scholarly journals HUBUNGAN KADAR ASAM URAT SERUM DENGAN KADAR HIGH-SENSITIVITY C-REACTIVE PROTEIN PADA REMAJA OBES

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Agustinus Mahardhika Sarayar
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Obese Subject ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Reactive Protein ◽  
Hs Crp ◽  
Spearman Test

Abstract: Uric acid has low water solubility. When the concentration exceeds its solubility, it will form monosodium urate (MSU) crystals which can trigger inflammation. High sensitivity C-reactive protein (hs-CRP) is one of the most liable inflammatory biomarker and recently considered as major modifiable risk factor of coronary heart disease. Serum uric acid and hs-CRP levels are often elevated in obese patients. The purpose of this study are to determine hs-CRP and serum uric acid levels and to determine the correlation between serum uric acid and hs-CRP  levels in obese adolescents. This is an analytic observational study with cross sectional design. Subject consist of 17 obese adolescents age 17-20 years with percentile of ≥ 95 in CDC BMI-for-age chart. Nonparametric analysis with Spearman test was applied to find the correlation between serum uric acid and hs-CRP levels. The mean serum uric acid and hs-CRP levels in obese subjects were 7.37 (SD 1.66) mg/dL and  1.73 (SD 1.44) mg/L respectively. In conclusion, a statistically insignificant correlation between serum uric acid and hs-CRP levels was found (p = 0.296, r = 0.14). Serum uric acid levels  are consistently higher in obese adolescents. Hs-CRP levels among obese subject shows moderate risk of developing cardiovascular disease in the future. Keywords: Adolescents, hs-CRP, obese, serum uric acid    Abstrak: Asam urat memiliki kelarutan yang rendah dalam air. Saat konsentrasi asam urat melebihi batas ambang solubilitas, akan terbentuk kristal monosodium urat yang akan memicu inflamasi. High sensitivity C-reactive protein (hs-CRP) merupakan salah satu biomarker inflamasi yang belakangan ini dijadikan faktor risiko mayor yang dapat dimodifikasi dari penyakit jantung koroner. Kadar asam urat serum dan hs-CRP biasanya meningkat pada penderita obesitas. Tujuan dari penelitian ini untuk mengetahui hubungan kadar asam urat serum dengan hs-CRP serta gambaran kadar asam urat serum dan hs-CRP pada remaja obes. Penelitian ini menggunakan desain penelitian analitik observasional  dengan pendekatan cross-sectional. Subjek terdiri dari 17 remaja obes usia 17-20 tahun dengan persentil ≥ 95 pada grafik IMT terhadap usia CDC. Analisis data menggunakan Spearman test digunakan untuk mengetahui korelasi antara kadar asam urat serum dengan hs-CRP. Nilai rata-rata kadar asam urat serum dan hs-CRP yang didapat secara berurutan mencapai 7,37 (SD 1,66) mg/dL dan 1,73 (SD 1,44) mg/L. Sebagai kesimpulan, hubungan kadar asam urat serum dengan hs-CRP tidak signifikan (p = 0,296) dan berkorelasi positif lemah (r = 0,14). Kadar asam urat serum pada remaja obes tergolong tinggi. Kadar hs-CRP remaja obes termasuk dalam risiko menengah untuk terkena penyakit kardiovaskular di masa mendatang. Kata kunci: Asam urat serum, hs-CRP, Obesitas, Remaja

scholarly journals HUBUNGAN KADAR TRIASILGLISEROL DARAH DENGAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN PADA REMAJA OBES

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Melda Melatunan
Keyword(s):  
Cardiovascular Disease ◽  
High Sensitivity ◽  
Nonparametric Test ◽  
Inflammatory Factors ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Reactive Protein ◽  
Triacylglycerol Level ◽  
Hs Crp

