scholarly journals Breast cancer in previously thyroidectomized patients: which thyroid disorders are a risk factor?

2021 ◽  
pp. FSO699
Author(s):  
Giuseppa Graceffa ◽  
Gregorio Scerrino ◽  
Gabriella Militello ◽  
Iole Laise ◽  
Brenda Randisi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Thyroid Cancer ◽  
Observational Study ◽  
Thyroid Hormones ◽  
Thyroid Surgery ◽  
Thyroid Autoimmunity ◽  
Thyroid Diseases ◽  
Thyroid Disorders

The aim of this study was to evaluate whether there are thyroid diseases in which breast cancer will appear later as well as the role of autoimmunity. This was a retrospective observational study. A total of 410 females (thyroid surgery and later breast cancer) and 524 females (thyroid surgery only) were compared with regard to pathological thyroid findings, thyroid hormones, thyroid autoimmunity and type of breast cancer. Thyroid autoimmunity, especially antithyroid peroxidase antibodies, significantly increased the risk of breast cancer (p < 0.01); however, this was not true for other thyroid diseases, including thyroid cancer. No variant of breast cancer was predominant, and only thyroid autoimmunity was associated with the risk of breast cancer. Further research is needed to explain the impacts of different antithyroid antibodies.

scholarly journals Immunomodulatory Effects of Vitamin D in Thyroid Diseases

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1444 ◽  
Author(s):  
Chiara Mele ◽  
Marina Caputo ◽  
Alessandro Bisceglia ◽  
Maria Teresa Samà ◽  
Marco Zavattaro ◽  
...  
Keyword(s):  
Vitamin D ◽  
Thyroid Cancer ◽  
Immune Responses ◽  
Thyroid Diseases ◽  
Thyroid Disorders ◽  
Bone Homeostasis ◽  
Immunomodulatory Effects ◽  
Autoimmune Thyroid ◽  
Physiological Processes

Vitamin D is a secosteroid with a pleiotropic role in multiple physiological processes. Besides the well-known activity on bone homeostasis, recent studies suggested a peculiar role of vitamin D in different non-skeletal pathways, including a key role in the modulation of immune responses. Recent evidences demonstrated that vitamin D acts on innate and adaptative immunity and seems to exert an immunomodulating action on autoimmune diseases and cancers. Several studies demonstrated a relationship between vitamin D deficiency, autoimmune thyroid disorders, and thyroid cancer. This review aims to summarize the evidences on the immunomodulatory effect of vitamin D on thyroid diseases.

scholarly journals Oxidative Stress and Immune System in Vitiligo and Thyroid Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Roberta Colucci ◽  
Federica Dragoni ◽  
Silvia Moretti
Keyword(s):  
Oxidative Stress ◽  
Immune System ◽  
Thyroid Autoimmunity ◽  
Thyroid Diseases ◽  
Thyroid Disorders ◽  
Autoimmune Thyroid ◽  
Dermatological Disease ◽  
Growing Body ◽  
And Oxidative Stress

Vitiligo is an acquired dermatological disease frequently associated with autoimmune thyroid disorders. Several theories have been proposed so far to unravel the complex vitiligo pathogenesis. Currently, the autocytotoxic and the autoimmune theories are the most accredited hypothesis, since they are sustained by several important clinical and experimental evidences. A growing body of evidences shows that autoimmunity and oxidative stress strictly interact to finally determine melanocyte loss. In this scenario, associated thyroid autoimmunity might play an active and important role in triggering and maintaining the depigmentation process of vitiligo.

scholarly journals Vignette Thyroid Surgery: A Glimpse Into its History

2013 ◽  
Vol 98 (1) ◽  
pp. 70-75 ◽  
Author(s):  
N. Dorairajan ◽  
P.V. Pradeep
Keyword(s):  
Thyroid Surgery ◽  
State Of The Art ◽  
Thyroid Diseases ◽  
Thyroid Disorders ◽  
Short History ◽  
Operating Theater ◽  
Modern Equipment ◽  
The Past ◽  
History Of

Abstract At present, physicians and surgeons treating thyroid disorders can rely on highly accurate and precise investigations, modern equipment, and state of the art operating theater to achieve optimum results; however, this was not the case at the beginning of the treatment of thyroid diseases centuries ago. We present a short history of the treatment and understanding of thyroid diseases in the past few decades. Also we present the contributions of the important surgeons who tried to perfect the treatment of thyroid diseases, including surgery, thus making modern day management easier.

scholarly journals The Evaluation of Thyroid Diseases in Patients with Pemphigus Vulgaris

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Mukaddes Kavala ◽  
Esra Kural ◽  
Emek Kocaturk ◽  
Ilkin Zindanci ◽  
Zafer Turkoglu ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Systemic Corticosteroid ◽  
Thyroid Autoimmunity ◽  
Pemphigus Vulgaris ◽  
Hashimoto Thyroiditis ◽  
Thyroid Diseases ◽  
Control Group ◽  
Thyroid Disorders ◽  
Thyroid Function Tests ◽  
Antithyroid Antibodies

