scholarly journals THE RELATIONSHIP BETWEEN INSULIN RESISTANCE AND FA-TIGUE SYMPTOM IN FIBROMYALGIA SYNDROME

2020 ◽  
Vol 8 (3) ◽  
pp. 271-278
Author(s):  
Türkan Turgay ◽  
Zekiye İpek Katirci Kirmaci ◽  
Pınar Günel Karadeniz ◽  
Mehmet Baştemir
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Fibromyalgia Impact Questionnaire ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Fatigue Severity ◽  
Group 2 ◽  
Severity Of The Disease ◽  
The Relationship ◽  
Group 1

The aim of this study is to examine the relationship between insulin resistance and fatigue in fi-bromyalgia. A total of 72 patients (4 males, 68 females) with fibromyalgia (FM) was investigated. Patients were divided into two groups by insulin resistance (IR), group 1; IR- (n=49), and group 2; IR+ (n=23). IR was determined using homeostasis model assessment (HOMA) formula. All subjects were evaluated with serum 25 (OH) D vitamin levels. The severity of the disease was measured with the Fibromyalgia Impact Questionnaire (FIQ); the level of fatigue was evaluated with Fatigue Severity Scale (FSS); and the pain level was evaluated with Visual Analog Scale (VAS). There were significant differences between the FIQ and FSS mean scores of two groups (IR+ and IR-), (p=0.031, p=0.005). There were no significant differences between two groups in respect to VAS and serum 25 (OH) D vitamin levels (p=0.789, p=0.875). There was no significant correlation be-tween vitamin D and FSS (IR+, r=-0.263, p=0.225; IR-, r=0.112, p=0.443), and also vitamin D and FIQ (IR+, r=-0.103, p=0.641; IR-, r=0.050, p=0.733) in both groups. There was no relationship be-tween insulin resistance and fatigue symptom in fibromyalgia patients, but it was observed that the severity of fatigue was higher in the group with insulin resistance.

Abstract 554: Vitamin D in Chronic Kidney Disease is Not Associated with Insulin Resistance

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
MARIA INES BARRETO SILVA ◽  
VANESSA VICENTE ◽  
CARLA LEMOS ◽  
MARCIA R KLEIN ◽  
RACHEL BREGMAN
Keyword(s):  
Insulin Resistance ◽  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Serum Levels ◽  
Model Assessment ◽  
Body Adiposity ◽  
Group 2 ◽  
Total Body ◽  
Group 1

INTRODUCTION: Vitamin D deficiency is reported to be associated with Insulin Resistance (IR) in general population. Although the impaired homeostasis of vitamin D and IR are common conditions in chronic kidney disease (CKD), the underlying mechanisms of IR remain unclear and it is not known if vitamin D status is associated with IR in nondialyzed CKD patients. OBJECTIVE: To investigate if serum levels of 25 hidroxivitamin D [25(OH)D] are associated with IR in nondialyzed CKD patients. Methods: Cross-sectional study conducted in nondialyzed CKD outpatients under regular treatment, clinically stable, age≥18 years, estimated glomerular filtration rate (CKD-EPI) (eGFR)≤ 60 ml/min., not using vitamin D, corticosteroids and immunosuppressive drugs and without malignant diseases. Body adiposity: body mass index (BMI); total body adiposity by dual-energy X-ray absorptiometry-DXA; waist-to-height ratio (WheiR). Vitamin D was determined by analysing 25(OH)D by Passing-Bablok method; insulin by radioimmunoassay; Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). Results: Patients included in this study were 158 (men:55%/n=87) nondialyzed CKD patients presenting age=66±13years; eGFR=29±13ml/min.; BMI=26±5kg/m2 (54%/n=86 overweight/obese: BMI>25). Total body adiposity-DXA=34±9% and central body adiposity-WheiR=0.6±0.08. Patients were grouped according to HOMA-IR as: Group 1 (HOMA-IR<2.7; n=110) and Group 2 (HOMA-IR ≥2.7; n=48). VitD levels (ng/ml) were not different (p≥0.05) between Group 1 (27±9) and Group 2 (28±9). Participants were also stratified as: VitD-deficient (<20ng/ml; 25%/n=40) and VitD-no-deficient (≥20 ng/ml; 75%/n=118). VitD-deficient patients compared to VitD-no-deficient presented, respectively, similar values (p≥0.05) of HOMA-IR (median; interquartil interval: 1.7; 1-3 vs. 1.6; 1-3.4), insulin (7; 5-12 vs. 6; 5-13 μU/mL); glucose (105±28 vs. 109±62 mg/dl), glycosylated hemoglobin (GHb=6±1 vs. 6±2 %). No correlation (adjusted for confounders) was observed between VitD with HOMA-IR (r=0.01,p=0.87), insulin (r=0.02,p=0.8), glucose (r=-0.05,p=0.5) and GHb (r=-0.1,p=0.6). Conclusion: The present study suggests that serum levels of 25(OH)D are not associated with IR in nondialyzed CKD patients.