Abstract: Obesity is one of the health problem in the world, also in Indonesia. Obesity is caused by an increased amount of fat that stored in the form triacylglycerol ( TAG ) which is acquired from food. Increase of triacylglycerol level may cause higher risk of cardiovascular disease. High Sensitivity C-Reactive Protein (hs-CRP) is a marker of inflammatory factors that can be used as a marker for cardiovascular disease. This study aimed to determine the correlations between TAG levels on blood and hs-CRP levels on obese adolescents. This study performed by observational analytic study design with the cross-sectional approach. The number of sample in this study were 17 sample who was willing to join. Analysis of bivariate using Spearman nonparametric test. The results showed a significance value ( p ) 0.272 which indicates that the correlation between TAG levels and hs-CRP levels were not significant. Spearman value showed 0.282 that indicates that the direction of a positive correlation with the strength of the correlation is weak. It can be concluded that there is no correlations between TAG levels in blood with hs-CRP levels on obese adolescents. Keyword: Obesity, TAG, hs-CRP, Adolescents    Abstrak: Obesitas merupakan masalah kesehatan di seluruh dunia, termasuk di Indonesia. Obesitas disebabkan akibat peningkatan jumlah lemak yang disimpan dalam bentuk triasilgliserol (TAG) yang diperoleh dari makanan. Peningkatan triasilgliserol ini akan meningkatkan risiko penyakit kardiovaskuler. High Sensitivity C-Reactive Protein (hs-CRP) merupakan faktor penanda inflamasi yang dapat digunakan sebagai penanda risiko penyakit kardiovaskuler. Penelitian ini bertujuan untuk mengetahui hubungan kadar TAG darah dengan kadar hs-CRP pada remaja obes. Penelitian ini menggunakan desain penelitian analitik observasional dengan pendekatan cross-sectional. Sampel pada penelitian ini berjumlah 17 sampel yang diambil dari seluruh populasi yang bersedia. Analisis bivariat menggunakan uji nonparametrik Spearman. Hasil penelitian didapatkan nilai signifikansi (p) 0,272 yang menunjukkan bahwa korelasi antara kadar TAG dan kadar hs-CRP tidak signifikan. Nilai Spearman sebesar 0,282 menunjukkan bahwa arah korelasi positif dengan kekuatan korelasi yang lemah. Dapat disimpulkan bahwa tidak terdapat hubungan antara kadar TAG darah dengan kadar hs-CRP pada remaja obes. Kata Kunci : Obesitas, TAG, hs-CRP, Remaja

scholarly journals Study of Correlation between High Sensitivity C-Reactive Protein and Serum Uric Acid in Acute Stroke

2021 ◽  
Vol 10 (15) ◽  
pp. 1074-1078
Author(s):  
Jayachandra Jayachandra ◽  
Arjun P. Chandrashekar ◽  
Sowrabha S. Bhat ◽  
Yoganand Yoganand ◽  
Chethan Chethan ◽  
...  
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Acute Stroke ◽  
Serum Uric Acid ◽  
High Sensitivity ◽  
Risk Marker ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Clinical Records

BACKGROUND Relationship between serum uric acid and cardiovascular system has been recognised since years. High-sensitivity C-reactive protein (hs-CRP) is a known risk factor for cardiovascular and cerebrovascular events. The role of uric acid as a risk factor for vascular disease and acute stroke is controversial and there is little information about it.1 It is unclear as to whether high uric acid concentrations promote or protect against the development of cerebrovascular disease, or simply acts as a passive marker of increased risk. As serum hs-CRP is an established risk factor for stroke, its positive correlation with serum uric acid levels would suggest that high serum uric acid could predict stroke risk. Also, it would prove to be a more cost-effective investigative tool in our present set up. METHODS In this cross-sectional study, we assessed 100 patients admitted with acute stroke in Victoria and Bowring and Lady Curzon Hospital from October 2016 to November 2018. Clinical records, routine investigations, radiological imaging, serum uric acid and hs-CRP of the patients were investigated. RESULTS Majority of the patients (33 %) belonged to the age group of > 70 yrs., followed by 61 - 70 yrs. (26 %). 69 % of the patients were males and 31 % were females. 67 % of them were hypertensive and 32 % were diabetic. 91 % had an hs-CRP level of > 3.0 mg / L and 8 % had hs-CRP levels between 1.0 and 3.0 mg / L. None of the female patients had a serum uric acid value > 6.5 mg / dL and none of the male patients had a uric acid level of > 7.0 mg / dL. There was a correlation between serum uric acid levels and serum hs-CRP levels in patients ≤ 50 yrs. of age. There was no correlation between serum hs-CRP levels and serum uric acid levels in patients more than 50 yrs. of age. CONCLUSIONS Our study showed that stroke is most common in persons > 70 yrs. of age and is more common in males compared to females. Hypertension is an independent risk factor for stroke. hs-CRP is a well-established risk marker for stroke, being raised in majority of stroke patients. Serum uric acid is not raised in all patients of acute stroke. So, it cannot be used as a risk marker for stroke. KEY WORDS hs-CRP, Serum Uric Acid, Acute Stroke

scholarly journals HUBUNGAN ANTARA WHR DENGAN KADAR Hs-CRP SERUM PADA MAHASISWA OBES DAN TIDAK OBES DI FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI MANADO

