scholarly journals To Compare the Efficacy of Ulipristal acetate and Mifepristone in Management of Uterine Fibroids in Symptomatic Patients of Reproductive Age Group

2019 ◽  
Vol 6 (11) ◽  
Author(s):  
Priyanka Dahiya ◽  
Isha Bansal ◽  
Richa Kansal ◽  
Atul Beniwal ◽  
Ankit Beniwal
Keyword(s):  
Uterine Fibroids ◽  
Reproductive Age ◽  
Age Group ◽  
Ulipristal Acetate ◽  
Reproductive Age Group

scholarly journals Comparison between Mifepristone and Ulipristal acetate as an alternative to surgical management of uterine fibroids (Leiomyoma) in symptomatic patients of reproductive age group in Asian population

2017 ◽  
Vol 7 (1) ◽  
pp. 109
Author(s):  
Ashish R. Kale
Keyword(s):  
Prospective Observational Study ◽  
Uterine Fibroids ◽  
Asian Population ◽  
Reproductive Age ◽  
Age Group ◽  
Transabdominal Ultrasound ◽  
Ulipristal Acetate ◽  
Reproductive Age Group

Background: Present study was a randomised prospective observational study carried out at Ashakiran Hospital and IVF centre Pune, Maharashtra, India to evaluate the efficacy, safety, and quality of life by using Ulipristal acetate 10 mg and Mifepristone 25 mg daily doses to treat uterine fibroids of two subgroups involving fibroids <3 cm and fibroids 3 to 5 cm all are in reproductive age group with symptomatic in nature over 3 months.Methods: A total number of 40 patients were recruited in the study of which they were divided into two groups according to the size of the fibroid as <3cm and 3-5cm as seen on transvaginal as well as transabdominal ultrasound. Further they were randomly assigned to either mifepristone or ulipristal orally with each category having 10 patients each to assess changes in fibroid size, in symptomatic pain reduction, menorrhagia and in quality of life.Results: The 25-mg dosage of Mifepristone is shown to be a good and effective way of treatment in fibroids less than 3 cm in achieving 40% reduction in size and 50% reduction in menorrhagia as compared to Ulipristal 10 mg which acts better in other subgroup of size 3-5 cm of fibroids.Conclusions: Still larger RCTs are needed to study the long-term benefits of these drugs.

scholarly journals Is it safe to perform myomectomy in first trimester of pregnancy? The report of two cases

2021 ◽  
Vol 6 (2) ◽  
pp. 170-174
Author(s):  
Murat Celiloglu ◽  
◽  
Samican Ozmen ◽  
Sefa Kurt ◽  
Orkun Ilgen
Keyword(s):  
Uterine Fibroids ◽  
First Trimester ◽  
Reproductive Age ◽  
Benign Tumors ◽  
Age Group ◽  
Second Trimester ◽  
Review Of The Literature ◽  
First Trimester Of Pregnancy ◽  
Reproductive Age Group

Uterine fibroids are the most common benign tumors in women in the reproductive age group. The incidence of fibroids during pregnancy varies between 1.6 and 10.7%. In 10% of these cases, fibroids lead to complications. The management in symptomatic patients is conservative, and the surgical treatment is delayed until after birth due to its risks. In the last two decades, it has been shown that myomectomy can be an alternative treatment in selected cases, especially in second-trimester pregnancies. However, the data on the success of myomectomies performed earlier in pregnancy are limited. In this case report, we present two cases who were admitted to our clinic during the first trimester of pregnancy and had complicated fibroids. The diagnosis, the follow up and the treatment are presented with the review of the literature.

scholarly journals Serum Oxidative Stress Markers in Women with Uterine Fibroids in Lagos, Nigeria.