Evaluation of TG-HDL Ratio Instead of HOMA Ratio as Insulin Resistance Marker in Overweight and Children with Obesity

2019 ◽  
Vol 19 (5) ◽  
pp. 676-682 ◽  
Author(s):  
Eman G. Behiry ◽  
Nazih Mohamed El Nady ◽  
Omima M. AbdEl Haie ◽  
May Kamel Mattar ◽  
Amira Magdy
Keyword(s):  
Insulin Resistance ◽  
Cross Sectional Study ◽  
Mean Value ◽  
P Value ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Cross Sectional ◽  
Laboratory Investigations ◽  
Group 2 ◽  
Group 1

Background: Homeostasis model assessment for insulin resistance (HOMA-IR) is widely used as a marker of insulin resistance in adults and has also been validated in children and adolescents. Triglyceride (TG) and HDL-C on the other hand is a routine test and inexpensive compared to insulin. Previous studies reported conflicting findings on the usefulness of the triglyceride to HDL-C ratio (TG:HDL-C ratio) as predictor or marker of IR. The aim of this work was to investigate the usefulness of Triglyceride to HDL-C ratio (TG/HDL-C) as an Insulin Resistance (IR) marker in overweight and children with obesity. Methods: This study was a comparative cross sectional study which was conducted on ninety overweight and children with obesity attending National Nutrition Institute “Pediatric obesity clinic. They were classified into 2 groups as follows: group (1) included overweight and children with obesity with insulin resistance, group (2) included overweight and children with obesity with non-insulin resistance. All the subjects were subjected to history, clinical examination and laboratory investigations including total lipid profile, fasting glucose, insulin and TG:HDL-C ratio instead of HOMA ratio. Results: Prevalence of IR among the studied sample was 42 (46.7%). Mean value of TG/ HDL-C ratio was greater among the insulin resistance group than non insulin resistance group (p value= < 0.001)value). TG/HDL ratio ≥1.36 had 85.7% sensitivity, 66.7% specificity. There was statistically significant positive correlation between TG/HDL ratio and HOMA-IR. Conclusion: TG:HDL ratio ≥1.36 is a significant early and sensitive predictor of insulin resistance in children instead of HOMA-IR.

scholarly journals Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance

2003 ◽  
Vol 149 (4) ◽  
pp. 331-335 ◽  
Author(s):  
JV Silha ◽  
M Krsek ◽  
JV Skrha ◽  
P Sucharda ◽  
BL Nyomba ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Adipose Tissue ◽  
Statistical Significance ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Homeostasis Model Assessment ◽  
Glucose Levels ◽  
Obese Subjects ◽  
The Relationship