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Ezra Toreh ◽  
Shirley E. S. Kawengian ◽  
Alexander S. L. Bolang
Keyword(s):  
Statistical Analysis ◽  
High Sensitivity ◽  
Medical Faculty ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Waist To Hip Ratio ◽  
Reactive Protein ◽  
Increased Risk ◽  
Hs Crp ◽  
Spearman Test

Abstract: Central obesity is recognized as a major factor that associated with increased risk for some chronic diseases. Waist to hip ratio described the increase in visceral adipose tissue and subcutaneous fat on waist circumference and hip circumference.C-reactive protein is the detection of cardiovascular disease risk in conventional but not sensitive enough to detect cardiovascular risk so  beused the new method is of high sensitivity C-reactive protein.The research have purpose to know the difference and relationship of waist to hip ratio and high sensitivity c-reactive protein level between obese and non-obese students at Medical Faculty of Sam Ratulangi University Manado. This research was an observational analytic cross-sectional approach. The results of statistical analysis using the Mann-Whitney U test revealed that there were significant differences (p = 0.000 <0.05) both WHR and hs-CRP level in both groups of students are. Conclusion: The results of statistical analysis using the Spearman test showed that there is a positive very weak relationship (r = 0309) and significant (p = 0017 <0.05) between the values ​​of WHR with hs-CRP level in obese and non-obese students at Medical Faculty of Sam Ratulangi University Manado. Key Words: WHR, hs-CRP     Abstrak: Obesitas sentral diakui sebagai factor utama yang dikaitkan dengan peningkatan resiko untuk beberapa penyakit kronis. Waist to hip ratio (WHR) menggambarkan peningkatan jaringan adiposa visceral dan lemak subkutan pada lingkar pinggang dan lingkar pinggul. C-reactive protein (CRP) merupakan deteksi risiko penyakit kardiovaskular tapi secara konvensional tidak cukup sensitif untuk mendeteksi risiko kardiovaskular sehingga digunakan metode baru yaitu high sensitivity C-reactive protein (hsCRP). Penelitian bertujuan untuk mengetahui perbedaan dan hubungan waist to hip ratio (WHR) dengan kadar high sensitivity c-reactive protein (hs-CRP) serum pada mahasiswa obes dan tidak-obes di Fakultas Kedokteran Universitas Sam Ratulangi Manado. Penelitian ini bersifat observasional analitik dengan menggunakan pendekatan cross-sectional. Hasil analisis statistic dengan menggunakan uji Mann-Whitney U menunjukan terdapat perbedaan yang bermakna (p=0.000<0.05) baik WHR maupun kadar hs-CRP serum pada kedua kelompok mahasiswa tersebut. Simpulan: Hasil analisis statistic dengan mengguna-kan uji Spearman menunjukan bahwa terdapat hubungan yang positif sangat lemah (r=0.309) dan bermakna (p=0.017<0.05) antara nilai WHR dengan kadar hs-CRP serum mahasiswa obes dan tidak-obes pada Fakultas Kedokteran Universitas Sam Ratulangi Manado. Kata Kunci: WHR, hs-CRP

scholarly journals HUBUNGAN KADAR KOLESTROL LOW DENSITY LIPOPROTEIN PLASMA DENGAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN PADA REMAJA OBES

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Daniel Budiono
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Low Density ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Reactive Protein ◽  
Spearman Correlation Test ◽  
Hs Crp

