scholarly journals Inverted J-Shaped Association of High-Sensitivity C-Reactive Protein with the Levels of Serum Uric Acid: Cross-Sectional and Longitudinal Analyses

2022 ◽  
Vol Volume 15 ◽  
pp. 341-344
Author(s):  
Xing Zhen Liu ◽  
Ya Jun Tian ◽  
Jie Fan ◽  
Lian Yong Liu
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
High Sensitivity ◽  
Longitudinal Analyses ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein

scholarly journals HUBUNGAN KADAR ASAM URAT SERUM DENGAN KADAR HIGH-SENSITIVITY C-REACTIVE PROTEIN PADA REMAJA OBES

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Agustinus Mahardhika Sarayar
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Obese Subject ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Reactive Protein ◽  
Hs Crp ◽  
Spearman Test

Abstract: Uric acid has low water solubility. When the concentration exceeds its solubility, it will form monosodium urate (MSU) crystals which can trigger inflammation. High sensitivity C-reactive protein (hs-CRP) is one of the most liable inflammatory biomarker and recently considered as major modifiable risk factor of coronary heart disease. Serum uric acid and hs-CRP levels are often elevated in obese patients. The purpose of this study are to determine hs-CRP and serum uric acid levels and to determine the correlation between serum uric acid and hs-CRP  levels in obese adolescents. This is an analytic observational study with cross sectional design. Subject consist of 17 obese adolescents age 17-20 years with percentile of ≥ 95 in CDC BMI-for-age chart. Nonparametric analysis with Spearman test was applied to find the correlation between serum uric acid and hs-CRP levels. The mean serum uric acid and hs-CRP levels in obese subjects were 7.37 (SD 1.66) mg/dL and  1.73 (SD 1.44) mg/L respectively. In conclusion, a statistically insignificant correlation between serum uric acid and hs-CRP levels was found (p = 0.296, r = 0.14). Serum uric acid levels  are consistently higher in obese adolescents. Hs-CRP levels among obese subject shows moderate risk of developing cardiovascular disease in the future. Keywords: Adolescents, hs-CRP, obese, serum uric acid    Abstrak: Asam urat memiliki kelarutan yang rendah dalam air. Saat konsentrasi asam urat melebihi batas ambang solubilitas, akan terbentuk kristal monosodium urat yang akan memicu inflamasi. High sensitivity C-reactive protein (hs-CRP) merupakan salah satu biomarker inflamasi yang belakangan ini dijadikan faktor risiko mayor yang dapat dimodifikasi dari penyakit jantung koroner. Kadar asam urat serum dan hs-CRP biasanya meningkat pada penderita obesitas. Tujuan dari penelitian ini untuk mengetahui hubungan kadar asam urat serum dengan hs-CRP serta gambaran kadar asam urat serum dan hs-CRP pada remaja obes. Penelitian ini menggunakan desain penelitian analitik observasional  dengan pendekatan cross-sectional. Subjek terdiri dari 17 remaja obes usia 17-20 tahun dengan persentil ≥ 95 pada grafik IMT terhadap usia CDC. Analisis data menggunakan Spearman test digunakan untuk mengetahui korelasi antara kadar asam urat serum dengan hs-CRP. Nilai rata-rata kadar asam urat serum dan hs-CRP yang didapat secara berurutan mencapai 7,37 (SD 1,66) mg/dL dan 1,73 (SD 1,44) mg/L. Sebagai kesimpulan, hubungan kadar asam urat serum dengan hs-CRP tidak signifikan (p = 0,296) dan berkorelasi positif lemah (r = 0,14). Kadar asam urat serum pada remaja obes tergolong tinggi. Kadar hs-CRP remaja obes termasuk dalam risiko menengah untuk terkena penyakit kardiovaskular di masa mendatang. Kata kunci: Asam urat serum, hs-CRP, Obesitas, Remaja

scholarly journals U-Shaped Association between Sleep Duration, C-Reactive Protein, and Uric Acid in Korean Women

2020 ◽  
Vol 17 (8) ◽  
pp. 2657
Author(s):  
Yea-Chan Lee ◽  
Da-Hye Son ◽  
Yu-Jin Kwon
Keyword(s):  
Uric Acid ◽  
Sleep Duration ◽  
High Sensitivity ◽  
Multiple Logistic Regression ◽  
Korean Women ◽  
Regression Analyses ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Health And Nutrition