OBJECTIVE: Adipose tIssue regulates insulin sensitivity via the circulating adipocytokines, leptin, resistin and adiponectin. The objective of this study was to compare the levels of resistin, adiponectin and leptin in lean and obese subjects and determine the relationship between circulating adipocytokines and insulin resistance. METHODS: We examined plasma levels of resistin, adiponectin and leptin in 17 lean subjects with a mean body mass index (BMI) of approximately 23 and 34 non-diabetic obese individuals with a mean BMI approximately 33. Insulin resistance was assessed using the homeostasis model assessment ratio (HOMA-R) formula derived from fasting insulin and glucose levels. RESULTS: Resistin levels were not significantly different between the two groups but were significantly higher in women compared with men, 35.4+/-6.5 (s.e.) vs 15.4+/-2.9 microg/L, P<0.01. Resistin did not correlate with BMI but did significantly correlate with HOMA-R, P<0.01, and this correlation remained significant after adjustment for gender and BMI. Adiponectin levels were significantly lower in obese compared with lean subjects, P<0.005, and higher in women, P<0.001, but showed no significant correlation with HOMA-R. Leptin levels were significantly higher in obese subjects and women and correlated with HOMA-R and resistin. DISCUSSION: In this small group of patients we demonstrated that insulin resistance correlated most strongly with leptin levels. A significant correlation between resistin levels and insulin resistance was also observed. Although a similar trend was apparent for adiponectin, the correlation with insulin resistance did not achieve statistical significance.

Insulin resistance is not a risk factor for oesophageal varices development in hepatitis C

2019 ◽  
Vol 49 (4) ◽  
pp. 281-285
Author(s):  
Ayman Alsebaey ◽  
Mostafa Elhelbawy
Keyword(s):  
Insulin Resistance ◽  
Risk Factor ◽  
Hepatitis C ◽  
Oesophageal Varices ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
End Stage Liver Disease ◽  
Pugh Class ◽  
End Stage ◽  
The Relationship

Chronic hepatitis C (HCV) patients commonly have insulin resistance which is a risk factor for disease progression. Oesophageal varices may bleed with high mortality. We aimed to assess the relationship between insulin resistance and oesophageal varices. HCV-related compensated liver cirrhosis patients (n = 146) underwent gastroscopy and homeostasis model assessment (HOMA)-IR, HOMA-β and HOMA-S calculations. Their average age was 54.98 years; most (84.9%) patients were men and non-diabetic (60.3%). Patients with oesophageal varices had higher median Model for End-Stage Liver Disease (MELD) scores and comparable Child-Pugh class. Patients with and without oesophageal varices had comparable ( P > 0.05) HOMA scores and insulin resistance percentage of 82.9% versus 85.5%. We therefore conclude that insulin resistance is unrelated to the presence of oesophageal varices.

scholarly journals Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia

2004 ◽  
pp. 483-489 ◽  
Author(s):  
E Setola ◽  
LD Monti ◽  
E Galluccio ◽  
A Palloshi ◽  
G Fragasso ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Folic Acid ◽  
Endothelial Dysfunction ◽  
Vitamin B12 ◽  
Model Assessment ◽  
Insulin Levels ◽  
Group 2 ◽  
Folate And Vitamin B12 ◽  
Group 1

OBJECTIVE: The purpose of this study was (a) to study whether a folate and vitamin B12 treatment, aimed at decreasing homocysteine levels, might ameliorate insulin resistance and endothelial dysfunction in patients with metabolic syndrome according to the National Cholesterol Education Program-Adult Treatment Panel-III criteria and (b) to evaluate whether, under these metabolic conditions, there is a relationship between hyperhomocysteinemia and insulin resistance. DESIGN AND METHODS: A double-blind, parallel, identical placebo-drug, randomized study was performed for 2 months in 50 patients. Patients were randomly allocated to two groups. In group 1, patients were treated with diet plus placebo for 2 months. In group 2, patients were treated with diet plus placebo for 1 month, followed by diet plus folic acid (5 mg/day) plus vitamin B12 (500 microg/day) for another month. RESULTS: In group 2, folate treatment significantly decreased homocysteine levels by 27.8% (12.2+/-1.2 vs 8.8+/-0.7 micromol/l; P<0.01). A significant decrement was observed for insulin levels (19.9+/-1.7 vs 14.8+/-1.6 microU/ml; P<0.01) accompanied by a 27% reduction in the homeostasis model assessment levels. A positive relationship was found between the decrement of homocysteine and insulin levels (r=0.60; P<0.002). In parallel, endothelial dysfunction significantly improved in the treated group, since post-ischemic maximal hyperemic vasodilation increased by 29.8% and cGMP by 13.6% while asymmetrical dimethylarginine levels decreased by 21.7%. On the contrary, in group 1 patients, treated with placebo, no changes were shown in any of the variables. CONCLUSIONS: Folate and vitamin B12 treatment improved insulin resistance and endothelial dysfunction, along with decreasing homocysteine levels, in patients with metabolic syndrome, suggesting that folic acid has several beneficial effects on cardiovascular disease risk factors.