Abstract: Atherosclerosis is the leading cause of mortality in the developed countries and in the future, it is predicted to be the leading cause of mortality in the developing countries. Low density lipoprotein, high sensitivity C-reactive protein, and obesity have been identified as risk factors of atherosclerosis. Obesity during childhood and adolescents tends to occur during adults life. The aim of this study is to know the levels of low density lipoprotein and high sensitivity C-reactive protein and the correlation between those two levels in obese adolescents. This observational cross sectional study design involved 17 obese adolescents and analyzed using Spearman Correlation Test. The results showed the mean levels of LDL was 123,0 mg/dL, and hs-CRP was 1,618 mg/L. Spearman correlation test showed significance value (p) was 0,024 and correlation significance value coefficient was 0,544. From the results can be concluded that the levels of low density lipoprotein levels in obese adolescents is in normal range, obese adolescents are associated with a moderate risk of cardiovascular disease at the future and there is a significant positive correlation between low density lipoprotein cholestrol levels and high sensitivity C-reactive protein levels in obese adolescents. Keywords : low density lipoprotein, high sensitivity c-reactive protein, obese adolescents   Abstrak: Aterosklerosis merupakan penyebab kematian utama di negara maju saat ini, dan diprediksi akan menjadi penyebab kematian utama di negara berkembang di masa mendatang. Peningkatan kadar low density lipoprotein dan kadar high sensitivity C-reactive protein (hs-CRP) serta obesitas telah diidentifikasi sebagai faktor risiko aterosklerosis. Remaja yang mengalami obesitas cenderung tetap mengalami obesitas pada saat dewasa. Tujuan dari penelitian ini untuk mengetahui gambaran kadar kolestrol low density lipoprotein dan kadar high sensitivity C-reactive protein pada remaja obes, serta hubungan kadar low density lipoprotein dengan kadar high sensitivity C-reactive protein pada remaja obes. Penelitian ini menggunakan desain penelitian analitik observasional dengan pendekatan cross sectional terhadap 17 remaja obes. Nilai rerata kadar LDL pada remaja obes 123,00 mg/dL, dan nilai rerata kadar hs-CRP pada remaja obes 1,618 mg/L. Berdasarkan hasil penelitian, dapat disimpulkan remaja obes memiliki kadar LDL dalam rentang normal, remaja obes memiliki risiko sedang terkena penyakit kardiovaskular di masa mendatang dan terdapat hubungan positif yang signifikan antara kadar low density lipoprotein dengan kadar high sensitivity c-reactive protein pada remaja obes. Kata Kunci: low density lipoprotein, high sensitivity c-reactive protein, remaja obes

scholarly journals Association of high-sensitivity C-reactive protein in middle-aged and elderly Chinese people with hyperuricaemia and risk of coronary heart disease: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e028351
Author(s):  
Mingsheng Xie ◽  
Dongxing Xie ◽  
Ye Yang ◽  
Yi Zhang ◽  
Kun Li ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Uric Acid ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Chd Risk ◽  
Hs Crp

ObjectivesPatients with hyperuricaemia are at relatively high risk of developing coronary heart disease (CHD). The purpose of this study was to examine the relationship between high-sensitivity C-reactive protein (hs-CRP) and CHD risk in a middle-aged and elderly population with hyperuricaemia.DesignA cross-sectional study.Setting and participantsThis study was conducted in a health examination centre of China. Participants were diagnosed with hyperuricaemia based on uric acid concentrations. Specifically, males with a uric acid concentration ≥416 μmol/L were included, as well as females with a concentration ≥360 μmol/L.Main outcome measures10-year CHD risk for each individual was evaluated using Framingham risk score based on the Adult Treatment Panel III charts.ResultsA total of 517 patients with hyperuricaemia (438 males and 79 females) aged from 40 to 85 years old were included in the present study. 193 (37.3%) patients were defined with relatively high 10-year CHD risk. Compared with the lowest quintile, the crude ORs of relatively high 10-year CHD risks were 1.43 (95% CI 0.78 to 2.63, p=0.245), 2.05 (95% CI 1.14 to 3.67, p=0.016), 2.77 (95% CI 1.54 to 4.98, p=0.001), 2.12 (95% CI 1.18 to 3.80, p=0.012) in the second, third, fourth and fifth quintiles of serum hs-CRP level, respectively (p for trend=0.057). The multivariable-adjusted ORs of relatively high 10-year CHD risk were 1.40 (95% CI 0.75 to 2.61, p=0.291) in the second, 2.05 (95% CI 1.13 to 3.72, p=0.019) in the third, 2.69 (95% CI 1.47 to 4.89, p=0.001) in the fourth and 2.10 (95% CI 1.15 to 3.84, p=0.016) in the fifth quintile of serum hs-CRP level when compared with the lowest quintile (p for trend=0.068).ConclusionThis study showed that ORs of relatively high 10-year CHD risk were raised in patients with hyperuricaemia with higher serum hs-CRP level; however, there was a not significant but borderline trend association and that more research is needed.

