Usefulness of combining serum uric acid and high-sensitivity C-reactive protein for risk stratification of patients with metabolic syndrome in community-dwelling women

BACKGROUND Relationship between serum uric acid and cardiovascular system has been recognised since years. High-sensitivity C-reactive protein (hs-CRP) is a known risk factor for cardiovascular and cerebrovascular events. The role of uric acid as a risk factor for vascular disease and acute stroke is controversial and there is little information about it.1 It is unclear as to whether high uric acid concentrations promote or protect against the development of cerebrovascular disease, or simply acts as a passive marker of increased risk. As serum hs-CRP is an established risk factor for stroke, its positive correlation with serum uric acid levels would suggest that high serum uric acid could predict stroke risk. Also, it would prove to be a more cost-effective investigative tool in our present set up. METHODS In this cross-sectional study, we assessed 100 patients admitted with acute stroke in Victoria and Bowring and Lady Curzon Hospital from October 2016 to November 2018. Clinical records, routine investigations, radiological imaging, serum uric acid and hs-CRP of the patients were investigated. RESULTS Majority of the patients (33 %) belonged to the age group of > 70 yrs., followed by 61 - 70 yrs. (26 %). 69 % of the patients were males and 31 % were females. 67 % of them were hypertensive and 32 % were diabetic. 91 % had an hs-CRP level of > 3.0 mg / L and 8 % had hs-CRP levels between 1.0 and 3.0 mg / L. None of the female patients had a serum uric acid value > 6.5 mg / dL and none of the male patients had a uric acid level of > 7.0 mg / dL. There was a correlation between serum uric acid levels and serum hs-CRP levels in patients ≤ 50 yrs. of age. There was no correlation between serum hs-CRP levels and serum uric acid levels in patients more than 50 yrs. of age. CONCLUSIONS Our study showed that stroke is most common in persons > 70 yrs. of age and is more common in males compared to females. Hypertension is an independent risk factor for stroke. hs-CRP is a well-established risk marker for stroke, being raised in majority of stroke patients. Serum uric acid is not raised in all patients of acute stroke. So, it cannot be used as a risk marker for stroke. KEY WORDS hs-CRP, Serum Uric Acid, Acute Stroke

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High-sensitivity c-reactive protein and gamma-glutamyl transferase levels are synergistically associated with metabolic syndrome in community-dwelling persons

Cardiovascular Diabetology ◽

10.1186/1475-2840-9-87 ◽

2010 ◽

Vol 9 (1) ◽

pp. 87 ◽

Cited By ~ 20

Author(s):

Ryuichi Kawamoto ◽

Yasuharu Tabara ◽

Katsuhiko Kohara ◽

Tetsuro Miki ◽

Tomo Kusunoki ◽

...

Keyword(s):

Metabolic Syndrome ◽

High Sensitivity ◽

Community Dwelling ◽

Gamma Glutamyl Transferase ◽

C Reactive Protein ◽

Gamma Glutamyl ◽

Reactive Protein ◽

Glutamyl Transferase

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Reduced High-Molecular-Weight Adiponectin and Elevated High-Sensitivity C-Reactive Protein Are Synergistic Risk Factors for Metabolic Syndrome in a Large-Scale Middle-Aged to Elderly Population: the Shimanami Health Promoting Program Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2007-0397 ◽

2008 ◽

Vol 93 (3) ◽

pp. 715-722 ◽

Cited By ~ 34

Author(s):

Yasuharu Tabara ◽

Haruhiko Osawa ◽

Ryuichi Kawamoto ◽

Rieko Tachibana-Iimori ◽

Miyuki Yamamoto ◽

...

Keyword(s):

Metabolic Syndrome ◽

Molecular Weight ◽

High Molecular Weight ◽

Metabolic Disorders ◽

High Sensitivity ◽

Community Dwelling ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein ◽

Hmw Adiponectin

Abstract Objective: In Western countries, one of the most important modifiable targets for the prevention of cardiovascular diseases is metabolic syndrome. Adiponectin is an adipose tissue-specific plasma protein that inversely associates with metabolic syndrome. Among several molecular isoforms, high-molecular-weight (HMW) complex is considered the active form. Increased serum high-sensitivity C-reactive protein (hsCRP) concentration also associates with metabolic syndrome, and adiponectin could modulate plasma C-reactive protein levels. Here, through cross-sectional investigation, we investigated whether reduced HMW adiponectin and increased hsCRP levels in plasma are synergistically associated with metabolic syndrome. Measurement of HMW complex of adiponectin is one of the novelties of this study. Design: We analyzed 1845 community-dwelling middle-aged to elderly subjects (62 ± 13 yr). Plasma HMW adiponectin levels were measured by ELISA. Clinical parameters were obtained from the subjects’ personal health records, evaluated at their annual medical check-up. Results: Each component of metabolic syndrome, except for raised blood pressure, showed significantly lower plasma HMW adiponectin concentrations for both men and women (P < 0.001). In contrast, plasma hsCRP levels were significantly higher in subjects with metabolic disorders (P < 0.001). After adjusting for other confounding factors, HMW adiponectin [log normalized, odds ratio 0.084 (95% confidence interval 0.050–0.142), P < 0.001] and hsCRP [3.009 (2.175–4.163), P < 0.001] were identified as independent determinants of metabolic syndrome. In addition to the direct associations, we also observed a synergistic effect between these two molecules (F = 11.8, P < 0.001). Conclusions: Reduced HMW adiponectin and elevated hsCRP are synergistically associated with the accumulation of metabolic disorders. The combination of these markers would be useful for identifying at-risk populations.