scholarly journals Vitamin D Supplementation Does Not Impact Insulin Resistance in Black and White Children

2016 ◽  
Vol 101 (4) ◽  
pp. 1710-1718 ◽  
Author(s):  
Ashley J. Ferira ◽  
Emma M. Laing ◽  
Dorothy B. Hausman ◽  
Daniel B. Hall ◽  
George P. McCabe ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Dose Response ◽  
Fasting Glucose ◽  
Vitamin D Supplementation ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
White Children ◽  
Black And White ◽  
Surrogate Measure

Abstract Context: Vitamin D supplementation trials with diabetes-related outcomes have been conducted almost exclusively in adults and provide equivocal findings. Objective: The objective of this study was to determine the dose-response of vitamin D supplementation on fasting glucose, insulin, and a surrogate measure of insulin resistance in white and black children aged 9–13 years, who participated in the Georgia, Purdue, and Indiana University (or GAPI) trial: a 12-week multisite, randomized, triple-masked, dose-response, placebo-controlled vitamin D trial. Design: Black and white children in the early stages of puberty (N = 323, 50% male, 51% black) were equally randomized to receive vitamin D3 (0, 400, 1000, 2000, or 4000 IU/day) for 12 weeks. Fasting serum 25-hydroxyvitamin D (25(OH)D), glucose and insulin were assessed at baseline and weeks 6 and 12. Homeostasis model assessment of insulin resistance was used as a surrogate measure of insulin resistance. Statistical analyses were conducted as intent-to-treat using a mixed effects model. Results: Baseline serum 25(OH)D was inversely associated with insulin (r = −0.140, P = 0.017) and homeostasis model assessment of insulin resistance (r = −0.146, P = 0.012) after adjusting for race, sex, age, pubertal maturation, fat mass, and body mass index. Glucose, insulin, and insulin resistance increased (F &gt; 5.79, P &lt; .003) over the 12 weeks, despite vitamin D dose-dependent increases in serum 25(OH)D. Conclusions: Despite significant baseline inverse relationships between serum 25(OH)D and measures of insulin resistance, vitamin D supplementation had no impact on fasting glucose, insulin, or a surrogate measure of insulin resistance over 12 weeks in apparently healthy children.

scholarly journals Meat Intake and Insulin Resistance in Women without Type 2 Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Larry A. Tucker ◽  
James D. LeCheminant ◽  
Bruce W. Bailey
Keyword(s):  
Insulin Resistance ◽  
Body Fat ◽  
Odds Ratio ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Meat Intake ◽  
Bod Pod ◽  
Food Records ◽  
The Relationship

Purpose. To examine the relationship between meat intake and insulin resistance (IR) in 292 nondiabetic women.Methods. IR was evaluated using the homeostasis model assessment (HOMA). Diet was assessed via 7-day weighed food records. Servings of very lean meat (VLM) and regular meat (meat) were indexed using the ADA Exchange Lists Program. Physical activity was assessed using accelerometers and body fat was measured using the Bod Pod.Results. Meat intake was directly related to HOMA (F= 7.4;P= 0.007). Women with moderate or high meat intakes had significantly higher HOMA levels than their counterparts. Adjusting for body fat weakened the relationship (F= 1.0;P= 0.3201). Odds ratio results showed that the low meat quartile had 67% lower odds of being IR (75th percentile) compared to their counterparts (OR = 0.33; 95% CI = 0.16–0.71). These findings changed little after adjusting for all covariates simultaneously (OR = 0.34; 95% CI = 0.14–0.83). Conversely, VLM intake was not related to HOMA, with or without the covariates.Conclusion. Moderate and high meat intakes are associated with increased insulin resistance in nondiabetic women. However, differences in body fat contribute significantly to the relationship. VLM is not predictive of IR. Prudence in the amount and type of meat consumed may be helpful in decreasing the likelihood of IR.

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