Background. Thyroid disorders may affect all of the organ systems of the body and they are also highly associated with a wide variety of skin disorders. The aim of this study was to investigate the prevalence of thyroid function abnormalities and thyroid autoimmunity in patients with pemphigus vulgaris (PV) and to determine the association between thyroid disorders and clinical involvement and systemic corticosteroid treatment in patients with PV.Methods. The study consisted of eighty patients with PV and eighty healthy individuals. Thyroid functions (fT3, fT4, and TSH) and thyroid autoimmunity (anti-thyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti-Tg) antibodies) were investigated in both groups. Primary thyroid disease (PTD) was diagnosed with one or more of the following diagnostic criteria: (i) positive antithyroid antibodies, (ii) primary thyroid function abnormalities.Results. Significant changes in the serum thyroid profile were found in 16% (13/80) of the PV group and 5% (4/80) of the control group. Positive titers of antithyroid antibodies (anti-TPO and anti-Tg) were observed in 7 patients (9%) with PV and one in the control group (1,2%). Hashimoto thyroiditis was diagnosed in 9% of PV patients and it was found to be more prevalent in the mucosal form of PV. PTD was found in 13 of (%16) PV patients which was significantly high compared to controls. PTD was not found to be associated with systemic corticosteroid use. Free T3 levels were significantly lower in PV group compared to the control group and free T4 levels were significantly higher in PV group compared to the controls.Conclusions. PV may exist together with autoimmune thyroid diseases especially Hashimoto thyroiditis and primer thyroid diseases. Laboratory work-up for thyroid function tests and thyroid autoantibodies should be performed to determine underlying thyroid diseases in patients with PV.

scholarly journals Human Papillomavirus in Breast Carcinogenesis: A Passenger, a Cofactor, or a Causal Agent?

Biology ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 804
Author(s):  
Rancés Blanco ◽  
Diego Carrillo-Beltrán ◽  
Juan P. Muñoz ◽  
Alejandro H. Corvalán ◽  
Gloria M. Calaf ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Human Papillomavirus ◽  
High Risk ◽  
Experimental Evidence ◽  
Potential Risk ◽  
Hpv Infection ◽  
Breast Carcinogenesis ◽  
Tumor Tissues

Breast cancer (BC) is the most commonly diagnosed malignancy in women worldwide as well as the leading cause of cancer-related death in this gender. Studies have identified that human papillomavirus (HPV) is a potential risk factor for BC development. While vaccines that protect against oncogenic HPVs infection have been commercially available, global disparities persist due to their high cost. Interestingly, numerous authors have detected an increased high risk (HR)-HPV infection in BC specimens when compared with non-tumor tissues. Therefore, it was suggested that HR-HPV infection could play a role in breast carcinogenesis in a subset of cases. Additional epidemiological and experimental evidence is still needed regarding the role of HR-HPV infection in the development and progression of BC.

scholarly journals Computational way of Classifying Thyroid Disorder Patients and Identifying the Similar Patients using a Novel Method

2020 ◽  
Vol 9 (5) ◽  
pp. 432-438
Keyword(s):  
Machine Learning ◽  
Thyroid Gland ◽  
Thyroid Hormones ◽  
Thyroid Diseases ◽  
Thyroid Disorders ◽  
Thyroid Disorder ◽  
Machine Learning Technique ◽  
Learning Technique ◽  
Novel Method ◽  
Fuzzy C Means Algorithm

The thyroid hormones secreted by thyroid gland are interrelated with many metabolic processes of our body. Any dysfunction of thyroid gland leads to thyroid diseases. Hypothyroidism and hyperthyroidism are the very common thyroid disorders which affect the large number of people nowadays. Prediction of thyroid diseases at right time and giving suitable medicines to the patients help them to overcome the health problems. A machine learning technique will definitely assist the physicians for the prediction and treatment of thyroid diseases. In this work, the datasets are taken from UCI repository and Fuzzy- C Means algorithm is used for the clustering the thyroid diseases

Screening Breast MRI and the Science of Premenopausal Background Parenchymal Enhancement

2021 ◽  
Author(s):  
Stephen Vong ◽  
Anthony J Ronco ◽  
Elham Najafpour ◽  
Shadi Aminololama-Shakeri
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Patient Outcomes ◽  
Cancer Detection ◽  
Premenopausal Women ◽  
Breast Mri ◽  
Breast Cancer Detection ◽  
Background Parenchymal Enhancement ◽  
Parenchymal Enhancement

Abstract The significance of background parenchymal enhancement (BPE) on screening and diagnostic breast MRI continues to be elucidated. Background parenchymal enhancement was initially deemed probably benign and followed or thought of as an artifact degrading the accuracy of breast cancer detection on breast MRI examinations. Subsequent research has focused on understanding the role of BPE regarding screening breast MRI. Today, there is growing evidence that a myriad of factors affect BPE, which in turn may influence patient outcomes. Additionally, BPE could represent an important risk factor for the future development of breast cancer. This article aims to describe the most up-to-date research on BPE as it relates to screening breast MRI in premenopausal women.

Sign in / Sign up

Export Citation Format

Share Document