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Acute Ingestion of Montmorency Tart Cherry Reduces Serum Uric Acid but Has no Impact on High Sensitivity C-Reactive Protein or Oxidative Capacity

Plant Foods for Human Nutrition ◽

10.1007/s11130-021-00879-7 ◽

2021 ◽

Author(s):

Angela R. Hillman ◽

Kathy Uhranowsky

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

High Sensitivity ◽

Oxidative Capacity ◽

Tart Cherry ◽

C Reactive Protein ◽

Reactive Protein ◽

Acute Ingestion

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HUBUNGAN KADAR ASAM URAT SERUM DENGAN KADAR HIGH-SENSITIVITY C-REACTIVE PROTEIN PADA REMAJA OBES

Jurnal e-Biomedik ◽

10.35790/ebm.2.1.2014.3756 ◽

2014 ◽

Vol 2 (1) ◽

Author(s):

Agustinus Mahardhika Sarayar

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Obese Subject ◽

High Sensitivity ◽

C Reactive Protein ◽

Cross Sectional ◽

Obese Adolescents ◽

Reactive Protein ◽

Hs Crp ◽

Spearman Test

Abstract: Uric acid has low water solubility. When the concentration exceeds its solubility, it will form monosodium urate (MSU) crystals which can trigger inflammation. High sensitivity C-reactive protein (hs-CRP) is one of the most liable inflammatory biomarker and recently considered as major modifiable risk factor of coronary heart disease. Serum uric acid and hs-CRP levels are often elevated in obese patients. The purpose of this study are to determine hs-CRP and serum uric acid levels and to determine the correlation between serum uric acid and hs-CRP levels in obese adolescents. This is an analytic observational study with cross sectional design. Subject consist of 17 obese adolescents age 17-20 years with percentile of ≥ 95 in CDC BMI-for-age chart. Nonparametric analysis with Spearman test was applied to find the correlation between serum uric acid and hs-CRP levels. The mean serum uric acid and hs-CRP levels in obese subjects were 7.37 (SD 1.66) mg/dL and 1.73 (SD 1.44) mg/L respectively. In conclusion, a statistically insignificant correlation between serum uric acid and hs-CRP levels was found (p = 0.296, r = 0.14). Serum uric acid levels are consistently higher in obese adolescents. Hs-CRP levels among obese subject shows moderate risk of developing cardiovascular disease in the future. Keywords: Adolescents, hs-CRP, obese, serum uric acid Abstrak: Asam urat memiliki kelarutan yang rendah dalam air. Saat konsentrasi asam urat melebihi batas ambang solubilitas, akan terbentuk kristal monosodium urat yang akan memicu inflamasi. High sensitivity C-reactive protein (hs-CRP) merupakan salah satu biomarker inflamasi yang belakangan ini dijadikan faktor risiko mayor yang dapat dimodifikasi dari penyakit jantung koroner. Kadar asam urat serum dan hs-CRP biasanya meningkat pada penderita obesitas. Tujuan dari penelitian ini untuk mengetahui hubungan kadar asam urat serum dengan hs-CRP serta gambaran kadar asam urat serum dan hs-CRP pada remaja obes. Penelitian ini menggunakan desain penelitian analitik observasional dengan pendekatan cross-sectional. Subjek terdiri dari 17 remaja obes usia 17-20 tahun dengan persentil ≥ 95 pada grafik IMT terhadap usia CDC. Analisis data menggunakan Spearman test digunakan untuk mengetahui korelasi antara kadar asam urat serum dengan hs-CRP. Nilai rata-rata kadar asam urat serum dan hs-CRP yang didapat secara berurutan mencapai 7,37 (SD 1,66) mg/dL dan 1,73 (SD 1,44) mg/L. Sebagai kesimpulan, hubungan kadar asam urat serum dengan hs-CRP tidak signifikan (p = 0,296) dan berkorelasi positif lemah (r = 0,14). Kadar asam urat serum pada remaja obes tergolong tinggi. Kadar hs-CRP remaja obes termasuk dalam risiko menengah untuk terkena penyakit kardiovaskular di masa mendatang. Kata kunci: Asam urat serum, hs-CRP, Obesitas, Remaja

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