Serum high-sensitivity C-reactive protein (hsCRP) and serum uric acid (SUA) are biomarkers that predict chronic inflammation and cardiovascular dysfunction. Therefore, we aimed to investigate the association between sleep duration, hsCRP, and SUA in Korean women. Cross-sectional data from the Seventh Korea National Health and Nutrition Examination Survey was analyzed. The odds ratio (OR) and 95% confidence intervals (CIs) for an association between higher hsCRP (>2.0 mg/L) or higher SUA (>5.6 mg/dL) and sleep duration were calculated using multiple logistic regression analyses after adjusting for potential confounders. In total, 6151 women were included in the analysis. There was a U-shaped relationship between continuous sleep duration, hsCRP, and SUA. Compared to those who slept for 7–8 h, the ORs (95% CIs) for higher hsCRP were 1.43 (0.95–2.16) in short sleepers and 1.64 (1.09–2.48) in long sleepers after adjusting for confounders. Compared with those who slept for 7–8 h, the ORs (95% CIs) for higher SUA were 1.54 (1.04–2.26) in short sleepers and 1.94 (1.27–2.96) in long sleepers after adjusting for confounders. We found a U-shaped association between sleep duration, hsCRP, and SUA in Korean women. 7–8 h sleep was associated with lower level of hsCRP and SUA in Korean women.

scholarly journals Study of Correlation between High Sensitivity C-Reactive Protein and Serum Uric Acid in Acute Stroke

2021 ◽  
Vol 10 (15) ◽  
pp. 1074-1078
Author(s):  
Jayachandra Jayachandra ◽  
Arjun P. Chandrashekar ◽  
Sowrabha S. Bhat ◽  
Yoganand Yoganand ◽  
Chethan Chethan ◽  
...  
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Acute Stroke ◽  
Serum Uric Acid ◽  
High Sensitivity ◽  
Risk Marker ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Clinical Records

BACKGROUND Relationship between serum uric acid and cardiovascular system has been recognised since years. High-sensitivity C-reactive protein (hs-CRP) is a known risk factor for cardiovascular and cerebrovascular events. The role of uric acid as a risk factor for vascular disease and acute stroke is controversial and there is little information about it.1 It is unclear as to whether high uric acid concentrations promote or protect against the development of cerebrovascular disease, or simply acts as a passive marker of increased risk. As serum hs-CRP is an established risk factor for stroke, its positive correlation with serum uric acid levels would suggest that high serum uric acid could predict stroke risk. Also, it would prove to be a more cost-effective investigative tool in our present set up. METHODS In this cross-sectional study, we assessed 100 patients admitted with acute stroke in Victoria and Bowring and Lady Curzon Hospital from October 2016 to November 2018. Clinical records, routine investigations, radiological imaging, serum uric acid and hs-CRP of the patients were investigated. RESULTS Majority of the patients (33 %) belonged to the age group of > 70 yrs., followed by 61 - 70 yrs. (26 %). 69 % of the patients were males and 31 % were females. 67 % of them were hypertensive and 32 % were diabetic. 91 % had an hs-CRP level of > 3.0 mg / L and 8 % had hs-CRP levels between 1.0 and 3.0 mg / L. None of the female patients had a serum uric acid value > 6.5 mg / dL and none of the male patients had a uric acid level of > 7.0 mg / dL. There was a correlation between serum uric acid levels and serum hs-CRP levels in patients ≤ 50 yrs. of age. There was no correlation between serum hs-CRP levels and serum uric acid levels in patients more than 50 yrs. of age. CONCLUSIONS Our study showed that stroke is most common in persons > 70 yrs. of age and is more common in males compared to females. Hypertension is an independent risk factor for stroke. hs-CRP is a well-established risk marker for stroke, being raised in majority of stroke patients. Serum uric acid is not raised in all patients of acute stroke. So, it cannot be used as a risk marker for stroke. KEY WORDS hs-CRP, Serum Uric Acid, Acute Stroke

scholarly journals Roma Ethnicity and Sex-Specific Associations of Serum Uric Acid with Cardiometabolic and Hepatorenal Health Factors in Eastern Slovakian Population: The HepaMeta Study

2020 ◽  
Vol 17 (20) ◽  
pp. 7673
Author(s):  
Maria Pallayova ◽  
Marek Brenisin ◽  
Alina Putrya ◽  
Martin Vrsko ◽  
Sylvia Drazilova ◽  
...  
Keyword(s):  
Uric Acid ◽  
High Sensitivity ◽  
Low Grade ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Roma Population ◽  
Reactive Protein ◽  
Health Factors ◽  
Unit Increase ◽  
Roma Ethnicity

