Matching ◽

Korean Adults

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Leptin, hs-CRP and HOMA-IR in patients with type 2 diabetes: The role of different levels of vitamin D deficiency

Functional Foods in Health and Disease ◽

10.31989/ffhd.v9i11.661 ◽

2019 ◽

Vol 9 (11) ◽

pp. 695

Author(s):

Salome Sadat Salehi‍ ◽

Soghra Rabizadeh ◽

Sahar Karimpour Reyhan Reyhan Karimpour ◽

Marjan Mouodi ◽

Manouchehr Nakhjavani ◽

...

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Levels ◽

Diabetic Patients ◽

Model Assessment ◽

Type 2 Diabetic Patients ◽

25 Hydroxy Vitamin D ◽

Hs Crp

Background: To evaluate the effects of different levels of vitamin D deficiency on blood glucose, leptin, and high sensitivity C-reactive protein (hs-CRP), insulin resistance and their associations.Methods: We quantified serum vitamin D level, hs-CRP, leptin, and fasting blood sugar (FBS) levels in 25 type-2 diabetic patients with very low serum levels of 25-hydroxy vitamin D (deficient), ≤15 ng/ml; and 25 age, sex, and body mass index (BMI)-matched type-2 diabetic patients with low serum levels of 25-hydroxy vitamin D (insufficient), 16 to 30 ng/ml. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated by a formula based upon values of FBS and insulin concentrations.Results: The mean value of vitamin D levels was 7.67±3.10 in vitamin D deficient group and 23.20±9.97 in vitamin D insufficient group. Patients with vitamin D deficiency had significantly higher FBS, postprandial glucose (PPG) and hemoglobin A1C (HbA1C) as compared to vitamin D insufficient group (p<0.01). We studied correlations of hs-CRP, HOMA-IR, and leptin in both vitamin D insufficient and deficient groups. There were significant positive correlations between leptin with hs-CRP (r = 0.58, p<0.01) and with HOMA-IR (r = 0.49, p<0.05) in vitamin D deficient group; Which these correlations remained significant after multiple adjustment for age, sex, BMI, systolic and diastolic blood pressure.Conclusion: In conclusion vitamin D deficient diabetic patients had elevated FBS, PPG and HbA1C compared with insufficient ones. The results also could possibly point the effect of vitamin D deficiency level on leptin associations with hs-CRP and insulin resistance.Keywords: Vitamin D deficiency, type 2 diabetes, leptin, C reactive protein, homeostasis model assessment of insulin resistance

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THE RELATIONSHIP BETWEEN INSULIN RESISTANCE AND FA-TIGUE SYMPTOM IN FIBROMYALGIA SYNDROME

International Journal of Research -GRANTHAALAYAH ◽

10.29121/granthaalayah.v8.i3.2020.157 ◽

2020 ◽

Vol 8 (3) ◽

pp. 271-278

Author(s):

Türkan Turgay ◽

Zekiye İpek Katirci Kirmaci ◽

Pınar Günel Karadeniz ◽

Mehmet Baştemir

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Fibromyalgia Impact Questionnaire ◽

Model Assessment ◽

Homeostasis Model Assessment ◽

Fatigue Severity ◽

Group 2 ◽

Severity Of The Disease ◽

The Relationship ◽

Group 1

The aim of this study is to examine the relationship between insulin resistance and fatigue in fi-bromyalgia. A total of 72 patients (4 males, 68 females) with fibromyalgia (FM) was investigated. Patients were divided into two groups by insulin resistance (IR), group 1; IR- (n=49), and group 2; IR+ (n=23). IR was determined using homeostasis model assessment (HOMA) formula. All subjects were evaluated with serum 25 (OH) D vitamin levels. The severity of the disease was measured with the Fibromyalgia Impact Questionnaire (FIQ); the level of fatigue was evaluated with Fatigue Severity Scale (FSS); and the pain level was evaluated with Visual Analog Scale (VAS). There were significant differences between the FIQ and FSS mean scores of two groups (IR+ and IR-), (p=0.031, p=0.005). There were no significant differences between two groups in respect to VAS and serum 25 (OH) D vitamin levels (p=0.789, p=0.875). There was no significant correlation be-tween vitamin D and FSS (IR+, r=-0.263, p=0.225; IR-, r=0.112, p=0.443), and also vitamin D and FIQ (IR+, r=-0.103, p=0.641; IR-, r=0.050, p=0.733) in both groups. There was no relationship be-tween insulin resistance and fatigue symptom in fibromyalgia patients, but it was observed that the severity of fatigue was higher in the group with insulin resistance.

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Vitamin D Status, Insulin Resistance, Leptin-To-Adiponectin Ratio in Adolescents: Results of a 1-Year Lifestyle Intervention

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2016.131 ◽

2016 ◽

Vol 4 (4) ◽

pp. 596-602 ◽

Cited By ~ 6

Author(s):

Christine Rambhojan ◽

Laurent Larifla ◽

Josiane Clepier ◽

Elodie Bouaziz-Amar ◽

Fritz-Line Velayoudom-Cephise ◽

...

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Lifestyle Intervention ◽

Healthy Lifestyle ◽

Model Assessment ◽

Vitamin D Status ◽

Z Score ◽

Linear Regression Models ◽

Hydroxyvitamin D

AIM: We aimed to study the relationships between circulating 25-hydroxyvitamin D [25(OH)D], insulin resistance and leptin-to-adiponectin (L/A) ratio in Guadeloupean children and adolescents and to analyse the changes in 25(OH)D levels after a 1-year lifestyle intervention program.METHODS: 25(OH)D concentrations were measured via a chemiluminescence assay. Cardiometabolic risk factors, homoeostasis model assessment of insulin resistance (HOMA-IR), and adipokines were measured. The lifestyle intervention included dietary counselling, regular physical activity.RESULTS: Among 117 girls and boys (11–15 years old, 31.6% obese), 40% had vitamin D deficiency (25(OH)D levels < 20 ng/mL). With linear regression models where 25(OH)D and HOMA-IR acted as independent variables and age, sex, BMI, L/A ratio as covariates, 25(OH)D was significantly associated with HOMA-IR alone (P = 0.036). HOMA-IR was also associated with BMI z-score ≥ 2, L/A ratio and an interaction term BMI z-score ≥ 2*L/A ratio (P < 0.001 for all). After one year, in 78 children/adolescent, mean serum 25(OH)D increased significantly from 21.4 ± 4.9 ng/mL at baseline to 23.2 ± 6.0 after 1 year; P = 0.003 whereas BMI z-score, HOMA-IR and L/A ratio decreased significantly (P = 0.003, P < 0.001 and P = 0.012; respectively).CONCLUSION: The association between 25(OH)D and HOMA-IR, independently of obesity and the high prevalence of vitamin D deficiency should be considered in order to prevent the later incidence of T2DM. A healthy lifestyle including non-sedentary and outdoor activities could be a way for improving vitamin D status.

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