2021 ◽  
Author(s):  
Adaiah Priscillia Soibi-Harry ◽  
Christian Makwe ◽  
Ayodeji Ayotunde Oluwole ◽  
Sunusi-Rimi Garba ◽  
Abisoye Towuromola Ajayi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Negative Correlation ◽  
Uterine Fibroids ◽  
Serum Levels ◽  
Reproductive Age ◽  
Age Group ◽  
Women Of Reproductive Age ◽  
Stress Markers ◽  
Median Serum ◽  
Reproductive Age Group

ABSTRACT Background: Uterine fibroid is the most common benign gynaecological tumour in women of reproductive age group, with significant impact on the quality of life, economy, morbidity and sometimes mortality of affected women. Black women of reproductive age group are more likely to develop uterine fibroids. Although available evidence suggests racial and genetic predisposition to the aetiology of uterine fibroid, oxidative stress has been implicated in the onset and progression of uterine fibroids. Epidemiological and experimental studies have suggested that oxidative stress may play an important role in the pathogenesis of gynaecological diseases including uterine fibroids. Aim and Objectives: This study aims to assess the serum levels of antioxidants (catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx)) and oxidants (protein carbonyl (PC), advanced oxidation protein products (AOPP)) in women with uterine fibroids and to identify any association between the size of uterine fibroids and serum levels of the analysed antioxidants and oxidants. Methods: Forty-four women with ultrasound diagnosis of uterine fibroids and 44 women without uterine fibroids were recruited from a University Teaching Hospital. Blood samples were obtained and analysed for serum levels of selected antioxidants (CAT, SOD, GPx) and oxidants (PC, AOPP). Pelvic ultrasonography was performed on all study participants. Results: The median serum levels of antioxidants: CAT (2.20 vs 4.32 ng/ml; p < 0.001); SOD (285.54 vs 380.96 ng/ml; p < 0.001) and GPx (9.67 vs 11.26 uU/ml; p < 0.001) were significantly lower in women with uterine fibroids. The median serum levels of oxidants: PC (162.08 vs 142.36 ng/ml; p = 0.04); and AOPP (22.42 vs 13.94 ng/ml; p < 0.001) were significantly higher in women with uterine fibroids. There was a strong negative correlation between serum levels of AOPP and SOD (r = -0.95; p < 0.001) in women with uterine fibroids. The maximum diameter of fibroids showed a significant positive correlation with AOPP (r = 1.000; p < 0.001) and a negative correlation with SOD (r = -1.000; p < 0.001). Conclusion: Women with uterine fibroids had lower levels of antioxidants and higher levels of oxidants. In women with uterine fibroids, AOPP negatively correlated with SOD. There was a positive correlation between fibroid size and AOPP and a negative correlation between fibroid size and SOD. The findings of this study suggests that AOPP and SOD may play an important role in uterine fibroids. Keywords: Uterine fibroids; Oxidative stress markers; antioxidants; oxidants

scholarly journals Predictors and symptomatic burden of uterine fibroids among women in South-Eastern India: a cross-sectional survey analysis

2019 ◽  
Vol 8 (2) ◽  
pp. 524
Author(s):  
Dharitri Swain ◽  
Chanchal Yadav ◽  
Jyoti Kumari ◽  
Monika Rani ◽  
Priyanka Daunrai Rongmei ◽  
...  
Keyword(s):  
Risk Factors ◽  
Uterine Fibroid ◽  
Uterine Fibroids ◽  
Overweight And Obesity ◽  
Reproductive Age ◽  
Age Group ◽  
Women Of Reproductive Age ◽  
Cross Sectional ◽  
Associated Risk Factors ◽  
Reproductive Age Group

Background: Uterine fibroid is the most common pelvic tumor in women of reproductive age and are asymptomatic in at least 50% of affected women. Various risk factors are associated with development of uterine fibroids during this reproductive age. The present study established various associated risk factors increases the prevalence of uterine fibroid among reproductive age group and clinical symptoms burden of diagnosed case.Methods: A cross sectional study design was used to collect samples for a period of six months in an OPD basis. Purposive sampling technique was used to select the 362 sample of reproductive age group (15-45 years) women in a tertiary care hospital, Southeastern India. Women diagnosed with uterine fibroid by ultrasonography were included as cases. Symptomatic features and associated risk factors of UF were collected through structure interview schedule.Results: Point prevalence of uterine fibroid among women in reproductive age group during the period of six months was 20%. Majority of them were in the age group of 30-39 years. Demographic factor such as overweight and obesity and consume dairy products daily has increased the prevalence of UF, whereas use of oral contraceptive pills and normal BMI had inverse relationship with UF risk. Most of the cases reported of having menstrual disturbances like heavy bleeding, passes blood clots during menstruation, prolonged period, urinary symptoms and pressure symptoms were considered independent predicting factors for the occurrence of uterine fibroid.Conclusions: Uterine fibroid is more prevalent among women of reproductive age causing various bleeding and renal symptoms that can have negative impact on quality of women’s life.