Background: Health characteristics associated with uric acid (UA) in the Roma minority remain less well known. The study sought to determine the ethnicity- and sex-specific associations of serum UA with health factors in Eastern Slovakian Roma and non-Roma populations. Methods: Data from the comparative cross-sectional HepaMeta study conducted in Slovakia in 2011 were used. The study enrolled 452 Roma subjects (35.2% men) and 403 non-Roma individuals (45.9% men) aged 18–55 years. Results: All study parameters differed between the sexes in both the Roma and non-Roma participants (p < 0.05). UA was related to sex with odds ratio for female sex 0.873, 95% CI 0.853–0.893 (p < 0.0001) per 10-unit increase of UA. Average level of UA ± standard deviation was lower in Roma than in non-Roma (226.54 ± 79.8 vs. 259.11 ± 84.53 umol/L; p < 0.0001). The Roma population presented with greater levels of high-sensitivity C-reactive protein (hsCRP) (3.07 ± 4 mg/L vs. 1.98 ± 2.83 mg/L; p < 0.0001) and ferritin in Roma males (403.78 ± 391.84 vs. 302.67 ± 236.26 mg/L; p < 0.0001). Conclusions: Serum UA is sex- and ethnicity specific. Elevated levels of hsCRP and ferritin particularly in Roma males can reflect low-grade systemic inflammation and thus serve as a marker of an increased cardiovascular risk.

scholarly journals Association of serum uric acid with high-sensitivity C-reactive protein in postmenopausal women

Climacteric ◽  
2016 ◽  
Vol 20 (1) ◽  
pp. 44-48 ◽  
Author(s):  
A. Raeisi ◽  
A. Ostovar ◽  
K. Vahdat ◽  
P. Rezaei ◽  
H. Darabi ◽  
...  
Keyword(s):  
Uric Acid ◽  
Postmenopausal Women ◽  
Serum Uric Acid ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Association of high-sensitivity C-reactive protein in middle-aged and elderly Chinese people with hyperuricaemia and risk of coronary heart disease: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e028351
Author(s):  
Mingsheng Xie ◽  
Dongxing Xie ◽  
Ye Yang ◽  
Yi Zhang ◽  
Kun Li ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Uric Acid ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Chd Risk ◽  
Hs Crp

ObjectivesPatients with hyperuricaemia are at relatively high risk of developing coronary heart disease (CHD). The purpose of this study was to examine the relationship between high-sensitivity C-reactive protein (hs-CRP) and CHD risk in a middle-aged and elderly population with hyperuricaemia.DesignA cross-sectional study.Setting and participantsThis study was conducted in a health examination centre of China. Participants were diagnosed with hyperuricaemia based on uric acid concentrations. Specifically, males with a uric acid concentration ≥416 μmol/L were included, as well as females with a concentration ≥360 μmol/L.Main outcome measures10-year CHD risk for each individual was evaluated using Framingham risk score based on the Adult Treatment Panel III charts.ResultsA total of 517 patients with hyperuricaemia (438 males and 79 females) aged from 40 to 85 years old were included in the present study. 193 (37.3%) patients were defined with relatively high 10-year CHD risk. Compared with the lowest quintile, the crude ORs of relatively high 10-year CHD risks were 1.43 (95% CI 0.78 to 2.63, p=0.245), 2.05 (95% CI 1.14 to 3.67, p=0.016), 2.77 (95% CI 1.54 to 4.98, p=0.001), 2.12 (95% CI 1.18 to 3.80, p=0.012) in the second, third, fourth and fifth quintiles of serum hs-CRP level, respectively (p for trend=0.057). The multivariable-adjusted ORs of relatively high 10-year CHD risk were 1.40 (95% CI 0.75 to 2.61, p=0.291) in the second, 2.05 (95% CI 1.13 to 3.72, p=0.019) in the third, 2.69 (95% CI 1.47 to 4.89, p=0.001) in the fourth and 2.10 (95% CI 1.15 to 3.84, p=0.016) in the fifth quintile of serum hs-CRP level when compared with the lowest quintile (p for trend=0.068).ConclusionThis study showed that ORs of relatively high 10-year CHD risk were raised in patients with hyperuricaemia with higher serum hs-CRP level; however, there was a not significant but borderline trend association and that more research is needed.

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