scholarly journals High Sensitivity CReactive Protein (hsCRP) Level on Premature Rupture of Membrane (PROM) at Term Pregnancy

2017 ◽  
pp. 12-15
Author(s):  
Meily Manoppo ◽  
Hermie MM Tendean ◽  
Joice MM Sondakh
Keyword(s):  
High Sensitivity ◽  
C Reactive Protein ◽  
Term Pregnancy ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference ◽  
Hs Crp ◽  
Cross Sectional Design ◽  
Parametric Statistical Test

Objective: To compare the level of high sensitivity C-Reactive Protein (hs-CRP) on patients with premature rupture of membranes (PROM) at term pregnancy. Methods: The study was cross-sectional design. The data collection included age, parity, gestational age, birth weight, and APGAR score on 28 pregnant women at term pregnancy consisting of 14 subjects of Premature Rupture of Membrane (PROM) less than 12 hours and the remaining one was equal or more than 12 hours. We took blood samples from the subjects for the examination of hs-CRP level. Data were analyzed using non-parametric statistical test and processed using Statistical Package for Social Sciences (SPSS) version 20. Results: The mean hs-CRP level on PROM <12-hour and 12-hour group was 12.9 and 17.8 mg/l. There was not significant difference on hs-CRP level between both of group at term pregnancy (p=0.734). Conclusion: The level of hs-CRP does not have association with the incidence of PROM. [Indones J Obstet Gynecol 2017; 5-1: 12-15] Keywords: high sensitivity C-Reactive Protein, premature ruptures of membranes, term pregnancy

scholarly journals Kadar High Sensitivity C-Reactive Protein Berkaitan dengan Lingkar Pinggang pada Lansia

2021 ◽  
Vol 8 (1) ◽  
pp. 21
Author(s):  
Deny Yudi Fitranti ◽  
Bunga Syifarahmi ◽  
Martha Ardiaria ◽  
Nurmasari Widyastuti
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
International Physical Activity Questionnaire ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Consecutive Sampling ◽  
Hs Crp ◽  
Activity Questionnaire

<p>Proses penuaan mempengaruhi peningkatan distribusi lemak abdominal dengan indikator lingkar pinggang (LP) dan rasio lingkar pinggang panggul (RLPP). Penimbunan lemak abdominal menyebabkan disfungsi jaringan adiposa sehingga mempengaruhi biomarker proinflamasi yaitu kadar serum <em>high-sensitivity C-reactive Protein</em> (hs-CRP). Penelitian bertujuan untuk mengetahui hubungan LP dan RLPP dengan kadar hs-CRP lansia wanita. Rancangan penelitian <em>cross sectional</em> pada 53 subjek dipilih secara <em>consecutive sampling</em>. Antropometri yang diukur adalah LP dan RLPP. Pengukuran kadar serum hs-CRP dianalisis dengan metode <em>enyme-linked immunosorbent assay</em> (ELISA). Wawancara yang dilakukan yaitu data diri, asupan, aktivitas fisik, dan riwayat konsumsi obat. Data asupan diperoleh dengan metode <em>food recall</em> 3x24 jam. Aktivitas fisik diperoleh menggunakan <em>International Physical Activity Questionnaire</em> (IPAQ). Analisis data digunakan uji korelasi <em>Spearman</em>. Hasil penelitian menunjukkan bahwa persentase LP pada lansia wanita yang berisiko sebesar 90,6%, RLPP yang berisiko sebesar 98,1%, dan kadar hs-CRP tinggi sebesar 30,2%. Terdapat hubungan positif antara LP dengan kadar serum hs-CRP (r=0,417 ; p=0,002). Dalam penelitian ini RLPP, aktivitas fisik, asupan energi, karbohidrat, protein, lemak, serat, vitamin A, vitamin C, vitamin D,vitamin E, dan selenium tidak berkorelasi dengan kadar hs-CRP. Simpulan penelitian ini adalah LP berkorelasi positif dengan kadar serum hs-CRP, namun RLPP tidak berkorelasi dengan kadar serum hs-CRP</p>