scholarly journals Large cervical fibroid: a rare case report

2019 ◽  
Vol 8 (8) ◽  
pp. 3414
Author(s):  
Sunanda N.
Keyword(s):  
Uterine Fibroids ◽  
Total Abdominal Hysterectomy ◽  
Large Mass ◽  
Abdominal Hysterectomy ◽  
Reproductive Age ◽  
Pelvic Tumors ◽  
Rare Case Report ◽  
Tender Mass ◽  
Restricted Mobility ◽  
Reproductive Age Group

Although leiomyomas are the most common pelvic tumors presenting in the reproductive age group, cervical fibroids are rare accounting for 2% of all uterine fibroids. We report a case of 40 year old lady presenting with a firm, non-tender mass of 22-24 weeks size pregnant uterus with restricted mobility. Laparotomy showed a large mass arising from the anterior lip of cervix, with a small uterus pushed posteriorly. Enucleation followed by total abdominal hysterectomy was done. Large cervical fibroids are rare, presenting with surgical difficulties. Careful dissection by expert hands is needed in the management of such cases. 

scholarly journals Prevalence of Goiter and Associated Factors among Women of Reproductive Age Group in Demba Gofa Woreda, Gamo Gofa Zone, Southwest Ethiopia: A Community-Based Cross-Sectional Study

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Befikaduwa Zekarias ◽  
Frehiwot Mesfin ◽  
Bezatu Mengiste ◽  
Adane Tesfaye ◽  
Lemma Getacher
Keyword(s):  
Logistic Regression ◽  
Iodine Deficiency ◽  
Associated Factors ◽  
Sampling Technique ◽  
Iodized Salt ◽  
Reproductive Age ◽  
Age Group ◽  
Women Of Reproductive Age ◽  
Cross Sectional ◽  
Reproductive Age Group

Background. Iodine deficiency disorder is a major public health problem in Ethiopia that is more common in women of reproductive age. However, it is not well addressed and there is a lack of information on its prevalence and associated factors in women of reproductive age group. Therefore, the objective of this study was to assess goiter prevalence and associated factors among women of reproductive age in the Demba Gofa woreda, Gamo Gofa Zone, Southwest Ethiopia. Methods. A community-based cross-sectional study was used among 584 randomly selected women in the reproductive age group from February 05 to April 20, 2016. A simple random sampling technique was used to select the study kebeles, and a systematic random sampling technique was used to select the study samples. Data were collected through a pretested questionnaire, and the goiter examination was done clinically for each participant. The collected data were coded and entered into a computer for statistical analysis using EpiData version 3.2 and analyzed using SPSS version 20. Variables with a P value ≤0.25 in bivariate logistic regression analysis were entered into multivariate logistic regression analysis, and finally, variables with a P value <0.05 in multivariate logistic regression were considered significantly associated with the dependent variable. Results. The total goiter rate was 43%, 95% CI = 39.2–46.9. Cassava consumption (AOR: 2.02, 95% CI: 1.03–4), salt wash before use (AOR: 3.14, 95% CI: 1.1–11.3), salt use after >2 months of purchase (AOR: 11, 95% CI: 5–26), family history of goiter (AOR: 4.6, 95% CI: 1.4–15.8), and poor knowledge of iodized salt (AOR: 2.7, 95% CI: 1.4–5.5) were significant factors associated with goiter. Conclusion. Iodine deficiency was found to be severe in women of reproductive age in the study area. This showed that women of reproductive age, especially during pregnancy, are exposed to iodine deficiency and its adverse effects at delivery. Thus, they need urgent supplementation with iodine, improved access to foods rich in iodine, and intake of iodized salt. Additionally, health education should focus on the importance of iodized salt, the proper method of use, and the prevention of iodine deficiency, which are highly recommended to minimize the problem.

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