A STUDY TO EVALUATE THE ROLE OF HIGH SENSITIVITY C-REACTIVE PROTEIN IN CEREBROVASCULAR ACCIDENT IN THE DARBHANGA MEDICAL COLLEGE AND HOSPITAL

2021 ◽  
pp. 71-73
Author(s):  
Amit Kumar Tiwari ◽  
Umesh Chandra Jha ◽  
Debarshi Jana
Keyword(s):  
Cerebrovascular Accident ◽  
High Sensitivity ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Abrupt Onset ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Medical College ◽  
Reactive Protein ◽  
Hs Crp

INTRODUCTION:Cerebrovascular accident (commonly called stroke) is dened as an abrupt onset of a neurologic decit that is attributable to a focal vascular cause. Thus, the diagnosis of stroke is clinical and laboratory studies including brain imaging are used to support the diagnosis AIMS AND OBJECTIVES: To evaluate the serum levels of high sensitivity C-reactive protein (hsCRP) in different types of cerebrovascular accidents on admission. MATERIALS AND METHODS: This study was an institution based cross-sectional study designed to investigate the association of hs-CRP levels with stroke and its types in Indian patients. The study was done in the Department of Medicine, Darbhanga Medical College and Hospital, Laheriasarai, Bihar from march 2019 to March 2020. 50 patients of either sex above 12 years of age admitted in Medicine Department of DMCH, Laheriasarai, Bihar with clinically or radiologically diagnosed stroke. RESULT: The mean level of hsCRP (mean ± s.d.) of the cases in our study was 7.65±7.01 with range 1.4 – 26 and the median was 3.7 and 58% of the cases were having level of hsCRP≥3 (p=0.023).Mean level of hsCRPof cases was signicantly higher than that of control (t98=7.25;p=0.001). CONCLUSION:We concluded that hs-CRPlevel is increased in cases of cerebrovascular accident- ischemic as well as haemorrhagic, suggesting an inammatory response in acute cerebrovascular accident. hs-CRP level is increased in patients with ischemic cerebrovascular accident dramatically but not in haemorrhagic cerebrovascular accident which might be considered as useful adjunct method for determining type of stroke in patients with cerebrovascular problems.

scholarly journals U-Shaped Association between Sleep Duration, C-Reactive Protein, and Uric Acid in Korean Women

2020 ◽  
Vol 17 (8) ◽  
pp. 2657
Author(s):  
Yea-Chan Lee ◽  
Da-Hye Son ◽  
Yu-Jin Kwon
Keyword(s):  
Uric Acid ◽  
Sleep Duration ◽  
High Sensitivity ◽  
Multiple Logistic Regression ◽  
Korean Women ◽  
Regression Analyses ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Health And Nutrition

Serum high-sensitivity C-reactive protein (hsCRP) and serum uric acid (SUA) are biomarkers that predict chronic inflammation and cardiovascular dysfunction. Therefore, we aimed to investigate the association between sleep duration, hsCRP, and SUA in Korean women. Cross-sectional data from the Seventh Korea National Health and Nutrition Examination Survey was analyzed. The odds ratio (OR) and 95% confidence intervals (CIs) for an association between higher hsCRP (>2.0 mg/L) or higher SUA (>5.6 mg/dL) and sleep duration were calculated using multiple logistic regression analyses after adjusting for potential confounders. In total, 6151 women were included in the analysis. There was a U-shaped relationship between continuous sleep duration, hsCRP, and SUA. Compared to those who slept for 7–8 h, the ORs (95% CIs) for higher hsCRP were 1.43 (0.95–2.16) in short sleepers and 1.64 (1.09–2.48) in long sleepers after adjusting for confounders. Compared with those who slept for 7–8 h, the ORs (95% CIs) for higher SUA were 1.54 (1.04–2.26) in short sleepers and 1.94 (1.27–2.96) in long sleepers after adjusting for confounders. We found a U-shaped association between sleep duration, hsCRP, and SUA in Korean women. 7–8 h sleep was associated with lower level of hsCRP and SUA in Korean women.

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